期刊名称：CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Aims & Scope
2007 Impact Factor: 5.037
Ranking: 1/25 (Medical Laboratory Technology)
?Thomson Scientific, Journal Citation Reports? 2008
Today's Clinical Laboratory occupies a central role in the diagnosis and management of illness, whether it be among hospital inpatients or outpatients, and in the prevention and detection of disease among apparently healthy persons living and working in the community. Its workload is constantly increasing as a consequence of a population that is both growing and aging, a rising proportion of subjects under life-long therapy for chronic diseases, the steady progression of new drugs and novel forms of treatment stemming from the activities of the industrial arm of Health Care, and the unwelcome advent of new diseases.
To meet these challenges, those whose vocation brings them within the domain of the Clinical Laboratory are required to understand and exploit a wide range of natural and applied sciences, many of which were unheard of a century ago. The educational mind-sets that determine the training of such individuals at the University level are twofold: scientists are required to learn more and more about less and less, while physicians have seen their undergraduate years significantly reduced by comparison with their predecessors in favor of postgraduate training and a future devoted to self-directed learning. How will clinical scientists be able to broaden their narrow primary knowledge base to include the vocabulary, concepts, and information from the various fields of medicine that they require to perform their work? How can laboratory physicians keep pace with the explosive developments taking place in scientific disciplines that directly impact their daily activities? This Journal was founded to meet the needs of both these constituencies and to establish a bridge between them. The Editorial Staff strive to ensure the inclusion of sufficient introductory background material in each article to allow a non-specialist reader to understand the text that follows. Jargon is excised or liberally defined. Illustrations are encouraged to display in a comprehensible way the inter-relationships of mechanisms, reactions, and pathways under discussion. Emphasis is devoted to the timeliness and completeness of the bibliography, which is intended not merely to support and validate the statements and conclusions of the text, but also to serve as a learning resource.
Reviews are usually solicited from international experts on the advice of a panel of individuals collectively forming the Editorial Advisory Board. However, we encourage other authors to submit outlines of proposed reviews to the Editor-in-Chief for consideration, following which a formal invitation may be issued. Primary authors are encouraged to recruit collaborators to help in forging a representative consensus and comprehensive coverage of the selected topic. The adjective “Critical?implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial. Sound judgment free of individual prejudice should guide the choice of themes and the findings that illustrate them. A single expert is assigned the task of refereeing the paper, and his name appears in the credits. This open process goes a long way towards promoting a fairer review than may be the case when the identity of the referee is concealed by the mask of anonymity. Conversely, no scientist will want his or her name to be associated with an inferior publication. Many of our reviews seriously impact the work of non-laboratory personnel (investigators and educators) in the scientific domains to which they are relevant and are frequently cited in the literature of that specialty. The emphasis upon “Sciences?generally disqualifies topics of a professional nature (such as instrumentation, quality assurance, and methodology) unless they are based upon novel scientific concepts.
Inevitably, not all that we publish will completely fulfill the ambitious criteria that we have stipulated, but it is our belief that most will reach a level of interest, usefulness, and quality sufficient to win them an enviable status in the body of literature upon which the Clinical Laboratory Sciences are based.
Instructions to Authors
Instructions for Authors
1. General Instructions. Manuscripts are usually accepted for review by invitation of the Editor-in-Chief on the recommendation of the Editorial Advisory Board. Authors wishing to receive an invitation are encouraged to submit an outline of a prospective paper. All correspondence should be forwarded to Dr. John R. Burnett, Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Wellington Street Campus, GPO Box X2213, Perth WA 6847 Australia; phone: 61-8-9224-3121, e-mail: john.burnett@health.wa.gov.au.
All papers should be submitted via the Journal's online Manuscript Central system - http://mc.manuscriptcentral.com/bcls. The general text of the document should be submitted as a Microsoft Word file. All tables and figures should be submitted as separate digital files. Each new submission should include a list of up to five (at least three) experts competent to review the paper, together with their full co-ordinates.
The review process usually takes 4-8 weeks, after which a set of recommendations is submitted to the author(s) for consideration. The final revision should be returned as described above.
2. Authorship. While this Journal encourages collaborative authorship, the guidelines developed by the International Committee of Medical Journal Editors should be followed. This requires that only authors who have contributed significantly to the preparation of the manuscript should be named in the credits. Colleagues of the author(s) who have offered advice and criticism or who may have made significant contributions to their research do not qualify on these grounds alone. Instead, they may quite properly be named in the Acknowledgments. The senior (corresponding) author should be indicated on the title page together with full co-ordinates.
3. Significance. A brief statement of up to 50 words must be provided in the text indicating the importance and relevance of the topic under review, and the fields of interest to which it applies. This is not intended as a summary, but will appear, possibly with editorial modification, below the title information in the Table of Contents as a means to interest potential readers.
4. Preparation of Manuscript. Manuscripts must be double-spaced, with margins of one inch on all sides. All pages should be numbered consecutively, starting with the title page. Tables and figures should not appear in the actual text, but should be submitted as separate digital files as per the instructions on Manuscript Central. Including all of the foregoing material, published papers are typically 25 to 75 printed journal pages in length (approximately 500 words per page). The minimum text length should be about 7,500 words. Authors may include previously unpublished data that may help to clarify an ongoing controversy. They should write in clear, concise English. Language and grammar should be consistent with Fowler's English Usage; spelling and meaning of words should conform to Webster's Dictionary. Latin terminology, including microbiological and species nomenclature, should be italicized. Use standard convention for human and animal genes and proteins: italics for genes and regular font for proteins, and upper case for human products and lower case for animal products. Extensive rewriting of the text will not be undertaken by the Editorial Staff. Material taken from previous reviews by the author(s) on the same topic may be included provided that this represents less than 50% of the manuscript; additionally, the relationship between the present and past reviews should be clearly stated in the Introduction, and an interval of at least two years should have elapsed between the dates of submission of the final versions of the new and the most recent of the previous reviews.
5. Abstract. This should comprise 100 to 200 words summarizing the central core of knowledge that is the focus of the review. It should be intelligible to the non-expert without further reference to the text.
6. Keywords. At least 10 should be provided in alphabetical order, without repeating terms already in the title, using the MeSH database to find Medical Subject Heading Terms (http://www.nlm.nih.gov/mesh).
7. Running Head. Please attach an abbreviated version of the title not exceeding 50 character spaces to serve as a running head.
8. Abbreviations and Glossary. All non-standard abbreviations must be fully defined when first used, including in the Abstract. Once defined, each abbreviation, and not the text for which it stands, should be consistently used thereafter. In addition, all abbreviations should be compiled in alphabetical order into a comprehensive list that will appear on the first page of the article. Most fields of medical science use combinations of letters and numbers to represent various entities such as genes, transcription factors, signal transducers, cytokines, cell cultures, etc. Authors owe a duty to their non-expert readers to explain the nature and action of these terms which are not strictly abbreviations. This can be most readily achieved by including them in the Abbreviations and Glossary followed by a brief description, e.g., tumor suppressor gene product, cell cycle inhibitor, mouse kidney cell line.
9. Headings. The general style of headings is as follows:
I. HEADING ONE - CAPS, BOLD
A. Heading Two - Title Case, Bold
1. Heading 3 - Title Case, Italic, Bold
a. Heading Four - Title Case, Italic
10. Introduction. For the benefit of non-expert readers, this should provide a sufficient background to the topic under review. Basic scientists should be aware that many clinicians will be included in the readership, while authors from the clinical disciplines should likewise seek to make their work intelligible to scientific professionals operating outside the health care environment. It is in this aspect that well-chosen illustrative material and a list of general references can be most useful.
11. Conclusion. The final section should bear this title. It is to be used to summarize progress made to the present, advances that appear likely in the next few years, and the major issues that remain to be resolved. Avoid overlap with the Abstract in its preparation.
12. Units. Always use SI units. Concentrations should be expressed as either moles or grams per liter or recognized multiples thereof using the prefixes k, m, m, n, p, etc. Standard SI abbreviation such as g (gram); L (liter); mol (mole); h (hour); min (minute); m (meter); s (seconds); cal (calories); U (unit of enzyme or hormone activity); Hz (hertz) should be used. Do not use fractional expressions; convert all such terms to percentages.
13. References. A comprehensive bibliography is expected, and will usually comprise more than 100 references. All citations must be drawn from peer-reviewed journals, textbooks, or treatises that are generally available. Abstracts, letters, theses, and conference proceedings (unless published in book form or within the contents of a peer-reviewed journal) will not be permitted. Personal communications may be cited in the text but may not be listed as references. Work of the author(s) or of other investigators that has been accepted but not yet published may be included if evidence of acceptance is provided.
All references should be numbered strictly in the order in which they are first cited, appearing as superscript at the end of the statement or sentence to which they are relevant, and following any punctuation mark. Follow these examples in numbering references: 2 references12,14, several contiguous references12-15. Such sequences as12-15 cited for the first time should always be numbered in chronological order. Where multiple references are cited, especially where some have already been used earlier, they should be in numerical order irrespective of chronology. References mentioned for the first occasion in Tables or Figures should be numbered from the point at which such Table or Figure is first described in the text.
Use the system of journal abbreviations employed by MEDLINE/PubMed, giving the names of ALL authors, surnames followed by initials and punctuated as in the example below. Italics or boldfaced type should be used as indicated. Inclusive page numbers must be provided. Article titles should be lower case even if this differs from the original, but in all other respects the original should be meticulously followed. For books, the names of all authors (or editors) must be included and the title should be lower case and italicized. The name and address of publisher and year of publication should be provided in the order and with the punctuation illustrated below. The edition should be stated if there is more than one. For book chapters, additional information must include the names of all authors, title of the chapter in lower case (not italicized), and inclusive page numbers.
Sauter BV, Martinet O, Zhang WJ, Mandeli J, Woo SL. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc Natl Acad Sci USA 2000; 97: 4802-4807.
Schuchman EH, Desnick RJ. Niemann-Pick disease types A and B: Acid sphingomyelinase deficiencies. In Scriver CR, Beaudet AL, Valle D, Sly WS, Eds. The Metabolic and Molecular Basis of Inherited Disease, 8th Ed. Pp 3601-3602. New York: McGraw-Hill, 2001.
14. Tables. These are encouraged as a means of displaying data illustrating or proving certain conclusions or opinions. We strive for consistency in Table format, and authors can help enormously by reviewing examples in the journal or those sent to them upon request. Tables should be prepared as Microsoft Word or Excel files. Submit tables as separate digital files.The author should include the appropriate Arabic numeral, along with a descriptive title in title case (first letter capitals). If required, the source of the table should be identified. All abbreviations not previously defined must be listed as footnotes. Indicate the position of the table in the text using the word Table and the appropriate Arabic numeral.
15. Figures. Figures should be submitted digitally as PDF, JPEG, TIFF or PowerPoint files, 300 dpi for photos or slides, and a minimum of 72 dpi for other images such as graphs or figures (small figures should be 300 dpi). Submit figures as separate digital files. If required, the source of the figure should be identified. Make sure that the symbols (open or closed circles, squares, triangles) and the lettering are large enough to be legible when reduced to page or half-page size; that the bars and columns of histograms are sufficiently contrasted (black, open, hatched, stippled); that multiple graphic lines (solid, dotted, broken, etc.) are sufficiently thick; and that solid areas in gray tones are sufficiently contrasted. Ensure that vertical and horizontal scales are numbered at intervals sufficiently infrequent to avoid cluttering and sufficiently often to avoid confusion. Use arrows and letters liberally in photographs of histological sections, whole organs or organisms, electron micrographs, electrophoretic separations, and the results of radiological examination to identify key components of the figure mentioned in the text. It is recommended that magnification be indicated by a line representing the actual scale of reproduction (0.1 mm, 1 mm, 10 mm); if not, this factor must be included in the legend. Number figures clearly. For each, include in the text, following the references, a legend starting with the word FIGURE and the appropriate Arabic numeral (both boldfaced); then a general descriptive title, followed by a key to the various symbols, bars, lines, arrows, and abbreviations not already defined.
There is no charge and no limit for figures; unless they are colored, in which case the author must agree to bear the charges. A letter acknowledging willingness to defray the cost of color reproduction must accompany the final revised manuscript. The charge for the first page of color is $900.00. The next three pages with color are $450.00 each. A custom quote will be provided for color art totaling more than four journal pages. Authors should not submit figures in colour unless they intend to pay for their reproduction.
16. Copyright. Submit written permission from the copyright holder (generally the publisher) for any figures or tables that have been published previously. This is not necessary if the original has been substantially modified. The paper in which the material was first published and the name of the publisher must be indicated in the table heading or figure legend. This journal and its publisher will not be liable for any reproduction fee levied by the copyright holder.
17. Acknowledgments. This is the place to thank colleagues who have helped the author(s) in his (their) research in general, and in the preparation of the submitted manuscript. Agencies that have funded the author's work in the specific field under review may be thanked. Please avoid trivial statements of appreciation.
18. Proofs and Reprints. Correction of the proofs is the responsibility of the author(s) although they will also be checked by the Editorial Staff. A turnaround of 48 hours is required. With the proofs, a reprint order form will be sent. A complimentary issue of the journal in which the paper appears will be sent to the corresponding author.
Instructions to Authors
1040-8363H.pdf
Editorial Board
Editorial Board
Editor-in-Chief
John R. Burnett
Department of Core Clinical Pathology and Biochemistry
PathWest Laboratory Medicine
Royal Perth Hospital
Perth, WA, 6847 Australia
E-mail: john.burnett@health.wa.gov.au
Executive Editor
Lynn C. Allen
Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
RR #3, 10570 Sixth Line
Georgetown, ON, L7G 4S6 Canada
Phone: 905-877-2341
E-mail: lcallen@stn.net
Editor Emeritus
David M. Goldberg
Professor Emeritus
Department of Laboratory Medicine and Pathobiology
University of Toronto
Toronto, ON, Canada
Associate Editor
Mario Plebani
Professor and Head
Department of Laboratory Medicine
Laboratorio Cenrale
Ospidale Civile
Via Giustiniani 2
35128 Padua, Italy
E-mail: mario.plebani@sanita.padova.it
Editorial Advisory Board
Wendy N. Erber - Department of Haematology, Addenbrooke's Hospital, Cambridge, UK
Jose M. Estrela - Department of Physiology, Faculty of medicine and Dentistry, University of Valencia, Valencia, Spain
Robert A. Hegele - Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
C. W. K. Lam - Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong
Ulf-Hkan Stenman - Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
George P. Studzinski - Department of Pathology and Laboratory Medicine, New Jersey Medical School, Newark, New Jersey, USA
Paolo M. Suter - Department of Internal Medicine, University Hospital, Zurich, Switzerland
Orestes Tsolas - Biochemical Laboratory, Sigmal University, Ioannina, Greece
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