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期刊名称：TOXINS ISSN： 2072-6651 出版频率： Monthly 出版社： MDPI, ST ALBAN-ANLAGE 66, BASEL, SWITZERLAND, CH-4052   出版社网址： http://www.mdpi.com/ 期刊网址： http://www.mdpi.com/journal/toxins 影响因子： 4.546 主题范畴： TOXICOLOGY 变更情况： Newly Added by 2013 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Imprint Full Journal Title Toxins ISO4 Abbreviated Title Toxins ISSN (electronic) 2072-6651 CODEN TOXIB7 Publisher MDPI AG Publisher Location Basel, Switzerland Postal Address MDPI AG, Klybeckstrasse 64, 4057 Basel, Switzerland Editors see: Editorial Board Publication Frequency monthly Publication Medium electronic only Publication Website http://www.mdpi.com/journal/toxins First Year Published 2009 Indexing Databases see: Indexing & Abstracting Covered by the Science Citation Index Expanded (SCIE, Web of Science). Impact Factor 2.129 (2012) 5-Year Impact Factor 2.109 (2012) About Toxins Aims Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal: manuscripts regarding research proposals and research ideas will be particularly welcomed electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material we also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds Subject Areas This journal covers toxinology and all kinds of toxins (biotoxins) from animals, microbes and plants. Some types of toxins covered are: aflatoxins exotoxins endotoxins neurotoxins necrotoxins hemotoxins mycotoxins phototoxins any other toxin from animal, plant or microbial origin MDPI Publication Ethics Statement Toxins is a member of the Committee on Publication Ethics (COPE). MDPI takes the responsibility to enforce a rigorous peer-review together with strict ethical policies and standards to ensure to add high quality scientific works to the field of scholarly publication. Unfortunately, cases of plagiarism, data falsification, inappropriate authorship credit, and the like, do arise. MDPI takes such publishing ethics issues very seriously and our editors are trained to proceed in such cases with a zero tolerance policy. To verify the originality of content submitted to our journals, we use CrossCheck (powered by iThenticate) to check submissions against previous publications. Book Reviews Authors and publishers are encouraged to send review copies of their recent related books to: MDPI AG Alexander Thiesen Klybeckstrasse 64 CH-4057 Basel Switzerland Received books will be listed as Books Received within the journal's News & Announcements section. Copyright / Open Access Articles published in Toxins will be Open-Access articles distributed under the terms and conditions of the Creative Commons Attribution License. MDPI will insert following note at the end of the published text: © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/). Reprints Reprints may be ordered. Please contact publisher@mdpi.com for more information on how to order reprints. Announcement and Advertisement Announcements regarding academic activities such as conferences are published for free. Advertisement can be either published or placed on the pertinent website. Contact e-mail address is toxins@mdpi.com. Toxins — Indexing & Abstracting Toxins is covered by following databases and archives: Indexing & Abstracting Services AGORA (FAO) Biological Abstracts (Thomson Reuters) BIOSIS Previews (Thomson Reuters) CAB Abstracts (CABI) CAS - Chemical Abstracts (ACS) DOAJ - Directory of Open Access Journals EMBASE (Elsevier) FSTA - Food Science and Technology Abstracts (IFIS) Global Health (CABI) Journal Citation Report (Thomson Reuters) MEDLINE (NLM) PubMed (NLM) SCIE - Science Citation Index Expanded (Thomson Reuters) SciSearch (Thomson Reuters) Scopus (Elsevier) Web of Science (Thomson Reuters) Full-text Archives CLOCKSS e-Helvetica (Swiss National Library Archive) LOCKSS (Digital Archive System) PubMed Central (NLM) Content Aggregators EBSCOhost (EBSCO Publishing) J-Gate (Informatics India) Instructions to Authors Toxins — Instructions for Authors Please first read the section 'Aims & Scope' to have an overview, and to assess if your manuscript is suitable for this journal. Shortcuts Submission Manuscript Preparation Potential Conflicts of Interest Peer-Review and Editorial Procedure Review / Referees English Corrections MDPI Publication Ethics Statement Supplementary Material Please use the MS Word template or LaTeX template to prepare your paper. Submission of Manuscripts Submission Process: Manuscripts for Toxins should be submitted online using the MDPI Submission System (SuSy) at susy.mdpi.com. To submit your manuscript using SuSy, register and log in to this website. Once you are registered, click here to go to the submission form for Toxins. Accepted File Formats: Microsoft Word: Manuscript prepared in MS Word must be converted into a single file before submission. When preparing manuscripts in MS Word, the Toxins Microsoft Word template file must be used. Please do not insert any graphics (schemes, figures, etc.) into a movable frame which can superimpose the text and make the layout very difficult. LaTeX: Manuscripts prepared in LaTeX must be zipped into one ZIP folder (include all source files and images, so that the Editorial Office can modify the manuscript before peer-review, if needed). Ensure to send a copy of your manuscript as a PDF file also, if you decided to use LaTeX. When preparing manuscripts in LaTeX, please use the Toxins LaTeX template files. Coverletter: Please provide a short cover letter where you detail the reasons why the editors of Toxins should consider your paper for publication in this journal. Check in your cover letter whether you supplied at least 5 possible referees. Check if the English corrections are done before submission. Note Regarding Conference Papers: Expanded and high quality conference papers are also considered in Toxins if they fulfill the following requirements: (1) The paper should be expanded to the size of a research article. (2) The conference paper should be cited and mentioned as a footnote on the first page of the paper. (3) If the authors do not hold the copyright to the published conference paper, authors should seek the appropriate permission from the copyright holder. (4) Authors are asked to disclose the conference paper in their cover letter including a statement on what has been changed compared to the conference paper. [Return to top] Manuscript Preparation Paper Format: A4 paper format, the printing area is 17.5 cm x 26.2 cm. The margins should be 1.75 cm on each side of the paper (top, bottom, left, and right sides). Formatting / Style: The paper style of Toxins should be followed. You may download a template file from the Toxins homepage to prepare your paper. It is not necessary to follow the manuscript structure showed in the template file for review papers. Authors List and Affiliation Format: Authors' full first and last names must be given. Abbreviated middle name can be added. For papers written by various contributors a corresponding author must be designated. The PubMed/MEDLINE format is used for affiliations: complete address information including city, zip code, state/province, country, and email address should be added. All authors who contributed significantly to the manuscript (including writing a section) should be listed on the first page of the manuscript, below the title of the article. Other parties, who provided only minor contributions, should be listed under Acknowledgments only. A minor contribution might be a discussion with the author, reading through the draft of the manuscript, or performing English corrections. Abstract and Keywords: The abstract should be prepared as one paragraph of about 200 words. For research articles, abstracts should give a pertinent overview of the work, its purpose, the main methods or treatments applied; summarize the article's findings or facts and indicate the authors' conclusions or interpretation. As such, the abstract aims at being an objective representation of the article and must not contain results or data which are not presented and substantiated in the main text. Note that abstracts serve two main purposes: on one hand abstracts are used by potential readers to assess the relevancy of an article for their own work. On the other hand, abstracts are used by indexing databases to catalog articles appropriately. Also, three to 10 pertinent keywords need to be added after the abstract. We recommend that the abstract and the keyword list use words that are specific to the article yet reasonably common within the subject discipline. Abstract Graphic: Authors are encouraged to provide a self-explanatory graphical abstract of the paper to be used along with the abstract on the Table of Contents and search results. The graphic should not exceed 600 pixels width/height and can be provided as a PDF, JPG, PNG or GIF file. Figures, Schemes and Tables: Authors are encouraged to prepare figures and schemes in color. Full color graphics will be published free of charge. We kindly request authors to provide figures and schemes at a sufficiently high resolution (min. 600 pixels width, 300 ppi). Figures and schemes must be numbered (Figure 1, Scheme I, Figure 2, Scheme II, etc.) and a explanatory title must be added. Tables should be inserted into the main text, and numbers and titles for all tables supplied. All table columns should have an explanatory heading. To facilitate the copy-editing of larger tables, smaller fonts may be used, but in no case should these be less than 10 pt in size. Authors should use the Table option of MS Word to create tables, rather than tabs, as tab delimited columns are often difficult to format for the final PDF output. Please supply captions for all figures, schemes and tables. The captions should be prepared as a separate paragraph of the main text and placed in the main text before a table, a figure or a scheme. Conflicts of Interest: Authors must identify and declare any personal circumstances or interest that may be perceived as inappropriately influencing the representation or interpretation of reported research results. If there is no conflict of interest, please state "The authors declare no conflict of interest." This should be conveyed in a separate "Conflicts of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Financial support for the study must be fully disclosed under the "Acknowledgments" section. Acknowledgments: Please clearly indicate grants that you have received in support of your research work (including funds for covering the costs to publish in open access). Note that some funders will not refund article processing charges (APC) if the funder and grant number are not clearly identified in the paper. The Acknowledgments section is placed just before the References section. References: Please ensure that a comprehensive list of all relevant references is provided, and that all references are cited within the paper. References should preferably be prepared with a bibliography software package, such as Zotero, EndNote or ReferenceManager. If references are prepared manually they must be checked for integrity and correctness. Reference Formatting: All the references mentioned in the text should be listed separately and as the last section at the end of the manuscript, and be numbered consecutively throughout the paper. Do not repeat references in the references list. Reference numbers should be placed in square brackets [ ], and placed before the punctuation; for example [4] or [1-3]. For embedded citations in the text with pagination, use both parentheses and brackets to indicate the reference number and page numbers; for example [5] (p. 10). or [6] (pp. 101–105). Include the full title for cited articles. See the Reference Preparation Guide for more detailed information. Electronic Supplementary Information (ESI): Conference slides, video sequences, software, etc., can be included with the submission and published as supplementary material. Please read the information about Supplementary Material Deposit beneath. [Return to top] Potential Conflicts of Interest It is the authors' responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there is no conflict, please state here "The authors declare no conflict of interest." This should be conveyed in a separate "Conflicts of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Financial support for the study must be fully disclosed under "Acknowledgments" section. [Return to top] Peer-Review and Editorial Procedure Initial Check All submitted manuscripts are received by the Editorial Office. The in-house Managing Editor will perform a preliminary check of the manuscript to assess if: it suits the scope of the journal, whether it is properly prepared, and whether the manuscript follows the ethical policies of the journal. In case of doubt, the Managing Editor may consult with the journals’ Editor-in-Chief or an Editorial Board member. Manuscripts that do not fit the journal or are not in line with our ethical policy may be rejected before peer-review. Manuscripts that are not properly prepared will be returned to the authors for revision and resubmission. Expert Peer-Review Once a manuscript passes the initial check, it will be assigned to several independent experts for peer-review. Experts may include past and present Editorial Board members and Guest Editors of the journal. However, we also actively seek other experts, which are identified during literature searches. Potential referees suggested by the authors are also carefully considered. As a general rule, referees should not have published with one or more of the co-authors during the past five years and should not currently work or collaborate with one of the institutes of the co-authors of the manuscript under consideration. At least two expert opinions will be collected for each manuscript. Revisions and Editorial Decision Based on the comments from the outside referees, the Editorial Office will usually ask the authors for minor or major revisions. If the comments are either very positive or very negative, the Editorial Office may directly ask the academic editor (usually the Editor-in-Chief or a Guest Editor) for a decision. Otherwise, the manuscript will be sent back to the authors for minor or major revisions. In case of minor revisions, the Editorial Office will ask the academic editor for a final decision on the revised version of the manuscript. In case of major revisions, the manuscript will usually be sent back to one or more of the outside referees before sending the paper to the academic editor for a decision. We allow a maximum of two rounds of major revisions. Author Appeals Authors may appeal editorial decisions by sending an e-mail to the Editorial Office of the journal. The Managing Editor of the journal will forward the manuscript and relating information (including the identities of the referees) to an appropriate Editorial Board member of the journal. If no appropriate Editorial Board member is available, the editor will identify a suitable external scientist. The Editorial Board member may judge the paper by himself or request additional expert opinions to judge the manuscript. The Editorial Board member will be asked to give an advisory recommendation on the manuscript. If the manuscript is rejected based on the Editorial Board member review, the decision will be final and cannot be revoked. Production and Publication Once accepted, a manuscript will undergo our standard production procedure. This entails professional copy-editing of the paper, English editing, proofreading by the authors, final corrections, pagination and publication on the www.mdpi.com website. [Return to top] Peer-Review / Referees During the submission process, authors are asked to suggest five potential referees with the appropriate expertise to review the manuscript. The editors will not necessarily approach these referees. Please provide as detailed contact information as possible (address, homepage, phone, e-mail address). The proposed referees should be experts in the field who can provide an objective report—they should not be current collaborators of the co-authors nor have published with any of the co-authors of the manuscript within the last 5 years. Proposed referees should be from different institutions to the authors. You may identify appropriate Editorial Board members of the journal as potential referees. Another possibility is to select referees from among the authors that you frequently cite in your paper. [Return to top] English Corrections This journal is published in English, so it is essential that for proper refereeing and quick publication all manuscripts are submitted in grammatically correct English. If you are not a native English speaker, we strongly recommend that you have your manuscript professionally edited before submission. Professional editing will mean that reviewers are better able to read and assess your manuscript. English-language editing will: improve grammar, spelling, and punctuation; improve clarity and resolve ambiguity; and ensure that the tone of the language is appropriate for an academic journal. We suggest that for this purpose your manuscript be revised by an English speaking colleague before submission. Authors can also use one of the English editing services for this purpose. Use of any editing supplier is not compulsory, and will not guarantee acceptance or preference for publication in Toxins. Additional information: see the English Editing Guidelines for Authors. [Return to top] Publication Ethics Statement Toxins is a member of the Committee on Publication Ethics (COPE). MDPI takes the responsibility to enforce a rigorous peer-review together with strict ethical policies and standards to ensure to add high quality scientific works to the field of scholarly publication. Unfortunately, cases of plagiarism, data falsification, image manipulation, inappropriate authorship credit, and the like, do arise. MDPI takes such publishing ethics issues very seriously and our editors are trained to proceed in such cases with a zero tolerance policy. [Return to top] Supplementary Material Deposit In order to maintain the integrity of research records, we encourage authors to send supplementary data and files in electronic format, so that important scientific data and information is retained in full. Supplementary data and files can be uploaded as "Supplementary Files" during the manuscript submission process. The supplementary files will be offered to the referees as part of the peer-review process, although referees are not specifically asked to review supplementary files. Accepted file formats include (but are not limited to): data tables and spreadsheets (text files, MS Excel, OpenOffice, CSV, XML, etc.) text documents (text files, PDF, MS Word, OpenOffice, etc.) images (JPEG, PNG, GIF, TIFF, BMP, etc.) videos (AVI, MPG, QuickTime, etc.) executables (EXE, Java, etc.) software source code Large data sets and files may also be deposited to specialized service providers (such as Figshare) or institutional repositories (preferably those that use the DataCite mechanism).   Editorial Board Toxins — Editors Journal Contact Toxins Editorial Office MDPI AG, Klybeckstrasse 64, 4057 Basel, Switzerland E-Mail: toxins@mdpi.com Tel. +41 61 683 77 34; Fax: +41 61 302 89 18 Editorial Office Editorial Board Section Editorial Boards Animal Venoms Bacterial Toxins Editorial Office Editor-in-Chief Prof. Dr. med. Florian Lang Physiologisches Institut I, Universität Tübingen, Gmelinstrasse 5, D-72076 Tübingen, Germany Tel. +49 (0)7071 29 72194; Fax: +49 (0)7071 29 5618 Website: http://www.physiologie.medizin.uni-tuebingen.de/DepI/#public E-Mail: florian.lang@uni-tuebingen.de Interests: mechanisms and clinical significance of cell volume regulation; erythrocyte death signaling; serum-and glucocorticoid inducible kinase isoforms; physiology and pharmacology of human ion channels and carriers expressed in oocytes; host cell physiology in hostpathogen interaction; mechanisms of apoptotic cell death Section Editor-in-Chief Prof. Dr. Bryan Fry * Venom Evolution Laboratory, School of Biological Sciences, University of Queensland, St. Lucia, QLD, 4072, Australia Website: http://www.venomdoc.com E-Mail: bgfry@uq.edu.au Interests: venom molecular evolution; phylogenetics and structure-function relationships; toxins * Section 'Animal Venoms' Section Editor-in-Chief Prof. Dr. Vernon L. Tesh * Department of Microbial and Molecular Pathogenesis, Medical Research and Education Building, Room 3002, College of Medicine, Texas A&M University System Health Science Center, 8447 State Highway 47, Bryan, TX 77807, USA Tel. +1 979 436 0357; Fax: +1 979 845 3479 Website: http://medicine.tamhsc.edu/basic-sciences/mmp/faculty/vernon-tesh.html E-Mail: tesh@medicine.tamhsc.edu Interests: shiga toxins; verotoxins; ribosome-inactivating proteins; intracellular signaling pathways activated by microbial toxins; ER stress response; regulation of cytokine expression; innate immune response to microbial toxins; microbial pathogenesis * Section 'Bacterial Toxins' Editor Ms. Kathy Lai MDPI Haidian Office, Yingu Mansion, Suite 815, North 4th Ring Road West, 9, Haidian District, Beijing 100190, China Tel. +86 10 6280 0830 E-Mail: kathy.lai@mdpi.com Publisher Dr. Shu-Kun Lin MDPI AG, Klybeckstrasse 64, CH-4057 Basel, Switzerland Tel. +41 79 322 33 79 Website: http://www.mdpi.org/lin/ E-Mail: lin@mdpi.com Editorial Board Prof. Dr. Arturo Anadón Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040-Madrid, Spain Tel. +34 1 394 38 34; Fax: +34 1 394 38 40 Website: http://ec.europa.eu/food/fs/sc/scan/cv/cv_anadon_en.pdf E-Mail: anadon@vet.ucm.es Interests: neurotoxicity; toxicokinetics Prof. Dr. Michael Aschner Department of Pediatrics, 2215-B Garland Avenue, 11415 MRB IV, Vanderbilt University, Medical Center, Nashville, TN 37232-0414, USA Tel. +1 615 322 8024; Fax: +1 615 936 4080 Website: http://kc.vanderbilt.edu/site/people/show.aspx?id=8993 E-Mail: michael.aschner@vanderbilt.edu Interests: transport mechanisms from the periphery into the brain; developmental neurotoxicology; role of metals in neurodegeneration; gulf war syndrome Dr. Charles W. Bacon Toxicology and Mycotoxin Research, Russell Research Center, 950 College Station Road, Athens, GA 30604, USA Tel. +1 706 546 3158; Fax: +1 706 546 3116 Website: http://www.ars.usda.gov/pandp/people/people.htm?personid=232 E-Mail: charles.bacon@ars.usda.gov Interests: regulation and biosynthesis of mycotoxins; fungal endophyte-grass relationships; bacterial endophytes, and the coevolution of secondary products; primarily mycotoxins, with grasses and other plants, as an adaptive strategy for mutualistic associations Contribution: Special Issue: Evolutionary/Phylogenetic Studies of Mycotoxin Biosynthetic Pathways Prof. Dr. John P. Berry Department of Chemistry and Biochemistry, Florida International University (FIU), 354/332 Marine Science, Biscayne Bay Campus, 3000 NE 151st St., North Miami, FL 33181, USA Tel. +1 305 919 4569; Fax: +1 305 919 4030 Website: http://www.fiu.edu/~berryj/ E-Mail: john.berry@fiu.edu Interests: cyanobacteria; toxins; bioactive compounds; zebrafish embryo model; natural products Contribution: Special Issue: Algal Toxins Special Issue: Cyanotoxins In other journals: Special Issue: Algal Toxins Dr. Deepak Bhatnagar Research Leader, Food and Feed Safety Research, USDA/ARS/, Southern Regional Research Institute, New Orleans, Louisiana 70124, USA Tel. +1 504 286 4388; Fax: +1 504 286 4269 Website: http://www.ars.usda.gov/pandp/people/people.htm?personid=446 E-Mail: deepak.bhatnagar@ars.usda.gov Interests: mycotoxins; secondary metabolism; genomics; toxin biosynthesis; Aspergillus species Contribution: Special Issue: Aflatoxins Prof. Dr. Wayne Briner Department of Psychology, Ashford University, 8620 Spectrum Center Blvd, San Diego, CA 92123 USA Tel. +858 705 2294 E-Mail: wayne.briner@ashford.edu Interests: neurotoxicology; heavy metals; teratology; behavioral teratology Contribution: In other journals: Special Issue: Heavy Metals and Health Special Issue: Heavy Metals Toxicology Dr. Jeffrey W. Cary Molecular Biologist USDA, ARS, SRRC, 1100 Robert E. Lee Blvd., New Orleans, LA 70124-4305, USA Tel. +1 504 286 4264; Fax: +1 504 286 4533 Website: http://www.ars.usda.gov/pandp/people/people.htm?personid=907 E-Mail: jeff.cary@ars.usda.gov Interests: molecular biology of mycotoxin biosynthesis and regulation; fungal-host plant interactions; secondary metabolism; gene clusters; genomics; antifungal peptides; transgenic approaches to mycotoxin elimination in plants Contribution: Special Issue: Advances in Mycotoxin Research Prof. Dr. Sang Ho Choi NRL of Molecular Microbiology and Toxicology, Department of Food Biotechnology, Seoul National University, Seoul 151-921, Korea Tel. +82 2 880 4857; Fax: +82 2 873 5095 Website: http://fst.snu.ac.kr/ E-Mail: choish@snu.ac.kr Interests: molecular biology of food-borne pathogenic bacteria; expression and regulation of genes encoding microbial virulence factors; quorum sensing of microorganisms; functional genomics of survival and toxigenesis of food-borne pathogenic bacteria Prof. Dr. Jean E. Crabtree Molecular Gastroenterology Section, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds LS9 7TF, UK Website: http://www.limm.leeds.ac.uk/research_sections/molecular_gastroenterology/groups/crabtree.htm E-Mail: j.crabtree@leeds.ac.uk Interests: Helicobacter pylori; host-pathogen interactions in gastrointestinal tract; infection and gastrointestinal cancer; mucosal immunology Contribution: In other journals: Special Issue: Gastric Cancer Special Issue: Gut Microbiome Prof. Dr. Daniel R. Dietrich Human and Environmental Toxicology, Jacob-Burckhardtstrasse 25, University of Konstanz, 78457 Konstanz, Germany Tel. +49 7531 883518 (Direct); +49 7531 883171 (Secretary); Fax: +49 7531 883170 Website: http://www.umwelttoxikologie.uni-konstanz.de/en/members/prof-dr-daniel-dietrich/ E-Mail: daniel.dietrich@uni-konstanz.de Interests: natural toxins; mycotoxins; cyanobacterial toxins; mechanisms of toxicity; renal toxicity and carcinogenesis; environemntal and human risk assessment Prof. Dr. Jia-You Fang Graduate Institute of Natural Products, Chang Gung University, Wen-Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan Tel. +886 3 2118800ext5521; Fax: +886 3 2118236 E-Mail: fajy@mail.cgu.edu.tw Interests: pharmaceutics; natural products; dermatology; nanotechnology; drug delivery; pharmacokinetics Contribution: Special Issue: The Toxicity of Natural Products Dr. Carmela Fimognari Laboratory for Genetic and Molecular Toxicology, Department of Pharmacology, University of Bologna, Italy Tel. +39 051 2095636; Fax: +39 051 2095624 Website: http://www.unibo.it/SitoWebDocente/default.htm?UPN=carmela.fimognari@unibo.it E-Mail: carmela.fimognari@unibo.it Interests: 1) antitumour pharmacology: identification of natural agents as potential antitumor drugs and definition of their cellular (analysis of apoptosis/necrosis; cell proliferation; cell-cycle progression; cytodifferentiation) and molecular (level of proteins involved in apoptosis and cell-cycle regulation) mechanism; 2) cellular and genetic toxicology: study of the cellular response after treatment with xenobiotics (cytotoxicity; analysis of DNA and RNA damage; fluorescence in situ hybridization) Contribution: Special Issue: Natural Products for Multi-Targeted Cancer Treatment: Where Are We Now? Prof. Dr. Maria Cristina Fossi Department of Environmental Sciences, University of Siena, Via Mattioli, 4, 53100 Siena, Italy Tel. +39 0 577232913; Fax: +39 0 577232930 Website: http://www.scientificjournals.com/sj/all/AutorenAnzeigeESS/autorenId/90108 E-Mail: fossi@unisi.it Interests: non invasive biomarkers; aquatic toxicology; aquatic environments; xenobiotics; marine mammals; genomics; environmental toxicology; endokrine Disruptoren; endocrine effects of chemicals; ecotoxicological effects; biomarkers Dr. Yukako Fujinaga Laboratory for Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan Tel. +81 6 6879 4250; Fax: +81 6 6879 4252 Website: http://www.biken.osaka-u.ac.jp/act/act_fujinaga_e.php E-Mail: yukafuji@biken.osaka-u.ac.jp Interests: bacterial protein toxins; enterotoxins; mechanism of toxicity; interaction of toxins with epithelial cell barriers Contribution: Special Issue: Bacterial Protein Toxins Prof. Dr. Helmut Greim Institute of Toxicology and Environmental Hygiene, Technical University of Munich, Hohenbachernstrasse 15-17, D-85354 Freising-Weihenstephan, Germany Tel. +49 8161 715600; Fax: +49 8161 715618 E-Mail: helmut.greim@lrz.tum.de Interests: general toxicology; mechanisms of toxicity, especially in mutagenicity and carcinogenicity; mode of action; risk assessment Prof. Dr. Arthur P. Grollman Laboratory of Chemical Biology, Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA Tel. +1 631 444 3080; Fax: +1 631 444 7641 Website: http://www.lcb.stonybrook.edu/ E-Mail: apg@pharm.stonybrook.edu Interests: nephrotoxins, enviromental mutagens Dr. Xiaohua He Research Molecular Biologist, USDA, ARS, WRRC, 800 Buchanan Street, Albany, CA94710, USA Tel. +1 510 559 5823; Fax: +1 510 559 5768 Website: http://www.ars.usda.gov/pandp/people/people.htm?personid=39023 E-Mail: xiaohua.he@ars.usda.gov Interests: molecular tools and technologies for rapid; accurate; and sensitive detection and quantification of zoonotic pathogens and toxins in food; mechanisms of interactions between bacterial toxins and host cells; binding between antigen and antibody or receptors Contribution: Special Issue: Advances in Toxin Detection Dr. Yasuhiko Horiguchi Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan Tel. +81 6 6879 8284; Fax: + 81 6 6879 8283 Website: http://www.biken.osaka-u.ac.jp/act/act_horiguchi_e.php E-Mail: horiguti@biken.osaka-u.ac.jp Interests: structure and domain organization of proteins; cell-to -cell or intracellular signaling; receptors for toxins; membrane-damaging toxins Contribution: Special Issue: Bacterial Protein Toxins Prof. Dr. R. Manjunatha Kini Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, Science Drive 4, 117543 Singapore Tel. + 65 65165235; Fax: + 65 67792486 Website: http://www.dbs.nus.edu.sg/staff/kini.htm E-Mail: dbskinim@nus.edu.sg Interests: protein chemistry; structure-function relationships; protein-protein interaction and protein design and engineering Prof. Dr. Brigitte König Otto-von-Guericke-University, Institute of Medical Microbiology, Molecular Microbiology and Molecular Diagnostics, Leipzigerstr. 44, 39120 Magdeburg, Germany Tel. +49 391 6713353; Fax: +49 391 6713938 Website: http://www.med.uni-magdeburg.de/Institute/Medizinische+Mikrobiologie.html E-Mail: brigitte.koenig@med.ovgu.de Interests: superantigens; microecology; microorganism-host-microorganism interactions; host-medical devices interactions; oxidative stress; staphylococci; enterococci; lactobacilli Dr. Emmanuel Lemichez INSERM U895, C3M, Université de Nice, Bâtiment Universitaire ARCHIMED, 151 route Saint Antoine de Ginestière, BP 2 3194, 06204 NICE CEDEX 3, France Website: http://www.unice.fr/c3m/EN/Equipe6.html E-Mail: lemichez@unice.fr Interests: microbial toxins in host pathogen interactions; host epithelium and endothelium barriers; inflammation; cell cytoskeleton; toxin and bacterial entry; cell signaling : Rho GTPases; regulation by ubiquitination; MAP Kinases Contribution: Special Issue: Cellular Microbiology of Bacterial Toxins Prof. Dr. Stephen P. Mackessy School of Biological Sciences, 501 20th. St., CB 92, University of Northern Colorado, Greeley, CO 80639-0017 USA Tel. +1 970-351-2429; Fax: +1 970-351-2335 Website: http://www.unco.edu/nhs/biology/faculty_staff/mackessy_stephen.htm E-Mail: stephen.mackessy@unco.edu Interests: reptile venom proteomics and evolution; toxin evolution and structure/function relationships; venom proteinases; biochemical ecology of venomous reptiles Dr. Azzam A. Maghazachi Department of Physiology, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, POB 1103, N-0317 Oslo, Norway Tel. +47 22851203; Fax: +47 22851279 E-Mail: azzam.maghazachi@medisin.uio.no Interests: drug toxicity; autoimmunity; innate immunity; lysophospholipids; chemokines Contribution: Special Issue: Toxicity and Therapeutic Interventions in the Immune System Prof. Dr. Richard A. Manderville Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada Tel. +1 519 824 4120; Fax: +1 519 766 1499 Website: http://www.chembio.uoguelph.ca/manderville/ E-Mail: rmanderv@uoguelph.ca Interests: DNA damage by phenolic toxins including ochratoxin A; Modified DNA bases as fluorescent probes Contribution: Special Issue: Ochratoxins Special Issue: Ochratoxins 2011-2012 Special Issue: Recent Advances in Ochratoxins Research Dr. Nicholas J. Mantis Division of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA Tel. +1 518 473-7487; Fax: +1 518 402-4773 Website: http://www.wadsworth.org/resnres/bios/mantis_pubs.html E-Mail: nmantis@wadsworth.org Interests: plant and bacterial protein toxins; neutralizing antibodies; vaccines; mucosal tissues; animal models; small molecule inhibitors Contribution: Special Issue: Toxin-Antibody Interactions Dr. Marc Maresca Aix Marseille Université, CNRS, iSm2 UMR 7313, Marseille 13397, France Tel. +33-491-288-445; Fax: +33-491-284-440 Website: http://www.ism2.univ-cezanne.fr/permanents/MARESCA.php E-Mail: m.maresca@univ-amu.fr Interests: gut physiology; intestinal epithelial cells; intestinal toxicology ; enterotoxins; bacterial toxins; virotoxins; mycotoxins; trichothecenes; deoxynivalenol; nutrient absorption Contribution: Special Issue: Recent Advances and Perspectives in Deoxynivalenol Research Dr. Mark P. Mattson Laboratory of Neurosciences, National Institute on Aging, Laboratory of Neurosciences, NIA Biomedical Research Center, Room 05C214, 251 Bayview Blvd. Baltimore, MD 21224, USA Tel. +1 410 558 8463; Fax: +1 410 558 8465 Website: http://www.grc.nia.nih.gov/branches/lns/index.html E-Mail: mattsonm@grc.nia.nih.gov Interests: oxidative stress and calcium regulation; apoptosis (programmed cell death); neuroprotective signal transduction; synaptic signaling and plasticity; genetic aberrancies and neurodegeneration; diet and neuronal vulnerability; neuroendocrine and neuroimmune mechanisms Contribution: Special Issue: Can Botanical Toxins Enhance Human Health? Prof. Dr. Shin-ichi Miyoshi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 1-1-1, Tsushima-Naka, Kita-Ku, Okayama-City, Okayama 700-8530, Japan Tel. +81 86 251 7966; Fax: +81 86 251 7926 Website: http://www.pharm.okayama-u.ac.jp/en/department/miyoshi.html E-Mail: miyoshi@pharm.okayama-u.ac.jp Interests: bacterial protein toxins; pore-forming toxins; cell membrane proteins/receptors; proteolytic enzymes Contribution: Special Issue: Protein Toxins as Proteases Special Issue: Pore-Forming Toxins Dr. Rex Munday AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand Tel. +64 7838 5138; Fax: +64 7838 5012 E-Mail: rex.munday@agresearch.co.nz Interests: toxicology of natural products; free radical toxicology; cancer chemoprevention Prof. Dr. Michio Murata Department of Chemstry, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan Tel. +81 66850 5774; Fax: +81 66850 5774 Website: http://www.chem.sci.osaka-u.ac.jp/lab/murata/english/index.html E-Mail: murata@chem.sci.osaka-u.ac.jp Interests: marine biotoxins; seafood poisoning; membrane-active toxins; mechanism of toxicity and solid state NMR Prof. Dr. Richard E. Peterson School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA Tel. +1 608 263 5453; Fax: +1 608 265 3316 E-Mail: repeterson@pharmacy.wisc.edu Interests: developmental toxicology of halogenated aromatic hydrocarbons and perfluorinated acids Prof. Dr. Annie Pfohl-Leszkowicz National Agronomical High School of Toulouse (ENSAT), Unit of Toxicology & Food safety, 1 avenue de l’Agrobiopôle, BP 32607, 31326, Auzeville-Tolosane, France Tel. +33 534 323 947; Fax: +33 534 323 947 E-Mail: leszkowicz@ensat.fr Interests: mycotoxin; ochratoxin; fumonisin; zearalenone; biomarker; risk evaluation; environmental toxicology; polycyclic aromatic compounds; genotoxicity; DNA adduct; balkan endemic nephropathy; kidney cancer; biotransformation Contribution: Special Issue: Ochratoxins Special Issue: Ochratoxins 2011-2012 Special Issue: Recent Advances in Ochratoxins Research Prof. Dr. Frances Pick Department of Biology, University of Ottawa, Ottawa, Ontario, Canada Tel. +1 613 562 5800; Fax: +1 613 562 5486 Website: http://www.careg.uottawa.ca/bio_frances_pick.htm E-Mail: frances.pick@uottawa.ca Interests: ecosystem ecology and state of environment reporting; aquatic microbial ecology Dr. Adam J. Ratner Columbia University, 650 West 168th Street (BB 4-443), office (212) 305-9807, lab (212) 342-2902, New York NY 10032, USA Tel. +1 212 305 9807; Fax: +1 212 342 5218 Website: http://www.ratnerlab.org E-Mail: ar127@columbia.edu Interests: bacterial toxins; toxin evolution; host cell responses to pore-forming toxins Prof. Dr. Des R. Richardson Professor of Cancer Cell Biology, NHMRC Senior Principal, Research Fellow; and Iron Metabolism and Chelation Program, Department of Pathology, University of Sydney, Sydney, NSW 2006, Australia Tel. +61 2 9036 6548; Fax: +61 2 9036 6549 Website: http://sydney.edu.au/medicine/people/academics/profiles/d.richardson.php E-Mail: d.richardson@med.usyd.edu.au Interests: metal ions; iron; copper; chelators; X-ray crystallography Dr. Jean-Marc Sabatier Laboratory INSERM U1097-ERT 62 'Ingenierie des Peptides a Visee Therapeutique', Universite de la Mediterranee, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille, Cedex 20, France Tel. +33 640 15 24 19; Fax: +33 442 29 16 12 E-Mail: sabatier.jm1@libertysurf.fr Interests: toxinology; animal toxins; ion channel blockers; toxin-derived drug; drug design; peptide and protein engineering; therapy Contribution: Special Issue: Toxins - Organic and Analytical Chemistry Special Issue: Animal Venoms In other journals: Special Issue: Toxins - Organic and Analytical Chemistry Prof. Dr. Jun Sakurai Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan Tel. +81 (0)88 602 8483; Fax: +81 (0)88 655 3051 E-Mail: sakurai@ph.bunri-u.ac.jp Interests: structure-function of bacterial toxins; molecular biology of bacterial toxins; membrane-damage induced by bacterial toxins; membrane translocation of bacterial toxins Prof. Dr. Gudula Schmidt Pharmakology and Toxikology, Albertstrasse 25, University of Freiburg, 79104 Freiburg, Germany Tel. +49 761 203 5316; Fax: +49 761 203 5311 Website: http://www.pharmakologie.uni-freiburg.de/i/index.htm E-Mail: gudula.schmidt@pharmakol.uni-freiburg.de Interests: bacterial toxins; GTPases; signal transduction; toxins and carcinogenesis Prof. Dr. David Sheehan Proteomic Research Laboratory, Department of Biochemistry, University College Cork, Western Gateway Building, Western Rd, Cork, Ireland Tel. +35 321 420 5424; Fax: +35 321 427 4034 Website: http://www.ucc.ie/ucc/depts/biochemistry/staff/dsheehan.html E-Mail: d.sheehan@ucc.ie Interests: enzymology and evolution of glutathione transferases; application of proteomics to study of oxidative stress; implications of reactive oxygen and nitrogen species for kidney function; environmental toxicology; nanomaterials as emerging toxicological threats Contribution: Special Issue: Toxins from Aquatic Organisms In other journals: Special Issue: Nanotoxicology Special Issue: Advances in Proteomic Research Special Issue: Advances in Proteomic Research 2014 Prof. Dr. J. Glenn Songer Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA Tel. +1 520 621 2962; Fax: +1 520 621 6366 Website: http://vetmed.iastate.edu/users/jgsonger E-Mail: jgsonger@iastate.edu Interests: microbial pathogenesis; epidemiology of clostridial enteric infections Prof. Dr. Peter S. Spencer Department of Neurology, School of Medicine, Global Health Center, and Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, L356, Portland, OR 97239, USA Tel. +1 503 4942517 Website: http://www.ohsu.edu/xd/research/centers-institutes/croet/faculty/profiles.cfm?facultyID=520 E-Mail: spencer@ohsu.edu Interests: neurotoxinology (plant, fungal); neurotoxicology; systems biology; human disease Contribution: Special Issue: Neurotoxins: Health Threats and Biological Tools Dr. Tammy E. Stoker MD-72, Endocrine Toxicology Branch, Toxicity Assessment Division, ORD, NHEERL, U.S. EPA, Research Triangle Park, NC 27711, USA Tel. +1 919 541 2783; Fax: +1 919 541 5138 E-Mail: Stoker.Tammy@epamail.epa.gov Interests: neuroendocrine control of reproductive function/LH surge and ovulation; pubertal development following gestational or peripubertal exposure to EDCs; perinatal exposures and effects on prostate development/prostatitis in the rat; in vitro/ex-vivo approaches to evaluate the effects of EDCs on the HPG/HPT/HPA axis Prof. Dr. David C. Straus Department of Immunology and Molecular Microbiology, Texas Tech University, Health Sciences Center, 3601 4th Street, Lubbock, Texas 79430, USA Tel. +1 806 743 2523; Fax: +1 806 743 2334 Website: http://www.ttuhsc.edu/som/immunology/faculty/FacultyStraus.aspx E-Mail: david.straus@ttuhsc.edu Interests: mycotoxins; the microbiology of indoor air Contribution: Special Issue: Mycotoxins and Human Diseases Prof. Dr. Bruce E. Tabashnik Department of Entomology, University of Arizona, Tucson, AZ 85721, USA Tel. +1 520 621 1141; Fax: +1 520 621 1150 Website: http://ag.arizona.edu/ento/faculty/tabashnik.htm E-Mail: brucet@cals.arizona.edu Interests: insect resistance to Bacillus thuringiensis toxins Prof. Dr. Jean-Nicolas Tournier Host-Pathogen Interactions Laboratory, Institut de Recherche Biomédicale des Armées, BP 73, 91223 Brétigny-sur-Orge cedex, France Bacterial Toxi-Infection Pathogenesis Laboratory, Institut Pasteur, 25 rue du docteur Roux, 75725 Paris cedex 15, France Tel. +33 140 613 301 E-Mail: jtournie@pasteur.fr Interests: microbial toxins in host pathogen interactions; cell cytoskeleton; toxins and immune system; MAP kinases; adeylate cyclase; toxins and cell signaling; anthrax toxins Contribution: Special Issue: Anthrax Toxin Special Issue: Scorpion Toxins Prof. Dr. Vítor Vasconcelos Department of Biology, Faculty of Sciences, Porto University, Rua do Campo Alegre 4069-007 Porto and Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Rua dos Bragas, 289, 4050.123 Porto, Portugal Tel. +351 223401817; Fax: +351 223380609 Website: http://www.ciimar.up.pt/member.php?id=103 E-Mail: vmvascon@fc.up.pt Interests: blue-biotechnology; emerging marine toxins; bioassay-guided approach; cyanobacteria bioactive compounds Contribution: Special Issue: Genomics and Proteomics of Cyanotoxins In other journals: Special Issue: Emerging Marine Toxins Dr. Jiujiang Yu Research Geneticist, United States Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, 1100 Robert E. Lee Blvd, New Orleans, LA 70124, USA Tel. +1 504 286 4405; Fax: +1 504 286 4419 E-Mail: jiujiang.yu@ars.usda.gov Interests: aflatoxins; mycotoxins; Aspergillus flavus; genomics; functional genomics; Next generation sequencing (NGS); plant-fungus interaction Dr. C. Chris Yun Emory University, School of Medicine, Division of Digestive Diseases, Whitehead Bldg., Suite 201, 615 Michael St. Atlanta, GA 30322, USA Tel. +1 404 712 2865; Fax: +1 404 727 5767 Website: http://med.emory.edu/faculty/profile_highlights.cfm?id=4021 E-Mail: ccyun@emory.edu Interests: effects of lysophosphoipids in colon cancer and colitis; sodium and fluid absorption in the intestine and kidney; protein-protein interaction; chemokine sin colon cancer; cancer therapeutics; GPCR signaling Contribution: Special Issue: Enterotoxins Prof. Dr. Gerald W. Zamponi Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr. N.W., Calgary, T2N 4N1, Canada Tel. +1 403 220 6597; Fax: +1 403 919 2212 Website: http://www.cell.ucalgary.ca/G.Zamponi.html E-Mail: zamponi@ucalgary.ca Interests: calcium channels; sodium channels; T-type channels; N-type channels; pain; G protein; second messengers; epilepsy Prof. Dr. Paul V. Zimba Center for Coastal Studies, Unit 5866, Texas A&M University Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, USA Tel. +1-361-825-2768; Fax: +1-361-825-2770 Website: http://sci.tamucc.edu/member.php?who=pzimba&program=lsci E-Mail: Paul.Zimba@tamucc.edu Interests: Algal toxins, aquatic ecosystem ecology, harmful algae, wetlands, aquaculture, microalgal taxonomy and physiology, remote sensing, carbon fixation assessment, aquatic ecosystem stressors, cyanobacteria secondary metabolites