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期刊名称：HAEMATOLOGICA ISSN： 0390-6078 出版频率： Monthly 出版社： FERRATA STORTI FOUNDATION, VIA GIUSEPPE BELLI 4, PAVIA, ITALY, 27100   出版社网址： http://www.haematologica.org/ 期刊网址： http://www.haematologica.org/ 影响因子： 9.941 主题范畴： HEMATOLOGY 变更情况： Newly Added by 2013,The journal is included in ISI Web of Knowledge as Haematologica-The Hematology Journal 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal ISSN 0390-6078 print ISSN 1592-8721 online Haematologica is the journal of the European Hematology Association and the Ferrata-Storti Foundation, reporting important novel findings in basic, clinical & translational research in the broad field of hematology. the oldest hematology journal, founded by Dr. Adolfo Ferrata in 1920 open access 2012 Impact Factor 5.935  (©JCR 2012)  ranking 9th journal in hematology (©JCR 2012)  Haematologica - general information Haematologica publishes peer-reviewed articles across all areas of experimental and clinical hematology. The journal is owned by a non-profit organization, the Ferrata Storti Foundation, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE, www.icmje.org) recommendations on publication ethics policies for medical journals. Haematologica was founded in 1920 by Adolfo Ferrata, and in 2005 merged with The Hematology Journal. Haematologica is the Official Organ of the following scientific societies European Hematology Association (EHA) European Association for Haematopathology (EAHP) Italian Society of Hematology (SIE) Spanish Society of Hematology and Hemotherapy (SEHH) Italian Society of Experimental Hematology (SIES) Haematologica is an Open Access Publication according to the Budapest Open Access Initiative (BOAI, www.earlham.edu/~peters/fos/boaifaq.htm#openaccess). Detailed information on Open Access can be found at the Directory of Open Access Journals (DOAJ) website (www.doaj.org). Haematologica is included in the National Library of Medicine catalog with the following data: Title: Haematologica ISSN: 0390-6078 (Print) 1592-8721 (Electronic) Title Abbreviation: Haematologica ISO Abbreviation: Haematologica Publication Start Year: 1920 Publisher: Ferrata Storti Foundation, Language: English Country: Italy Subject Term(s): Hematology NLM ID: 0417435 The journal can be retrieved from PubMed database using Haematologica. The journal is included in ISI Web of Knowledge as Haematologica-The Hematology Journal (abbreviation Haematol Hematol J). The journal can be searched in Web of Science, including JCR (Impact Factor), as Haematol*. Instructions to Authors Haematologica - information for authors Download here the Copyright Transfer Form and the Author Contribution Form (both are mandatory for accepted papers)   A. General information Haematologica publishes articles in the broad field of hematology, reporting on novel findings in basic, clinical and translational research. The scope of the journal is to report novel research results that have an important impact on our understanding of normal hematology or the development of hematological diseases, or are likely to bring important changes to the diagnosis or treatment of hematological diseases. All articles are evaluated based on an international peer review process. Less than 20% of submitted articles can be accepted. Articles will be selected based on novelty, importance for the field and experimental quality. Haematologica is an Open AccessJournal, as the Ferrata Storti Foundation (FSF) and the European Hematology Association (EHA) believe that works reporting the results of scientific research should be openly accessible and freely usable by the entire scientific community. The current impact factor of Haematologica is 5.9 (JCR 2012 impact factor). Haematologica ranks 9th of all hematology journals.   Follow us on Facebook: www.facebook.com/haematologica   Manuscript submission Manuscripts should be submitted through the online manuscript processing system: http://submit-haematol.highwire.org. At submission, these files will be requested: one word file with the text and tables, separate files for each figure, and one pdf file with supplemental data.   Submission fees A nonrefundable fee of 50 Euro (including VAT)  is due on submission of all articles, except for letters and invited articles (such as invited review articles, invited perspectives, invited news articles). This fee covers the cost of the manuscript processing through the journal's online submission system, and is not refundable once the manuscript has been submitted. This is not a review or publication fee, and the payment of the submission fee is in no way related to the outcome of the in-house or external peer-review process.   Review process All manuscripts submitted to Haematologica are critically assessed by external and/or inhouse experts in accordance with the principles of Peer Review (http://www.icmje.org/ethical_3peer.html), which is fundamental to the scientific publication process and the dissemination of sound science. Each paper is first evaluated by one or more editors, who will assess the overall quality and novelty of the work and the article's appropriateness for the scope of Haematologica. Articles that are not found to be relevant for Haematologica will not be send out for external review and will be returned to the authors. The remaining articles are reviewed by external referees (second step of classical peer-review). We aim to provide feedback to the authors in less than 4 weeks after submission.   Publications charges Once an article is accepted and in press, authors are required to pay publication charges. These fees cover the cost for Open Access and for publication of the article in print, online and through various other applications. All Haematologica articles are also uploaded to PubMed Central as a digital preservation service to our authors.   Fees for 2013 & 2014: Articles: a publication charge of € 1500,00 (plus VAT when needed) is due before publication. Letters: a publication charge of € 100,00 (plus VAT when needed) is due before publication. Editorials, perspective articles and review articles (on invited basis only): Free of charge These fees include all publication charges, including page charges, costs for color images, and costs for online supplements. No other costs will be charged.   Copyright Authors will grant copyright of their articles to the Ferrata Storti Foundation. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties. Please contact the office for requests: office@haematologica.org Download here the Copyright Transfer Form   Clinical trials Obligation to Register Clinical Trials We believe that it is important to foster a comprehensive, publicly available database of clinical trials. We therefore request, as a condition of consideration for publication, the registration of all clinical trials in a public trials registry. The ICMJE provides specific guidelines on this topic (http://www.icmje.org/publishing_10register.html). The ICMJE defines a clinical trial as any research project that prospectively assigns human subjects to intervention or concurrent comparison or control groups to study the cause-and-effect relationship between a medical intervention and a health outcome. Medical interventions include drugs, surgical procedures, devices, behavioral treatments, process-of-care changes, and the like. Haematologica does not advocate one particular registry, but follows the ICMJE recommendations. Because it is critical that trial registries are independent of for-profit interests, the ICMJE policy requires registration in a WHO primary registry rather than solely in an associate registry, since for-profit entities manage some associate registries. The details of the ICMJE policy are published online (http://www.icmje.org/faq_clinical.html). Randomized Clinical Trials When submitting manuscripts that report on randomized clinical trials, authors should provide - as a separate document - a flow diagram in CONSORT format and all of the information required by the CONSORT checklist (http://www.consort-statement.org). When submitting meta-analyses of randomized controlled trials, authors should provide both the QUOROM statement checklist and the QUOROM statement flow diagram http://www.consort-statement.org/index.aspx?o=1065). Documented review and approval from a formally constituted review board (Institutional Review Board - IRB - or Ethics committee) is required for all studies (prospective or retrospective) involving people, medical records, and human tissues. Haematologica requires that the authors provide this information on the manuscript's website, and also that they report it explicitly under 'Methods'.   Ethical considerations Protection of human individuals in research When reporting experiments on human individuals, authors should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. If doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain the rationale for their approach and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. Patients have a right to privacy that should not be violated without informed consent. Identifying information, including names, initials, or hospital numbers, should not be published in written descriptions, photographs, or pedigrees unless the information is essential for scientific purposes and the patient (or parent or guardian) gives written informed consent for publication. Protection of animals in research When performing experiments on animals or animal tissues, authors should seek approval by an institutional ethics committee and should strictly follow the institutional and national guide for the care and use of laboratory animals. At time of manuscript submission, authors should provide information on the study approval by an institutional ethical committee. We can only consider manuscripts reporting on studies on animals or animal tissues if ethical committee approval of the study can be documented.     B. Manuscript preparation   1. Manuscript style Manuscripts should be prepared according to the Uniform Requirements established by the International Committee of Medical Journal Editors (ICMJE): http://www.icmje.org/manuscript_1prepare.html Manuscripts should be prepared using American English spelling, and should be submitted as Word files. Submit one manuscript file with the main text, figure legends and tables. Save your file in .doc format (not as .docx files). Abbreviations or acronyms should only be used when necessary (do not use abbreviations of words that are only used once or twice in the entire text), and should be explained at their first use. Abbreviations should be avoided in the abstract. Units and measurements: The SI system should be used for all scientific units. Please refer to http://www.bloodindex.com/normal_laboratory_values.php for hematological measures. Authors can also refer to http://www.unc.edu/~rowlett/units/scales/clinical_data.html for conversions from conventional units to SI units. Please adopt standardized abbreviations and define full forms in footnotes, e.g. “NA” (not applicable) ; “ND” (not determined). The use of commercial names of drugs should be avoided. Drugs should only be referred to under their generic names unless different products are being compared. (for example: Use deferiprone, not Ferriprox) Use the official gene symbols when referring to genes, transcripts, proteins. (for example: Use ABL1, not ABL or c-ABL ; use ETV6, not TEL). Please use this database as a reference: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene References: Please follow the recommendations of ICMJE for the style of the referenc-es available at http://www.nlm.nih.gov/bsd/uniform_requirements.html Image size and layout: Image layout should be simple, clear and precise. In order to promote good management of the space, images must take up the least space possible without compromising clarity. Figures can be either one column width (8 cm) or 2 column widths (16 cm). If the figure contains different panels their content should be identified (use capital letters to identify each panel) and described in the order in which they are presented. Please ensure that a description is provided for all parts of the figure. Please ensure that different parts of the image are all in proportion to each other, e.g. axis scales and labels, internal descriptive text. Data which has no graphic significance to any part of the figure content and form should be presented as a separate table. Figure quality: When a manuscript is accepted for publication, high quality figures will be required and will be asked to the authors. High quality figures should be submitted in jpg, tiff or adobe illustrator (.ai) format. Note that we can not accept figures as presentation slides (Microsoft Powerpoint, Apple Keynote, or similar) as these can not be printed in high quality. The resolution of figures should be minimum 300 dpi for color, 600 dpi for greyscale and figures containing lots of text. For 1 column figures (8 cm wide) this means 945 pixels (300dpi) or 1890 pixels (600dpi) wide. For 2 column figures (16 cm wide) this means 1890 pixels (300dpi) or 3780 pixels (600dpi) wide. We can not accept low quality figures. The final acceptance of a manuscript will be delayed if the authors fail to provide high quality figures. In case assistance with the preparation of high quality figures is needed, we recommend contacting Somersault1824: website: www.somersault1824.com ; e-mail: info@somersault1824.com ; prices starting at 45 Euro per figure. Reproductions and adaptations: The author must obtain written permission for the reproduction and adaptation of material that has already been published. Permission should be obtained from the copyright holder or publisher. Before a manuscript goes into print, Haematologica will need to receive a copy of the written permission. All material presented from other sources should be identified and should be accompanied by a specific reference in the legend confirming that permission for its use had been obtained, for example: “Adapted from Berger et al. Leukemia 2003, 17, 1820-1826; with permission.”   2. Types of manuscripts Articles are the main type of manuscripts, reporting both clinical and experimental hematology research studies. These articles are to be divided into sections under the following subheadings: Abstract, Introduction, Methods, Results, Discussion, References. Results and Discussion can be combined in one section if appropriate. We do no longer have the separate category of "brief reports", but we do encourage the submission of short definitive articles that report conclusive novel results in a brief format. The abstract should be a summary of the work in maximum 250 words. State clearly the rationale for the study, how the study was performed, the most important results obtained, and the conclusions that can be drawn from this study. Articles reporting clinical trials should provide the trial registration number at the end of the abstract. The main text (introduction, methods, results, discussion) can be maximum 4000 words. The methods section in the article should be a brief summary of the most important methods (maximum 500 words), and is placed after the introduction. Describe basic material (patient samples, cell lines, specific methods, special reagents, ...). A completely detailed methods section needs to be provided in an online supplement that will be published with the online version of the article. There is no restriction to the length of the online methods section, but avoid making this part to be unnecessary long. Figures and tables: Original articles can contain several display items (figures and/or tables), in total taking maximum 3 full pages in the final published article (including legends). Authors are requested to provide the tables as text files in the manuscript file (word file). Tables should only contain data that is essential for the manuscript. Authors are requested to provide the figures as high resolution images (jpg, tiff, or adobe illustrator files – power point figures are not accepted) in the final size in which they will be published, taking the relative size of all the graphs into account, as well as the size of letters and symbols in the graphs. If you have large tables or figures, note that the maximum space for figures and tables in the final version of the published article is only 3 pages. Any additional display items will need to be moved to the supplement. In case assistance with the preparation of high quality figures is needed, we recommend contacting Somersault1824: website: www.somersault1824.com ; e-mail: info@somersault1824.com ; prices starting at 45 Euro per figure. References should be given in NLM Style (see further), with a maximum of 50 references. All supplementary material should be prepared and submitted as one single pdf file. This file will also be reviewed by the reviewers. In case of acceptance of the manuscript, this supplemental pdf file will be published as provided by the authors (this file will not be edited by the journal office). Review articles are invited articles, direct submission without invitation is not possible. Review articles are maximum 5000 words long (excluding figure legends and references) and do not have a specific structure. The articles should contain an abstract (short summary of the topic without specific structure) of maximum 250 words, may contain several display items in color, and have a reference list of maximum 100 references. These articles should not simply go over or summarize general information which is already known, but also discuss the importance of the data and provide a clear view on how these insights have transformed or will transform the hematology field. Authors of review articles are encouraged to include 4 to 6 figures. Authors should only provide a draft of the figures (all formats acceptable), as the final high quality figures for review articles will be generated by Somersault1824 (www.somersault1824.com). Decision Making and Problem Solving articles should consist of meta-analyses and/or guidelines carried out and prepared by scientific societies. These articles are up to 4000 words long (excluding figure legends and references) and do not have a specific structure. The articles should contain an unstructured abstract (short summary/ introduction) of maximum 200 words, may contain several display items in color, and have a reference list. Editorials and Perspectives are commentaries or opinions on specific articles or on general concepts in hematology practice or research. These articles are usually invited articles, but proposals are welcome and should be addressed to the editorial office (office@haematologica.org).  These articles have a free structure (no abstract, no specific subheadings), contain about 1,500 words (excluding references), up to 20 references and may contain two display items (figures and/or tables). Haematologica has a wide international readership both in the field of hematology and in other sectors of the medical profession. Its aim is to reach also those without specialized knowledge. Authors are asked to use simple, straightforward language to promote the understanding by all readers. Letters to the Editor: We encourage submission of important new findings that fit into the format of a letter. Alternatively, letters can provide comments, discuss cutting edge ideas or developments, raise questions or discuss a recently published article in Haematologica. Letters have no abstract and a maximum of 1000 words, excluding title, affiliations, figures legends or references. We can only accept a maximum of 2 tables and/or figures, and only 15 essential references. Letters will appear in the online version of the journal, will appear in the table of contents, and are indexed in pubmed.   Conflict of interest note: Conflict of interest regarding papers that do not report original research (primary data). As detailed under Policies and Practices (http://www.haematologica.org/misc/policies.dtl) authors must disclose all relationships that could be viewed as potential conflicts of interest both in the online manuscript submission system and in the manuscript. These disclosures are expected to help readers in establishing whether the reported relationships may influence the authors’ judgment. Haematologica believes that this procedure is appropriate with respect to papers reporting original research (original articles, brief reports and research letters) as primary data speak for themselves. This procedure may be insufficient with respect to papers that do not report primary data, such as editorials, perspective articles, commentaries, review articles, guidelines, consensus papers and position papers. As stated by Kassirer & Angell [Kassirer JP, Angell M. Financial conflicts of interest in biomedical research. N Engl J Med. 1993 Aug 19;329(8):570-1. PubMed PMID: 8204121] “unlike reports of original research, these articles represent the judgment of their authors, based on their evaluation of the literature. What studies they select to discuss and their analysis of them are necessarily subjective. Bias may be extremely difficult to detect because these articles contain no primary data to speak for themselves.” Nonetheless, disclosing relationships that could be viewed as potential conflicts of interest may be acceptable in many of these papers. Haematologica, however, no longer considers for publication papers not reporting primary data - such as those listed above - whose preparation has been promoted, sponsored or supported in any way by a company whose product is discussed in the paper. In fact, the clear conflict of interest is very likely to influence judgment in these cases, and there are no primary data that can speak for themselves. This point is detailed in the online manuscript processing system; if doubts exist about this issue, the authors are invited to contact the editorial office (office@haematologica.org) before proceeding with submission.   3. Manuscript structure 3.1. Title Page Information provided on the title page should correspond exactly with the information provided in the online system. The title should consist of a phrase or a sentence; question forms should be avoided. Capitalize the first letter of the sentence only, and do not use abbreviations. Study group names may be presented in the title, however, all members’ names should be listed in an appendix and presented at the end of the main text; Add for example: A complete list of the members of the European Prospective Investigation into Cancer and Nutrition Group appears in a supplement. Acronyms such as EBMT, GOELAMS, GEIL, are acceptable. Commercial names of drugs should be avoided (use only the generic names), unless different products are being compared. Names of authors should be presented as full first name, initial of middle name (if applicable) and full last name. Use a comma between each author, use “and” before the final author. Number authors’ affiliation in superscript. Do not include professional titles or abbreviations of qualifications or positions held. Authors’ affiliations should be provided on a new line immediately after the authors’ names. Every affiliation on a new line. Provide only the city and country of each institute, not full address, the postal code is not needed. Statement of equal authors’ contribution: In cases in which authors share equal responsibility for the study, a statement of equal contribution can be stated here. Use authors’ initials rather than full names, e.g. “GGH and FS contributed equally to this manuscript.” Running heads: please provide a shortened title as running head of maximum 50 characters. The use of acronyms and abbreviations is permitted. Contact information for correspondence should confirm the name and e-mail address of the corresponding author or authors. Word count: Provide a word count for the abstract and for the main text (= introduction + methods + results + discussion). Indicate how many tables and figures are present in the manuscript. Indicate how many supplemental files are associated with the manuscript. Trial registration: Confirmation and details of trial registration should be given on the first page; please use the following form: “clinicaltrials.gov identifier: NCT00123456.” Acknowledgments should refer to secretarial and editorial assistance, technical and intellectual input and advice, funding, fellowships and grants. The form to be used is “The authors would like to thank...” 3.2. Abstract Summary of the work, word limit is dependent on the type of article. Letters and editorials have no abstract. 3.3.Main text Word limit is dependent on the type of article. Tables and Figures: The presentation of Tables and Figures should always follow the same order in which they are presented in the main text. All references to Tables and Figures should be presented in brackets and should only specify “Table” or “Figure” and the relevant identification number. When reference is made to more than one Table or more than one Figure, please separate the identification numbers with a hyphen and use “and” to present Tables or Figures that are not consecutive. Please pay particular attention to spacing (for example: Figures 1-2; Tables 1 and 3; Figures 2-4 and 6; Tables 2, 4 and 6). References referring to Figure panels and subpanels should be presented by adding a capital letter in alphabetic order immediately after the identification number (for example: Figure 1A, Figure 1B). When reference is made to more than one Figure panel or subpanel, please separate the capital letters with a hyphen and use a comma followed by a space to separate capital letters that are not consecutive (for example: Figure 2 B-C ; Figure 3 B, D). Authorship and Disclosures: please describe the contribution of each author to the work and the manuscript, and disclose any potential conflict of interest. This information is essential and failure to disclose conflicts of interest may result in the definitive rejection of a manuscript. Use authors’ initials rather than full names. For example: JM was the principal investigator and takes primary responsibility for the paper; FKN, DB, FG, and RG recruited the patients; IB, VDL, CR, JMK, LL, and PJ performed the laboratory work for this study; PYA participated in the statistical analysis; IB, GG, and JM co-ordinated the research; IB, JM, and RG wrote the paper. The authors report no potential conflicts of interest. 3.4. Tables Provide tables in a simple format, without specific layout. The final layout will be given by journal staff at time the final manuscript pdf file is prepared. Tables should have a short clear title. Provide a legend to the table (if needed) directly below the table. Explain all abbreviations that are used in the table in the legend. 3.5. Figure legends Figures should be numbered consecutively in the order in which they are presented in the main text, e.g. Figure 3. Give every figure a short clear title, followed by a brief description of figure content. Provide sufficient detail in the figure legend, but do not repeat what is discussed in the text. 3.6. References Please see the most recent issue of Haematologica (www.haematologica.org) for exact style of the references in the text and in the reference list. In the main text, refer to published litterature by using a number, for example:          Melick and colleagues previously reported IDH1 mutations in AML.5          Several groups previously reported the presence of IDH1 mutations in AML.5-9          Two studies previously reported IDH1 mutations in AML.5,6 To generate the reference list, follow the style recommended by the US National Library of Medicine (NLM), also adopted by ICMJE: http://www.nlm.nih.gov/bsd/uniform_requirements.html - For references with less than 7 authors, list all authors: Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7. - For references with more than six authors, list the first 6 authors followed by "et al." Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6. Articles published ahead of print: Those articles which have already been accepted for publication and which have been published ahead of print should follow the same reference format as a journal article, using the date on which the article was published ahead of print, e.g. Bonci D, Musumeci M, Coppola V, Addario A, Conticello C, et al. Blocking the APRIL circuit enhances acute myeloid leukemia cell chemosensitivity. Haematologica 2008 Oct 6. [Epub ahead of print] Personal communications: Authors should specify the name of the person concerned, the affiliation, whether the reference concerns an oral or a written communication, and the date on which the communication was made. Written permission for the reference to be made must be obtained from the person concerned, a copy of which may be requested by the journal. Unpublished data: Authors should provide the names of all persons responsible for the resource, a short description, and the relevant date. 3.7. Supplements If addition to the main Word file, and additional pdf file can be submitted containing supplemental material. Please prepare one single pdf file containing all supplemental data (supplemental methods, supplemental data, supplemental figures, supplemental tables). Additional files that can not be incorporated in a pdf file (such as video, large excel tables running over several pages, etc.) can be provided separately.   Any specific inquiry must be addressed to: office@haematologica.org     Editorial Board Editor-in-Chief Jan Cools (Leuven) Deputy Editor Luca Malcovati (Pavia) Associate Editors Clara Camaschella (Milan), Elias Campo (Barcelona), Claire Harrison (London), Ross Levine (New York), Andreas Rosenwald (Wuerzburg), Juerg Schwaller (Basel), Pieter Sonneveld (Rotterdam), Jean Soulier (Paris), Freda K. Stevenson (Southampton), Matthias Theobald (Mainz), Ivo P. Touw (Rotterdam) Assistant Editors Gaetano Bergamaschi (CME), Matteo Giovanni Della Porta (CME), Anne Freckleton (English Editor), Rosangela Invernizzi (CME), Cristiana Pascutto (Statistical Consultant), Rachel Stenner (English Editor), Vittorio Rosti (CME) Editorial Office Michele Moscato (Production Manager), Paola Cariati (Production), Igor Ebuli Poletti (Production) Lorella Ripari (Peer Review Manager), Marta Fossati (Peer Review)