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期刊名称：NUCLEIC ACID THERAPEUTICS ISSN： 2159-3337 出版频率： Bi-monthly 出版社： MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, USA, NY, 10801   出版社网址： http://www.liebertpub.com/Default.aspx 期刊网址： http://www.liebertpub.com/nat 影响因子： 5.486 主题范畴： BIOCHEMISTRY & MOLECULAR BIOLOGY;    CHEMISTRY, MEDICINAL;    MEDICINE, RESEARCH & EXPERIMENTAL 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Nucleic Acid Therapeutics is the leading journal in its field focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. The Journal examines many new approaches for using nucleic acids as therapeutic agents or in modifying nucleic acids for therapeutic purposes including: oligonucleotides, gene modification, aptamers, RNA nanoparticles, and ribozymes.   Nucleic Acid Therapeutics coverage includes: RNAi: siRNAs, shRNAs, and miRNAs Antisense applications; nucleoside and nucleotide analogs and modifications Peptide nucleic acids DNA-modified gene therapy Nucleic acid-based nanoparticles Ethical, legal, and regulatory issues Nucleic Acid Therapeutics is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center; C.A. Stein, MD, PhD, Department of Oncology, Albert Einstein-Montefiore Cancer Center, Montefiore Medical Center; and Executive Editor Fintan Steele, PhD; as well as other leading investigators. View the entire editorial board.   Audience: Molecular biologists, biochemists, DNA and cell biologists, and biopharmaceutical researchers, among others.   Nucleic Acid Therapeutics is a rapid-publication Journal, with peer review averaging 25 days from submission to first decision, and online publication of the article within four weeks of acceptance. Indexed/Abstracted in: MEDLINE; PubMed; PubMed Central; Current Contents®/Life Sciences; Science Citation Index Expanded; Social Sciences Citation Index®; Biotechnology Citation Index®; Biological Abstracts; BIOSIS Previews; Journal Citation Reports/Science Edition; Derwent Drug File; EMBASE/Excerpta Medica; EMBiology; Scopus; ProQuest; SIIC Data Bases   Instructions to Authors The leading peer-reviewed journal in its field, focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids.  Comprehensive coverage includes oligonucleotides; RNAi: siRNAs, shRNAs, and miRNAs; aptamers; RNA nanoparticles; gene modification with oligos; antisense applications; nucleoside and nucleotide analogs; peptide nucleic acids; ribozymes; and DNA-modified gene therapy. Manuscripts must be submitted online using the following URL: http://mc.manuscriptcentral.com/nucleicacidtherapeut  PLEASE READ ALL THE INSTUCTIONS TO AUTHORS BEFORE SUBMITTING.   Preparation of Manuscript. Manuscripts should be submitted double-spaced.  Leave ample margins on both sides, top and bottom. Be prepared to give the title of the article, name(s) of the author(s) and institutional affiliation(s), and supply a running title of about 45 characters. You also will be required to supply an abstract of about 200 words, stating the aims, results, and conclusions drawn from the study. This should be followed by the Introduction, Materials and Methods, Results, Discussion, Acknowledgments, references, tables, figures, and figure legends. Begin each of these sections on a separate page. We require an e-mail address for each author listed on your article. Authors should review the style and clarity of their manuscripts with colleagues before submission, especially if English is not their native language, to ensure clear grammatical English usage. The editors welcome suggestions concerning potential reviewers. We encourage authors to report all of the oligonucleotides or constructs that were studied, not just those that gave the “best” result. Authors should also note the editorial policy of this journal, as described in C.A. Stein and A. Krieg, “Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides,” Antisense and Nucleic Acid Drug Development, 1994, (4), 67–69. All manuscripts that claim antisense efficacy must, in addition to the antisense oligodeoxynucleotide construct, include at least two control oligodeoxynucleotides. The sequences of the two controls are to be decided by the authors. Manuscripts that do not include at least two controls will be returned without review. Brief Communications may be submitted to report negative findings, useful techniques, or unusual artifacts, or to present studies that are interesting but not definitive enough to warrant publication as a full-length manuscript. In a Brief Communication, the Results and Discussion sections may be combined, the Abstract should be limited to about 150 words, and there should be no more than three figures or tables. All authors of a manuscript must have agreed to its submission and are equally responsible for its content. By submitting a manuscript, the authors guarantee that the manuscript, or one substantially the same, was not published previously and is not being considered or published elsewhere. A preliminary disclosure of research findings published in abstract form as an adjunct to a meeting is not considered prior publication. Copies of “in press” and “submitted” manuscripts that are important for consideration of the present manuscript should be enclosed to facilitate the review process. Include written permission to cite any personal communications and preprints. Every effort will be made to complete the review process within 4–6 weeks of receipt of the manuscript. Tables and Illustrations. Use arabic numerals to number tables. Do not repeat information that is given in the text, and do not make a table for data that can be given in the text in one or two sentences. Bar graphs should use different fill patterns (e.g., horizontal or diagonal lines) rather than variations in gray scale shading, which do not print well. Please observe the following guidelines when submitting art: • Do not include any illustrations as part of your text file. • Do not prepare any figures in Word as they are not workable. • Line illustrations must be submitted at 1200 DPI. • Halftones and color photos should be submitted at a minimum of 300 DPI. • Adobe is the preferred software. Avoid submitting PowerPoint files. • Save art as either TIFF or EPS files. Avoid submitting JPEG files. • Color art must be saved as CYMK, not RGB. The Journal will publish color photographs, but the author must subsidize the cost of the color printing. For further details, contact the Publisher.   Disclosure Statement   Immediately following the Acknowledgments section, include a section entitled “Author Disclosure Statement.” In this portion of the paper, authors must disclose any commercial associations that might create a conflict of interest in connection with submitted manuscripts. This statement should include appropriate information for EACH author, thereby representing that competing financial interests of all authors have been appropriately disclosed according to the policy of the Journal. It is important that all conflicts of interest, whether they are actual or potential, be disclosed. This information will remain confidential while the paper is being reviewed and will not influence the editorial decision. Please see the Uniform Requirements for Manuscripts Submitted to Biomedical Journals at http://www.icmje.org/index.htlm#conflicts for further guidance. If no conflicts exist, the authors must state “No competing financial interests exist." When naming your figure files, please label them with your manuscript number, followed by a period (.), and then list the figure number.  Ex:  MET-2008-0123.Fig1.  Label figures and tables inside the files in addition to naming the file with the figure or table number.  (ie:  When figures or table files are opened, the figure or table number should appear inside the file.) IMPORTANT: Please upload individual files of all manuscript material — do NOT upload a single PDF file containing all text, figure, and table files of your paper.  Once all individual files are uploaded on to Manuscript Central, the system will automatically create a single PDF proof for you and the peer-review process. If no conflicts exist, the authors must state “No competing financial interests exist."   References.  Reference citations are not permitted in the abstract of a paper. All references should be cited by authors and dates within the text, i.e., Previous studies indicate this protein to be expressed in HEL cells (Doe and Smith, 1988). If more than two authors are involved, use “et al.” after the first author’s name, i.e., Doe et al., 1987.  If several papers published in the same year by the same authors are to be cited, use a lowercase letter designation to indicate individual papers, i.e., (Doe and Smith, 1988a), (Doe and Smith, 1988b). Use the same designation in the reference list. All references in the Bibliography should be typed double-spaced and listed in alphabetical order at the end of the article. Each reference should include all authors and the complete title of the article cited. Journal citation: DOE, J., and SMITH, N. (1988). A new vector system for antisense modulation in hematopoietic cell lines. Blood Cells 11, 666–674.           Book citation: DOE, J. (1989). Synthetic oligonucleotides for antisense applications. In: Horizons in Antisense Investigations. N.V. Smith, ed. (Generic Publishing, New York), pp. 41–49.           When dates from an unpublished source are given, supply the researcher’s name. If work is in press, give journal in which it is to be published or name of publisher. Abbreviations of journal names should follow the style of MEDLINE.   Permissions. The author must obtain permission whenever it is required in conjunction with the reproduction of material such as figures and tables from copyrighted material. Written permission must be obtained from the publisher of the journal or book concerned. The publication from which the figure or table is taken must be listed in the reference list. Finally, a footnote of a reprinted table, or of the legend of a reprinted figure, should read, “reprinted by permission from Doe et al.” and list the appropriate reference. All permission listings must be shown in the manuscript; they cannot be entered on proofs.   Reprints. Reprints may be ordered by following the special instructions that will accompany page proofs, and should be ordered at the time the corresponding author returns the corrected page proofs to the Publisher. Reprints ordered after an issue is printed will be charged at a substantially higher rate. Nucleic Acid Therapeutics is published by Mary Ann Liebert, Inc., 140 Huguenot Street, New Rochelle, NY 10801-5215. Telephone: (914) 740-2100; fax: (914) 740-2101. Editorial Board Co-Editors-in-Chief Bruce A. Sullenger, PhD Director, Duke Translational Research Institute Joseph and Dorothy Beard Professor Department of Surgery Duke University Medical Center Durham, NC   bruce.sullenger@duke.edu C.A. Stein, MD, PhD Chair of Medical Oncology and Experimental Therapeutics City of Hope National Medical Center 1500 E.  Duarte Road Duarte, CA 91010 cstein@coh.org Executive Editor Graham C. Parker, PhD gparker@liebertpub.com Senior Editors Mark A. Kay, MD, PhD Dennis Farrey Family Professor Departments of Pediatrics and Genetics Vice Chair for Basic Research (Pediatrics) Stanford University School of Medicine Stanford, CA markay@stanford.edu Dieter C.  Gruenert, PhD The Department of Otolaryngology-Head and Neck Surgery Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research University of California, San Francisco San Francisco, CA  dgruenert@ohns.ucsf.edu European Editor Jens Kurreck, PhD Technische Universität Berlin Institute of Biotechnology, TIB 4/3-2 Department of Applied Biochemistry Berlin, Germany jens.kurreck@tu-berlin.de  Asian Editor Dong-ki Lee, PhD Global Research Laboratory for RNAi Medicine Department of Chemistry Sungkyunkwan University Suwon, Korea dklee@skku.edu; dklee0318@gmail.com Editorial Board Sidney Altman Yale University New Haven, CT Serge L. Beaucage Food & Drug Administration Bethesda, MD Mark A. Behlke Integrated DNA Technologies Coralville, IA Ben Berkhout University of Amsterdam Medical Center Amsterdam, The Netherlands Bob D. Brown Dicerna Pharmaceuticals Watertown, MA Natasha Caplen National Cancer Institute Bethesda, MD Marvin H. Caruthers University of Colorado Boulder, CO David Corey University of Texas Southwestern Medical Center Dallas, TX Mark E. Davis California Institute of Technology Pasadena, CA Steven F. Dowdy University of California San Diego  La Jolla, CA   Fritz Eckstein Max-Planck Institute for Experimental Medicine Göttingen, Germany Michael Gait Medical Research Council Cambridge, United Kingdom Krishna N. Ganesh Indian Institute of Science Education and Research Pune, India Peter M. Glazer Yale University New Haven, CT Martin Gleave Vancouver General Hospital Vancouver, Canada Peixuan Guo University of Kentucky Lexington, KY   Gunther Hartmann Universitatsklinikum Bonn Bonn, Germany Richard I. Hogrefe TriLink BioTechnologies, Inc San Diego, CA Leaf Huang University of North Carolina  Chapel Hill, NC Kuan-Teh Jeang NIAID/NIH Bethesda, MD Dong-Yan Jin University of Hong Kong Pokfulam, Hong Kong Anthony D. Keefe X-Chem Pharmaceuticals Waltham, MA Soyoun Kim Dongguk University Seoul, Korea Troels Koch Santaris Pharma A/S Hørsholm, Denmark Ryszard Kole University of North Carolina  Chapel Hill, NC Arthur M. Krieg RaNA Therapeutics, Inc. Cambridge, MA Bernard Lebleu Universite Montpellier Montpellier, France Seong-Wook Lee Dankook University Yongin, Korea Ian MacLachlan Tekmira Pharmaceuticals  Burnaby, Canada   Claude Malvy Institut Gustave Roussy Villejuif, France Paul S. Miller Johns Hopkins University Baltimore, MD Brett P. Monia Isis Pharmaceuticals, Inc. Carlsbad, CA Barbara Nawrot Polish Academy of Sciences Lodz, Poland Georg Sczakie University of Lübeck Lübeck, Germany Michael Seidman National Institute on Aging Baltimore, MD Barbara Ramsay Shaw Duke University Durham, NC Hermona Soreq Hebrew University of Jerusalem  Jerusalem, Israel Wojciech Stec Polish Academy of Sciences Lodz, Poland J.-J. Toulmé Universite Victor Segalen  Bordeaux, France Thomas Tuschl Rockefeller University New York, NY Takeshi Wada University of Tokyo Kashiwa, Japan Jesper Wengel University of Southern Denmark Copenhagen, Denmark Steve Wilton University of Western Australia Nedlands, Western Australia   Yun Yen City of Hope National Medical Center  Duarte, CA