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期刊名称:JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

ISSN:1932-6254
出版频率:Monthly
出版社:WILEY, 111 RIVER ST, HOBOKEN, USA, NJ, 07030-5774
  出版社网址:http://onlinelibrary.wiley.com/
期刊网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1932-7005
影响因子:3.963
主题范畴:CELL & TISSUE ENGINEERING;    BIOTECHNOLOGY & APPLIED MICROBIOLOGY;    CELL BIOLOGY;    ENGINEERING, BIOMEDICAL

期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)   



About the journal

Aims and Scope

Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs.

The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.

Coverage Includes

Studies on the interactions between cells and constructs are welcome, particularly where they advance our understanding of these processes or provide clear suggestions for improvements to existing systems. Surface modification technologies, their effects on protein adsorption and on cell seeding adhesion and proliferation are of major interest to the journal. Both in vitro and in vivo approaches will be considered, as the journal also aims to focus on in vivo responses to cell-material constructs. Typically, papers presenting the design, development or refinement of biomaterials or scaffolds will only be considered when these have been tested for their ability to support cellular attachment/interaction and/or growth, development and differentiation.

The journal also publishes manuscripts dealing with novel approaches to regenerative medicine that apply some type of controlled/sustained release strategy. Papers dealing with the development of carrier systems, cell encapsulation, release of drugs, growth factors, differentiation agents, and other types of bioactive agents, especially when they apply nanotechnology and/or non-invasive approaches, are particularly welcome. Works on the use of tissue engineering to develop novel drug discovery/testing methodologies and models are also of special interest. A particular emphasis is also to be placed on inductive scaffolds and matrices and on smart systems, including self-assembly materials, which will react to physiological stimuli and will elicit some exact and controllable response of specific cell types.

Research on the use of different cell types and methods for controlling their isolation, expansion and differentiation, and manuscripts describing the effects of manipulating cells, such as by gene therapy, or by supplying proteins, DNA or other biomolecules within the constructs used are also encouraged. Submissions of works on the derivation and maintenance of new stem cell lines and on the development of novel cocktails and serum free media for their culturing are also invited. Manuscripts addressing fundamental issues of stem cell biology, namely those related with stem cell plasticity, potency, clonality, etc., will be considered only if there is some discussion on potential strategies for their application in relevant clinical situations, in cell based therapies or regenerative medicine approaches. Papers on cell transplantation technologies, as well as on the use of stem cells in drug discovery are welcome. Works on relevant regulatory and ethical issues might also be considered.

The journal also focuses on the use of bioreactors for cell seeding, culturing and stimulation of cell differentiation. Papers on the effects of diffusion and mechanical stimulation of stem and progenitor cells are welcome. The design of novel bioreactors, the use of bioreactors for 2D and 3D tissue growth, as well as all production and scale-up aspects related to the use of bioreactors and its effect on the clinical introduction of new technologies will be welcomed. Papers on industrial and patent aspects of tissue engineering and regenerative medicine are also within the scope of the journal.

Readership

Cell and molecular biologists, materials and biomaterials scientists, biomedical engineers, chemists, medical researchers, clinicians and surgeons specialising in chronic and degenerative diseases, on cell therapies and trauma surgery

Keywords

Tissue Engineering; Regenerative Medicine; Stem Cells; Biomaterials; Scaffolds; Clinical Trials; Cell Therapy; Cell Culture; Smart Materials; Animal Models; Bioreactors; Surgery; Tissues; Organs; Progenitor Cells; Gene Therapy; In vitro; In vivo; Biodegradable; Polymers; Self-Assembly; Minimally-invasive; Surface Modification; Constructs; Transplantation; Repair; Replacement; Regeneration; Artificial Organs; Protein Adsorption

Abstracting and Indexing Information
  • Biological Abstracts® (Thomson ISI)
  • BIOSIS Previews® (Thomson ISI)
  • Biotechnology Citation Indexâ„?(Thomson ISI)
  • INSPEC (IET)
  • Journal Citation Reports/Science Edition (Thomson ISI)
  • MEDLINE/PubMed (NLM)
  • Science Citation Index Expanded (also known as SciSearch®)

Instructions to Authors

Instructions To Authors


AimsAndScope

Manuscript Submission. The Journal of Tissue Engineering and Regenerative Medicine operates an online submission and peer review system that allows authors to submit articles online and track their progress via a web interface. Please read the remainder of these instructions to authors and then click http://mc.manuscriptcentral.com/term to navigate to the Journal of Tissue Engineering and Regenerative Medicine online submission site. Further information can be found there, including a detailed description of the coverage of TERM. All articles must be submitted via the online system.

For assistance, please contact our Editorial office (in the office of Prof. Rui L. Reis at the University of Minho): TERM@wiley.com

Each paper will be evaluated by three independent reviewers. Authors are welcome to submit the names and contact details of up to three suggested reviewers, using the online system, however please note that the Editors are not obliged to use the suggested reviewers. Only those contributions that the Editor-in-Chief or the relevant Associate Editor considers to be of sufficient interest will be sent out for peer review. The criteria for this are based on the aims and scope of the journal, its high quality standards, the originality and potential outcomes of the work, and its significance to the multidisciplinary research fields related to the Journal of Tissue Engineering and Regenerative Medicine .

Submission of a manuscript will be held to imply that it contains original unpublished work and is not being submitted for publication elsewhere at the same time. The first named author is responsible for ensuring that all authors have read and approved the contents of the manuscript, and this should be confirmed in the covering letter to be signed by the senior author.

If a paper has more than 7 authors, the inclusion of each name must be clearly justified. Methods of recognizing contributors have been proposed ( Lancet 1995; 345: 668). The Editors believe that those with a peripheral association with the work should simply be acknowledged ( BJS 2000; 87: 1284-6).

File types. Preferred formats for the text and tables of your manuscript are .doc, .rtf. Figures must be provided in .tiff or .eps format.

Upon acceptance , authors must supply immediately , by postal mail to the Content Editor, quoting the journal name and the manuscript code:

  • a Copyright Transfer Agreement with original signature(s).
  • If the manuscript contains extracts, including illustrations, from other copyright works (including material from on-line or intranet sources) it is the author's responsibility to obtain written permission from the owners of the publishing rights to reproduce such extracts using the Wiley Permission Request Form .
  • For human clinical studies, written consent must be obtained from the patient, legal guardian or executor for publication of any detail or photograph that might identify an individual. Evidence of such consent must be submitted.
  • If relevant, a Conflict of Interest Disclosure Form should be completed by each author.

Copies of these forms are available from the journal website; included in the first print issue of each volume; and may also be obtained from the journal publisher.

Submitted material will not be returned to the author unless specifically requested. Content Editor: David Sheppard, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Ethics. Human investigation and animal experiments must have local ethics committee approval. TERM will not publish an article if appropriate ethical standards have not been met.

Manuscript Style. The language of the journal is English. Please ensure that your manuscript has been checked by a native English speaker, or an English language service, if there is concern for grammatical or other errors. All submissions must have a title, be double-line spaced with type no smaller than 12 point, and have a margin of 3cm all round. Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate image files.

  • The title page must list the full title, short title of up to 70 characters and names and affiliations of all authors. Give the full address, including email, telephone and fax, of the author who is the senior author due to check the proofs.
  • Include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s) if applicable.
  • Supply an abstract of up to 250 words for all articles. An abstract should be a concise summary of the whole paper, not just the conclusions, and it must be understandable without reference to the rest of the paper. It should contain no citation to any other published work.
  • Include up to eight keywords that describe your paper for indexing purposes.
  • Number the sections and sub-sections of papers , in the style: 1. Introduction, 2. Materials and Methods, 2.1. Scaffold Preparation, 2.2. Cell Sourcesâ€?3. Results and Discussion, etc.
  • A concise introduction is required of the present state-of-the-art, the background to the subject, its significance and its relationship to earlier works, with well selected and relevant references.
  • Materials and methods should be presented with clarity and detail in order to allow others to reproduce the work. State the original and important findings in the results . Illustrate these with figures or tables where necessary but keep these to a minimum.
  • Results and discussion may be combined as one section. Discuss the principal conclusions drawn from the results and their important implications.
  • Use Chemical Abstracts nomenclature for chemical names and structures. Use proper or proprietary names with caution. Common acronyms for biomedical names are acceptable but define all others when first mentioned. Define abbreviations when first mentioned and do not use in the title or abstract. Define non-standard units.
  • Keep acknowledgements brief and place them at the end of the paper.
  • Abbreviations; Avoid using abbreviations. Terms that are mentioned frequently may be abbreviated but only if this does not impair comprehension. Abbreviations must be used consistently and must be defined on first use.
  • Numbers and units; Provide absolute numbers; percentages may be given in addition, but never on their own. Use the decimal point, not a comma, for example 5.7. Use a space and not a comma after thousands and multiples thereof, for example 10 000. Use SI units (International System of Units).

Types of Manuscripts. TERM will publish original research papers on all topics that fall within the aims and scope. In addition it will publish peer-reviewed authoritative reviews and perspectives articles submitted by world recognized experts that are invited to or wish to submit, with the aim of sharing opinions, establishing good practice and stimulating discussions of emerging topics or the future evolution of a certain area within the remit of TERM. In order to make sure that new and relevant results are published as quickly as they deserve, while still observing the high peer-review standards of TERM, short communications will also be accepted by the journal. Clinical case studies describing the application of these technologies in human patients are also welcomed.

Original research papers. These should not exceed eight printed pages including typically a maximum of six figures and/or four tables and 30/40 references (one page comprises 860 words or the equivalent in illustrative and tabular material).

Short communications. These must be complete, self-contained papers, and not preliminary reports. They should report on particularly new and relevant results that deserve to be published quickly, and should not exceed 2 printed pages including typically a maximum of 2 figures and/or two tables and 10 to 15 references. To exceed the limit may delay acceptance or publication of the paper, although exceptions may be considered. These papers should be organized in the form of an extended abstract, without sub-headings, but with a clear order of presentation and adequate detail of the relevant experimental methods and the results obtained.

Clinical case studies. These should not exceed eight printed pages including typically a maximum of six figures and/or four tables and 30/40 references, (where one page comprises 860 words or the equivalent in illustrative and tabular material). The reported cases should be highly relevant to the field of TERM, namely with regard to their novelty. Authors should state clearly how many patients were involved in the study and, whenever relevant, a statistical analysis should be included, as well as a detailed section on the experimental methods and ethical protocols followed during the study.

Reviews. These will usually be written by leaders in the field, and at the invitation of the Editors. Unsolicited reviews and manuscripts, especially when based on major conference Plenary/Keynote Lectures will be welcome but authors wishing to submit these are requested to consult the Editor-in-Chief beforehand, ideally prior to commencement of writing. They should start by submitting a synopsis for evaluation. Reviews should include a Table of Contents, and will normally be limited to 12 to 15 printed pages, that is to 10,500 to 13,000 words including references.

Perspectives. These will be short authoritative reviews presenting an outlook on the likely evolution of a chosen subject area. They will usually be written by leaders in the field, typically by invitation. Unsolicited perspective papers may be considered if they are of special relevance to the field and the authors are recognized or clearly emerging in that specific scientific area. Again, authors wishing to submit such articles are requested to consult the Editor-in-Chief beforehand, ideally prior to commencement of writing. They should start by submitting a short synopsis for evaluation. Perspectives will normally be limited to 3 to 6 pages, that is to 2,600 to 5,200 words including references.

Reference style. References should be quoted in the text as name and year e.g. (Smith et al ., 2006), and listed at the end of the paper alphabetically. Where three or more authors are listed in the reference list, please cite in the text as (Collins et al., 1998). If 2 authors are listed then both should be shown in the text (Collins and Williams 2001).

All references must be complete and accurate, and reference to abstracts and personal communications is strongly discouraged. The Journal of Tissue Engineering and Regenerative Medicine uses MEDLINE journal title abbreviations; to look up the correct abbreviation of a journal title, visit: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals

References should be listed in the following style:

Journal articles: Salgado AJ, Coutinho OP, Reis RL. 2004, Bone tissue engineering: State of the art and future trends, Macromol Biosci , 4 : 743-765

Books: Reis RL. San Roman J. 2004, Biodegradable Systems in the Journal of Tissue Engineering and Regenerative Medicine , CRC Press, Boca Raton, FL, USA

Chapters in books: Gomes ME, Mikos AG, Reis RL. 2004, ‘Injectable Polymeric Scaffolds for Bone Tissue Engineering�in Biodegradable Systems in Tissue Engineering and Regenerative Medicine , eds. Reis RL, San Roman J, CRC Press, Boca Raton, FL, USA; 29-38

Illustrations. Upload each figure as a separate file in either .tiff or .eps format, with the figure number and the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of a reasonable size that would still be clearly legible upon reduction, and consistent within each figure and set of figures. Please supply artwork at the intended size for printing, sized to the text width of 84mm/single column, 176mm/double column. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All illustrations must be supplied at the correct resolution:

  • Black and white and colour photos - 300 dpi
  • Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
  • Combinations of photos and drawings (black and white and colour) - 500 dpi

The cost of printing colour illustrations in the journal will be charged to the author, at a rate of £500 per page. If colour illustrations are supplied electronically in either TIFF or EPS format, they may be used in the PDF of the article at no cost to the author, even if this illustration was printed in black and white in the journal. The PDF will appear on the Wiley InterScience site.

Copyright. To enable the publisher to disseminate the author's work to the fullest extent, the author must sign a Copyright Transfer Agreement , transferring copyright in the article from the author to the publisher, and submit the original signed agreement with the article presented for publication. A copy of the agreement to be used (which may be photocopied) can be found in the first issue of each volume of the Journal of Tissue Engineering and Regenerative Medicine. Copies may also be obtained from the journal editor or publisher, or may be printed from the journal website.

Proofs and offprints. Proofs will be sent to the author for checking. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue. Free access to the final PDF offprint or your article will be available via Author Services. Please therefore sign up for Author Services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers.


Editorial Board
EDITOR IN CHIEF
Rui L. Reis
University of Minho, Braga, Portugal
ASSOCIATE EDITORS
Samuel I. Stupp
Northwestern University
Chicago, USA
Hajime Ohgushi
Research Institute for Cell Engineering (RICE),
AIST, Osaka, Japan
Anthony Atala
Wake Forest University, North Carolina,
USA
EDITORIAL BOARD
C. Mauli Agrawal
University of Texas at San Antonio
San Antonio
USA
Nureddin Ashammakhi
Keele University
Oswestry, UK
Augustinus Bader
University of Leipzig
Leipzig
Germany
Besim Ben-Nissan
University of Technology Sydney
Sydney
Australia
Paolo Bianco
University of Rome “La Sapienza�BR>Rome
Italy
Aldo R. Boccaccini
Imperial College Sci
Tech & Medicine
London
UK
Barbara D. Boyan
Georgia Institute of Technology
Atlanta
USA
Robert A. Brown
University College of London
London
UK
Joaquim Sampaio Cabral
Instituto Superior Técnico
Lisbon
Portugal
Ranieri Cancedda
University of Genova
Genova
Italy
Yilin Cao
Shanghai Tissue Engineering Center
Shanghai
China
Arnold I. Caplan
Case Western Reserve University
Cleveland
USA
Emo Chiellini
University of Pisa
Pisa
Italy
Daniel Cohn
Hebrew University of Jerusalem
Jerusalem
Israel
Fu Zhai Cui
Tsinghua University
Beijing
China
Jed Davies
University of Toronto
Toronto
Canada
Joost D. de Bruijn
Queen Mary University of London
London
UK
Paul Ducheyne
University of Pennsylvania
Philadelphia
USA
Andres J. Garcia
Georgia Institute of Technology
Atlanta
USA
Paul Gatenholm
Chalmers University of Technology
Göteborg
Sweden
Dan Gazit
Hebrew University of Jerusalem
Jerusalem
Israel
Jeffrey M. Gimble
Louisiana State University
Baton Rouge
USA
Alicia El Haj
Keele University
Keele
UK
Vasif Hasirci
Middle East Technical University
Ankara
Turkey
Paul V. Hatton
University of Sheffield
Sheffield
UK
Jons Hilborn
Uppsala University
Uppsala
Sweden
Jeffrey Hubbell
École Polytechnique Fédérale de Lausanne
Lausanne
Switzerland
Dietmar Hutmacher
National University Singapore
Singapore
Joseph Itskovitz-Eldor
Technion Israel Institute of Technology
Haifa
Israel
John A. Jansen
University of Nijmegen
Nijmegen
Netherlands
David L. Kaplan
Tufts University
Boston
USA
Byung-Soo Kim
Hanyang University
Seoul
South Korea
Charles James Kirkpatrick
Johannes Gutenberg Universität
Mainz
Germany
Hai Bang Lee
Korea Research Institute of Chemical Technology
Daejeon
Korea
Wei Liu
Shanghai Tissue Engineering Center
Shanghai
China
Ivan Martin
University Hospital of Basel
Basel
Switzerland
Claudio Migliaresi
University of Trento
Trento
Italy
Antonios G. Mikos
Rice University
Houston
USA
Ralph Müller
Swiss Federal Institute of Technology
Zurich
Switzerland
Robert M. Nerem
Georgia Institute of Technology
Atlanta
USA
Gordana V. Novakovic
Columbia University
New York
USA
Teruo Okano
Tokyo Women's Medical University
Tokyo
Japan
Gerjo van Osch
Erasmus University
Rotterdam
The Netherlands
Erhan Piskin
Hacettepe University
Ankara
Turkey
Julia M. Polak
Imperial College Sci
Tech & Medicine
London
UK
Buddy D. Ratner
University of Washington
Seattle
USA
A. Hari Reddi
University of California at Davis
Sacramento
USA
Heinz Redl
Ludwing Boltzmann Institute for
  Experimental and Clinical Traumatology
Vienna
Austria
Julio San Roman
Instituto de Ciencia y Tecnologia de Polímeros
CSIC
Madrid
Spain
Nicole Rotter
University Hospital of Schleswig-Holstein
Lübeck
Germany
Allan J. Russell
University of Pittsburgh
Pittsburgh
USA
Frantisek Rypacek
Academy of Sciences of the Czech Republic
Prague
Czech Republic
Michael V. Sefton
University of Toronto
Toronto
Canada
Michael Sittinger
Charité - University Medicine
Berlin
Germany
Bjorn Stark
University of Freiburg
Freiburg
Germany
Hwal Suh
Yonsei University
Yonsei
Korea
Yasuhiko Tabata
Kyoto University
Kyoto
Japan
Tetsuya Tateishi
National Institute of Materials Science
Tsukuba
Japan
Swee Hin Teoh
National University of Singapore
Singapore
Minoru Ueda
Nagoya University
Nagoya
Japan
Takashi Ushida
University of Tokyo
Tokyo
Japan
Clemens A. van Blitterswijk
University of Twente
Enschede
The Netherlands
Catherine M. Verfaillie
Catholic University of Leuven
Leuven, Belgium
William R. Wagner
University of Pittsburgh
Pittsburgh
USA
Anna M. Wobus
Institute Plant Genetics & Crop Plant Research
Gatersleben
Germany


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