期刊名称:JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Aims and Scope
Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs.
The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.
Coverage Includes
Studies on the interactions between cells and constructs are welcome, particularly where they advance our understanding of these processes or provide clear suggestions for improvements to existing systems. Surface modification technologies, their effects on protein adsorption and on cell seeding adhesion and proliferation are of major interest to the journal. Both in vitro and in vivo approaches will be considered, as the journal also aims to focus on in vivo responses to cell-material constructs. Typically, papers presenting the design, development or refinement of biomaterials or scaffolds will only be considered when these have been tested for their ability to support cellular attachment/interaction and/or growth, development and differentiation.
The journal also publishes manuscripts dealing with novel approaches to regenerative medicine that apply some type of controlled/sustained release strategy. Papers dealing with the development of carrier systems, cell encapsulation, release of drugs, growth factors, differentiation agents, and other types of bioactive agents, especially when they apply nanotechnology and/or non-invasive approaches, are particularly welcome. Works on the use of tissue engineering to develop novel drug discovery/testing methodologies and models are also of special interest. A particular emphasis is also to be placed on inductive scaffolds and matrices and on smart systems, including self-assembly materials, which will react to physiological stimuli and will elicit some exact and controllable response of specific cell types.
Research on the use of different cell types and methods for controlling their isolation, expansion and differentiation, and manuscripts describing the effects of manipulating cells, such as by gene therapy, or by supplying proteins, DNA or other biomolecules within the constructs used are also encouraged. Submissions of works on the derivation and maintenance of new stem cell lines and on the development of novel cocktails and serum free media for their culturing are also invited. Manuscripts addressing fundamental issues of stem cell biology, namely those related with stem cell plasticity, potency, clonality, etc., will be considered only if there is some discussion on potential strategies for their application in relevant clinical situations, in cell based therapies or regenerative medicine approaches. Papers on cell transplantation technologies, as well as on the use of stem cells in drug discovery are welcome. Works on relevant regulatory and ethical issues might also be considered.
The journal also focuses on the use of bioreactors for cell seeding, culturing and stimulation of cell differentiation. Papers on the effects of diffusion and mechanical stimulation of stem and progenitor cells are welcome. The design of novel bioreactors, the use of bioreactors for 2D and 3D tissue growth, as well as all production and scale-up aspects related to the use of bioreactors and its effect on the clinical introduction of new technologies will be welcomed. Papers on industrial and patent aspects of tissue engineering and regenerative medicine are also within the scope of the journal.
Readership
Cell and molecular biologists, materials and biomaterials scientists, biomedical engineers, chemists, medical researchers, clinicians and surgeons specialising in chronic and degenerative diseases, on cell therapies and trauma surgery
Keywords
Tissue Engineering; Regenerative Medicine; Stem Cells; Biomaterials; Scaffolds; Clinical Trials; Cell Therapy; Cell Culture; Smart Materials; Animal Models; Bioreactors; Surgery; Tissues; Organs; Progenitor Cells; Gene Therapy; In vitro; In vivo; Biodegradable; Polymers; Self-Assembly; Minimally-invasive; Surface Modification; Constructs; Transplantation; Repair; Replacement; Regeneration; Artificial Organs; Protein Adsorption
Abstracting and Indexing Information
- Biological Abstracts® (Thomson ISI)
- BIOSIS Previews® (Thomson ISI)
- Biotechnology Citation Indexâ„?(Thomson ISI)
- INSPEC (IET)
- Journal Citation Reports/Science Edition (Thomson ISI)
- MEDLINE/PubMed (NLM)
- Science Citation Index Expanded (also known as SciSearch®)
Instructions to Authors
Instructions To Authors AimsAndScope
Manuscript Submission. The Journal of Tissue Engineering and Regenerative Medicine operates an online submission and peer review system that allows authors to submit articles online and track their progress via a web interface. Please read the remainder of these instructions to authors and then click http://mc.manuscriptcentral.com/term to navigate to the Journal of Tissue Engineering and Regenerative Medicine online submission site. Further information can be found there, including a detailed description of the coverage of TERM. All articles must be submitted via the online system.
For assistance, please contact our Editorial office (in the office of Prof. Rui L. Reis at the University of Minho): TERM@wiley.com
Each paper will be evaluated by three independent reviewers. Authors are welcome to submit the names and contact details of up to three suggested reviewers, using the online system, however please note that the Editors are not obliged to use the suggested reviewers. Only those contributions that the Editor-in-Chief or the relevant Associate Editor considers to be of sufficient interest will be sent out for peer review. The criteria for this are based on the aims and scope of the journal, its high quality standards, the originality and potential outcomes of the work, and its significance to the multidisciplinary research fields related to the Journal of Tissue Engineering and Regenerative Medicine .
Submission of a manuscript will be held to imply that it contains original unpublished work and is not being submitted for publication elsewhere at the same time. The first named author is responsible for ensuring that all authors have read and approved the contents of the manuscript, and this should be confirmed in the covering letter to be signed by the senior author.
If a paper has more than 7 authors, the inclusion of each name must be clearly justified. Methods of recognizing contributors have been proposed ( Lancet 1995; 345: 668). The Editors believe that those with a peripheral association with the work should simply be acknowledged ( BJS 2000; 87: 1284-6).
File types. Preferred formats for the text and tables of your manuscript are .doc, .rtf. Figures must be provided in .tiff or .eps format.
Upon acceptance , authors must supply immediately , by postal mail to the Content Editor, quoting the journal name and the manuscript code:
- a Copyright Transfer Agreement with original signature(s).
- If the manuscript contains extracts, including illustrations, from other copyright works (including material from on-line or intranet sources) it is the author's responsibility to obtain written permission from the owners of the publishing rights to reproduce such extracts using the Wiley Permission Request Form .
- For human clinical studies, written consent must be obtained from the patient, legal guardian or executor for publication of any detail or photograph that might identify an individual. Evidence of such consent must be submitted.
- If relevant, a Conflict of Interest Disclosure Form should be completed by each author.
Copies of these forms are available from the journal website; included in the first print issue of each volume; and may also be obtained from the journal publisher.
Submitted material will not be returned to the author unless specifically requested. Content Editor: David Sheppard, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
Ethics. Human investigation and animal experiments must have local ethics committee approval. TERM will not publish an article if appropriate ethical standards have not been met.
Manuscript Style. The language of the journal is English. Please ensure that your manuscript has been checked by a native English speaker, or an English language service, if there is concern for grammatical or other errors. All submissions must have a title, be double-line spaced with type no smaller than 12 point, and have a margin of 3cm all round. Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate image files.
- The title page must list the full title, short title of up to 70 characters and names and affiliations of all authors. Give the full address, including email, telephone and fax, of the author who is the senior author due to check the proofs.
- Include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s) if applicable.
- Supply an abstract of up to 250 words for all articles. An abstract should be a concise summary of the whole paper, not just the conclusions, and it must be understandable without reference to the rest of the paper. It should contain no citation to any other published work.
- Include up to eight keywords that describe your paper for indexing purposes.
- Number the sections and sub-sections of papers , in the style: 1. Introduction, 2. Materials and Methods, 2.1. Scaffold Preparation, 2.2. Cell Sources�3. Results and Discussion, etc.
- A concise introduction is required of the present state-of-the-art, the background to the subject, its significance and its relationship to earlier works, with well selected and relevant references.
- Materials and methods should be presented with clarity and detail in order to allow others to reproduce the work. State the original and important findings in the results . Illustrate these with figures or tables where necessary but keep these to a minimum.
- Results and discussion may be combined as one section. Discuss the principal conclusions drawn from the results and their important implications.
- Use Chemical Abstracts nomenclature for chemical names and structures. Use proper or proprietary names with caution. Common acronyms for biomedical names are acceptable but define all others when first mentioned. Define abbreviations when first mentioned and do not use in the title or abstract. Define non-standard units.
- Keep acknowledgements brief and place them at the end of the paper.
- Abbreviations; Avoid using abbreviations. Terms that are mentioned frequently may be abbreviated but only if this does not impair comprehension. Abbreviations must be used consistently and must be defined on first use.
- Numbers and units; Provide absolute numbers; percentages may be given in addition, but never on their own. Use the decimal point, not a comma, for example 5.7. Use a space and not a comma after thousands and multiples thereof, for example 10 000. Use SI units (International System of Units).
Types of Manuscripts. TERM will publish original research papers on all topics that fall within the aims and scope. In addition it will publish peer-reviewed authoritative reviews and perspectives articles submitted by world recognized experts that are invited to or wish to submit, with the aim of sharing opinions, establishing good practice and stimulating discussions of emerging topics or the future evolution of a certain area within the remit of TERM. In order to make sure that new and relevant results are published as quickly as they deserve, while still observing the high peer-review standards of TERM, short communications will also be accepted by the journal. Clinical case studies describing the application of these technologies in human patients are also welcomed.
Original research papers. These should not exceed eight printed pages including typically a maximum of six figures and/or four tables and 30/40 references (one page comprises 860 words or the equivalent in illustrative and tabular material).
Short communications. These must be complete, self-contained papers, and not preliminary reports. They should report on particularly new and relevant results that deserve to be published quickly, and should not exceed 2 printed pages including typically a maximum of 2 figures and/or two tables and 10 to 15 references. To exceed the limit may delay acceptance or publication of the paper, although exceptions may be considered. These papers should be organized in the form of an extended abstract, without sub-headings, but with a clear order of presentation and adequate detail of the relevant experimental methods and the results obtained.
Clinical case studies. These should not exceed eight printed pages including typically a maximum of six figures and/or four tables and 30/40 references, (where one page comprises 860 words or the equivalent in illustrative and tabular material). The reported cases should be highly relevant to the field of TERM, namely with regard to their novelty. Authors should state clearly how many patients were involved in the study and, whenever relevant, a statistical analysis should be included, as well as a detailed section on the experimental methods and ethical protocols followed during the study.
Reviews. These will usually be written by leaders in the field, and at the invitation of the Editors. Unsolicited reviews and manuscripts, especially when based on major conference Plenary/Keynote Lectures will be welcome but authors wishing to submit these are requested to consult the Editor-in-Chief beforehand, ideally prior to commencement of writing. They should start by submitting a synopsis for evaluation. Reviews should include a Table of Contents, and will normally be limited to 12 to 15 printed pages, that is to 10,500 to 13,000 words including references.
Perspectives. These will be short authoritative reviews presenting an outlook on the likely evolution of a chosen subject area. They will usually be written by leaders in the field, typically by invitation. Unsolicited perspective papers may be considered if they are of special relevance to the field and the authors are recognized or clearly emerging in that specific scientific area. Again, authors wishing to submit such articles are requested to consult the Editor-in-Chief beforehand, ideally prior to commencement of writing. They should start by submitting a short synopsis for evaluation. Perspectives will normally be limited to 3 to 6 pages, that is to 2,600 to 5,200 words including references.
Reference style. References should be quoted in the text as name and year e.g. (Smith et al ., 2006), and listed at the end of the paper alphabetically. Where three or more authors are listed in the reference list, please cite in the text as (Collins et al., 1998). If 2 authors are listed then both should be shown in the text (Collins and Williams 2001).
All references must be complete and accurate, and reference to abstracts and personal communications is strongly discouraged. The Journal of Tissue Engineering and Regenerative Medicine uses MEDLINE journal title abbreviations; to look up the correct abbreviation of a journal title, visit: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals
References should be listed in the following style:
Journal articles: Salgado AJ, Coutinho OP, Reis RL. 2004, Bone tissue engineering: State of the art and future trends, Macromol Biosci , 4 : 743-765
Books: Reis RL. San Roman J. 2004, Biodegradable Systems in the Journal of Tissue Engineering and Regenerative Medicine , CRC Press, Boca Raton, FL, USA
Chapters in books: Gomes ME, Mikos AG, Reis RL. 2004, ‘Injectable Polymeric Scaffolds for Bone Tissue Engineering�in Biodegradable Systems in Tissue Engineering and Regenerative Medicine , eds. Reis RL, San Roman J, CRC Press, Boca Raton, FL, USA; 29-38
Illustrations. Upload each figure as a separate file in either .tiff or .eps format, with the figure number and the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of a reasonable size that would still be clearly legible upon reduction, and consistent within each figure and set of figures. Please supply artwork at the intended size for printing, sized to the text width of 84mm/single column, 176mm/double column. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All illustrations must be supplied at the correct resolution:
- Black and white and colour photos - 300 dpi
- Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
- Combinations of photos and drawings (black and white and colour) - 500 dpi
The cost of printing colour illustrations in the journal will be charged to the author, at a rate of £500 per page. If colour illustrations are supplied electronically in either TIFF or EPS format, they may be used in the PDF of the article at no cost to the author, even if this illustration was printed in black and white in the journal. The PDF will appear on the Wiley InterScience site.
Copyright. To enable the publisher to disseminate the author's work to the fullest extent, the author must sign a Copyright Transfer Agreement , transferring copyright in the article from the author to the publisher, and submit the original signed agreement with the article presented for publication. A copy of the agreement to be used (which may be photocopied) can be found in the first issue of each volume of the Journal of Tissue Engineering and Regenerative Medicine. Copies may also be obtained from the journal editor or publisher, or may be printed from the journal website.
Proofs and offprints. Proofs will be sent to the author for checking. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue. Free access to the final PDF offprint or your article will be available via Author Services. Please therefore sign up for Author Services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers.
Editorial Board
EDITOR IN CHIEF |
Rui L. Reis University of Minho, Braga, Portugal |
ASSOCIATE EDITORS |
Samuel I. Stupp Northwestern University Chicago, USA |
Hajime Ohgushi Research Institute for Cell Engineering (RICE), AIST, Osaka, Japan |
Anthony Atala Wake Forest University, North Carolina, USA |
EDITORIAL BOARD |
C. Mauli Agrawal University of Texas at San Antonio San Antonio USA |
Nureddin Ashammakhi Keele University Oswestry, UK
|
Augustinus Bader University of Leipzig Leipzig Germany |
Besim Ben-Nissan University of Technology Sydney Sydney Australia |
Paolo Bianco University of Rome “La Sapienza�BR>Rome Italy |
Aldo R. Boccaccini Imperial College Sci Tech & Medicine London UK |
Barbara D. Boyan Georgia Institute of Technology Atlanta USA |
Robert A. Brown University College of London London UK |
Joaquim Sampaio Cabral Instituto Superior Técnico Lisbon Portugal |
Ranieri Cancedda University of Genova Genova Italy |
Yilin Cao Shanghai Tissue Engineering Center Shanghai China |
Arnold I. Caplan Case Western Reserve University Cleveland USA |
Emo Chiellini University of Pisa Pisa Italy |
Daniel Cohn Hebrew University of Jerusalem Jerusalem Israel |
Fu Zhai Cui Tsinghua University Beijing China |
Jed Davies University of Toronto Toronto Canada |
Joost D. de Bruijn Queen Mary University of London London UK |
Paul Ducheyne University of Pennsylvania Philadelphia USA |
Andres J. Garcia Georgia Institute of Technology Atlanta USA |
Paul Gatenholm Chalmers University of Technology Göteborg Sweden |
Dan Gazit Hebrew University of Jerusalem Jerusalem Israel |
Jeffrey M. Gimble Louisiana State University Baton Rouge USA |
Alicia El Haj Keele University Keele UK |
Vasif Hasirci Middle East Technical University Ankara Turkey |
Paul V. Hatton University of Sheffield Sheffield UK |
Jons Hilborn Uppsala University Uppsala Sweden |
Jeffrey Hubbell École Polytechnique Fédérale de Lausanne Lausanne Switzerland |
Dietmar Hutmacher National University Singapore Singapore |
Joseph Itskovitz-Eldor Technion Israel Institute of Technology Haifa Israel |
John A. Jansen University of Nijmegen Nijmegen Netherlands |
David L. Kaplan Tufts University Boston USA |
Byung-Soo Kim Hanyang University Seoul South Korea |
Charles James Kirkpatrick Johannes Gutenberg Universität Mainz Germany |
Hai Bang Lee Korea Research Institute of Chemical Technology Daejeon Korea |
Wei Liu Shanghai Tissue Engineering Center Shanghai China |
Ivan Martin University Hospital of Basel Basel Switzerland |
Claudio Migliaresi University of Trento Trento Italy |
Antonios G. Mikos Rice University Houston USA |
Ralph Müller Swiss Federal Institute of Technology Zurich Switzerland |
Robert M. Nerem Georgia Institute of Technology Atlanta USA |
Gordana V. Novakovic Columbia University New York USA |
Teruo Okano Tokyo Women's Medical University Tokyo Japan |
Gerjo van Osch Erasmus University Rotterdam The Netherlands |
Erhan Piskin Hacettepe University Ankara Turkey |
Julia M. Polak Imperial College Sci Tech & Medicine London UK |
Buddy D. Ratner University of Washington Seattle USA |
A. Hari Reddi University of California at Davis Sacramento USA |
Heinz Redl Ludwing Boltzmann Institute for Experimental and Clinical Traumatology Vienna Austria |
Julio San Roman Instituto de Ciencia y Tecnologia de PolÃmeros CSIC Madrid Spain |
Nicole Rotter University Hospital of Schleswig-Holstein Lübeck Germany |
Allan J. Russell University of Pittsburgh Pittsburgh USA |
Frantisek Rypacek Academy of Sciences of the Czech Republic Prague Czech Republic |
Michael V. Sefton University of Toronto Toronto Canada |
Michael Sittinger Charité - University Medicine Berlin Germany |
Bjorn Stark University of Freiburg Freiburg Germany |
Hwal Suh Yonsei University Yonsei Korea |
Yasuhiko Tabata Kyoto University Kyoto Japan |
Tetsuya Tateishi National Institute of Materials Science Tsukuba Japan |
Swee Hin Teoh National University of Singapore Singapore |
Minoru Ueda Nagoya University Nagoya Japan |
Takashi Ushida University of Tokyo Tokyo Japan |
Clemens A. van Blitterswijk University of Twente Enschede The Netherlands |
Catherine M. Verfaillie Catholic University of Leuven Leuven, Belgium
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William R. Wagner University of Pittsburgh Pittsburgh USA |
Anna M. Wobus Institute Plant Genetics & Crop Plant Research Gatersleben Germany |
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