Instructions to Authors
Initial Manuscript Submission. Submit four copies of the manuscript (including copies of tables and illustrations) to the Office of the Editor-in-Chief or the North American Editorial Office.
Authors must also supply:
- an electronic copy of the final version (see section below),
- a Copyright Transfer Agreement with original signature(s) - without this we are unable to accept the submission, and
- permission grants - if the manuscript contains extracts, including illustrations, from other copyright works (including material from on-line or intranet sources) it is the author's responsibility to obtain written permission from the owners of the publishing rights to reproduce such extracts using the Wiley Permission Request Form. Permission grants should be submitted with the manuscript.
Submitted manuscripts should not have been previously published and should not be submitted for publication elsewhere while they are under consideration by Wiley. Submitted material will not be returned to the author unless specifically requested.
All contributions should be accompanied by an e-mail address to enable rapid resolution of queries and the e-mailing of proofs to authors.
Electronic submission. The electronic copy of the final, revised manuscript, where available, should be sent to the Editor together with the four paper copies. Disks should be PC or Mac formatted; write on the disk the software package used, the name of the author and the name of the journal. We are able to use files produced by most word processing packages, but prefer them in Word or WordPerfect format. Illustrations must be submitted in electronic format where possible. Save each figure as a separate file, preferably in eps, ps, pdf or tif format, and include the source file. Write on the disk the software package used to create them; we favour dedicated illustration packages over tools such as Excel or Powerpoint.
Manuscript style. The language of the journal is English. All submissions, including book reviews, must have a title, be printed on one side of the paper, be double-line spaced and have a margin of 3cm all round. Illustrations and tables must be printed on separate sheets, and not be incorporated into the text.
- Include on the title page the full title of the paper, a short title of up to 70 characters and the names and affiliations of all authors. Give the full address, including e-mail, telephone and fax, of the author who is to check the proofs.
- Give the name(s) of any sponsors of the research contained in the paper, along with grant numbers.
- Supply an abstract of up to 300 words for all articles except book reviews. An abstract is a concise summary of the whole paper, not just the conclusions, and is understandable without reference to the rest of the paper.
- Include up to eight keywords that describe your paper for indexing purposes.
- Supply a list of abbreviations used, excluding standard abbreviations.
Full Length Papers. These papers will describe, in detail, original methods and their applications in the fields covered by the journal. Original papers should not include material that has been published elsewhere, except in abstracts. The manuscripts should be organised as follows (consult a recent journal issue for style and format):
Introduction. For the reader's benefit, a concise background summary of the subject material should be presented, concentrating on the specific aspects that have led to the current report (purpose, goals), with citation of important previous work and useful review articles. Lengthy repetition of 'common' knowledge or an in-depth literature review is not appropriate.
Experimental. All necessary information should be given to completely describe the system under investigation. Technical information and methodologies should be presented in sufficient detail so that a thorough evaluation of the meaning and accuracy of the work can be made and the experiments can be repeated by others. References may be made to previously published work that presents directly relevant details (e.g. preparation and purification procedures, cell culture details, pulse sequences). However, the understanding and critical judgement of the current work should be possible without extensive recourse to the literature.
For example, for animal studies procedures for maintaining and/or monitoring anaesthesia, body temperature, blood pressure, and blood gases are of interest. For cell culture work details concerning the medium, serum type and concentration, substrate material (flask type and size), atmospheric composition, pH, medium volume and change interval, and harvesting procedures should be provided. Animal strains, cell culture lines, chemicals and drugs (including generic names), doses, routes of administration, etc. should be precisely defined. Sources should be defined (company or institution, city, state (USA) and country). The work must have met local ethical and legal standards. For MRS, chemical shifts should be referenced to a commonly used standard; for external standards (e.g. capillary) the precise composition of the reference and the geometry should be defined. For pH measurements via chemical shifts, define the titration curve used or cite literature reference.
The following information regarding MR measurements should be included wherever appropriate:
- MR instrumentation: manufacturer and model; magnetic field strength in T; bore size and orientation (horizontal or vertical); designation of probehead type, shim and gradient systems, computer system and software.
- For non-standard probeheads and for in vivo work for imaging, further details concerning rf coil or resonator configurations should be supplied. For asymmetric samples, give the orientation of the long axis with respect to the B0 field and the orientation of the coil configuration with respect to the sample.
- Hardware efficiency and calibrations should be defined as completely as possible, e.g. rf: transmitter and decoupler powers, pulse length for 90?or 180?pulses (e.g. at the centre of a surface coil); field gradients: max. strength used in mT/m, efficiency in mT/m/A (when known), was pre-emphasis used, min. dead time.
- Commonly used pulse sequences should be defined by the accepted name; modified or more specialised sequences should be clearly presented or a literature reference given. The timing of all sequences should be completely defined in terms of the delays and pulse lengths used (including gradients). Specify the total measurement time required for each experiment. In multidimensional studies the spatial and frequency domains and the phase-encoding and rf phase-cycling schemes should be defined. For 2D MRS the following points are of interest: spectral width, time increments, and number of data points in each time domain; techniques for quadrature detection and digitisation (sequential or simultaneous); phase cycling or gradient-echo techniques for selection of coherence transfer pathways, magnitude or phase-sensitive mode.
- Where appropriate, define TR and TE, their relationship to relaxation times, and correction factors used for quantitative analysis.
- Fourier transformation methods should be clearly defined in terms of window functions (appodization) used, zero-filling, final data sizes in each dimension, modes and algorithms used (magnitude or phase-sensitive, real or complex).
Methods of data processing and analysis and software packages used should be clearly defined. The use of established statistical methods is encouraged when making comparisons or defining trends and dependencies. For linear regression analysis the correlation coefficient r is required, and when the regression coefficient (slope) b is used, its estimated standard error should be given; from these parameters a t- or F-test for the significance of a correlation can be made. For a general least-squares fit the mean squared residuals and the standard errors for fitted parameters should be given. When a t-test is used, the type of comparison being made or the 'null' hypothesis for which p values will be quoted should be described (e.g. two-sample comparison of means, one sample t statistic for comparing one value to a sample mean, confidence level analysis, etc); always specify whether a one or two-sided test is applied and for a two-sample test specify whether equal variances for the two groups (e.g. large populations with n > 5) or unequal variances (conservative test more appropriate for small samples of unequal size) have been assumed. Note that the F-test for equal variances can be misleading for non-normal or skewed distributions. A critical discussion of these tests can be found in Introduction to the Practice of Statistics by D.S. Moore and G.P. McCabe (W.H. Freeman & Co., 1989). Other useful texts are: Statistics: A Biomedical Introduction, B.W. Brown Jr and M. Hollander (John Wiley & Sons, 1977) and Introduction to Probability and Statistics, 7th Ed., W. Mendenhall (Duxbury Press, 1989).
Results. The most important original data and findings should be presented in a logical sequence, using the minimum number of tables and figures necessary for clarity and completeness. Representative spectra or images should be included as necessary to demonstrate the quality of the primary data and the strength of the conclusions drawn. Avoid lengthy explanations or comparisons that are redundant with the Experimental or Discussion sections.
Authors may, if they wish, provide an electronic address (e.g. an anonymous ftp site) for access to additional material such as images, spectra etc., as a service to the readers. This additional material will not form part of the paper and will not be reviewed. Addresses should be given at the end of the Discussion section, before Acknowledgements. State (a) the address; (b) the data available; (c) the log-in procedure; (d) the minimum time for which the data will be available.
Discussion. This section is reserved for the presentation of justifiable conclusions based on the material in the Results section, for comparisons with previous work, and for the discussion of implications. Where appropriate, alternative interpretations should be considered and ruled out if possible. If preferred, the Results and Discussion may be combined.
Acknowledgements. These should be brief and placed at the end of the paper.
Units and Symbols. In general SI units should be used, but blood pressures should be given in mmHg. Concentrations in vivo should be described where possible in molar terms, e.g. mmol/kg wet wt. M should be used for mol/L. (The letter M is not an abbreviation for mole, it is reserved for molar. Use mM for 10-3 mol/L and µM for 10-6mol/L). Unusual symbols should be defined in the margin on first use.
Abbreviations. Common abbreviations (e.g. NMR, MRS, MRI, Pi, TE, TR, T1, T2, ATP etc) may be used without definition. The IUPAC nomenclature for chemical names and abbreviations should be used as first choice (e.g. phosphocholine, not phoshorylcholine; Glc for glucose, not Glu or Gluc), e.g. Eur. J. Biochem. 1970; 15: 203-308; 1977; 79: 1-21, and Biochem. J. 1996; 313: 4-15. A list of non-standard abbreviations should be included. Acronyms e.g. for pulse sequences, are acceptable in principle, subject to their relevance/value/elegance/wit.
Rapid Communications. These should not normally exceed four journal pages in length. A letter justifying the request for rapid publication must be included with the manuscript. The content and organisation should follow the guidelines for full papers. Page proofs will not be sent to the authors before publications.
Reviews. These will usually be written at the invitation of the Editors. Unsolicited reviews are welcome but authors wishing to submit a review are requested to consult the Editors prior to commencement.
Letters to the Editor. These, which need have no fixed format, are intended for constructive comments on published work or for putting forward new ideas, and are published at the discretion of the Editors.
Book Reviews. The Editors will be pleased to receive books for possible review.
Forthcoming Events. Please send details to the Editor-in-Chief.
Reference style. References should be cited by superior numbers and listed at the end of the paper in the order in which they appear in the text. Authors should cite only available published work. If necessary, cite unpublished or personal work in the text but do not include them in the references list. References should be listed in the following style:
- Saeed N. Magnetic resonance image segmentation using pattern recognition, and applied to image registration and quantitation. NMR Biomed. 1998; 11: 157-167.
- Gillies RJ, Alger JR, den Hollander JA, Shulman, RG. Intracellular pH measured by NMR: methods and results. In Intracellular pH: Its Measurement, Regulation and Utilisation in Cellular Functions, Nuccitelli R, Deamer DW (eds). Alan R Liss: New York, 1982; 79-104.
Illustrations. Supply each illustration on a separate sheet, with the lead author's name, figure number and orientation on the reverse. Supply original photographs; photocopies or previously printed material will not be used. Line artwork must be high-quality laser output (not photocopies). Use hatching, not tints; lettering must be of a reasonable size that would still be clearly legible in case of reduction, and consistent within each figure and set of figures. Supply artwork at the intended size for printing. The cost of printing colour illustrations in the journal will be charged to the author. If colour illustrations are supplied electronically in one of the formats specified earlier, they may be used in the PDF of the article at no cost to the author, even if this illustration was printed in black and white in the journal. The PDF will appear on the Wiley InterScience site.
Copyright. In order to enable the publisher to disseminate the author's work to the fullest extent, the author must sign a Copyright Transfer Agreement, transferring copyright in the article from the author to the publisher, and submit the original signed agreement with the article presented for publication. A copy of the agreement to be used (which may be photocopied) is reproduced occasionally in the journal. Copies may also be obtained from the Editors or Publisher.
Further Information. Typeset proofs will be sent to the author for checking, e-mail being used wherever possible. Authors are therefore requested to supply their e-mail address with their papers. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue. 25 complimentary offprints will be provided to the author who checked the proofs, unless otherwise indicated. There is no page charge to authors.
Editorial Board
| EDITOR-IN-CHIEF
John R. Griffiths
CRC Biomedical Magnetic Resonance
Research Group
Department of Biochemistry
St George's Hospital Medical School
Cranmer Terrace
London SW17 0RE, UK
Tel: (+44) 020 8725 5811
Fax: (+44) 020 8725 2992
e-mail: sgbc100@sghms.ac.uk |
NORTH AMERICAN EDITOR
J. A. Helpern
Department of Radiology
New York University School of Medicine
560 First Avenue-OBV-D120
New York NY 10016
Tel: (+1) 212 263 6246
Fax: (+1) 212 263 7541
e-mail: joseph.helpern@med.nyu.edu |
| JAPANESE ASSOCIATE EDITOR
S. Naruse
Koyoto Prefectural University of Medicine
Department of Neurosurgery
Kawaramachi-Hirokoji
Kamigyo-ku, Kyoto 602
Japan
Tel: (+81) 75 253 1025
Fax: (+81) 75 253 1026
e-mail: snaruse@koto.kpu-m.ac.jp |
EUROPEAN ASSOCIATE EDITOR
Chris Boesch
Department of Magnetic Resonance Spectroscopy & Methodology
MR Center 1, University and Inselspital
Bern, Switzerland
Tel: (+41) 31 6328 174
Fax: (+41) 31 3822 486
e-mail: chris.boesch@insel.ch
http://www.cx.unibe.ch/dkf1/amsm/cboesch-0.htm |
EDITORIAL ADVISORY BOARD |
B Chance
Philadelphia, PA, USA |
M Cohn
Philadelphia, PA, USA |
G K Radda
Oxford, UK |
EDITORIAL BOARD |
J J H Ackerman
St Louis, MO, USA |
T R Brown
Philadelphia, PA, USA |
S Cerd¨¢n
Madrid, Spain |
H Degani
Rehovot, Israel |
R Deslauriers
Winnipeg, Canada |
J Frahm
Göttingen, Germany |
D Gadian
London, UK |
M Garwood
Minneapolis, MN, USA |
J D Glickson
Philadelphia, PA, USA |
J A den Hollander
Birmingham, AL, USA |
M Hoehn
Köln, Germany |
W E Hull
Heidelberg, Germany |
R A Iles
London, UK |
P W Kuchel
Sydney, Australia |
J C Lindon
London, UK |
R A Meyer
East Lansing, MI, USA |
F Podo
Rome, Italy |
S M Rao
Milwaukee, WI, USA |
P-M L Robitaille
Columbus, OH, USA |
D Rothman
New Haven, CT, USA |
C S Springer
Upton, NY, USA |
P Styles
Oxford, UK |
K Ugurbil
Minneapolis, MN, USA |
M W Weiner
San Francisco, CA, USA |
P C M van Zijl
Baltimore, MD, USA |
刊名字顺( Alphabetical List of Journals):1099-1492/asset/cover.gif?v=1&s=7f88958d6a8e1ce4e85055c646c8110c2575d407 "Cover image for NMR in Biomedicine")
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