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期刊名称：LABORATORY INVESTIGATION ISSN： 0023-6837 版本： SCI-CDE 出版频率： Monthly 出版社： SPRINGERNATURE, CAMPUS, 4 CRINAN ST, LONDON, ENGLAND, N1 9XW   出版社网址： http://www.nature.com/ 期刊网址： http://www.nature.com/labinvest/index.html 影响因子： 5.662 主题范畴： MEDICINE, RESEARCH & EXPERIMENTAL;    PATHOLOGY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology (USCAP) and edited by a board appointed by the Council of the Academy. Laboratory Investigation offers prompt publication of high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease. Both human and experimental studies are welcome. Particular emphasis is given to original research exploring the pathobiology of disease, including insights gained into the structural and molecular pathogenesis of disease, and the biological basis for morphologic manifestations of disease. Laboratory Investigation also constitutes a forum for translation of basic research findings into the progress of diagnosis and assessment of human disease, by means of any laboratory diagnostic methodology. Consideration is given to novel technical advances in the diagnosis of human disease or in the investigation of human or experimental disease. Laboratory Investigation also publishes occasional concise Minireviews and comprehensive Biology of Disease articles. ISSN 0023-6837    EISSN 1530-0307 Instructions to Authors FOR AUTHORS Did you know? | Submitting an article | Benefits of publishing with NPG | Top of page Did you know? That over 65,000 recipients will receive via e-mail a copy of the table of contents for Laboratory Investigation issue in which your article is published. That there is an average of 75,000 page views across Laboratory Investigation website per month. That Laboratory Investigation has an impact factor of 4.479. That on average authors receive a first decision on their paper within 15 working days. Top of page Submitting an article To read about how to prepare your article, please click on Instructions for Authors. If you are ready to submit an article please click on Online Submission. Additional information and news can be found at Nautilus, the NPG blog for authors and aspiring authors. Top of page Benefits of publishing with Laboratory Investigation Laboratory Investigation is the official journal of the United States and Canadian Academy of Pathology, which is committed to publishing high quality, independently peer-reviewed research and review material. The journal is published in partnership with Nature Publishing Group (NPG), which uses pioneering technologies, innovative formats and world class production to provide premium information for scientific researchers in the public and private sectors, government agencies and educators. A key strength of NPG is its close relationship with the scientific community. By working closely with scientists, listening to what they say, and always placing emphasis on quality rather than quantity, NPG is the leading scientific publisher at finding innovative solutions to scientists' information needs, both for the Nature-branded publications and those published on behalf of society partners, including USCAP. Publishing with Laboratory Investigation and NPG provides an author with a wide range of benefits: Copyright and licence to publish United States and Canadian Academy of Pathology does not require authors of original research papers to assign copyright of their published contributions. Authors grant United States and Canadian Academy of Pathology an exclusive licence to publish, in return for which they can re-use their papers in their future printed work. NPG's author licence page provides details of the policy and a sample form. Authors are encouraged to submit their version of the accepted, peer-reviewed manuscript to their funding body's archive, for public release six months after publication. In addition, authors are encouraged to archive their version of the manuscript in their institution's repositories (as well as on their personal websites), also six months after the original publication. Authors should cite the publication reference and doi number on any deposited version, and provide a link from it to the published article on the NPG website. This policy complements the policies of the US National Institutes of Health, the Wellcome Trust and other research funding bodies around the world. NPG recognizes the efforts of funding bodies to increase access of the research they fund, and strongly encourages authors to participate in such efforts. Online presence - reducing publication times Laboratory Investigation has adopted NPG's online submission system, which allows authors to submit papers via the Web. Speeding up the submission and refereeing process, this system also allows you to view the status of your paper online. Weekly publication online New articles in Laboratory Investigation, as in all NPG journals, are published weekly online ahead of the archival print issue, ensuring the research is made publicly available and can be cited as soon as possible after acceptance for publication. The online publication is identical to the printed version and is not a preliminary, unedited version, thus maintaining the journal's tradition of excellence and the integrity of the published record. Supplementary online material Authors are invited to submit additional supporting material such as data sets or video for publication in the online version of the journal. Online supplementary material makes the most of the Web as a delivery platform and can often give articles greater depth, making them more useful to readers. Quality Authors who choose to publish in any NPG journal can be assured that its staff's publishing, editorial and production skills are committed to maintaining the highest possible quality and standards. Exposure - widest possible readership All NPG journals including Laboratory Investigation, are available online via site licenses to academic, corporate and government institutions and consortia. Journals are available to members of these institutions at the click of a mouse, adding speed and visibility to authors' research papers. Regular free e-mail alerts Content published in Laboratory Investigation has the potential to reach scientists around the world who have signed up for NPG's free table of contents e-alerts, ensuring additional exposure to authors. These e-alerts allow recipients to click through to the full article if they subscribe or work at an institution with a site license, or click through to the article's abstract for other readers. Focused subject areas on nature.com From immunology to physics, genetics to materials, subject-specific areas provide a focused environment for readers, providing a monthly updated focus for a particular field. Laboratory Investigation articles are regularly featured at nature.com/pathology. Abstracting and indexing Laboratory Investigation is included in the leading abstracting and indexing services including ISI, MEDLINE, EMBASE and BIOSIS. Extensive reference linking to MEDLINE, ISI, Chemport and others via services such as Crossref and DOI numbers provide seamless online linking between articles and databases. Media coverage The Nature press office provides information about exceptionally interesting papers published throughout NPG. More than 2,000 journalists and media organizations worldwide subscribe to the press service, ensuring that papers receive maximum exposure in the world's most important media channels including newspapers, magazines, radio and television. Extending science further - global collaborations NPG and Laboratory Investigation support some projects aimed at making current research available to a broader community of scientists and practitioners. All NPG journals, including Laboratory Investigation, are in WHO's HINARI (Health InterNetwork Access to Research Initiative) program, which provides free access to public institutions in developing countries.   Instructions to Authors 0023-6837.pdf Editorial Board Editor-in-Chief JAMES M. CRAWFORD, MD, PhD is Professor and Chair of Pathology at the University of Florida College of Medicine. He graduated from Duke University School of Medicine, Durham, NC, in 1983, and trained in Anatomic Pathology and Gastrointestinal/Liver Pathology at Brigham and Women¡¯s Hospital, Boston MA. After nine years on faculty at Harvard Medical School, he moved to Yale University, New Haven, CT, to be Director of Gastrointestinal Pathology. In 1999, he came to the University of Florida. He is certified in Anatomic Pathology by the American Board of Pathology and has been a USCAP member since 1990. He has authored 140 publications and book contributions and authored or edited 3 books. He served as an Executive Editor (Associate Editor) of Laboratory Investigation while at Yale (1997-1998), and has also been Associate Editor for Hepatology (1997-2001). He is an authority in hepatic pathology, the pathophysiology of bile formation, and hepatic development and microanatomy. Senior Associate Editor ANTHONY T. YACHNIS, MD, is an Associate Professor of Pathology at the University of Florida College of Medicine and Chief of Neuropathology. He graduated from George Washington University School of Medicine in 1986 and completed residency and fellowship training in Anatomic Pathology and Neuropathology at the University of Pennsylvania between 1986 and 1991. He subsequently received specialized training in Pediatric Neuropathology at Children's Hospital of Philadelphia. Dr. Yachnis is certified in Anatomic Pathology and Neuropathology by the American Board of Pathology and has been a USCAP member since 1986. He has authored over 80 publications and has won national and local awards for research and teaching. He is a member of the Arthur Purdy Stout Society of Surgical Pathologists. He is an authority in neuropathology, especially in neurooncology and pediatric neuropathology. Associate Editor RAUL C. BRAYLAN, MD, is Professor of Pathology at the University of Florida College of Medicine and Chief of Hematopathology, holding the Whisenant Endowed Chair for Experimental Pathology. He earned his MD from Buenos Aires Medical School in Buenos Aires, Argentina in 1960, and trained in Pathology at Mount Sinai Hospital, Chicago IL, Albert Einstein College of Medicine, Bronx NY and Memorial Hospital for Cancer/Sloan Kettering Institute, New York NY. Following several years at the National Cancer Institute he joined the faculty at University of Florida in 1977. He is certified in Anatomic Pathology by the American Board of Pathology and has been a USCAP member since 1980. He has authored over 130 original publications and book chapters. He has been a pioneer in the use of flow cytometry for the diagnosis and assessment of hematopoietic malignancies, and is an authority in diagnostic and molecular hematopathology. MICHAEL CLARE-SALZLER, MD, is Professor of Pathology at the University of Florida College of Medicine, Director of Academic and Research Affairs for the department, and holds the Stetson Endowed Chair for Experimental Pathology. He earned his MD degree from the State University of New York (SUNY) Buffalo School of Medicine, Buffalo NY in 1979, and trained in Internal Medicine at SUNY Buffalo followed by Endocrinology at the University of California Los Angeles (UCLA), Los Angeles CA. He is certified in Internal Medicine and in Endocrinology by the American Board of Internal Medicine. He served on faculty at UCLA until joining the University of Florida Department of Pathology and Department of Medicine in 1993. He serves as Medical Director of the Laboratory Medicine Endocrinology Unit, and also is a clinical endocrinologist. He is author of some 60 publications and book contributions. His research focuses on investigation of the cellular, molecular and genetic basis for the immunopathogenesis of type 1 diabetes (T1D), and hence development of methods to prevent this disease. He is an authority especially in the role of dendritic cells and of prostanoid metabolism in autoimmune-mediated disease. Associate Editor LAURENCE MOREL, PhD, is an Associate Professor of Pathology at the University of Florida College of Medicine. She earned her PhD degree in Neurosciences from the University of Aix-Marseille, France in 1983. She trained as a post-doctoral fellow at the CNRS, Marseille, France, at the University of Georgia, and in the Department of Pathology at the University of Florida, where she joined the faculty in 1999. She has authored over 60 peer-reviewed publications and book chapters. Her research interests include genetics and immunopathology of autoimmune diseases, and the genetic analysis of complex traits in rodents. Associate Editor NAOHIRO TERADA, MD, PhD, is an Associate Professor of Pathology at the University of Florida College of Medicine. He earned his MD from Osaka University, Osaka, Japan in 1981, and received postdoctoral research training in cancer, signal transduction and stem cell at Osaka University and National Jewish Medical and Research Center, Denver CO, culminating in the awarding of his PhD in cell biology. From 1994-1999, he was an Assistant Professor of Pediatrics at the University of Colorado. He joined the faculty at the University of Florida in 2000. He has authored 80 original publications on signal transduction, cell cycle regulation, and stem cell biology. In recent years he has become a leader in the field of stem cell and regenerative medicine. Associate Editor for Reviews MARY E. SUNDAY, MD, PhD, is an Associate Professor of Pathology at Harvard Medical School, Boston. She received her MD and PhD degrees from Harvard University in 1982, interned in Medicine at Johns Hopkins University 1982-1983, and then trained in Anatomical Pathology at the Massachusetts General Hospital in Boston, finishing in 1987. She has been on faculty at Harvard Medical School and has been staff pathologist at Brigham and Women's Hospital since that time. She received the Stowell Orbison Award from USCAP in 1987, and the Young Investigator Award of USCAP in 2000. She is also a member of the American Society for Clinical Investigation. She has authored over 60 peer review publications. She is an authority in pulmonary pathology and pathobiology. Associate Editor for Pathology Elsewhere SWAN N. THUNG, MD , is a graduate from the University of Indonesia Medical School, Dr. Thung did her residency in Pathology at the VA Medical Center in Bronx, NY; then joined the Mount Sinai Medical Center, where she is now a Professor of Pathology, and Professor of Gene Therapy & Molecular Medicine. Her special interest is in Hepatopathology and Immunopathology. She has published more than 270 papers and book chapters, and co-authored a book in Liver Pathology. Managing Editor CATHERINE M. KETCHAM, PhD, earned her Ph.D. degree in Biochemistry and Molecular Biology from the University of Florida. Her postdoctoral studies were carried out at Washington University in St. Louis School of Medicine, in the Division of Hematology-Oncology. She then spent seven years in the San Diego biotechnology community focusing on manufacturing issues and business development. Subsequently, she spent three years as a research and development scientist in laboratories associated with the University of Florida Interdisciplinary Center for Biotechnology Research and the Sid Martin Biotechnology Development Incubator. Editorial Board Asif Ahmed Edgbaston, UK Michael Hart Madison, WI Linda McManus Vancouver, Canada Cheryl Willman Albuquerque, NM Charles Alpers Seattle, WA William Hickey Lebanon, NH Stephen Meredith Chicago, IL Daniel Zelterman New Haven, CT Dario Altieri Worcester, MA Peter Howley Boston, MA George Michalopoulos Pittsburgh, PA X. Joseph Zhou Dallas, TX Renato Baserga Philadelphia, PA Renato Iozzo Philadelphia, PA Brooke Mossman Burlington, VT Marina Ziche Florence, Italy Judith Berliner Los Angeles, CA Luisa Iruel-Arispe Los Angeles, CA William A. Muller New York, NY Stanley Zucker Northport, NY Kenneth Bernstein Atlanta, GA Elaine Jaffe Bethesda, MD George Murphy Philadelphia, PA   L. Maximilian Buja Houston, TX J. Charles Jennette Chapel Hill, SC Roberto Nicosia Seattle, WA   Charles Capen Columbus, OH Agnes Kane Providence, RI George Perry Cleveland, OH   Tito Cavallo Cincinnati, OH Yashpal Kanwar Chicago, IL Bruce Pitt Pittsburgh, PA   Samuel Cohen Omaha, NE David Kaufman Chapel Hill, NC Salvatore Pizzo Durham, NC   Robert Colvin Boston, MA Nathan Kaufman Kingston, Canada Peter Polverini Minneapolis, MN   Riccardo Dalla-Favera New York, NY Gordon Klintworth Durham, NC Stanley Prusiner San Francisco, CA   Ivan Damjanov Kansas City, KS Daniel Knowles New York, NY Michael Prystowsky New York, NY   Patricia D'Amore Boston, MA Alisa Koch Chicago, IL Marlene Rabinovitch Toronto, Canada   Vishva Dixit San Francisco, CA Olivier Kocher Boston, MA Elaine Raines Seattle, WA   Thomas Doetschman Cincinnati, OH David Lagunoff St Louis, MO Janardan Reddy Chicago, IL   G. Paolo Dotto Charlestown, MA Virginia Lee Philadelphia, PA Emanuel Rubin Philadelphia, PA   Harold Dvorak Boston, MA Leslie Leinwand Boulder, CO E. Helene Sage Seattle, WA   Jack Elias New Haven, CT William Lewis Atlanta, GA Jonathan W. Said Los Angeles, CA   Eric Fearon Ann Arbor, MI Michael Lieberman Houston, TX Alfred Sanfilippo Columbus, OH   Susan Fisher San Francisco, CA Megan S. Lim Salt Lake City, UT Gene P. Siegal Birmingham, AL   Blas Frangione New York, NY Lance Liotta Bethesda, MD Fred Silva Augusta, GA   Leo Furcht Minneapolis, MN Virginia A. LiVolsi Philadelphia, PA Mark Sobel Bethesda, MD   Giulio Gabbiani Geneva, Switzerland Paul Lizardi New Haven, CT Michael Sporn Hanover, NH   Stephen Galli Stanford, CA Ricardo Lloyd Rochester, MN Ivan Stamenkovich Lausanne, Switzerland   Murray Gardner Davis, CA Diane Louie Rahway, NJ David Stern New York, NY   A. Julian Garvin Mount Pleasant, SC , Nicholas W. Lukacs Ann Arbor, MI Gary Striker Miami, FL   Stephen A. Geller Los Angeles, CA Michael Madaio Philadelphia, PA Clive Taylor Los Angeles, CA   Nicholas Gonatas Philadelphia, PA James Madara Atlanta, GA John Trojanowski Philadelphia, PA   Fred Gorstein Philadelphia, PA Antonio Martinez-Hernandez Memphis, TN Jerrold R. Turner Chicago, IL   Avrum Gotleib Toronto, Canada Eliezer Masliah La Jolla, CA Manjeri Venkatachalam San Antonio, TX   Allen Gown Seattle, WA Robert T. McCluskey Boston, MA F. Stephen Vogel Augusta, GA   Joe Gray San Franciscico, CA Jay McDonald Birmingham, AL Ronald Weinstein Tucson, AZ   William E. Grizzle Birmingham, AL Bruce McManus Vancouver, Canada Lawrence Weiss Duarte, CA