期刊名称：JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
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The Journal of Clinical Endocrinology & Metabolism is the world's leading peer-reviewed journal of clinical practice and applied clinical research. Each issue provides fast and in depth coverage of diabetes, reproductive endocrinology, growth hormone therapy, thyroid disease, and other critical areas of clinical endocrinology. Regular features highlight current topics in clinical medicine, such as clinical studies, clinical case seminars, management of endocrine disorders, practice management issues, original patent oriented research studies, and other significant new endocrine studies related to human physiology and disease. According to the latest ISI Journal Citation Report, JCE&M articles were cited 42,935 times in 2002. It has an Impact Factor of 5.199 and is ranked 13th out of 88 journals in the ISI category of Endocrinology and Metabolism (overall ranking 235th out of 5876).
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About the journal |
Instructions to Authors
Purpose and Scope
Expectation of Ethical Conduct
General Information
Manuscript Categories
Manuscript Submission Procedures
Manuscript Preparation
General Format
Title Page
Structured Abstracts
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
Tables
Figures and Legends
Supplemental Data
Units of Measure
Standard Abbreviations
Editorial Policies and Guidelines
Prior Publication
Authorship Criteria
Guidelines for considering authors of non-research articles who have a potential COI
Obligations of Reviewers
Experimental Subjects
Experimental Animals
Clinical Trials Registration
Genetic and Genome-Wide Association Studies
Microarray Expression Studies
Nomenclature and Technical Requirements
Manuscripts Reporting New Amino Acid or Nucleotide Sequence
Manuscripts Reporting Novel Compounds
Validation of Data and Statistical Analysis
Digital Image Integrity
Publication and Production Guidelines
Proofs and Reprints
Page and Color Charges
NIH Deposits and Institutional Repositories
Journal Facts
Purpose and Scope
The Journal of Clinical Endocrinology & Metabolism (JCEM) publishes original research articles, reviews, and other special features related to endocrinology and metabolism in humans and human tissue.
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Expectation of Ethical Conduct
The Endocrine Society's mission is to advance excellence in endocrinology and be an integrative force in scientific research and medical practice. Such progress depends on integrity in the conduct of scientific research and truthful representation of findings. Specific guidelines regarding the Society's expectations for ethical conduct can be found in the Code of Ethics of The Endocrine Society and the Ethical Guidelines for Publications of Research. The journal editors and publication oversight committees of The Endocrine Society are dedicated to upholding high ethical standards in its publications and expect authors and reviewers to do the same.
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General Information
Manuscripts must be written in idiomatic English and conform to the specifications described below. Papers that do not meet these requirements will be returned to the author for necessary revision before formal review. Manuscripts submitted to JCEM are usually evaluated by peer reviewers who remain anonymous; but the disposition of some manuscripts is determined by the editors alone. Authors of manuscripts requiring modifications have three (3) months to resubmit a revision of their paper. Manuscripts returned after more than three (3) months will be treated as new submissions. An unsolicited revision of a rejected manuscript will either be returned or treated as a new submission, at the editor's discretion.
All papers accepted during each publishing year are eligible for The Endocrine Society and Pfizer, Inc. International Award for Excellence in Published Clinical Research in The Journal of Clinical Endocrinology & Metabolism (information at http://www.endo-society.org/awards/JournalAwards/index.cfm).
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Manuscript Categories
Reports of original research may be submitted to JCEM as an Original Article or Brief Report. Other special categories of manuscripts are described below. All manuscripts must adhere to the word count limitations, as specified below, for text only; the word count does not include the abstract, references, or figure/table legends. The word count must be noted on the title page, along with the number of figures and tables.
Original Articles should be no longer than 3600 words and include no more than six figures and tables and 40 references. The Journal has a special interest in publishing results of major prospective randomized clinical trials, which may be eligible for submission through Endocrine Trials Express, a pathway for expedited manuscript review that aims to provide an initial editorial decision within two weeks. Authors who wish to request consideration by Endocrine Trials Express should contact the Managing Editor by e-mail (sherman@endo-society.org) before submitting their paper.
Brief Reports are succinct descriptions of focused studies with important, but very straightforward, negative or confirmatory results. These manuscripts should be no longer than 1800 words and include no more than two figures and tables and 20 references.
Clinical Reviews and other Reviews should address topics of importance to clinical endocrinologists and endocrine clinical investigators, including scholarly updates regarding the molecular and biochemical basis for normal physiology and disease states; the state-of-the-art in diagnosis and management of endocrine and metabolic disorders; and other topics relevant to the practice of clinical endocrinology. Authors considering the submission of uninvited reviews should contact the editors in advance to determine whether the topic that they propose is of current potential interest to the Journal. These manuscripts should be no longer than 4000 words and include no more than four figures and tables and 120 references.
Clinical Case Seminars are descriptions of a case or small number of cases revealing novel and important insights into a condition's pathogenesis, presentation, and/or management. The case report is to be accompanied by a concise scholarly review of the literature regarding relevant aspects of the disorder. These manuscripts should be 2400 words or less, with no more than four figures and tables and 30 references.
Extensive Clinical Experiences are learned descriptions of substantial clinical experience with a specific endocrine or metabolic disorder, or class of disorders, by a single clinical endocrinologist or facility. This experience should expose novel aspects of the condition's presentation, diagnosis, natural history, and/or treatment. These manuscripts should be no longer than 3600 words and include no more than four figures and tables and 40 references.
Position and Consensus Statements related to the endocrine and metabolic health standards and healthcare practices may be submitted by professional societies, task forces, and other consortia. All such submissions will be subjected to peer review, must be modifiable in response to criticisms, and will be published only if they meet the Journal's usual editorial standards. These manuscripts should typically be no longer than 3600 words and include no more than six figures and tables and 120 references.
Controversies in Clinical Endocrinology describe and justify different approaches to diagnosis and/or management of patients with an endocrine or metabolic condition. This feature typically consists of a pair of manuscripts authored by two individuals who thoughtfully describe their respective clinical perspectives on a problem, their related practices, and the rationale and evidence supporting them. The entire manuscript should be no longer than 2400 words and include no more than two figures and tables and 30 references.
Images in Endocrinology are to be comprised of a single figure or two closely related figures that illustrate the value of visual information in clinical diagnosis of endocrine and metabolic disorders, with a caption that is 50 words or less, an accompanying commentary that is 250 words or less, and five or fewer references.
Commentaries are essentially uninvited editorials, which should concisely address and take a well-reasoned position on a timely issue of importance to clinical endocrinologists and/or endocrine clinical investigators. These manuscripts should be no longer than 1200 words with no more than 10 references; no figures or tables are permitted.
Letters to the Editor may be submitted in response to work that has been published in the Journal. Letters should be short commentaries related to specific points of agreement or disagreement with the published work. Letters are not intended for presentation of original data unrelated to a published article. Letters can only be submitted electronically via the Journal website, by clicking on the link entitled "Submit a Letter to the Editor" on the abstract page or the article itself. Letters should be no longer than 500 words with no more than five complete references, and may not include any figures or tables.
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Manuscript Submission Procedures
JCEM only uses electronic manuscript submission at Rapid Review (https://www.rapidreview.com/tes/CALogon.jsp).
If this is your first submission through E-Review, click on "New to Rapid Review?" to create an author account. If you already have an account from a previous submission, enter your username and password to submit a new or revised manuscript. If you have forgotten your username and/or password, e-mail the editorial office (sherman@ endo-society.org) for assistance.
Note that your author account is the same for JCEM, Endocrinology, Molecular Endocrinology, and Endocrine Reviews. Authors should be aware that in submitting a manuscript for consideration by JCEM, they are submitting their paper to The Endocrine Society Central Journals Office database, which is accessible by the Editors-in-Chief of all the Society's journals.
All submissions must include:
A cover letter requesting that the manuscript be evaluated for publication in JCEM and any information relevant to your manuscript. Elsewhere on the submission form authors may suggest up to five specific reviewers and/or request the exclusion of up to three others.
Completed Copyright Assignment & Affirmation of Originality form. This form should be faxed to the Editorial Office at 301-951-2617 and should include the manuscript number in the space provided on the form.
At least three key terms
Completed Disclosure of Potential Conflict of Interest form. The corresponding author must acquire all of the authors' completed disclosure forms and fax them, together, to the editorial office along with the Author Disclosure Summary. Revised manuscripts will not be processed until all signatures and the summary are received.
Authors are encouraged to submit a PDF for the initial submission. See the instructions on the JCEM homepage. If you do submit original files, E-Review will create a PDF of your files, but it may take some time depending on the size of the files.
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Manuscript Preparation
General Format
The Journal requires that all manuscripts be submitted in a single-column format that follows these guidelines:
All text should be double-spaced with 1-inch margins on both sides using 11-point type in Times Roman font.
All lines should be numbered throughout the entire manuscript and the entire document should be paginated.
All tables and figures must be placed after the text and must be labeled. Submitted papers must be complete, including the title page, abstract, figures, and tables. Papers submitted without all of these components will be placed on hold until the manuscript is complete.
Authors are encouraged to cite primary literature rather than review articles in order to give credit to those who have done the original work.
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Title Page
The title page should include the following:
Full title (a concise statement of the article's major contents)
Authors' names and institutions. At least one person must be listed as an author; no group authorship without a responsible party is allowed. A group can be listed in the authorship line, but only on behalf of a person or persons. All group members not listed in the authorship line must be listed in the Acknowledgments.
All papers with U.S. National Institutes of Health funding must include the paragraph indicated in the The Endocrine Society NIH statement.
Abbreviated title of not more than 40 characters for page headings
At least three key terms for indexing and information retrieval
Word count (excluding abstract, figure captions, and references)
Corresponding author's e-mail and ground mail addresses, telephone and fax numbers
Name and address of person to whom reprint requests should be addressed
Any grants or fellowships supporting the writing of the paper
Disclosure summary (see Disclosure of Potential Conflict of Interest form for instructions)
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Structured Abstracts
All Original Articles, Brief Reports, Clinical Reviews, Clinical Case Seminars, Consensus and Position Statements, Controversies in Endocrinology, and Extensive Clinical Experiences should be submitted with structured abstracts of no more than 250 words. All information reported in the abstract must appear in the manuscript. The abstract should not include references. Write the abstract with a general medical audience in mind. Please use complete sentences for all sections of the abstract. Detailed instructions on writing Structured Abstracts are at http://jcem.endojournals.org/misc/Structured_Abstracts.shtml.
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Introduction
The article should begin with a brief introductory statement that places the work to follow in historical perspective and explains its intent and significance.
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Materials and Methods
These should be described and referenced in sufficient detail for other investigators to repeat the work. The source of hormones, unusual chemicals and reagents, and special pieces of apparatus should be stated. For modified methods, only the modifications need be described.
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Results and Discussion
The Results section should briefly present the experimental data in text, tables, and/or figures. For details on preparation of tables and figures, see below. The Discussion should focus on the interpretation and significance of the findings with concise objective comments that describe their relation to other work in that area. The Discussion should not reiterate the Results.
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Acknowledgments
The Acknowledgments section should include the names of those people who contributed to a study but did not meet the requirements for authorship. The corresponding author is responsible for informing each person listed in the acknowledgment section that they have been included and providing them with a description of their contribution so they know the activity for which they are considered responsible.
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References
References to the literature should be cited in numerical order (in parentheses) in the text and listed in the same numerical order at the end of the manuscript on a separate page or pages. The author is responsible for the accuracy of references. The number of references cited should be limited, as indicated above for each category of submission. Appropriate recent reviews should be cited whenever possible.
Examples of the reference style that should be used are given below. Further examples will be found in the articles describing the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (Ann Intern Med.1988; 208:258-265, Br Med J. 1988; 296:401-405). The titles of journals should be abbreviated according to the style used in the Index Medicus.
Journal articles and abstracts: List all authors. The citation of unpublished observations, of personal communications, and of manuscripts in preparation or submitted for publication is not permitted in the bibliography. Such citations should be inserted at appropriate places in the text, in parentheses and without serial number, or be presented in the footnotes. The citation of manuscripts in press (i.e., accepted for publication) is permitted in the bibliography; the name of the journal in which they appear must be supplied. If references to personal communications are made, authors are encouraged to keep written proof of the exchange. If it is necessary to cite an abstract because it contains substantive data not published elsewhere, it must be designated at the end of the reference [e.g., 68:313 (Abstract)].
Books: List all authors or editors.
Sample References
Binoux M, Hossenlopp P 1986 Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph. J Clin Endocrinol Metab 67:509-514
MacLaughlin DT, Cigarros F, Donahoe PK 1988 Mechanism of action of Mullerian inhibiting substance. Program of the 70th Annual Meeting of The Endocrine Society, New Orleans, LA, 1988, p 19
Bonneville F, Cattin F, Dietemann J-L 1986 Computed tomography of the pituitary gland. Heidelberg: Springer-Verlag; 15-16
Burrow GN 1987 The thyroid: nodules and neoplasia. In: Felig P, Baxter JD, Broadus AE, Frohman LA, eds. Endo crinology and metabolism. 2nd ed. New York: McGraw-Hill; 473-507
For general aid in the preparation of manuscripts, authors should consult: CBE Style Manual: A Guide for Authors, Editors and Publishers. 5th ed. Bethesda, MD: Council of Biology Editors; 1983.
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Tables
Tables must be constructed as simply as possible and be intelligible without reference to the text. Each table must have a concise heading. A description of experimental conditions may appear together with footnotes at the foot of the table. Tables must not simply duplicate the text or figures. The width of the table must be designed to occupy one or two journal columns, with no more than four table columns or 8-10 table columns, respectively.
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Figures and Legends
Please review the detailed instructions for preparing digital art at http://art.cadmus.com/da/index.jsp. E-mail queries can be sent to digitalart@cadmus.com. All figures must display the figure number.
Sizing the figure: The author is responsible for providing digital art that has been properly sized, cropped, and has adequate space between images. Plan the size of the figure to fill 1, 1.5, or 2 columns in the printed journal (see chart below for dimensions). In most cases, figures should be prepared for 1-column width. Produce original art at the size it should appear in the printed journal. (Note for PowerPoint users: The sizing instructions do not apply if you are submitting PowerPoint files for print production in E-Review. On the submission page, check boxes to indicate that the figures are the correct size and resolution.)
1 column = 18 picas, 7.5 cm, 3.0 in
1.5. columns = 30 picas, 12.5 cm, 5.0 in
2 columns = 38 picas, 16.0 cm, 6.5 in
Lettering: At 100% size, no lettering should be smaller than 8 point (0.3 cm high) or larger than 12 point (0.4 cm high). Use bold and solid lettering. Lines should be thick, solid, and no less than 1-point rule. Avoid the use of reverse type (white lettering on a darker background). Avoid lettering on top of shaded or textured areas. Titles should be clear and informative. Keep wording on figures to a minimum, and confine any explanation of figures to their separate-page legends. Label only one vertical and one horizontal side of a figure. Freehand lettering or drawing is unacceptable.
Color Figures: Figures should now be submitted as RGB (red, green, blue) format. Saving color figures to this format will be more convenient for authors as RGB is the standard default on most programs. Color images will be preserved as RGB up until the time of printing and will be posted online in their original RGB form. Using RGB color mode for online images will be a significant improvement for figures that contain fluorescent blues, reds, and greens. Therefore the online journal will accurately reflect the true color of the images the way the author intended. For print, the images will be converted to CMYK through an automated color conversion process.
Shading: Avoid the use of shading, but if unavoidable, use a coarse rather than a fine screen setting (80-100 line screen is preferred). Avoid 1-20% and 70-99% shading; make differing shades vary by at least 20%, i.e., 25%, 45%, 65%. Instead of shading, denote variations in graphs or drawings by cross-hatching; solid black; or vertical, horizontal, or diagonal striping. Avoid the use of dots.
Grouped figures: For grouped figures, indicate the layout in a diagram. Place grouped figures so that they can be printed in 1 column width with uniform margins. Indicate magnification in the legends and by internal reference markers in the photographs. Their length should represent the fraction or multiple of a micrometer, appropriate to the magnification.
Graphs: Graphs with axis measures containing very large or small numbers should convert to easily readable notations. Example: For an ordinate range of "counts per minute" values from 1,000 to 20,000, the true value may be multiplied by 10-3 (scale would read from 1 to 20) and the ordinate axis display "cpm (¡Á10-3)." Similarly, for a Scatchard plot with values ranging from 0.1 to 2 femtomolar (10-15 m), the scale may run from 0.1 to 2 with the abscissa labeled "m (¡Á10-15)." Three-dimensional bar graphs will not be published if the information they refer to is only two-dimensional.
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Supplemental Data
Supplemental Data allows authors to enhance papers in JCEM by making additional substantive material available to readers. Supplemental Data may take the form of figures, tables, datasets, derivations, or videos, and is published only in JCEM online; it does not appear in the printed version of the journal. Authors who wish to include Supplemental Data should state so in the cover letter when the manuscript is submitted.
Supplemental Data files should be submitted through Rapid Review at the time of manuscript submission, and will be reviewed along with the manuscript. The files should be uploaded in the field marked "Upload Supplemental Data Files", and should NOT be attached with the manuscript and figure files. Authors should refer to the Supplemental Data in the manuscript at an appropriate point in the text or figure/table legend.
The file formats listed below may be used for Supplemental Data. Provide a brief description of each item in a separate HTML or Word file (i.e., figure or table legends, captions for movie or sound clips, etc.). Do not save figure numbers, legends, or author names as part of an image. File sizes should not exceed 5 MB. Images should not exceed 500 pixels in width or height. Do not use tabs or spaces for Word or WordPefect tables; please use the table functions available within these word processing programs to prepare tables. For web pages, provide a complete list of files and instructions for creating directories.
.htm, HTML*
.jpg, JPEG image*
.gif, Graphical image
.pdf, Adobe Portable Document Format
.xls, MS Excel Spreadsheet
.mov, Quick Time
.wav, Sound
.doc, MS Word 6 documents**
.txt, Plain ASCII*
*These files can be viewed directly on standard web browsers.
**MS Word may be used for text only.
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Units of Measure
Results should be expressed in metric units. Syst¨¨me Internationale (SI units) must be added in parentheses. Temperature should be expressed in degrees Celsius (e.g., 28 C) and time of day using the 24-hour clock (e.g., 0800 h, 1500 h).
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Standard Abbreviations
All nonstandard abbreviations in the text must be defined immediately after the first use of the abbreviation. The list of Standard Abbreviations is given in the link.
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Editorial Policies and Guidelines
Prior Publication
Failure to notify the editor that some results in the manuscript are being or have been previously published will result in placement of a notice in the journal that the authors have violated the Ethical Guidelines for Publication of Research in The Endocrine Society Journals. The journal publishes original research and review material. Material previously published in whole or in part shall not be considered for publication. This includes materials published in any form of mass communication. At the time of submission, authors must divulge in their cover letter all prior publications or postings of the material in any form of media. Abstracts or posters displayed for colleagues at scientific meetings need not be reported. Other postings of any part of the submitted material on web pages, as well as those essential for participation in required registries will be evaluated by the Editor-In-Chief, who shall determine if those postings are material enough to constitute prior publication.
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Authorship Criteria
An author should have participated in either the conception or planning of the work, the interpretation of the results and the writing of the paper. An acknowledgment accompanying the paper is appropriate recognition for others who have contributed to a lesser extent, e.g., provision of clones, antisera or cell lines, or reading and reviewing manuscripts in draft. The signature of each author on the Affirmation of Originality and Copyright Release form that must be submitted with the manuscript indicates that all authors have had a part in the writing and final editing of the report, all have been given a copy of the manuscript, all have approved the final version of the manuscript, and all are prepared to take public responsibility for the work, sharing responsibility and accountability for the results.
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Guidelines for considering authors of non-research articles who have a potential COI
The editors of The Endocrine Society's journals appreciate the importance of assuring unbiased authorship of editorials, reviews, and other non-research features involving selection of evidence to be discussed and perspectives to be presented. Consequently, special care is taken in choosing authors for such articles to assure their views are balanced and unencumbered, and that the Society's policies on disclosure of conflicts of interest are implemented.
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Obligations of Reviewers
The critical and confidential review of manuscripts is an essential element of research publications. Every scientist has an obligation to contribute to the peer review process by serving as a reviewer. Among the obligations of reviewers is the commitment to providing an expert, critical, and constructive scientific and literary appraisal of research reports in their fields of knowledge, skills, and experience in a fair and unbiased manner. In order to facilitate the prompt sharing of scientific results, it is also the obligation of each reviewer to complete their assignments promptly, within the editor's deadline. Should a delay in their review occur, the reviewer has the obligation to notify the editor at once. Reviewers should not review a manuscript if: 1) they do not think that they are competent to assess the research described, 2) they believe there is a conflict of interest or personal or professional relationship with the author(s) that might bias their assessment of the manuscript, or (3) there is any other situation that could bias their review. Employment at the same institution as one of the authors does not automatically represent a conflict. Having previously reviewed the article for another journal does not disqualify a reviewer, although the editor should be informed so the reviewer's perspective can be considered. In circumstances when reviewers need to recuse themselves, they should notify the editor promptly, preferably with an explanation. If reviewers are uncertain whether they should recuse themselves, they should consult with the editor.
The reviewer should strive to provide accurate, detailed, and constructive criticisms, and the review should be supported by appropriate references, especially if unfavorable. The reviewer should also note whether the work of others is properly cited. If the reviewer notes any substantial resemblance of the manuscript being reviewed to a published paper or to a manuscript submitted at the same time to another journal, they should promptly report this to the editor.
No part of the manuscript under review should ordinarily be revealed to another individual without the permission of the editor. If a reviewer consults a colleague on a particular point, this fact, and the name of the collaborator or consultant, should be reported to the editor, preferably in advance. With these exceptions, a reviewer must obtain through the editor written permission from the authors to use or disclose any of the unpublished content of a manuscript under review.
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Experimental Subjects
To be considered, all clinical investigations described in submitted manuscripts must have been conducted in accordance with the guidelines in The Declaration of Helsinki and must have been formally approved by the appropriate institutional review committees or its equivalent. All manuscripts must indicate that IRB approval was acquired; and that when informed consent was required by the IRB, that this was obtained from subjects in experiments involving humans. The study populations should be described in detail. In many studies details of age, race, and sex are important. However, subjects must be identified only by number or letter, not by initials or names. Photographs of patients' faces should be included only if scientifically relevant. Authors must obtain written consent from the patient for use of such photographs. For further details, see the Ethical Guidelines.
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Experimental Animals
A statement confirming that all animal experimentation described in the submitted manuscript was conducted in accord with accepted standards of humane animal care, as outlined in the Ethical Guidelines, should be included in the manuscript.
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Clinical Trials Registration
For clinical trial reports to be considered for publication in the Journal, the Endocrine Society requires their prospective registration, as endorsed by the International Conference of Medical Journal Editors. We recommend use of www.clinicaltrials.gov. The Society's full Position Statement on Clinical Trials Registration is at the following web site: http://jcem.endojournals.org/misc/ClinicalTrials.pdf. All trials beginning after January 1, 2007 must have been prospectively registered before enrollment of the first subject. All trials begun before that date must be retroactively registered before submission.
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Genetic and Genome-Wide Association Studies
To ensure rigor in genetic and genome-wide association studies and permit readers to assess their biological and clinical significance, submitted manuscripts describing such work should generally conform to the following study design criteria, which will be applied by the Journal's reviewers and editors in their evaluations.
Sample Size and Multiple Testing: Studies should include sufficient samples to have the power to detect an effect. In addition, since multiple hypotheses are often tested (e.g., multiple SNPs, substratification, and multiple phenotypes), analyses and interpretations should account for the influence of such multiple testing on the findings' biological and clinical significance.
Validation Samples: The most rigorous association studies should include both a testing (or training) sample set and an independent validation series.
Functional Data: Functional data strengthen association data if the functional assay(s) have demonstrable relevance to the associated phenotype. In some instances, association studies with a single testing sample set and highly relevant functional data may be acceptable without an independent validation series.
Single Genetic Marker (e.g., SNP) versus Whole Gene/Genome Studies: Single SNP studies are acceptable when the particular SNP has strong prior claims for involvement in the phenotype of interest. However, it is desirable to examine genetic variation at least across and flanking the gene of interest when this is feasible.
Negative Association Studies: Well-designed and executed association studies that demonstrate significant negative findings will be considered if the gene in question has clear relevance to disease pathogenesis or has been implicated in prior published association studies.
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Microarray Expression Studies
Genome-wide expression studies require both technical validation and an independent validation series. Technical validation entails application of a different technique (e.g., RT-PCR of single genes or immunohistochemistry) to confirm the differential expression detected by genome-wide expression. An independent validation series of samples should be utilized to confirm the differential expression noted by genome-wide analysis of the initial testing sample set.
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Nomenclature and Technical Requirements
The value of study data is enhanced if, where relevant, manuscripts:
Use standard terminology for variants, providing rs numbers for all variants reported. These can be easily derived for novel variants uncovered by the study. Where rs numbers are provided, the details of the assay (primer sequences, PCR conditions, etc.) should be described very concisely.
Describe measures taken to ensure genotyping accuracy, e.g., percentage of genotype calls, number of duplicate samples that were genotyped, and percentage concordance.
Provide approved GDB/HUGO approved gene names, in the appropriate cases and italics.
Provide linkage disequilibrium (LD) relationships between typed variants.
Provide information and a discussion of departures from Hardy-Weinberg equilibrium (HWE). The calculation of HWE may help uncover genotyping errors and impact on downstream analytical methods that assume HWE.
Provide raw genotype frequencies in addition to allele frequencies. It is also desirable to provide haplotype frequencies.
Provide the criteria they have used to select tagSNPs.
Denote the boundaries considered when studying SNPs within a gene of interest. For example, "gene X and 100 kb upstream of the first translational start site and 150 kb downstream of the stop codon."
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Manuscripts Reporting New Amino Acid or Nucleotide Sequence
Manuscripts reporting amino acid or nucleotide sequences of proteins with sequences already known from other tissues or species will be considered only if they provide new biological insight. Manuscripts dealing with partial sequence data are not likely to be considered. The Endocrine Society has established policy that deals with submission of new protein or nucleic acid sequences. When a manuscript is accepted that contains novel sequences, such sequences must be deposited in the appropriate database (such as GenBank) and an accession number obtained before the manuscript is sent to the printer. It is recommended that the following statement containing the assigned accession number be inserted as a footnote: "These sequence data have been submitted to the DDBJ/EMBL/GenBank databases under accession number Ul2345."
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Manuscripts Reporting Novel Compounds
Manuscripts describing experiments with new compounds must provide their chemical structures. For known compounds, the source and/or literature reference to the chemical structure and characterization must be provided.
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Validation of Data and Statistical Analysis
Assay validation: Bioassay and radioimmunoassay potency estimates should be accompanied by an appropriate measure of the precision of these estimates. For bioassays, these usually will be the standard deviation, standard error of the mean, coefficient of variation, or 95% confidence limits. For both bioassays and radioimmunoassays, it is necessary to include data relating to within-assay and between-assay variability. If all relevant comparisons are made within the same assay, the latter may be omitted. Authors should be aware that the precision of a measurement depends upon its position on the dose-response curve.
In presenting results for new assays, it is necessary to include data on the following: 1) within-assay variability; 2) between-assay variability; 3) slope of the dose-response curve; 4) mid-range of the assay; 5) least-detectable concentration (concentration resulting in a response two standard deviations away from the zero dose response); 6) data on specificity; 7) data on parallelism of standard and unknown and on recovery; and 8) comparison with an independent method for assay of the compound. When radioimmunoassay kits are utilized or hormone measurements are conducted in other than the authors' laboratories and the assay is central to the study, data regarding performance characteristics should be included.
Pulse analysis: Data from studies of pulsatile hormone secretion should be analyzed using a validated, objective pulse detection algorithm. The algorithm used should require that false-positive rates of pulse detection be defined in relation to the measurement error of the data set being analyzed, and the methods used to determine the measurement error should be described. The author(s) also should describe the methods used: 1) to deal with missing or undetectable values; 2) to determine peak frequency, interpeak interval, and pulse amplitude; and 3) for statistical comparisons of peak parameters.
Data analysis: It is the author's responsibility to document that the results are reproducible and that the differences found are not due to random variation. No absolute rules can be applied, but in general quantitative data should be from no fewer than three replicate experiments. Appropriate statistical methods should be used to test the significance of differences in results. The term "significant" should not be used unless statistical analysis was performed, and the probability value used to identify significance (e.g., P > 0.05) should be specified.
When several t tests are employed, authors should be aware that nominal probability levels no longer apply. Accordingly, the multiple t test, multiple range test, or similar techniques to permit simultaneous comparisons should be employed. Also, in lieu of using several t tests, it is often more appropriate to utilize an analysis of variance (ANOVA) to permit pooling of data, increase the number of degrees of freedom, and improve reliability of results. Authors should use appropriate nonparametric tests when the data depart substantially from a normal distribution. Analysis of variance tables should not be inserted in manuscripts. F values with the degrees of freedom as subscripts together with the P values are sufficient.
In presenting results of linear regression analyses, it is desirable to show 95% confidence limits. When data points are fitted with lines (as in Scatchard or Lineweaver-Burk plots), the method used for fitting (graphical, least squares, computer program) should be specified. If differences in slopes and/or axis intercepts are claimed for plotted lines, these should be supported by statistical analysis.
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Digital Image Integrity
When preparing digital images, authors must adhere to the following guidelines as stated in the CSE's White Paper on Promoting Integrity in Scientific Journal Publications:
No specific feature within an image may be enhanced, obscured, moved, removed, or introduced.
Adjustments of brightness, contrast, or color balance are acceptable if they are applied to the entire image and as long as they do not obscure, eliminate, or misrepresent any information present in the original.
The grouping of images from different parts of the same gel, or from different gels, fields, or exposures must be made explicit by the arrangement of the figure (e.g., dividing lines) and in the figure legend.
Deviations from these guidelines will be considered as potential ethical violations.
Note that this is an evolving issue, but these basic principles apply regardless of changes in the technical environment. Authors should be aware that they must provide original images when requested to do so by the Editor-in-Chief who may wish to clarify an uncertainty or concern.
[Please see paper of Rossner and Yamada (Journal of Cell Biology, 2004, 166:11-15), which was consulted in developing these policy issues, for additional discussion, and the CSE's White Paper on Promoting Integrity in Scientific Journal Publications, published by the Council of Science Editors, 2006.]
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Publication and Production Guidelines
Proofs and Reprints
Proofs and a reprint order form are sent to the corresponding author unless the Editorial Office is advised otherwise. The author should designate by footnote on the title page of the manuscript the name and address of the person to whom reprint requests should be directed. Questions about reprints should be referred to Cadmus Professional Communications at 410-819-3912 (direct) or 800-407-9190 (toll-free).
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Page and Color Charges
There is no submission fee for The Endocrine Society journals.
There will be a charge of $90 per printed page for members of The Endocrine Society and $110 per printed page for non-members. There will be a charge of $235 per color figure for members of The Endocrine Society and $735 per color figure for non-members. Authors must submit usable digital art that passes Cadmus's Rapid Inspector. Queries on page charges may be directed to Joy Carter at Cadmus Professional Communications (410-691-6439; fax 410-684-2792).
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NIH Deposits and Institutional Repositories
For articles that were funded by NIH, accepted manuscripts will be submitted to PubMed Central. These manuscripts will be made freely available online twelve months after print publication. NIH will contact the author to confirm submission.
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Journal Facts for JCEM
Publisher: The Endocrine Society
Editor-in-Chief: Paul W. Ladenson
Editorial Board: JCEM Editorial Board
Impact Factor 2007: 5.493
Frequency of Publication: Monthly
Print Journal Circulation: 9,250
Pages published per year: 5,000
Avg Acceptance Rate: 25%
ISSN (print journal): 0021-972X
ISSN (online): 1945-7197
Indexing: BIOSIS, Current Contents, Index Medicus, Elsevier BIOBASE / Current Awareness in Biological Sciences, National Biological Service, EMBASE / Excerpta Medica, and Sociedad Iberoamericana de Informaci¨®n Cientifica (SIIC), Global Health
Supplements: Contact Editorial Office
Contact:
Dr. Paul W. Ladenson, Editor-in-Chief
The Journal of Clinical Endocrinology & Metabolism
8401 Connecticut Avenue, Suite 900
Chevy Chase, MD 20815-5817
Phone: 301-951-2615
Fax: 301-951-2617
sherman@endo-society.org
Editorial Board
Editor-in-Chief
Paul W. Ladenson
Deputy Editors
David S. Cooper
Steven E. Kahn
Editors
Robert L. Barbieri
Shalender Bhasin
George S. Eisenbarth
Charis E. L. Eng
Abhimanyu Garg
Sally Radovick
Janet A. Schlechte
Dolores M. Shoback
William F. Young, Jr.
Editorial Board
John S. Adams
Beverley Adams Huet
Gail K. Adler
Anil K. Agarwal
Micheala A. Aldred
Bradley D. Anawalt
Andre Araujo
Wiebke Arlt
Douglas W. Ball
Elizabeth Barrett-Connor
Luisa L. Barzon
Shehzad S. Basaria
Murat Bastepe
Albert M. Beckers
Alicia Belgorosky
Lars F. Berglund
Corrado Betterle
Bernadette Biondi
Steen Bonnema
Marco Boscaro
Glenn D. Braunstein
Eliot Brinton
Thierry Brue
Jacqueline Capeau
Anne R. Cappola
Patrizio Caturegli
Marcelle I. Cedars
Wenhan Chang
Philippe Chanson
Steven D. Chernausek
Shern L. Chew
Emanuel R. Christ
Pinchas Cohen
Robert V. Considine
Andrea D. Coviello
William F. Crowley
David A. D¡¯Alessio
Mehul T. Dattani
Colin M. Dayan
Cheri L. Deal
Stefano Del Prato
Hong-Wen Deng
Francis E. de Zegher
Evanthia Diamanti-Kandarakis
Gabriel Dickstein
Eleni V. Dimaraki
Marc K. Drezner
David A. Ehrmann
Dariush Elahi
Rossella Elisei
Eva Marie Erfurth
Hector F. Escobar-Morreale
William J. Evans
Ismaa S. Farooqi
Martin Fassnacht
Bart C. Fauser
Ulla Feldt-Rasmussen
Ele Ferrannini
Kenji Fujieda
John C. Gallagher
W. Timothy Garvey
Saul Genuth
Emily L. Germain-Lee
Ezio G.G.M. Ghigo
Gilberta Giacchetti
Roberto Gianani
Benjamin Glaser
Ronald B. Goldberg
Peter A. Gottlieb
Carla J. Greenbaum
Andrew Grey
Melvin M. Grumbach
Stephanie Hahner
David J. Handelsman
David M. Harlan
Frances J. Hayes
Geoffrey N. Hendy
James V. Hennessey
Jerome M. Hershman
Kathleen M. Hoeger
Robert P. Hoffman
Michael F. Holick
Mark Hornstein
Mara J. Horwitz
Ieuan A. Hughes
Jennifer L. Hunt
Lourdes Ibanez
Jorge A. Iniguez-Lluhi
Henry N. Jabbour
Serge A. Jabbour
Suzanne M. Jan de Beur
Ishwarlal Jialal
Takashi Kadowaki
George J. Kahaly
C. Ronald Kahn
Jean-Marc Kaufman
Philip A. Kern
Irwin Klein
Robert F. Klein
Marta Korbonits
Sudhesh Kumar
Markku Laakso
Peter Laurberg
John H. Lazarus
Phillip D. K. Lee
Richard S. Legro
Lynne L. Levitsky
Stafford L. Lightman
Rogerio A. Lobo
Barbara Lukert
Christos Mantzoros
Enio Martino
Norman A. Mazer
Janette M. McAllister
Elizabeth A. McGee
T. Joseph McKenna
Robert I. McLachlan
Ram K. Menon
Fabio Monzani
Paolo Mulatero
Ana A. Murphy
Marlina D. Nasution
Maria I. New
John D. Newell-Price
Tuan V. Nguyen
Yuri E. Nikiforov
Janelle Noble
Robert J. Norman
Errol R. Norwitz
Edward H. Oldfield
Elif Oral
Mark R. Palmert
Renato R. Pasquali
Elizabeth N. Pearce
Simon H. S. Pearce
Leonid Poretsky
Daniel Porte, Jr.
Alvin C. Powers
Jonathan Q. Purnell
Marcus Quinkler
Richard Reindollar
James M. Roberts
Ferdinand Roelfsema
Alan D. Rogol
Ron G. Rosenfeld
Douglas Ross
Roberto Salvatori
Mary H. Samuels
Massimo Santoro
Nanette F. Santoro
Naveed Sattar
Deborah Sellmeyer
Jan L. Shifren
Olli Simell
William F. Simonds
Robert C. Smallridge
Johannes Smit
Roger Smith
Julie A. Sosa
Mark A. Sperling
Christine Spitzweg
Alex Stagnaro-Green
Gunter K. Stalla
Michael Stowasser
Bin T. Teh
Jorma Toppari
Thomas G. Travison
Robert M. Tuttle
Randall J. Urban
Aart J. van der Lely
Mark P. Vanderpump
Gary S. Wand
Frank Weber
Corrine K. Welt
Peter W. Wilson
Selma F. Witchel
Mingzhao Xing
Jack A. Yanovski
Mylene Yao
Philip S. Zeitler
Michael Zitzmann
Senior Director and
Publisher
Rebecca Rinehart
Group Managing Editor,
Associate Director
Scott C. Herman
Assistant Managing Editor
Chris Forsberg
Medical Writer
Jacqueline Ruttimann
Manuscript Coordinators
Danielle C. Jordon
Rebecca Kelly
Liliana Medel
JCEMTM
THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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Editorial Board
editors.pdf
editors.pdf
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