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期刊名称：GENOME RESEARCH ISSN： 1088-9051 版本： SCI-CDE 出版频率： Monthly 出版社： COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 1 BUNGTOWN RD, COLD SPRING HARBOR, USA, NY, 11724   出版社网址： http://genome.cshlp.org/ 期刊网址： http://genome.cshlp.org/ 影响因子： 9.043 主题范畴： BIOCHEMISTRY & MOLECULAR BIOLOGY;    BIOTECHNOLOGY & APPLIED MICROBIOLOGY;    GENETICS & HEREDITY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal  In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, GENOME RESEARCH. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.     Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, proteomics, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns. New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context. . Instructions to Authors   GENOME RESEARCH welcomes high-quality research papers presenting novel data on the topics of gene discovery, comparative genome analyses, molecular and human evolution, informatics, genome structure and function, proteomics, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, systems biology and other reports that present data where sequence information is used to address biological concerns. New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also publishes review articles, commentaries, perspectives, and Insight/Outlook articles. All submissions to the journal undergo an initial editorial review. Those selected by the Editor as suitable for the scope and aims of the journal are peer-reviewed. Publication time from acceptance of manuscript is two months. For papers accepted subject to revision, only one revised version will be considered; it should be submitted within two months of the provisional acceptance. The journal only accepts papers that present original research that has not been published previously. Submission to the journal implies that another journal or book is not currently considering the paper. Data Release Policy for papers published in Genome Research Researchers who submit papers to this journal are prepared to make available to researchers all materials needed to duplicate their work. Material from a publication must be easily available to the broader community in publicly held databases and repositories when available, and at the Genome Research web site, and if desired at the author's web site, when they are not. Genome Research will NOT consider manuscripts where data used in the paper is not freely available on either a publicly held website, or in the absence of such a website, on the Genome Research website. There are NO exceptions. (For details on websites for data submission see Website Links below.) Authors submitting papers whose main purpose is to describe or present a new computer program or algorithm should be prepared to make either the source code or a downloadable program freely available. Accession numbers for data should be available by the page proof stage. (Note, making material available is meant to be within reason, given the limited supply of some reagents etc..) Genome Research encourages all data producers to make their data as freely accessible as possible prior to publication. Open data resources accompanied by fair use will serve to greatly enhance the scientific quality of work by the entire community and for society at large. Fair Use and Acknowledgement of Data Resources For acknowledging data obtained from publicly held databases, accession numbers for all such data must be included where appropriate in the text or tables of the manuscript, and the website should be placed in the text and in the Website References. For use of publicly held data, Genome Research follows the recent guidelines for fair use of community resource data as detailed in the recent publication produced from the Fort Lauderdale Meeting, 2003. Use of such data requires the material be cited with website and accession numbers as described above, and in cases where a large amount of unpublished information is used from one lab or center, authors should cite the laboratory or center that produced this information in conjunction with the publicly held site where the data were obtained. Genome Research encourages data users to embrace the spirit of the Fort Lauderdale, 2003, agreement by using this material in creative new ways rather than producing early and incomplete versions of the producers aims; the Editors will be considering material in this light. When using data from a laboratory's or center's private website, the laboratory or center should be contacted for permission and the website should be placed in the text AND in the references, appropriately denoting it as a source of reference material for this work. Clones from centers must be cited by the names associated with the center's nomenclature, which is approved nomenclature. In any instance where individuals have contributed more than just standard data release information, these individuals should be contacted, shown the manuscript, and their status on the paper (whether they prefer authorship or not) determined prior to submission. Papers should be submitted to: Laurie Goodman Executive Editor Genome Research Cold Spring Harbor Laboratory Press One Bungtown Road Cold Spring Harbor, NY 11724 e-mail: goodman@cshl.org Tel: (516) 422-4012; Fax: (516) 422-4092 Online manuscript submission All papers can be submitted on by the author to our online manuscript submission system available at http://submit.genome.org, alternatively, the Genome Research editorial office will submit the manuscript on behalf of the authors, it is, however, faster for authors to submit their own work. If you do prefer to have the Genome Research office submit your manuscript for you, it is imperative that any manuscripts submitted by post must include 3 hardcopies of the manuscript text, tables and figures as well as an electronic version of the manuscript text and, preferably, as many figures and tables as possible in an electronic format. Files that can be used by the online system are: Word, WordPerfect, and PDF (Portable Document File). LaTex currently can not be used by the system- please submit in a PDF format (and include the .tex file as your 'source' file). Image and Table file formats accepted are GIF, TIFF, EPS, PDF, and JPEG. (Please note: for accepted manuscripts, only .tif and .eps electronic formats can be used by the printer (see below for details on figure format for accepted manuscripts). For reviewing purposes all of the above are fine.) For tables, the system accepts most word processing formats as well; NOTE the system does not accept excel files at this time- please paste tables made in excel into a word document format; these can then be easily submitted. Supplemental files can be submitted in any format as these will be downloaded as needed, and will not be converted into a PDF with the text figures and tables. PAGE numbers must be included on all pages, and Figure and Table numbers must be presented on the FRONT of the figures and tables when posted online, as which figure and table is which may not be clear in the PDF version created for the reviewers unless a reference to figure or table number is on the FRONT. Please note: Files that CAN NOT be used by the online system include: Any Tex-type files [convert to a PDF], Excel (.xls) [convert to Word], and Bitmap (.bmp), PICT (.pict), photoshop (.psd), PowerPoint (.ppt), CorelDRAW (.cdr) [convert all figure files to Word, GIF, TIFF, EPS, or JPEG. There is a graphics converter program available as shareware that can convert electronic figures to usable formats at http://www.webattack.com/get/imagetransformer.shtml. This program will NOT upgrade the quality of the image, but can convert file type to one that can be used by the online system and make your figures suitable for review purposes. If you are having difficulty with the website, please submit your problem through the feedback button at the online submission site. If you have specific questions about your manuscript, please contact the editor via e-mail. Manuscript preparation Author signatures required. All manuscript submissions to Genome Research must now include signatures from all all the authors on the manuscript indicating that they have read and approved the content of the work and agreed to its submission in its current format. Please mail or fax a letter or statement along with the required signatures confirming that all authors have reviewed the manuscript as soon as possible. Manuscripts submitted online, prior to our receipt of author signatures, will continue to be processed. Failure to provide this material if the work is accepted, however, can result in a delay (or ultimately a decline on our part) to publish your manuscript. Other material that needs to be sent to the Editorial office: Manuscripts submitted ONLINE do not require anything to be sent to the editorial office besides the signatures of the authors, unless the editorial office specifically requests it. For manuscripts that are NOT submitted online, three copies of the manuscript must be submitted (computer printouts of the manuscript should be of letter quality, and each page should be labeled with the first author's name and a page number); at least two of these copies should have original art. A computer diskette (3-1/2", zip, or CD) containing a copy of the text of the manuscript and as many of the display items as possible MUST accompany all submissions, as this is necessary for the review process. DO NOT e-mail manuscripts to the editor or the editorial secretary to be posted online. We require a formal mailed submission if the work is to be submitted for consideration. All related manuscripts in press, submitted, or in preparation MUST be disclosed. Additional supplemental files are encouraged as neccessary for a thorough review process.These can be uplaoded as supplementary information online or mailed to the office. A cover letter should include: (a) name, address, telephone number, FAX number, and e-mail address of author responsible for correspondence regarding the manuscript (b) paragraph highlighting the main points of the work (c) statement that the manuscript has been seen and approved by all listed authors (including, or followed by, a mailed or faxed letter with signatures indicating approval from all authors) (d) a list of potential referees (we need the referees name and either Insitution or e-mail (more information is always great), and if desired, a (reasonable) list of individuals with potential conflict, as we work very hard to avoid sending manuscripts to competitors (e) any specific requirements for reproduction of art (f) status of any statements of personal communication or other permissions needed (any data presented as unpublished results from individuals other than the authors require permission for use) and (g) statement regarding databank submission of data. The title page should include: the title, all authors names and institutions, the corresponding author's complete contact information, a running title (50 characters or less, including spaces), and at least two key words. Manuscript Type: The general format for all manuscript types (Article, Letter, Methods, Resource) is identical (as described below). The selection of type is based on the content of the manuscript, and will ultimately be decided by the Editor. Research: ARTICLES generally contain extensive conceptual advances as well as extensive analyses with wide appeal for a variety of readers. LETTERS are the most common manuscript published in Genome Research and contain a solid advance of general interest to the our readers, but are likely of greatest interest to specific fields. Methods and Resources: METHODS are manuscripts where the primary focus is on a novel methodology; these manuscripts often contain extensive supportive biological data. RESOURCE reports present information on useful tools, databases, or large-scale informational resources, such as detailed maps or data sources, that hold broad appeal for the community at large and include novel biological information or technology. General manuscript format: We prefer the manuscript be written in active rather than passive voice. Print only on ONE side of the page. Manuscript sections should be presented in the following order: title page, ABSTRACT (the abstract can be no more than 200 words. There should be a second paragraph (not counted in the 200 words) that indicates if there are going to be accession numbers (for all data types) and/or supplementary material; this second paragraph should also include a list of names of all individuals (not authors) who provided reagents, samples, any unpublished information or any other materials for this work), followed by INTRODUCTION, RESULTS, DISCUSSION, METHODS, ACKNOWLEDGMENTS, FIGURE LEGENDS, FIGURES, TABLES, REFERENCES, WEBSITE REFERENCES. Tables providing information (such as primers and sequences) that are essential for reproducing the work, but not essential for understanding the content of the paper should be included only as supplementary data. In addition extremely lengthy tables are best presented in complete form as online supplementary material. We recommend that authors with long tables e.g. more than one page at 6.5" X 9" with no smaller than 8 pt. type) create a sample single page table for inclusion in print (it should include anything discussed in the text) and include a copy (electronic) of the complete table for display as an online supplement. Some consideration for altered layout format (e.g. inclusion of extra long tables, or METHODS preceding RESULTS) for manuscripts will be taken into account for reports where an altered format aids in subject comprehension; altering the format should be discussed with the Editor. The methods should be detailed enough to allow any qualified researcher to duplicate the results. Additional material for reviewers can be included and marked as such (especially appreciated, when possible, are disks containing material from websites that need to be examined by referees as websites with passwords may compromise referee anonymity). You MUST use approved nomenclature for protein and gene names (including appropriate use of italics (NOTE: using italics is a standard for genes, so put ALL gene symbols, loci, d-numbers etc. in italics) and capitalization as it applies for each organisms' standard nomenclature format, in text, tables, and figures To aid you in doing this, you will find links below to nomenclature sites for a variety of organisms). You must submit novel genes and proteins to the appropriate databases. Sequence data, SNP data, array data, molecular interaction data, and any other data where there is a publicly held database MUST be submited to these databases. Genome Researchwill NOT consider manuscripts where data used in the paper is not freely available on either a publicly held website, or in the absence of such a website on the Genome Research website. There are NO exceptions. Novel gene and protein names must be approved prior to publication. For website links for data submission, or for nomenclature rules or for submission of gene or protein names, see Website Links below.) Failure to use appropriate nomenclature for manuscripts that have been accepted can result in change fees at the time of manuscript processing. References are of two types: Standard article and book references and website references. Article and book references. Cite as (name date) in text, not by number. Undated citations (unpublished, in preparation, personal communication) should include first initials and last names of authors, e.g. (F. Smith pers. comm.) and do not appear in the reference list. The reference list should be presented in alphabetical order. Note ALL authors names should be included when there are TEN names or less. If more than ten names, the reference should include the first TEN names, followed by et al.. Bibliographic information should be supplied in the following order. For journal articles: Last name, first initial of up to ten authors. The year. Article title. Journal title, abbrev. Volume: First-last pages. e.g. Saiki, R.K., Scharf, S., Faloona, F., Mullis, K.B., Horn, G.T., Erlich, H.A., and Arnheim, N. 1985. Enzymatic amplification of X-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230: 1350--1354. For books: Last name, first initial of up to ten authors. The year. Chapter title, if used. Book title. (editors, if included) First-last pages. Publisher, city, state. e.g.Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: A laboratory manual, 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. Miller, J.H. 1972. Generalized transduction; use of P1 in strain construction. In Experiments in molecular genetics (ed. Miller, J.H.), pp. 201--205. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. Website References: If the paper includes website URLs as references for places where material was obtained for doing the work, the URL should be included next to that information in the text, and an additional reference list, entitled "Web Site References" containing all websites cited in the paper should be placed after the article and book reference list. The format of the website reference list should be the URL followed by the author or the site and/or name of the site (if it has one). e.g. http://www.genome.org, Genome Research Home page Figures For online submission- be sure figures have figure number included on the front. If we are submitting your manuscript to the system for you, we prefer that electronic copies of figures also be included with the manuscript (GIF, TIFF, EPS, or JPEG) to enable the staff to more easily put your manuscript into our online system, but this is not absolutely essential as we can scan the figures. Inclusion of electronic copies does, however, speed up the conversion process especially when large numbers of figures are included in a manuscript. All hardcopies of figures should be labeled with the first author's name, the figure number, and an indication of the top of the figure. (Electronic files for figures should be named with the first author's name and the figure number, for example Smith_Fig1. Also, be sure to include the figure number on the front of the figure in the file). If the manuscript is accepted for publication, the size of the figures will be adjusted to fit the journal format; therefore, please try to keep labels, symbols, and other call-out-devices (i.e., A, B, C, etc.) in proportion to the figure size and detail (Use Helvetica (or similar) typeface in point sizes no smaller than 8 pt and no larger than 10 pt, except for the main callouts (e.g. A, B, C, etc.), which should be 12 pt). NOTE ALSO: For publication purposes, file type and format are very stringent and ONLY the type of files described below under "Submission of Electronic Figures for Accepted Manuscripts: Detailed Instructions" below can be used. Any of the above formats can be used for reviewing puproses, but if the author wants us to use electronic figure files (which reproduce best), specific file formats must be provided. Authors wishing to publish color art must pay the associated publication costs; price estimates will be provided on acceptance of the paper. In cases where the authors can not cover color art fees, but it is clear the figure must be presented in color, such fees may be waived at the discretion of the Editor. A letter explaining the circumstances should be sent to the Editor. Website Links for Data Submission and Appropriate Nomenclature Public Database data submission sites Sequence data EMBL, GenBank, or DDBJ Expression data (Array and Sage) GEO (Gene Expression Omnibus) Expression data (Array data only) Array Express Interaction data (two hybrid system, protein-protein interactions or any other biomolecular interaction data) BIND(The Biomolecular Interaction Network Database) Protein 3-D structure data PDB Protein domain information is available from a number of databases such as PFAM, ProSite, and PRINTS. We encourage authors to make these databases aware of newly published material, if possible, but such data should be made available as a G enome Research supplement (include a printout of the material and a diskette with an electronic version labeled as online supplementary material). Nomenclature for genes and proteins should be in the appropriate nomenclature format (including appropriate italics and/or capitalization as it applies for each organisms' standard nomenclature format, in text and figures), and where available submitted and approved by the appropriate nomenclature committees. Nomenclature information and approval committee links include the following: Arabidopsis C. elegans Chicken EC Enzyme nomenclature Fly Human Mouse Plants (general) Rat S. cerevisiae Zebrafish We will be happy to add additional public database links. Please inform the Editor of sites that should be included. Accepted manuscripts Paper length in the journal is between 2 and 12 journal pages. A manuscript of 28-32 typed, DOUBLE-SPACED pages with 27 lines of 11-point text per page (a manuscript of 63,000 characters) with 4-6 figures and 1 or 2 tables will translate to 12 printed pages in the journal. Accepted manuscripts: Hardcopy submission requires two copies of the manuscript and figures and an electronic version of the manuscript in a WORD format. For online submission, a Microsoft WORD source-file needs to be included in the submission, no hard copy of the manuscript text is required. Electronic versions of figures as TIFF or EPS files ONLY can be used at this stage. Details on electronic figure format requirements from our PRINTER are described below. We do require 2 hardcopies of all original artwork for sizing and also for any color matching required, regardless of the availability of electronic files. We regret, we CAN NOT use electronic versions of manuscripts written in any Tex-related programs. In cases where manuscripts have been written in Tex-type programs, submit two hardcopies of the manuscript, (or submit a PDF (that is properly formatted as compared to the Tex version) to our online site). Provide a .txt version of the Tex file online or on disk. (That is a Tex file that does not have any of the coding embedded in the text. We are currently testing a new Tex to Word conversion system and hope to have this in place soon. Proofs are considered the final form of the paper and corrections at this stage do incur charges, so changes should be kept to a minimum as much as possible. Making sure the details of formating and nomeclature have been followed prior to final acceptance will greatly reduce the need for changes at this stage. If additional data or substantive changes to the text, figures or tables need to be made at this stage, it must be approved by the Editor. To help defray the cost of publication, a charge of $30 per page will be made for publication in Genome Research. Authors unable to meet these charges should include a letter of explanation upon acceptance for publication; inability to meet these charges will have no effect on acceptance and publication of submitted papers. Submission of Electronic Figures for Accepted Manuscripts: Detailed Instructions **For our printer- electronic art files can only be in a TIFF or an EPS file. We also require two hardcopies of the files at the final acceptance stage to properly size and color match your figures. Detailed instructions for electronic artwork format are available below which may aid you in converting files to those suitable for processing by our printer. Artwork does not need to be supplied electronically, but this provides the best uality for both the print kjournal and especially for PDFs. Cover proposals must include an electronic version as a TIFF.** Please note we CAN NOT accept Canvas, PowerPoint, SuperPaint, Corel Draw, Harvard Graphics, PDFs, or Excel graphics because they are not compatible with our printer's output devices. 1. For final publication purposes, we can only accept your electronic art as an EPS or TIFF file. See specific instructions below on saving your files in the most common programs. (For reviewing purposes, other file types are okay, as outlined above under manuscript submission.) 2. AUTHORS MUST PROVIDE A GOOD CAMERA-READY COPY QUALITY PRINT WITH THEIR ELECTRONIC FILE for cases when electronic versions of the art fail, and as an additional check for the quality of the electronic version for publication. Always include a printout of the art at the same size it is saved on the disk. Do not enlarge or reduce the printout. This is important in case we cannot read your file and to make sure that what is on the disk is the same as what you provided. We will also be using this printout to size the artwork. If the art is in color, please provide a high quality color print so we can use your print as a guide for colors. 3. The artwork should be put on a zip disk or CD-ROM. We do not accept Syquest disks. Please make sure that your files are properly labeled by first author's name/figure number (for example, Smith_Fig1, Smith_Fig5) and that the printout is properly labeled and corresponds to the file name. Let us know the program you created your artwork in as well. 4. Send only FINAL electronic art files. Do not send text, such as figure legends, on the same disk with the art files. DO NOT EMBED FIGURES WITHIN THE MANUSCRIPT TEXT FILES or embed legends with the figures. If there are color keys to the figures, these should be included in the body of the figrue rather than in the legend, as it can be difficult to match legend and figure colors. 5. Use Helvetica (or similar) typeface in point sizes no smaller than 8 pt and no larger than 10 pt, except for the main callouts (e.g. A, B, C), which should be 12 pt. 6. We cannot make any art corrections to TIFF or EPS files. All figures should be proof-read carefully before they are sent to us. Electronic Artwork Requirements Line Art Line art (without halftone dots) should be scanned or produced at a minimum of 1200 dpi in bitmap mode and saved as EPS files. Halftone or Grayscale Art Art to be reproduced as halftones should be scanned or produced at 350 dpi in grayscale mode and saved as TIFF files. This is for halftone/grayscale art only (art that doesn't also have line art within it). If within the halftone artwork there also exists line art, please follow the dpi specifications for Combo Art instead. When in doubt with halftone art, always default to the Combo Art specifications to ensure that halftone digital art will be used. Combo Art Combo art, which means both halftone art and line art within the same piece of art, must be 900 dpi in grayscale mode and saved as TIFF files. Color Art Color art to be reproduced as halftones should be scanned or produced at 350 dpi in CMYK mode and saved as TIFF files. Always save your color scans into the CMYK color space. Never submit color electronic files in the RGB mode. When color files are converted from RGB into CMYK the color can change significantly and type can be lost. Please convert any RBG files to CMYK files prior to submitting such artwork to make sure the file is correct. Why electronic art file submission has so many restrictions: Cold Spring Harbor Laboratory Press makes every effort to use the electronic files from the authors. We are well equipped and trained with many of the graphics software programs that are used in the scientific community. Adobe Illustrator, Adobe Photoshop, and Freehand are the main "true" graphics programs that all publishers and printing industries support. The file formats from these programs are universal and can easily be read by high-end imagesetters. Canvas, Corel Draw, Powerpoint, Harvard Graphics, and SuperPaint are typical graphics programs that excel at creating visual presentations, slides, and overheads. They may print well to a laser printer and look great on the computer screen (from within their own application format), but they do not always export in file formats that can be printed through high-end imagesetters. The printer uses the electronic files to output film off of their high-end imagesetters. Graphics created from Canvas, for example, can sometimes lose text or the screens may fill in as solids when outputting film from these high-end imagesetters. Canvas does not actually create screens, as Illustrator and Photoshop do. Canvas creates patterns to simulate screens and this can cause problems on press. Also, printers print in CMYK. Most authors submit their files in RGB. When we convert these files to printing industry standards, the colors often change completely. This is why it is very important for the artwork to be created as CMYK and for us to have a printout of your artwork. If we do not have at least a laser printout of your artwork, we will not know if type has been lost. A good quality print is preferable, because we will be able to make sure that the color and data have not changed. Also, in the event that we cannot use your file, we will be able to shoot film from this print. We understand the frustration authors have when publishers say they cannot use their files when everything looks fine on the computer screen and prints well to the laser printer. Please understand that publishers want to use the files, but these files MUST comply with printing industry standards. The problem arises when we have to take these files and transfer them into a file format that a printer can use. Illustrator, Photoshop, and Freehand support the printing industry standards. We hope the other graphics programs will eventually support printing industry standards as well.   Editorial Board EXECUTIVE EDITOR Laurie Goodman [Cold Spring Harbor Laboratory Press]   EDITORS Aravinda Chakravarti [Johns Hopkins University School of Medicine] Evan E. Eichler [Case Western Reserve University] Richard Gibbs [Baylor College of Medicine] Eric Green [National Human Genome Research Institute] Richard Myers [Stanford University School of Medicine] William J. Pavan [National Human Genome Research Institute]   ASSISTANT EDITOR Maureen D. Megonigal [Cold Spring Harbor Laboratory Press]