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期刊名称:ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

ISSN:1081-1206
版本:SCI-CDE
出版频率:Monthly
出版社:ELSEVIER SCIENCE INC, STE 800, 230 PARK AVE, NEW YORK, USA, NY, 10169
  出版社网址:http://allergy.mcg.edu/
期刊网址:http://www.annallergy.org/
影响因子:6.347
主题范畴:ALLERGY;    IMMUNOLOGY

期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)   



About the journal
The Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of the Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.
Instructions to Authors
The purpose of these instructions is to provide authors with clear and concise guidelines for preparing a manuscript in acceptable Annals style. In general, exceptions to the published guidelines are not made. Authors who believe they have compelling reasons to alter and/or exceed the published guidelines may appeal to the editorial office for a variance PRIOR TO submission. Appeals may be sent to annallergy@umc.edu. Otherwise, manuscripts that do not meet these guidelines will be returned to the submitting author for revision prior to any further consideration for peer review.

Manuscript Submission
To submit a manuscript, access the Annals of Allergy, Asthma & Immunology via the Internet at www.annallergy.org. Click on "Submit article to Annals." Only manuscripts submitted through this medium will be considered for review. At the time of submission, complete contact information (mailing address, telephone number, fax number and e-mail address) for the corresponding author is required. First and last names, abbreviated-highest academic degrees, e-mail addresses, and institutional affiliations of all co-authors are also required. NOTE: The following items are required at the time of submission: a cover letter, title page, manuscript text file, references, and a completed authorship form for each author. If the article type is a "CME Review" the following items are required in addition to those stated above: CME Questions, Disclosure of Faculty Interests or Affiliations form for each author, and an Honorarium form.

Article Types
The Annals publishes original articles, reviews, case reports (by invitation only), editorials, letters, correspondence and many other categories of articles. Topics of interest include all subjects that relate to the practice of allergy-immunology. The most frequent published types are described herein.

Original Articles
Original articles should have a structured abstract of no more than 255 words with the following headings: Background, Objective, Methods, Results and Conclusions, a minimum of 3 keywords for indexing, and no more than 50 references. Text should not exceed 3,000 words and should be organized into the following sections: Introduction, Methods, Results and Discussion.

Review Articles
Review articles address a specific question or issue that is relevant for clinical practice and provide an evidence-based, balanced, patient-oriented review on a focused topic, either clinical or basic science. These articles should focus on current advancements in the field, and should be based on the latest "cutting-edge" clinical, translational, or basic science. Review Articles should have a structured abstract of no more than 255 words with the following headings: Objective, Data Sources, Study Selections, Results and Conclusion, a minimum of 3 keywords for indexing, and no more than 50 references. Text should not exceed 3,000 words and should be organized into the following sections: Introduction, Discussion and Conclusions. Because of space concerns, authors interested in submitting a review article should submit a brief description to the Editor-in-Chief to determine interest via e-mail PRIOR TO submitting a full manuscript.

CME Review Articles
CME Review articles, offered as part of a Continuing Medical Education endeavor, must include a minimum of 5 multiple-part questions, with five answers each, related to the material in the review article. CME Review articles should have a structured abstract of no more than 255 words with the following headings: Objective, Data Sources, Study Selections, Results and Conclusion, a minimum of 3 keywords for indexing, and no more than 50 references. Text should not exceed 4,000 words and should be organized into the following sections: Introduction, Discussion and Conclusions. In addition to Authorship forms, CME Review articles require all authors read and sign an original Disclosure of Faculty Interests or Affiliations form at the time of submission. This form is available online at External link http://ees.elsevier.com/annallergy/. Note, authors interested in submitting a CME Review article should submit a brief description to the Editor-in-Chief to determine interest via e-mail PRIOR TO submitting a full manuscript.

Case Reports
Case Reports will only be considered for publication in the Letters category.

Letters
Letters are the primary means for an author to communicate brief clinical or scientific observations to our readership. Letters should not begin with the salutation "To the Editor", and are limited to 750 words, one figure OR table, and 8 references.

Correspondence
Correspondence are brief opinions about recently published articles in the Annals and other current topics of general interest to our readership. Correspondence may or may not have a response, should begin with the salutation "To the Editor" and are limited to 400 words and 5 references. Figures and tables are not allowed for this category. Correspondence submissions are reviewed in the Editorial Office and do not undergo outside peer review. Correspondence discussing a recently published Annals article will generally be considered only if it is received within 2 months of the article's publication date. Exceptions to this policy must have the approval of the Editor-in-Chief. The previously published article should be cited in the text.

Perspectives
On occasion, important topics of general interest to the readership are identified that warrant commentary by a specific expert. The Editor-in-Chief will invite such an expert to write commentary on a specific topic. There is no structured abstract and the text should not exceed 2,000 words and 20 references. Because of space constraints, unsolicited Perspective manuscripts will not be considered.

Editorials
Guest Editorials are solicited by the Editor-in-Chief or Associate Editors to accompany certain special articles, CME review articles, and original articles that are published in the Annals. Text should not exceed 750 words and 10 references. Guest Editorials should reference the previously published article in the Annals. Unsolicited editorials will not be considered.

Book Reviews
Short reviews of recently published books of central interest to our readers are published only by invitation from the Editor-in-Chief. Books for review should be sent to the Annals Editorial Office located at University of Mississippi Medical Center, 2500 North State Street, N416, Jackson, MS 39216. Review text should not exceed 250 words and the review must include the title of the book, the author, publisher and address, edition and year of publication, availability in hard or soft copy, the number of pages, the price and ISBN #.

Editorial Policies for Authors

Authorship
It is assumed that a submitted manuscript is the work of the listed authors and represents the effort (data generation, accumulation and interpretation with subsequent manuscript writing) to generate the manuscript. While outside editorial assistance may be utilized, "ghost written" articles are not accepted for review by the Annals. By submitting a manuscript the authors certify that they have (collectively) personally written at least 80 percent of the manuscript. Authorship credit should only be given when at least three of the following criteria are met: (1) conception and design of the study; (2) data generation (when applicable); (3) analysis and interpretation of the data and (4) preparation or critical revision of the manuscript. Additionally all authors must approve the final version of the manuscript. If there are more than 5 authors, the contribution of each author must be substantiated on the title page. Authors may insert a footnote on the title page to explain the order of authorship and the specific contribution of each author. Assistance of other participants in a study may be indicated as an acknowledgment if the authors have written permission from each person listed in the acknowledgment. On request, the authors must provide the data on which the manuscript is based for examination by the editor or reviewers assigned by the editor. Authors are responsible for all statements, opinions, conclusions, and methods of presenting their data in articles submitted to the Annals of Allergy, Asthma & Immunology for possible publication. The Authorship form is available online at External link http://ees.elsevier.com/annallergy/.

Clinical Trial Registration
All manuscripts that present therapeutic data involving a pharmaceutical agent (commercial or non-commercial) must be registered with an approved Registry that meets the minimum registration data set as described by the International Committee of Medical Journal Editors (ICJME). The minimum registration data set can be viewed at External link http://www.icmje.org/icmje.pdf.
Approved Registries include those listed below.

(1) External link http://www.clinicaltrials.gov
(2) External link http://isrctn.org
(3) External link http://www.umin.ac.jp/ctr/index/htm
(4) External link http://www.actr.org.au
(5) External link http://www.trialregister.nl

The Registry URL and assigned database number should be clearly identified on the title page and recorded during the electronic submission process.

Corresponding Author
If the manuscript is accepted, the corresponding author will serve on behalf of all coauthors as the primary correspondent with the editorial office, will receive electronic versions of the page proofs for their articles from Elsevier, and agrees to make only necessary changes and return the corrected page proofs to Elsevier within 48 hours of electronic receipt.

Conflict of Interest
A conflict of interest may exist when an author (or the author's institution or employer) has financial or personal relationships that could potentially influence (or bias) the author's decisions, work, or manuscript. All authors are required to report potential conflicts of interest for the 3 years prior to submission of the manuscript or the duration of the reported study, whichever is longer. Potential conflicts of interest include, but are not limited to, speaker's bureau membership, consultantancies, research support and/or stock interest by an author and/or his/her first-degree relatives. Disclosure of potential conflicts should be made in the authors' title page. Authors without relevant conflicts of interest in the manuscript should indicate no such interest. These conflicts of interest will be published in footnote form for all manuscripts accepted for publication by the Annals. Failure to comply with this requirement will result in the manuscript being returned without review.

Funding/Support
All financial support for the research and the work should be clearly and completely identified on the title page.

Ethical Approval of Studies and Informed Consent
For all research studies involving animal or human subjects or research material derived from humans, appropriate institutional review board (IRB) review and approval is required and should be stated in the Methods section of the manuscript. The Annals will not publish human research which has not undergone IRB review. For investigations involving human subjects, the manner in which informed consent was obtained from the study participants (i.e., oral or written) should also be stated in the Methods section of the manuscript. Studies exempted from IRB approval by their respective boards should be so indicated in the methods section. When reporting experiments on animals, authors should indicate whether the institutional and national guide for the care and use of laboratory animals was followed. Such review and approval or waiver should also be described in the Methods sections of the manuscript. Failure to comply with this requirement will result in the manuscript being returned without review.

Reproduced Materials
When previously published figures or tables are used, the author must obtain written permission from the copyright holder (usually the publisher) to reproduce the material in print and online. An appropriate credit line should be included in the figure legend or table footnote, and full publication information should be cited in the reference list. Letters of permission must accompany the submission.

Revised Manuscripts
Submitted manuscripts may be returned to authors with request for revision. A revised manuscript should be received within one month of the date of the decision letter and must include a point-by-point reply to all reviewer comments. As with new submissions, revisions must be electronically submitted through the online manuscript submission and peer review system. Follow the instructions in the Author Tutorial (located on the home page) for submitting a revised manuscript. Changes in the revised manuscripts must be highlighted and/or underlined in red. The original text limits (word count, references, tables/figures) are still in effect. If the revision exceeds these limits, it will be the authors' responsibility to fully explain why the revision cannot be edited to comply with the limits. This explanation should be provided in the response to the reviewers. Note: A revised manuscript not returned within one month of the date of the decision letter will automatically be rejected. Any further action will require an entire new submission process. Extensions to this deadline will be provided in extenuating circumstances and requires the prior approval of the Editor-in-Chief.

Editorial Review and Publication
Corresponding authors are sent notifications of the receipt of manuscripts and editorial decisions by e-mail. Authors can check the status of their submitted manuscript, during the review process, via the online manuscript submission and peer review system.

Editing
Accepted manuscripts are edited in accordance with the American Medical Association Manual of Style 10th ed. New York: Oxford Press; 2007.

Proofs
Corresponding authors will receive electronic versions of the page proofs for their articles from Elsevier. Authors should make only necessary changes and return the corrected page proofs to Elsevier within 48 hours. If return of page proofs are delayed, the manuscript may at the discretion of the Editor-in-Chief be accepted for publication as is. Accurate proofreading and clear marking of corrections are essential for the production of a quality article. Please note that careful proofreading is solely your responsibility. Errata are generally not published for this oversight unless the error is significant. Five alterations on the page proofs are allowed without cost to the author. Additional changes, not including printer errors, will be billed directly to the author at the current cost, and are subject to approval by the Annals editorial staff.

Reprints
The Annals of Allergy, Asthma & Immunology makes available high quality reprints to its authors and the public.

For commercial reprints please contact:

Anne Rosenthal
Elsevier Inc.
360 Park Avenue South
New York, NY 10010-1710
Tel: +1 212-633-3812
Fax: +1 212-633-3820
E-mail: reprints@elsevier.com

For authors, the Reprint Order Form is sent with the electronic manuscript acknowledgment letter. Please complete the form and send the order form and purchase order or prepayment either by mail or fax to

ANAI, Elsevier Philadelphia, Journals Production

For the public, e-prints and reprints are available through Elsevier. For information and prices call 212-633-3812; fax: 212-633-3820.

Editorial and Peer Review
Manuscripts are initially reviewed by the Annals Editor-in-Chief. Manuscripts with insufficient priority for publication are declined and returned to the authors. Other manuscripts are assigned to an Associate Editor and sent to expert consultants for peer review.

Manuscript Preparation and Submission Requirements
Manuscripts that do not adhere to the following requirements will be returned to the corresponding author before peer review is initiated.

Basic Formatting (Page Setup/Fonts)
Manuscripts should be prepared in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication" (http://www.icmje.org/icmje.pdf) updated October 2007. The entire manuscript should be in a standard font such as Times New Roman, Arial, or Courier, size 12. Each manuscript component should be attached as a separate submission item, be double-spaced and have a one inch margin on all sides. Page numbering should begin with the manuscript file. The page number should appear in the upper right corner of each page. Line numbers (i.e., 1, 2, 3 etc.) should be displayed in the left-hand margin of the manuscript file. Line numbering can be added from the File/Page Setup menu of word processing programs and should be continuous throughout the manuscript file. Do not restart numbering from each page. File names should not contain brackets [ ].

Article Lengths
Authors must comply with text limits that have been established for each type of article. Articles of excessive length require prior approval from the Editor-in-Chief. Text limit excludes abstracts, acknowledgments, E-supplement material, figures, references or tables.

Manuscript Components
Each submission must be comprised of the following submission items, unless otherwise specified. Each component should be attached as a separate submission item in the following order: a cover letter, title page, manuscript, acknowledgments, references, a completed Authorship form for each author, and, as appropriate, tables, figures and figure legends, CME Questions, Disclosure of Faculty Interests or Affiliation form, Honorarium form, and E-Supplement material.

Cover Letter
A cover letter should be submitted with each article type and, include complete contact information for the corresponding author (mailing address, telephone number, fax number and e-mail address) and a full statement to the editor that the manuscript has been read and approved by all the authors, that the requirements for authorship as stated earlier in this document have been met, and the authors certify that they have (collectively) personally written at least 80 percent of the manuscript.

Title Page
The title page should be concise and easy to read. Each author who meets authorship criteria should be listed, including the Author's full name, abbreviated-highest academic degree, and institutional affiliation. The name, mailing address, telephone number, fax number, and e-mail address of the author responsible for correspondence should also be noted. If there are more than 5 authors, the contribution of each author must be substantiated on the title page in context of the authorship criteria identified in the Editorial Policies for Authors section of this document. The source of any financial support should also be included on the title page. A word count for the manuscript (excluding abstract, acknowledgments, e-supplement material, figure legends, references and tables) and the number of figures and tables accompanying the manuscript should be specified. Potential conflicts of interest should be included on the title page immediately following the number of figures and tables. Authors without conflicts of interest should indicate no such interest. Failure to include the above information on the title page will delay the evaluation and review of the manuscript.

Manuscript
In order to ensure a double-blind review, it is imperative that author identifying information not be included in the manuscript text. Abstracts, acknowledgments, E-supplement material, figures, references or tables should not be included in the manuscript text file. The text of the manuscript should be divided into sections with the following headings in this order, unless otherwise specified in Article Types section of this document.

Introduction: Provide an overview of the scope and relevance of the study.

Methods: Describe the design (randomized, double-blind, placebo control), subjects, setting (general community, private practice, and hospital), interventions, and main outcome measures. For all research studies including human subjects (excluding Case Reports) the specific IRB that has approved the research must be indicated. Additionally a statement that informed consent was obtained from all research participants must be included. Both should be clearly noted and, upon request, must be made available to the Editor-in-Chief for review. If clinical trials were used, a statement of registration is required also.

Results: Describe the experimental data and results as well as the particular statistical significance of the data.

Discussion: Provide and quantify the main outcomes of the study. Identify limitations of the presented data including plausible explanations for discrepancies between the data and the literature, any differences not expected from the initial hypothesis presented in the introduction and a measured description of the conclusions of the study with implications for future research, biological understanding and/or clinical applications.

For guidance regarding grammar, punctuation, and scientific writing see the American Medical Association Manual of Style. 10th ed. New York: Oxford Press; 2007.

Abbreviations
Avoid using acronyms and abbreviations except for tests or procedures better known by their abbreviation than by the full term, such as VDRL. Expand all abbreviations at first mention. Abbreviate units of measurement only when they appear with numerals ("measured in centimeters" but "87 cm"). Abbreviations may be used in figures and tables, but such abbreviations must be explained in the figure legend or a footnote to the table.

Units of Measure
Authors should express all laboratory values in conventional units with Systeme Internationale (SI) units included in parentheses after the conventional units. For those components with a conversion factor that is a multiple of 10, for example, cholesterol, aspartate aminotransferase, and the immunoglobulins, there is no need to dual report; use conventional units only. Use the degree Celsius for temperatures, metric mass units for drug dosages, and mm Hg for blood pressure and blood gas tensions. Conversion equations should be supplied as footnotes to tables and should be included in legends to figures. Conversion tables are available in the American Medical Association Manual of Style.

Names of Drugs
Use generic names for drugs except when a specific trade preparation was used in a study or involved in an adverse reaction or when unique properties of the proprietary drug require its identification.

Acknowledgments
Acknowledgments should be uploaded as a separate submission item and include the names, affiliations, and specific contributions of all persons who have contributed to the work reported in the manuscript (e.g., data collection, analysis, writing or editing assistance) but do not meet authorship criteria. In addition, the corresponding author must sign the Acknowledgment statement on the Annals Authorship form.

References
Authors are responsible for the accuracy and completeness of their references and format. Refer to the Article Types section of this document as there are a maximum number of references for each category. References should be numbered consecutively in the order in which they are first cited in the text, recorded during the electronic submission process, and uploaded as a separate submission item. In text, tables and legends, identify references with superscript Arabic numerals. For guidance regarding reference style, consult the National Library of Medicine (NLM) and abbreviate the names of journals according to Index Medicus. List all authors up to 6; if more than 6, list the first 3 followed by "et al." Try to avoid using abstracts as references. Unpublished observations, including personal communications, may not be included in the reference list but may be cited parenthetically in the text with the permission of the cited person, (e.g., Edward J. O'Connell, MD, unpublished data, 2003). Authors must indicate whether personal communications were written or oral. Articles or books accepted for publication but not yet published may be included as references with the name of the journal or publisher and the addition of "In press."

Example:

1. Macy E, Bernstein JA, Castells MC, et al. Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper. Ann Allergy Asthma Immunol. 2007;98:172-174.
2. Li J, Lockey RF, Bernstein IL, Portnoy JM, Nicklas RA. Allergen immunotherapy: a practice parameter. Ann Allergy Asthma Immunol. 2003;90(suppl 1):1- 40.
3. Lieberman P, Kemp SF, Oppenheimer J, Lang DM, Bernstein IL, Nicklas RA. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol. 2005;115(suppl 2):S483-S523.

Authorship Form(s)
Completed authorship forms are required at the time of submission. Effective March 1, 2009, the editorial office will no longer accept authorship faxes. As a result, an authorship for each author must be completed by hand, scanned and uploaded at the time of submission. Each author must read and sign the statements on 1.) Authorship Responsibility and 2). Copyright Transfer. In addition, the corresponding author must sign statements on 3.) NIH Funding and if applicable section 4.) Acknowledgments. If necessary, photocopy this document to distribute to coauthors. This form is available online at External link http://ees.elsevier.com/annallergy/.

Tables
It is a requirement that tables be prepared using Microsoft Word. Tables should be numbered in the order in which they are first cited in the text with superscript Arabic numerals, recorded during the electronic submission process, and uploaded as a separate submission item. Each table should have a concise heading that makes it comprehensible without reference to the text of the article. Use horizontal lines only at the top and bottom of the table and between column headings and the body of the table. Use no vertical lines. Explain any nonstandard abbreviations in alphabetical order in a footnote to the table, e.g., Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; OR, odds ratio

Figures
Figures (graphs, charts, photographs, and illustrations) should be numbered in the order in which they are first cited in the text, recorded during the electronic submission process, and uploaded as a separate submission item. Each figure should have a legend and be prepared using a program which can save files in a format that can ultimately be saved and submitted as EPS or TIFF. Figures should not be embedded within the manuscript text file, but submitted as separate EPS or TIFF files. Graphics should be saved in CMYK (cyan, magenta, yellow, black) rather than RGB (red, green, blue).

The Artwork Quality Check (Artwork QC) feature in Editorial Manager is designed to inform authors whether an uploaded figure file is acceptable for production. At the time of submission, the author must view the Artwork Quality Results. If our automated system warns us that one or more of your figures are not of publication quality, the manuscript will be considered for peer review. If the article, however, is accepted, publication will be contingent upon you providing the editorial office with figures which pass the artwork quality check program.

Image Editing Applications
Adobe Photoshop TIFF & EPS Corel Photo-Paint TIFF & EPS.

Drawing Applications
Adobe Illustrator TIFF & EPS
CorelDRAW TIFF & EPS
Deneba Canvas TIFF & EPS
Macromedia Freehand TIFF & EPS

Resolution Reminders
Line art should be created at 1200 dpi and saved in a bitmap/monochrome color mode. Gray halftones should be created at 300 dpi and saved in grayscale color mode. Color halftones should be created at 300 dpi and saved in CMYK color mode. Combination halftones should be created at 600 dpi and saved as either CMYK or grayscale color modes. Please Note: An image should be saved and submitted in the size at which it will be printed. For optimal results, scaling, rotation, and cropping should be done using an image editing program, rather than a page layout program.

Assembled Artwork
There are a few essential items that should be checked prior to submitting an assembled figure:
  • Check the final size to ensure that it will fit within the designated column width
  • Check the final image for proper gutter spaces/tooling
  • Check for proper placement of labels (if applicable)
  • Check to ensure straightness of figure
  • Check for proper resolution
  • Check for proper color mode

The resolution specification for TIFF and EPS files is 1200 dpi for monochrome, figures that are black and white only and line shots; 300 dpi for gray/ CMYK or color photographs, and 600 dpi for combinations, such as photographs labeled with letters or other markings. For additional information on submitting graphics, please visit the Elsevier website at External link http://www.elsevier.com/artwork

E-Supplement Material
Authors may submit supporting material to accompany their article for online-only publication when there is insufficient space to include the material in the print article. This material should be important to the understanding and interpretation of the report and the amount of material should be limited. E-Supplement material will undergo editorial and peer review with the main manuscript. If the manuscript is accepted for publication and if the material is approved for publication by the editors, it will be posted online at the time of publication of the article as online extra material provided by the authors. E-Supplement material should be submitted in a single Word document with pages numbered consecutively and uploaded with an E-supplement submission item. Each element included in the material should be cited in the text of the main manuscript (i.e., see eTable) and numbered in order of citation in the text (i.e, eTable 1, eTable 2, eFigure 1, eFigure 2, eMethods). The first page of the E-supplement document should list the number and title of each element included in the document.

CME Questions
CME Review articles, offered as part of a Continuing Medical Education endeavor, must include a minimum of 5 multiple-part questions, with five answers each, related to the material in the review article. These questions should be uploaded as a separate submission item.

Disclosure of Faculty Interests or Affiliation Form(s)
In addition to Authorship forms, CME Review articles require all authors read and sign an original Disclosure of Faculty Interests or Affiliations form at the time of submission. This form is available online at External link http://ees.elsevier.com/annallergy/ and should be uploaded as a separate submission item.

Honorarium Form
Upon publication of a CME Review article, the Annals offers a $1,000.00 honorarium. This form is available online at External link http://ees.elsevier.com/annallergy/ and should be uploaded as a separate submission item.

Letter of Permission
If your article contains previously published figures or tables, a letter of permission from the copyright holder should be uploaded as a separate submission item.

Manuscript Checklist
Please read and check off the relevant items listed on the checklist as you prepare your manuscript. This form can also be found on the manuscript login site.



Manuscript Checklist

Please read and check off the relevant items listed on the checklist as you prepare your manuscript.

• Review full manuscript submission instructions on our Web-based submission and review system at External link http://ees.elsevier.com/annallergy/.

• Manuscript should be in a standard font such as Times New Roman or Courier, size 12. Each manuscript component should be attached as a separate submission item, begin on a new page, be double-spaced and have a one inch margin on all sides. Page numbering should begin with the manuscript file. The page number should appear in the upper right corner of each page. Line numbers (i.e., 1, 2, 3 etc.) should be displayed in the left-hand margin of the manuscript file. Abstracts, acknowledgments, author identifying information, E-supplement material, figures, references or tables should not be included in the manuscript text file.

• On the title page, designate a corresponding author and provide a complete mailing address, telephone number, fax number, and e-mail address. Provide first and last names, abbreviated- highest academic degree, e-mail addresses, and institutional affiliations for any coauthors. Identify all financial support for the research and the work. Include a word count for the manuscript (excluding abstract, acknowledgments, e-supplement material, figure legends, references and tables), the number of figures and tables accompanying the manuscript, the Clinical Trial database and registration number if applicable, and potential conflicts of interest. Authors without conflicts of interest should indicate no such interest. If there are more than 5 authors, the contribution of each author should be substantiated on the page too.

• Provide an abstract that conforms to the structured abstract format.

• Provide a minimum of 3 key words or short phrases that capture the main topics of the article.

• Include the following section headings for Text: Introduction, Methods, Results, and Discussion. If appropriate, include information on institutional review board/ethics committee approval or waiver and informed consent in the Methods section.

• Include in Acknowledgements the names, affiliations, and specific contributions of all persons who have contributed to the work reported in the manuscript but do not meet authorship criteria.

• Check all references for accuracy and completeness. Put references in proper format in numerical order, making certain that each is cited in sequence in the text.

• Include a brief title (no longer than 10 to 15 words) for each table and figure and a succinct, explanatory legend for each figure.

• Have all authors read and sign an Authorship Form. Each form should be uploaded at the time of submission. This form is available online at External link http://ees.elsevier.com/annallergy/.

• If this is a CME review article, each author will need to read and sign a Disclosure of Faculty Interests or Affiliations" form. Each form should be uploaded as a separate submission item at the time of submission. The corresponding author should also read, sign and upload the Honorarium form as a separate submission file during the submission process.

Editorial Board
Editor-in-Chief:
Gailen D. Marshall, MD, PhD
Jackson, MS

Associate Editors:
Kimberly K. Stamper, Managing Editor, Jackson, MS
Richard W. Weber, MD, Cover Section Editor, Denver, CO
Sami L. Bahna, MD, DRPH, Shreveport, LA
Leonard Bielory, MD, Newark, NJ
Vincent R. Bonagura, MD, Great Neck, NY
G. Walter Canonica, MD, Genoa, Italy
Mitchell H. Grayson, MD, Milwaukee, WI
William D. Johnson, PhD, Biostatistics Editor, Jackson, MS
Michael S. Tankersley, MD, San Antonio, TX
Stephen A. Tilles, MD, Redmond, WA
Richard W. Weber, MD, Denver, CO

Editorial Board:
I. Leonard Bernstein, MD, Cincinnati, OH (2010)
Jonathan A. Bernstein, MD, Cincinnati, OH (2010)
Paula J. Busse, MD, New York, NY (2010)
Donald W. Cockcroft, MD, Saskatoon, Canda (2010)
Linda S. Cox, MD, Ft. Lauderdale, FL (2010)
Timothy J. Craig, DO, Hershey, PA (2010)
Chitra Dinakar, MD, Kansas City, MO (2010)
Sten Dreborg, MD, Lerum, Sweden (2010)
Robert E. Esch, PhD, Lenoir, NC (2010)
Alessandro Fiocchi, MD, Milan, Italy (2010)
Michael David Goldman, MD, Amarillo, TX (2010)
Richard W. Honsinger, MD, Los Alamos, NM (2010)
Stephen F. Kemp, MD, Jackson, MS (2010)
Lyndon E. Mansfield, MD, El Paso, TX (2010)
John B. Meiser, MD, Plano, TX (2010)
Ervin C. Mingomataj, MD, Tirana, Albania (2010)
Richard J. Morris, MD, Maple Grove, MN (2010)
Talal M. Nisouli, MD, Washington, DC (2010)
John J. Oppenheimer, MD, Denville, NJ (2010)
David B. Peden, MD, Chapel Hill, NC (2010)
Brian A. Smart, MD, Buffalo Grove, IL (2010)
Daniel L. Venarske, MD, Jackson, MS (2010)
Ronald S. Walls, MD, Concord, Australia (2010)
David R. Weldon, MD, College Station, TX (2010)
Phillip Brock Williams, PhD, Olathe, KS (2010)
Avni Y. Joshi, MD, Rochester, MN (2011)
Madhu B. Narra, MD, Houston, TX (2011)
Michael Blumberg, MD, Richmond, VA (2012)
Malcolm N. Blumenthal, MD, Minneapolis, MN (2012)
Christopher W. Calabria, MD, San Antonio, TX (2012)
Adrian M. Casillas, MD, Shreveport, LA (2012)
Christopher Albert Coop, MD, Anchorage, AK (2012)
Richard DeShazo, MD, Jackson, MS (2012)
Lawrence M. DuBuske, MD, Gardner, MA (2009)
Anne K. Ellis, MD, Kingston, ONtario (2012)
Enrique Fernandez-Caldas, MD, Seefeld, Germany (2012)
Stanley M. Fineman, MD, Marietta, GA (2012)
Michael B. Foggs, MD, Chicago, IL (2012)
Fred Hsieh, MD, Cleveland, OH (2012)
Guha Krishnaswamy, MD, Johnson City, TN (2012)
D. Betty Lew, MD, Memphis, TN (2012)
Philip Lieberman, MD, Germantown, TN (2012)
Bryan L. Martin, DO, Washinton, DC (2012)
Travis A. Miller, MD, Sacramento, CA (2012)
Todor A. Popov, MD, PhD, Sophia, Bulgaria (2012)
Gary S. Rachelefsky, MD, Los Angeles, CA (2012)
Roland Solensky, MD, Corvallis, OR (2012)
James L. Sublett, MD, Louisville, KY (2009)
Richard Tan, MD, Los Angeles, CA (2012)

Publications Committee:
Susan R. Bailey, MD, Chair, Ft. Worth, TX
Sami L. Bahna, MD, DrPH, President, Shreveport, LA
Dann V. Wallace, MD, President-Elect, Ft. Lauderdale, FL
Michael B. Foggs, MD, Treasurer, Chicago, IL
Richard G. Gower, MD, Immediate Past President, Spokane, WA
Phillip Liberman, MD, Fellow, Germantown, TN
Bryan L. Martin, DO, Training Program Director, Columbus, OH
Timothy J. Craig, DO, 2nd Year Regent, Hershey, PA
Dennis K. Ledford, MD, Fellow, Tampa, FL
Lyndon E. Mansfield, MD, 3rd Year Regent, El Paso, TX
Gailen D. Marshall, MD, PhD, Editor-in-Chief, Annals, Jackson, MS
Anthony Montanaro, MD, Editor-in-Chief, AllergyWatch, Portland, OR
James M. Seltzer, MD, 1st Year Regent, Worcester, MA

Board of Regents
Sami L. Bahna, MD, DrPH, President, Shreveport, LA
Dana V. Wallace, MD, President-Elect, Ft Lauderdale, FL
Stanley M. Fineman, MD, Vice President, Marrietta, GA
Michael B. Foggs, MD, Treasurer, Chicago, IL
Richard G. Gower, MD, Immediate Past President, Spokane, WA
Jay M. Portnoy, MD, Past President, Kansas City, MO
J. Allen Meadows, MD, Speaker, House of Delegates, Montgomery, AL
Mark L. Corbett, MD, 3rd Year Regent, Louisville, KY
Lawrence M. Dubuske, MD, 3rd Year Regent, Gardner, MA
Lyndon E, Mansfield, MD, 3rd Year Regent, El Paso, TX
Timothy J. Craig, DO, 2nd Year Regent, Hershey, PA
David I. Bernstein, MD, 2nd Year Regent, Cincinnati, OH
Russell A. Sethpane, MD, 2nd Year Regent, Providence, RI
Kevin P. McGrath, MD, 1stYear Regent, Wethersfield, CT
Talal Nsouli, MD, 1stYear Regent, Washington, DC
James M. Seltzer, MD, 1stYear Regent, Worcester, MA
Christopher R. Martin, MD, Sr. FIT Representative, Potomac, MD
John R, Seyerle, MD, Jr. FIT Representative, Bexley, OH


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