期刊名称：CHEMMEDCHEM ISSN： 1860-7179 出版频率： Semi-monthly 出版社： WILEY-V C H VERLAG GMBH, POSTFACH 101161, WEINHEIM, GERMANY, 69451   出版社网址： http://www3.interscience.wiley.com/cgi-bin/home?CRETRY=1&SRETRY=0 期刊网址： http://www3.interscience.wiley.com/journal/110485305/home 影响因子： 3.466 主题范畴： CHEMISTRY, MEDICINAL;    PHARMACOLOGY & PHARMACY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal With an impact factor of 3.150 (2008), ChemMedChem on its way to become a premier journal at the interface of chemistry, biology and medicine. ChemMedChem is made in Europe, but publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies”to name just a few topics. ChemMedChem replaces Il Farmaco”An International Journal of Medicinal Chemistry and Pharmaceutical Chemistry, which was published by the Società Chimica Italiana until the end of 2005 and generously given up in order to limit the crowding of journals in these sciences. Contents ChemMedChem publishes an attractive mixture of: Short Communications and Full Papers Minireviews and Reviews Highlights and Concepts Book and Multimedia Reviews Fields of Interest ChemMedChem tears down the walls between chemistry, biology, and medicine: drug design and discovery drug development and delivery target validation lead generation ADMET studies screening biological activity studies combinatorial techniques molecular modeling synthesis of biologically active compounds metabolism in drug actions molecular recognition at receptors interaction of ligands and receptors applications of NMR and X-ray crystallography ChemMedChem is accepted for coverage in MEDLINE. Readership medicinal, pharmaceutical and organic chemists, chemical and molecular biologists, pharmacists and pharmacologists Keywords drug design, drug discovery, drug development, drug delivery, target validation, lead generation, ADMET studies, screening, biological activity studies, combinatorial techniques, molecular modeling, synthesis, biologically active compounds, metabolism in drug actions, molecular recognition, receptors, interaction of ligands and receptors, NMR spectroscopy, X-ray crystallography Abstracting and Indexing Information   Biological Abstracts (Thomson ISI) BIOSIS Previews(Thomson ISI) Cambridge Structural Database (CSA/CIG) CAS: Chemical Abstracts Services () Chemical Abstracts Service/SciFinder (ACS) ChemInform (Wiley-VCH/FIZ Chemie) COMPENDEX (Elsevier) Current Contents®/Life Sciences (Thomson ISI) EMBASE/Excerpta Medica (Elsevier) EMNursing (Elsevier) GEOBASE/Geographical & Geological Abstracts (Elsevier) IBIDS: International Bibliographic Information on Dietary Supplements () Index Medicus/MEDLINE/PubMed (NLM) International Pharmaceutical Abstracts (Thomson Scientific) Journal Citation Reports/Science Edition (Thomson ISI) MEDLINE/PubMed (NLM) Mosby Yearbooks (Elsevier) Science Citation Index Expanded (also known as SciSearch) SCOPUS (Elsevier) VINITI (All-Russian Institute of Science & Technological Information) Web of Scien (Thomson ISI) Instructions to Authors General Information ChemMedChem is a European journal of medicinal chemistry, co-owned by a group of European chemical societies (ChemPubSoc Europe) and published by Wiley-VCH. Contributions in ChemMedChem cover medicinal and pharmaceutical sciences, drug design and discovery, drug development and delivery, molecular modeling, combinatorial chemistry, target validation, lead generation, ADMET studies, and more. ChemMedChem publishes Communications and Full Papers, Reviews, Minireviews, Highlights, Concepts, Book Reviews, and Conference Reports. Except for original research papers, the other article types are generally written upon invitation. Unsolicited manuscripts, however, are welcome, as long as they fit into the scope of the journal. Viewpoints, Correspondence, Essays, Web Sites, and Databases are also occasionally featured. ChemMedChem does not publish manuscripts that have already appeared in print or electronically. The author must inform the Editor of manuscripts submitted, soon to be submitted, or in press at other journals that have a bearing on the manuscript being submitted to ChemMedChem. The Ethical Guidelines for Publication in Journals and Reviews issued by the European Association of Chemical and Molecular Sciences are followed and applied by the Editors of ChemMedChem. In particular, authors should reveal all sources of funding for the work presented in the manuscript and should declare any conflicts of interest. Authors submitting a manuscript to ChemMedChem for the first time are asked to characterize their main research interests with a maximum of five keywords from the Keyword List for Authors and Reviewers. With the exception of Book Reviews, Conference Reports, Web Sites, and Databases, all manuscripts that are suitable for consideration will be peer-reviewed and, if accepted for publication, edited with a view to clarity, brevity, and consistency. The conditions for publication are available on the journal's homepage. Authors are welcome to suggest referees. If a manuscript was previously submitted to Angewandte Chemie, Chemistry–A European Journal, ChemBioChem, ChemPhysChem, or any other of ChemMedChem's sister journals, then please state the manuscript number of the previous submission in the cover letter. This will help the peer-review process. Manuscript Submission We request that you submit your manuscript by using our online submission service, manuscriptXpress, which can also be accessed through our homepage (http://www.chemmedchem.org). For the initial submission of a manuscript please prepare a single file (allowed formats: Word, RTF, Postscript, PDF) containing all Schemes, Figures, Tables (integrated into the text), and Supporting Information (where appropriate) though not crystallographic CIF files. Then follow the simple instructions at the submission site. (If you encounter any problems please make use of the contact form at this site.) Please include a short text justifying why your article should appear in ChemMedChem and avoid formatted text in your cover letter. If, for any reason, you are unable to use this system, then you can also send one copy of the manuscript, original artwork, a disk containing the text and graphics, and a signed copy of the Copyright Agreement (available as a PDF file from www.chemmedchem.org) by post, to the address given at the end of this document; or you can send your manuscript as an e-mail attachment to chemmedchem@wiley-vch.de. Please note, however, that online submission is preferred, as this will considerably speed up the manuscript-handling process. Types of Contribution 1. Reviews Reviews deal with topics of current interest in any of the areas covered by ChemMedChem. Rather than an assemblage of detailed information with a complete literature survey, a critically selected treatment of the material is desired. Unsolved problems and possible developments should also be discussed. Reviews should be divided into numbered sections. Cross-references in the text refer to these section numbers. The review starts with a Lead-in (1000-500 characters). This text should not be a mere summary; rather, it should arouse the readers' interest. The Introduction should introduce the nonspecialist to the subject as clearly as possible. A Review should conclude with a Summary and Outlook section, in which the achievements and new challenges for the subject are presented succinctly. In addition, a biographical sketch (500-100 characters) and a portrait-quality black-and-white photograph of each author, as well as a graphical suggestion for a full-page picture (Frontispiece) to face the first page, should be submitted. Please note that a color frontispiece carries a charge of 95 (including tax). A Review should consist of a maximum of 40 pages (approximately 65000 characters) of main text, footnotes, literature citations, tables, and legends. 2. Minireviews A Minireview introduces the reader to a particular area of an author's research through a concise overview of a selected topic. The content should balance scope with depth, and references to important works from others that are significant to the topic, should be included. As a Minireview is much more focused than a Review, it is shorter (15 pages of text, approximately 25000 characters) and does not contain a frontispiece or biographical sketch(es). It should still have an Abstract. 3. Highlights In the Highlights section, very important new results of original research are described, in general by a third person, with a view to highlighting their significance. The results should be presented clearly, but as succinctly as possible, without the comprehensive details required for an original article. Highlights may be organized as the author wishes, but should not be more than five manuscript pages (approximately 8500 characters) in length. Chemical formulae, figures, and schemes should be restricted to important examples, and the number of references kept to a minimum. 4. Concepts Concepts are short articles that emphasize the general concepts that have guided important developments in a specific area and their implications for future research. The reference section should only include the key papers that have contributed to conceptual advances in the field under review, rather than being fully comprehensive. The author should aim to provide the nonspecialist reader with a useful guide and the expert with a new angle on a familiar problem. Concept articles may be organized as the author wishes, but should include a short Abstract (approximately 600-1000 characters) that succinctly describes the concepts under discussion. Articles should consist of around ten pages of text (approximately 17000 characters) including references, tables, and legends. The liberal use of schemes and figures is encouraged. 5. Communications and Full Papers Communications and Full Papers present results of experimental or theoretical studies of general interest or great importance to the development of a specific area of research. A short text justifying why the manuscript should appear in ChemMedChem should be submitted. The quality of original research contributions is usually assessed by two or more independent referees. Detailed information that could be of importance to the referees, but that is unlikely to be of interest to the reader can be submitted as an enclosure or clearly marked as Supporting Information. Only articles that have already been published in a scientific journal should be cited. The citation should be fair and informative but not excessive. Copies of cited publications not yet available publicly should be submitted along with the manuscript. Unpublished results and lectures should only be cited in exceptional circumstances. Inclusive of all references, footnotes, and tables, a Communication should be no longer than six manuscript pages (approximately 10000 characters). Chemical formulae, figures, and schemes may also be added. Longer Communications will be accepted only if their quality warrants special consideration, and a written justification of their length is provided. Communications should not be divided into sections. However, experimental details can be succinctly summarized separately under the heading Computational Methods or Experimental Section. Please note, only pertinent experimental information should be included in this section, and any additional experimental data should be detailed in the Supporting Information. The first paragraph of a Communication should give an introduction to enable readers unfamiliar with the subject to become acquainted with the importance of the results presented. In the final paragraph the results should be summarized succinctly, and one sentence should be devoted to their significance and, if appropriate, to remaining challenges. Full Papers, which generally contain a Computational Methods or Experimental Section, have no length restrictions. However, the Editorial Office requests that space be used thoughtfully and economically. ChemMedChem will not publish Full Papers that consist mainly of results reported in previous Communications with an added experimental section. Full Papers contain an Abstract, which should be brief (600-1000 characters) and not too technical, and an Introduction including relevant references. The presentation of Results and Discussion may be combined or kept separate. These sections may be further divided by subheadings. 6. Book Reviews Reviews of books are written on invitation. Suggestions for books to be reviewed and for reviewers are welcome. Publishers should send brochures or, preferably, the books directly to the Editorial Office. Unsolicited books will not be returned. 7. Conference Reports, Viewpoints/Essays, Correspondence, etc. Reports on recent events and comments on publications in ChemMedChem or on topics of high current interest are welcome if they contribute to the scientific discussion in the area of medicinal chemistry. General Remarks The following remarks aim to assist you in preparing your manuscript for submission to ChemMedChem, and can also be found here as a PDF file (Manuscript Preparation Guide). We strongly encourage our authors to adhere closely to these guidelines as it facilitates both the peer-review and the editorial process. Printing of Figures and Schemes in color is expensive, and we request that part of the additional costs be carried by the author. If color printing is essential and the author does not have access to funds for color printing, the Editor can make an exception. Spelling may be either UK or US standard English, but consistency should be maintained within a manuscript. Authors are asked to make their manuscripts suitable for a heterogeneous readership of biologists and chemists and to be considerate to our many readers for whom English is a foreign language”please use a simple, clear style and avoid jargon. Abbreviations and acronyms should be used sparingly and consistently, following the system of abbreviations and symbols recommended by the International Union of Pure and Applied Chemistry (IUPAC) and the International Union of Biochemistry and Molecular Biology (IUBMB). Where they first appear in the text, they should”apart from the most common ones such as NMR, IR, or UV”be defined. You may prefer to explain large numbers of abbreviations and acronyms in a Glossary at the end of the text. Names of organisms should comply with genetic conventions, with genus and species names written in italics and spelled out in full on first appearance. Abbreviations for genes should be written in lower-case letters and italicized, those of the corresponding protein products should start with a capital letter and should not be italicized (e.g., hsp70 and Hsp70, respectively). Enzyme names should be accompanied by the respective Enzyme Commission (EC) numbers. For all types of contribution described in Sections 1?, a short text for the Table of Contents should be included. This text should be about five lines (approximately 300 characters) in length and formulated to arouse curiosity. Repetition or paraphrasing of the title and presentation of experimental details should be avoided. The use of graphics (formula or part of a figure) is encouraged, and color pictures will be reproduced free of charge. Pictures should be kept small with minimum detail, as the maximum final width is 5 cm. In addition, for all manuscripts mentioned in Sections a maximum of five keywords should be given. In order to aid online searching, at least two of the keywords should be taken from the Keyword List. Detailed facts of importance to specialist readers can be submitted as Supporting Information and will be made accessible on the Internet. Color and animated multimedia applications are welcome. If a crystal structure analysis or sequence determination is not an essential part of a manuscript, only a footnote is required indicating where the detailed results can be found. This can be a separate publication or a freely accessible database. Suggestions for the Front and Inside cover pictures (180 mm wide×170 mm high) with an explanatory text (Front, ~500; Inside, ~350 characters) beginning with "The (inside) cover picture shows...", are welcome. The cover pictures are chosen by the Editor shortly before an issue is to be published. Part of the additional cost for color printing must be paid by the author. Details will be provided upon selection of the cover pictures. The correspondence author will receive page proofs, in most cases, as compressed PDF files. They should be returned to the Editorial Office within three days. The main correspondence author will also receive a complementary copy of the journal and a reprint PDF file, restricted to 25 print-outs, free of charge. If a manuscript is not accepted, all original material is returned to the correspondence author. However, if a manuscript is accepted for publication, graphical material and electronic storage media will only be returned upon request. Guidelines for the Preparation of Manuscripts Your manuscript can be processed more rapidly if it is arranged as described below. Unless stated otherwise, the following instructions apply to all categories of contributions. Title page (in order): title; authors names with academic titles, alphabetical footnotes ([a],[b],...) referring to addresses, and an asterisk to denote the correspondence author; footnotes containing affiliations of all authors including the full postal address, fax number, and e-mail address of the correspondence author; series title, number, and reference to the previous paper in the series, if applicable; dedication, if applicable. QSAR/QSPR Manuscripts: topics in quantitative structure“activity relationships appear frequently in ChemMedChem, and in light of the recent broadening of this field, it is important that prospective authors are aware of our editorial policy toward QSAR/QSPR manuscripts. First, the novelty of the QSAR/QSPR study should be clearly stated, preferably in the article's Abstract and Introduction. Second, if a new method or theory is reported, it should be validated against at least one other published dataset using at least one other commonly used method or theory; all QSAR/QSPR models must be validated using external data, and not data that were used for the development of the model. Finally, all data used in performing the QSAR study should be reported in the manuscript itself, provided in the Supporting Information, or otherwise readily available without restriction. Keywords: A maximum of five keywords to appear in the printed and online indexes should be given in alphabetical order. At least two keywords should be taken from the Keyword List to aid online searching. Experimental Section (applicable to Full Papers and Communications only) should be given in sufficient detail to enable others to repeat your work. Minimum spectral requirements: Communications and Full Papers: 1H NMR, 13C NMR and MS data are required for intermediate compounds, and 1H NMR, 13C NMR, IR and HRMS data for all final compounds and those used in biological testing. [α]D20 should be given for all optically active compounds described. The following data are desirable for all compounds: melting point ranges for solids, Rf with solvent details. In so far as is practical, authors should use a systematic name for each title compound in the Experimental Section (as suggested by IUPAC, IUBMB, or Chemical Abstracts) followed by the compound number in bold; parentheses for the compound number should be used only if the name identifies the compound uniquely and unambiguously (for example: "...2-ethyl-4-cyanobenzoate (7) was used..." or: "...cyanobenzoate 7 was used..."). Please do not use computer programs to generate elaborate systematic names or use extremely long compound names. For the sake of clarity general descriptors such as compound 1, dendrimer 2, or alcohol 3 should be used. Equipment (including make, model, and software version) and conditions used for the measurement of physical data, as well as any organisms, proteins, or nucleic acids used, should be described at the beginning of the Experimental Section. Sources of less-common starting materials must be given, and solvent details should also be described. Quantities of reactants, solvents, etc. should be included in parentheses rather than in the running text (e.g., "Triphenylstannyl chloride (0.964 g, 2.5 mmol) in toluene (20 mL)..."). Physical data (in SI units whenever possible) should be quoted with decimal points and negative exponents (e.g., 25.8 JK?mol?). Products should be described, and yields should be given as both a quantity (mol or g) and in percent (e.g., "...compound 7 as a white powder (34 mg, 89%)..."). ±0.4%), HRMS or HPLC analysis. Data should be included in the Experimental Section or Supporting Information. We understand the associated limitations involved in chemical synthesis, these requirements are flexible within reason; please contact the ChemMedChem editorial office with any questions. Manuscripts containing animal experiments must include a statement in the Experimental Section to state that permission was obtained from the relevant national or local authorities. The institutional committees that have approved the experiments must be identified and the accreditation number of the laboratory or of the investigator given where applicable. If no such rules or permissions are in place in the country where the experiments were performed, then this must also be clearly stated. Manuscripts with experiments with human subjects or tissue samples from human subjects must contain a disclaimer in the Experimental Section to state that informed signed consent was obtained from either the patient or from next of kin. References: In the text numbers corresponding to the appropriate reference should be typed in square brackets as superscript (e.g., Blobel[3]) and after any punctuation, where applicable. References must be listed in order of their appearance in the text. Please do not format the references section with the Numbering function on your word-processing program. If you use the automatic reference collation system of your word-processing program (Footnotes, EndNote), please convert the references into normal, typed text before submission of the final manuscript, otherwise they may disappear when typeset. Journal titles should be abbreviated according to the Chemical Abstracts Service Source Index (CASSI). Unpublished results and lectures should only be cited for exceptional reasons. Please follow the examples below. The page range is optional but its presence or absence should be consistent throughout any given manuscript. Books (Without editor): [3] E. Wingender, Gene Regulation in Eukaryotes, VCH, Weinheim, 1993, p. 215. Books (With editor): [4] T. D. Tullius in Comprehensive Supramolecular Chemistry, Vol. 5 (Eds.: J. L. Atwood, J. E. D. Davies, D. D. MacNicol, F. Vgtle, K. S. Suslick), Pergamon, Oxford, 1996, pp. 31743. Miscellaneous: [5] a) C. R. A. Botta (Bayer AG), DE-B 2235093, 1973 [Chem. Abstr. 1974, 80, 55356 c]; b) A. Student, PhD thesis, University of Newcastle (UK), 1991; c) "Synthesis in Biochemistry": R. Robinson, J. Chem. Soc. 1936, 1079. Legends: each figure and scheme should have a legend. These should be listed together at the end of the reference section of the text file rather than being included with the drawings in the graphics files. Tables must have a brief title and should only be subdivided by three horizontal lines (head rule, neck rule, foot rule). Footnotes in tables are denoted [a], [b], [c], etc. Tables should not be created as graphics files or contain line brakes within single cells. Illustrations (structural formulae, figures, schemes) should, if possible, be designed for reduction to a one-column format (8.5 cm wide). The maximum width is the two-column format (17.5 cm wide). For optimum reproduction, illustrations should be larger than the desired final size. We recommend: Helvetica font for script; size of lettering, 3��?.5 mm; total maximum width, 14 cm (or 28 cm for two-column width) for 60% reduction. Please use only one size of writing in any one diagram. Writing above the arrow in a scheme may be a little smaller. Good quality graphics should be submitted for referees and editors. For high quality reproduction, high resolution graphics must be supplied. Computer-aided image enhancement is often unavoidable. However, such manipulation cannot result in data that are less relevant or unrepresentative being shown and/or genuine and significant signals being lost. A clear relationship must remain between the original data and the electronic images that result from those data. If an image has been electronically modified, the form of the modification must be given in the Figure caption. If computer-aided processing or modification of an image is a fundamental part of the experimental work, then the form that this processing takes must be clearly described in the Experimental Section. Please italicize symbols of physical quantities in both graphics and the text, but not their units (e.g., T for temperature, in contrast to T for the unit Tesla; J, but Hz; a, but nm). Stereochemical information (cis, Z, R, etc.), locants (N-methyl, α-amino), and symmetry designations (C2v) should also be italicized. Chemical formulae should be numbered with boldface Arabic numerals (e.g., 1). Labels of axes should be separated from their units by a slash (e.g., T/K). Abbreviations such as Me, Et, nBu, iPr, sBu, tBu, and Ph (not φ) may be used. General substituents should be indicated by R1, R2 (not R2, which means 2R), or R, R��? The spatial arrangement of the substituents should be indicated by hatched lines or a wedge. A minus sign must be as long as the crossbar of a plus sign. Mathematical formulae should not be incorporated into the text as graphic files. Please type mathematical formulae as normal text in the body of the text as far as is possible. Guidelines for the Preparation of Final Revised Versions of Manuscripts The final revised version of the manuscript should be submitted after the paper has been accepted for publication either as a compressed ZIP or StuffIt file through your homepage, by e-mail, or as an uncompressed file on disk. Please note however, that the preferred method of submission of the final versions of manuscript is through your personal homepage. To save unnecessary work with the electronic version of the text, please ensure your manuscript fulfills the following criteria: 1. Graphics should not be integrated in the text. Please store each chemical formula, figure, and scheme in a separate file. Though several graphics programs and formats can be used by the editorial staff and the printer, they are not equally suitable. To ensure trouble-free reproduction of the electronic graphics files, it is important to refer to the information given in the Guidelines for the Preparation of Graphical Material on our homepage. 2. The text should be stored in two formats: in the standard format of the word-processing program and in RTF (rich text format). Any Supporting Information should be saved as a separate document in word and RTF formats. 3. Tables are edited in the text and therefore should not be sent as graphical elements. The tables should be set up with tabulators, not with the space bar or line breaks. 4. Preferred word-processing programs are: Microsoft Word for Windows 6.0, 7.0, and updates, WordPerfect, and Macintosh files, preferably stored in Word format on a DOS-formatted disk. Documents prepared with other word-processing programs should be converted if possible. ChemTex files, for example, cannot be used. 5. Avoid end-of-line word divisions. Please use only one font type, except for Greek letters, which should be typed in the Symbol font. 6. The text should be typed as "continuous text", that is, with carriage returns only at the end of a paragraph, title, heading, and similar features. Formula numbers, and in the reference section, the year of publication (but not headings such as "Table 1" or "Figure 1") should be in boldface or doubly underlined. The symbols for 1 (one) and l ("ell"), 0 (zero) and O ("oh") should be distinct. If you are submitting the final revised version of your manuscript on disk then please make sure it is labeled with the name of the main author and your manuscript number. The manuscript should not be fragmented into separate files. Please save only the graphics and the Supporting Information as separate files. Structure and Sequence Data Prior to manuscript submission, the author(s) must deposit the following information in the appropriate databases: the data of X-ray structure analyses of inorganic and organic compounds, proteins, or nucleic acids; structure determination of proteins and nucleic acids by NMR spectroscopy (together with a list of NEOs), and sequence determinations of proteins or nucleic acids. The name of the database and the deposition number(s) assigned by this database must be stated in the part of the manuscript where the respective structure or sequence determination(s) is described so that referees can retrieve the information electronically. Detailed instructions for data submission can be found on the WWW homepages of the databases listed below. Structure Data Organic and organometallic compounds: Cambridge Crystallographic Data Centre (CCDC; http://www.ccdc.cam.ac.uk). Inorganic compounds: Fachinformationszentrum Karlsruhe (FIZ; http://www.fiz-karlsruhe.de). Proteins and nucleic acids: Protein Data Bank (http://www.rcsb.org/pdb). NMR spectroscopy data: BioMagResBank (http://www.bmrb.wisc.edu). Sequence Data Nucleic acids: GenBank (WWW: http://www.ncbi.nlm.nih.gov/) or EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl/index.html). Proteins: Protein Information Resource (PIR; http://pir.georgetown.edu/) or SWISS-PROT (http://www.expasy.ch/sprot/sprot-top.html). Please note that the data in databanks must be released, at the latest, upon publication of your manuscript. Supporting Information Supporting Information may be included for deposition on the internet. The author must keep a copy to make available to readers who do not have internet access. This material is peer-reviewed and must therefore be included with the original submission. After acceptance, succinct text and the necessary graphics should then be sent as a separately saved single MS Word (preferably Word 7) or MS Word for Macintosh file, with the final revised version of the manuscript. Only in this case should the graphics be present as imports in the file and not as separate files. Supporting Information should not include crystallographic or sequence data that are available from the relevant databases. Color and animated multimedia applications are welcome for Supporting Information. Keyword List A Keyword List has been developed for the readers of Wiley-VCH journals. To enable this option, the editors of these journals have compiled a common keyword catalogue. This catalogue is subdivided to facilitate the search for keywords but can also be completely searched. Some of the keywords are used in more than one area. As with all such records, a few guidelines facilitate its use, and these are briefly explained below: 1. At least two of the maximum of five keywords assigned to an article must come from this list. 2. Named reactions will be incorporated only in exceptional cases. Generally the reaction type is selected instead. For example, Diels–Alder reactions will be found under "cycloadditions" and Claisen rearrangements under "rearrangements". 3. Heteroanalogues of compounds are mainly classified under the C variants, for example, (hetero)cumulenes, (hetero)dienes. A few aza and phospha derivatives are exceptions. 4. Compounds with inorganic components that are central to the article are listed under the element, for instance, iron complexes under "iron" and, if appropriate, the ligand type. Some group names such as "alkali metals" exist alongside the names of important members of the group, for example, "lithium". In such cases the group name is used for these members only when comparative studies are described. The members that do not appear separately are also categorized under the group name. 5. A keyword in the form "N ligand" is only chosen if a considerable portion of the paper deals with the coordination of any ligand that coordinates through the atom concerned (in the example, nitrogen). 6. Spectroscopic methods are assigned as keywords only if the article is about the method itself or if the spectroscopic technique has made an important contribution to the problem under investigation. 7. "Structure elucidation" is intended only if the crux of the paper is a structural elucidation or if a combination of several spectroscopic techniques were needed for conclusive solution of the structure. 8. An attempt has been made to avoid synonyms and to select more general concepts rather than specialized terms. Thus the term "double-decker complexes" is excluded in favor of "sandwich complexes". See also points 3 and 4 in these guidelines. 9. Enzymes should be assigned to one of the six main enzyme classes (hydrolases, isomerases, ligases, lyases, oxidoreductases, transferases). This list is a "living" catalogue, flexible enough to absorb new developments in chemistry. We therefore welcome all suggestions from our readers and authors that might improve its user-friendliness. The current version of the Keyword List can be found online. Contact Information Regular mail: ChemMedChem, Postfach 101161, 69451 Weinheim, Germany Courier services:ChemMedChem, Boschstrasse 12, 69469 Weinheim, GermanyTelephone: (+49)6201-606-142 Fax: (+49)6201-606-331 or -328 E-mail: chemmedchem@wiley-vch.de Homepage:http://www.chemmedchem.org Manuscript submission:http://www.manuscriptxpress.com Editorial Board Chairmen of the Editorial Board Rainer Metternich (USA) Giorgio Tarzia (Università degli Studi di Urbino) Editorial Board Karl-Heinz Altmann (ETH Zürich) Paul A. Bartlett (University of California, Berkeley) Maurizio Botta (Università di Siena) Gloria Cristalli (Università di Camerino) Harren Jhoti (Astex Technology, Cambridge) Gerhard Klebe (Philipps-Universität Marburg) Martin Stahl (F. Hoffmann–La Roche, Basel) Hans-Ulrich Stilz (Aventis Pharma, Frankfurt) Renxiao Wang (Shanghai Institute of Organic Chemistry) Yasuyoshi Watanabe (Osaka City University) David A. Winkler (CSIRO, Clayton) Steven Young (Merck & Co., West Point, PA)