期刊名称：PHARMACOGENOMICS JOURNAL
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
The Pharmacogenomics Journal is a print and electronic journal, which is dedicated to the rapid publication of original research on pharmacogenomics and its clinical applications.
Key areas of coverage include:
- Effects of genetic variability on drug toxicity and efficacy
- Identification and functional characterization of polymorphisms relevant to drug action
- Pharmacodynamic and pharmacokinetic variations and drug efficacy
- Integration of new developments in the genome project and proteomics into clinical medicine, pharmacology, and therapeutics
- Clinical applications of genomic science
- Identification of novel genomic targets for drug development
- Potential benefits of pharmacogenomics.
Instructions to Authors
Welcome to the electronic manuscript submission website for The Pharmacogenomics Journal. The instructions below are structured so you can quickly and easily answer the following questions:
- Is my manuscript suitable for The Pharmacogenomics Journal? (Scope + Editorial Policy)
- How do I format my manuscript for The Pharmacogenomics Journal? (Format of Papers)
- How do I submit my manuscript to The Pharmacogenomics Journal? (Submission of Papers)
The Pharmacogenomics Journal is published six times a year by Nature Publishing Group, and is abstracted/indexed in:
- BIOSIS
- Biotechnology Abstracts
- Cambridge Scientific Abstracts
- Embase/Excerpta Medica
- Index Medicus/Medline
Scope
The Pharmacogenomics Journal is dedicated to the rapid publication of original research on pharmacogenomics and its clinical applications. Key areas of coverage include:
- Effects of genetic variability on drug toxicity and efficacy
- Identification and functional characterization of polymorphisms relevant to drug action
- Pharmacodynamic variation and drug efficacy
- Pharmacokinetic variation and drug toxicity
- Integration of new developments in the genome project and proteomics into clinical medicine, pharmacology, and therapeutics
- Clinical applications of genomic science
- Identification of novel genomic targets for drug development
- Potential benefits of pharmacogenomics
The Pharmacogenomics Journal is essential reading for geneticists, molecular biologists, clinical and molecular pharmacologists, as well as the biotechnology and pharmaceutical industries.
Editorial Policy
Editor: Julio Licinio, MD, University of California, Los Angeles, USA
Authors will be notified of acceptance, rejection or request for revision. When a manuscript is returned to the corresponding author for revision, it should be resubmitted to The Pharmacogenomics Journal within three months, and it should be accompanied by a covering letter detailing the response to each point raised by the Editor/reviewers. Manuscripts not returned within this time frame will be considered as new submissions. Extensions to this deadline may be requested from the Editor by e-mail: tpj@mednet.ucla.edu. The peer review process on The Pharmacogenomics Journal is anonymous.
Format of Papers
Preparation of manuscripts
All contributions should be written in English, typed double-spaced, with wide margins. Number each page following the title page, and include line-numbers (every 5 lines are sufficient) if this option is available. Manuscripts MUST be formatted in the order below; the editorial office reserves the right to return any papers to authors that are not organized in this order.
- Title page-should consist of the title, running title of less than 50 characters, authors, affiliations, and the address/telephone/fax/email of corresponding author
- Abstract - one single paragraph of no more than 150 words
- Keywords and Abbreviations - three to six keywords
- Introduction
- Results
- Discussion
- Materials and methods
- References
- Acknowledgement/Duality of Interest
- Tables
- Figure legends
Please prepare the text of the manuscript using one of the following preferred formats: Word for Windows, WordPerfect for Windows, Microsoft Word for Mac, or ASCII. Please note that for revised manuscripts, a copy of the author's response to referees' and editor's comments should accompany each copy of the manuscript. Manuscripts should be accompanied by one copy of a covering letter from the authors, containing the full current postal address, telephone and fax numbers, and e-mail address for the corresponding author.
The content of the letter should indicate that the article has not been published or is not under consideration for publication elsewhere; any duality of interest; that each author has participated sufficiently in the conception, design, analysis and/or writing of the article [see Uniform Requirements for Manuscripts Submitted to Biomedical Journals (N Eng J Med 336: 309-315, 1997)]; that each author takes public responsibility for it; and that each author has viewed the final article and approves it for publication. All authors should sign this letter. Any changes in authorship must be approved in writing by all the original authors.
The Editor reserves the right to request preprints of any "in press" papers written by the author(s). Acknowledgement of receipt of the manuscript will be sent to the corresponding author, including the unique manuscript number it has been assigned, which should be quoted in all subsequent correspondence.
Types of Submission Permitted
- Original Articles - are reports whose conclusions represent a substantial advance in the understanding of an important problem.
- Review Articles - survey recent developments in topical areas of scientific research or, on occasion, more wide-ranging subjects. Review articles should have a title; short title; abstract of no more than 150 words; and main text of between 3000 and 5000 words (excluding references); references. Authors are encouraged to include tables and figures, as well as suitable material to be used in text boxes (to highlight salient points of the paper or expand on certain concepts) and a glossary of specialist terms.
- News and Commentary - inform readers about new scientific advances, as reported either in recently published papers or at scientific meetings. The opening paragraph should consist of a precis of 20-30 words. News and Commentary articles should not exceed 1500 words and 15 references. Up to two tables and two figures may be included.
- Perspectives - provide an update on developments in fast-moving areas of interest. Perspectives articles should not exceed 1500 words and 15 references. Up to two tables and two figures may be included.
- Ethical, Economics, Legal and Social (EELS) - present well-argued, thought-provoking analysis of issues and considerations involved in both basic research and in practice. EELS articles should not exceed 2000 words and 30 references. Up to two tables and two figures may be included.
- Clinical Implications - are either hypothetical or based on current clinical trials and encourage the transition from basic research to clinical practice by presenting a diagnostic or treatment challenge. Clinical Implications articles should not exceed 2000 words and 30 references. Up to two tables and two figures may be included.
Gene Nomenclature: Authors should use approved nomenclature for gene symbols, and use symbols rather than italicized full names (Ttn, not titin). Please consult the appropriate nomenclature databases for correct gene names and symbols. Approved human gene symbols are provided by HUGO Gene Nomenclature Committee (HGNC), e-mail: nome@galton.ucl.ac.uk; see also http://www.gene.ucl.ac.uk/nomenclature. Approved mouse symbols are provided by The Jackson Laboratory, e-mail: nomen@informatics.jax.org; see also http://www.informatics.jax.org/mgihome/nomen. For proposed gene names that are not already approved, please submit the gene symbols to the appropriate nomenclature committees as soon as possible, as these must be deposited and approved before publication of an article.
Avoid listing multiple names of genes (or proteins) separated by a slash, as in 'Oct4/Pou5f1', as this is ambiguous (it could mean a ratio, a complex, alternative names or different subunits). Use one name throughout and include the other at first mention: 'Oct4 (also known as Pou5f1)'.
Duality of Interest
Authors are responsible for recognizing and disclosing any duality of interest that could be perceived to bias their work, acknowledging all financial support and any other personal connections.
Informed Consent/Experimental Animals
Where a paper describes experimental work with humans or animals, it must: i) indicate informed consent was obtained where relevant; and ii) include evidence that approval was obtained from the local ethics committee, and/or indicate that it was carried out in accordance with the principles of the Declaration of Helsinki as revised in 1996 [JAMA 227: 925-926, 1997].
References
Authors are responsible for the accuracy of all references. References are to be numbered sequentially as they appear in the text, tables and figure legends and should be double-spaced. Only articles that have been published or are in press may be included in the references. They should follow the Vancouver format and abbreviations of journal names should conform to the Index Medicus style. For references with more than six authors, list the first six names, followed by et al.
1. Dodt HU. Infrared-interference videomicroscopy of living brain slices. Adv Exp Med Biol 1993; 333: 245-249.
2. Schiller J, Schiller Y, Stuart G, Sakmann B. Calcium actions potentials restricted to the distal apical dendrites of rat neocortical pyramidal neurons. J Physiol 1997; 505: 605-616.
3. Casari G, De Fusco M, Ciarmatori S, Zeviani M, Mora M, Fernandez P, et al. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Cell 1998; 93: 973-983.
4. Heilman KM, Valenstein E. Clinical Neuropsychology. Oxford University Press: New York; 1995.
Figures
Figures and images should be labeled sequentially, numbered and cited in the text. Figure legends should be printed, double spaced, on a separate sheet titled ¡®Titles and legends to figures¡¯. Figures should be referred to specifically in the text of the paper but should not be embedded within the text. The use of three-dimensional histograms is strongly discouraged when the addition of the third dimension gives no extra information. If a table or figure has been published before, the authors must obtain written permission to reproduce the material in both print and electronic formats from the copyright owner and submit it with the manuscript. This follows for quotes, illustrations and other materials taken from previously published works not in the public domain. The original source should be cited in the figure caption or table footnote. Color figures can be reproduced if necessary, but the authors will be expected to contribute towards the cost of publication. A quote will be supplied upon acceptance of the paper.
Figure legends
Legends must be submitted for all figures. They should be brief and specific, and should appear on a separate manuscript page after the Reference section. Use scale markers in the image for electron micrographs, and indicate the type of stain used.
Artwork guidelines Detailed guidelines for submitting artwork can be found by downloading the guidelines PDF. Using the guidelines, please submit production quality artwork with your initial online submission. If you have followed the guidelines, we will not require the artwork to be resubmitted following the peer-review process, if your paper is accepted for publication.
Figures in Print Authors are requested to follow our instructions on how to prepare their figures, for more information see http://www.nature.com/aj/artworkguidelines.pdf. We request that at submission, ALL figures are of a high enough quality to be assessed in the peer review process. Minimum Resolutions:
| Halftone images |
300 dpi (dots per inch) |
| Color images |
300 dpi saved as CMYK |
| Images containing text |
400 dpi |
| width=100>Line art |
1000 dpi |
Sizes:
| Figure Width ¨C single image |
86 mm
(Should be able to fit into a single column of the printed journal) |
| Figure Width ¨C multi-part image |
178 mm
(Should be able to fit into a double column of the printed journal) |
| Text Size |
8 point
(Should be readable after reduction ¨C avoid large type or thick lines) |
| Line Width |
Between 0.5 and 1 point |
Authors will be required to pay the cost of color illustrations published in print.
Color on the web
Authors who wish their articles to have FREE color figures on the web (only available in the HTML (full text) version of manuscripts) must supply separate files in the following format. These files should be submitted as supplementary information and authors are asked to mention they would like color figures on the web in their submission letter.
For Single Images:
| Width |
500 pixels (authors should select "constrain proportions", or equivalent instructions, to allow the application to set the correct height automatically.) |
| Resolution |
72 dpi (dots per inch) or "Save for Web" if using Photoshop |
| Format |
JPEG for photographs
GIF for line drawings or charts |
| Filenaming |
Please save image with .jpg or .gif extension to ensure it can be read by all platforms and graphics packages. |
For Multi-part Images :
| Width |
900 pixels (authors should select "constrain proportions", or equivalent instructions, to allow the application to set the correct height automatically.) |
| Resolution |
72 dpi (dots per inch) or "Save for Web" if using Photoshop |
| Format |
JPEG for photographs
GIF for line drawings or charts |
| Filenaming |
Please save image with .jpg or .gif extension to ensure it can be read by all platforms and graphics packages. |
Authors may be asked to pay the full colour fee for figures that are not submitted in the format described above. Tables
These should be labeled sequentially as Table 1, Table 2, etc. Each table should be typed on a separate page, numbered and titled, and cited in the text. Reference to table footnotes should be made by means of Arabic numerals. Tables should not duplicate the content of the text. They should consist of at least two columns; columns should always have headings. Authors should ensure that the data in the tables are consistent with those cited in the relevant places in the text, totals add up correctly, and percentages have been calculated correctly. Unlike figures or images, tables may be embedded into the word processing software if necessary, or supplied as separate electronic files.
House Style
As the electronic submission will provide the basic material for typesetting, it is important that papers are prepared in the general editorial style of the journal.
- See the artwork guidelines for information on labeling of figures
- Do not make rules thinner than 1pt (0.36mm)
- Use a coarse hatching pattern rather than shading for tints in graphs
- Color should be distinct when being used as an identifying tool
- Use Si units throughout
- Spaces, not commas should be used to separate thousands
- Abbreviations should be proceded by the words for which they stand in the first instance of use
- Text should be double spacing with a wide margin
File Formats:
File formats for manuscript files, figures and tables that are acceptable for our electronic manuscript submission process are given on the online forms. Further advice on file types is also available from the Tips webpage. Please follow our artwork guidelines for submitting figures, and use a common word-processing package (such as Microsoft Word) for the text. Either embed tables converted into images at the end of your Word document, or as a separate files in which ever program you used to generate them. If you submit raw data, this can be done in Excel, or tab/comma delimited format.
Supplementary information
Supplementary information is peer-reviewed material directly relevant to the conclusion of an article that cannot be included in the printed version owing to space or format constraints. It is posted on the journal's web site and linked to the article when the article is published and may consist of data files, graphics, movies or extensive tables.
The printed article must be complete and self-explanatory without the supplementary information. Supplementary information enhances a reader¡¯s understanding of the paper but is not essential to that understanding.
Supplementary information must be supplied to the editorial office in its final form for peer review. On acceptance the final version of the peer reviewed supplementary information should submitted with the accepted paper. Supplementary information is not subedited, so authors should ensure that it is supplied ready for publication online.
To ensure that the contents of the supplementary information files can be viewed by the editor(s), referees and readers, please also submit a ¡®read-me¡¯ file containing brief instructions on how to use the file.
The supplementary information may not be altered, nor new supplementary information added, after the paper has been accepted for publication.
Supplying supplementary information files
Please supply the supplementary information via eJP, the electronic manuscript submission and tracking system, in an acceptable file format (see below).
Authors should:
Include a text summary (no more than 50 words) to describe the contents of each file.
Identify the types of files (file formats) submitted.
Include the text ¡®Supplementary information is available at (the journal¡¯s name)¡¯s website¡¯ at the end of the article and before the references.
Accepted file formats
Quick Time files (.mov)
Graphical image files (.gif)
HTML files (.html)
MPEG movie files (.mpg)
JPEG image files (.jpg)
Sound files (.wav)
Plain ASCII text (.txt)
Acrobat files (.pdf)
MS Word documents (.doc)
Postscript files (.ps)
MS Excel spreadsheet documents (.xls)
File sizes must be as small as possible, so that they can be downloaded quickly. Images should not exceed 640 x 480 pixels (9 x 6.8 inches at 72 pixels per inch) but we would recommend 480 x 360 pixels as the maximum frame size for movies. We would also recommend a frame rate of 15 frames per second. If applicable to the presentation of the supplementary information, use a 256 colour palette. Please consider the use of lower specification for all of these points if the supplementary information can still be represented clearly. Our recommended maximum data rate is 150 KB/s.
The number of files should be limited to eight, and the total file size should not exceed 8 MB. Individual files should not exceed 1 MB. Please seek advice from the editorial office before sending files larger than our maximum size to avoid delays in publication.
Further questions about the submission or preparation of supplementary information should be directed to the editorial office.
Submission of papers
The first thing you need to do, if you have not done so already, is register for an account. After this, please consult the instructions below to enable you to submit your article through our secure server.
For optimum performance, we recommend that your browser should be either Netscape 4.7 or above, or Internet Explorer 5.0 and above.
Please be sure that your browser is set to accept cookies. Our tracking system requires cookies for proper operation. (If you have Windows XP the defaults will need changing. For more details on this, please refer to the 'Tips' function on this site.)
Navigating the System
When you first access our tracking system, you will be taken to your Home page, where different categories of tasks are listed. If you are required to perform a pending action item or task, there will be a red arrow  next to a 'Manuscript' link. Throughout the system, red arrows reflect pending action items which you should address. If there are no red arrows visible on your Home page, then you are finished and have no outstanding tasks to complete.
At any time please press HOME to go to the submission home page.
Process for Manuscript Submission
Please make sure you have gathered all the required manuscript information listed above BEFORE starting the submission process. The manuscript submission process starts by pressing the "Submit Manuscript" link on your "Home" page. The manuscript submission process is broken down into a series of 4 screens which gather detailed information about your manuscript and allow you to upload the pertinent text and figure/image files. The screens run in this order:
- A form asking for author details, the manuscript title, abstract, other associated manuscript information and types/number of files to be submitted.
- A screen asking for the actual file locations (via an open file dialogue). You will be able to browse for the relevant files on your computer or disk. After completing this screen, your files will be uploaded to our server.
- A file upload completion screen that will provide you with a unique manuscript number for your submission. You will also need to specify the order in which you want your manuscript files presented during peer review.
- An approval screen which will allow you to verify that your manuscript has been uploaded and the files converted correctly to PDF format. You will need to approve PDF conversion to complete your manuscript submission.
You will need to have the following details for all authors before commencing online submission. Items in parenthesis may not be compulsory for co-authors:
- Email Addresses
- First and Last Names
- Institution
- (Full Postal Address)
- (Work Telephone Numbers)
- Fax Numbers
In addition you will need:
- Covering letter
- Title and Running Title (you can copy and paste this from your manuscript)
- Abstract (you can copy and paste this from your manuscript)
- Manuscript files in Word, WordPerfect, text or any RTF format
- Figures/Images in external files in TIFF or JPG, in either grayscale or CMYK colour, not in RGB
- Tables in Excel (preferred) as separate files or embedded at the end of the manuscript file
Do not embed images and figures within the text from word processing software as embedded images are not acceptable for production. (Tables are an exception to this rule as you may be generating them using the same software and as resolution quality tends to be less important for tables.)
Adobe Acrobat
We recommend that for accessing the PDF files, best results are achieved if you have access to Adobe Acrobat Reader (4.0 or above). Should you require installation of this FREE program, please download from the link here and follow the on-screen instructions. (We recommend that on completion of installation, you amend one of the default settings. Select: File - Preferences - General, and UNCHECK Web Browser Integration. This will open PDF files in Acrobat Reader itself rather than in your browser. The amendment will not affect any functionality of either Acrobat Reader or your browser software.)
Please refrain from submitting your manuscript by e-mail attachment. If the site replicates your details on screen, then your paper has been successfully submitted.
Once you have submitted your files and the conversion is in progress, you may log off the Internet and come back later to check and approve the conversion. This process can take up to 5 - 10 minutes before the PDF, created in the conversion process, is ready for approval. Please remember that your manuscript will not be submitted until you have approved the converted files.
Getting Help
If you need additional help, you can click on the help signs  spread throughout the system. A help dialogue will pop up with context sensitive help. Should further assistance be required, then please contact the editorial office, tpj@mednet.ucla.edu
Manuscript Status
After you approve your manuscript it is submitted and you will receive an acknowledgement email. You can check the status of your manuscript at any time in the review process by:
- Accessing the system with your password or link sent to you in the acknowledgement email
- Clicking on the link represented by your manuscript tracking number and abbreviated title.
- Clicking on the "Check Status" link at the bottom of the displayed page.
This procedure will display tracking information about where your manuscript is in the submission/peer review process.
License to Publish
The corresponding author must complete and sign the Licence to Publish form upon acceptance of the manuscript and return it to the editorial office. Failure to do so will result in delays to the publication of your paper. A copy of the Licence to Publish form can be found at http://mts-tpj.nature.com/letters/tpj_copyright.pdf.
Nature Publishing Group does not require authors of original research papers to assign copyright of their published contributions. Authors grant NPG an exclusive licence to publish, in return for which they can re-use their papers in their future printed work. NPG's author licence page provides details of the policy and a sample form. Authors are encouraged to submit their version of the accepted, peer-reviewed manuscript to their funding body's archive, for public release six months after publication. In addition, authors are encouraged to archive their version of the manuscript in their institution's repositories (as well as on their personal web sites), also six months after the original publication. Authors should cite the publication reference and doi number on any deposited version, and provide a link from it to the published article on the NPG website. This policy complements the policies of the US National Institutes of Health, the Wellcome Trust and other research funding bodies around the world. NPG recognizes the efforts of funding bodies to increase access of the research they fund, and strongly encourages authors to participate in such efforts.
Advance Online Publication
All original articles are published ahead of print on Advance Online Publication. This will be the final version of the manuscript and will subsequently appear, unchanged, in print.
Proofs
An e-mail will be sent to the corresponding author with a URL link from where proofs can be collected. Proofs must be returned by fax within 48 hours of receipt. Failure to do so may result in a delay to publication. Extensive corrections cannot be made at this stage.
Offprints
Offprints may be ordered using the order form available for download with the proofs.
Business Matters
To find out who to contact for business correspondence and enquiries such as advertising, subscriptions, permissions, papers in production or publishing a supplement, please visit our publisher¡¯s contacts page.
Alternatively, you can write to: The Pharmacogenics Journal, Academic Journals Division, Nature Publishing Group, 345 Park Avenue South, 10th Floor, New York, NY 10010-1707, USA.
Editorial Board
Editor
Julio Licinio, MD
Editorial Board
J Azuma, Japan
E Boerwinkle, USA
U Brinkmann, Germany
R G H Cotton, Australia
D Flockhart, USA
P Froguel, France
L M Furness, UK
T Gingeras, USA
M Hashida, Japan
W Kalow, Canada
T Klein, USA
I Kola, USA
K Lindpaintner, Switzerland
R Long, USA
P Nadkarni, USA
D Nickerson, USA
L Peltonen, USA
M Polymeropoulos, USA
G Poste, USA
A Rane, Sweden
M Ratain, USA
A D Roses, USA
M A Rothstein, USA
J C Venter, USA
R Weinshilboum, USA
S Weiss, USA
J Woodcock, USA
R Wolf, UK
M-L Wong, USA
A Wright, UK
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