期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ISSN： 1449-2288 出版频率： Monthly 出版社： IVYSPRING INT PUBL, PO BOX 4546, LAKE HAVEN, AUSTRALIA, NSW, 2263   出版社网址： http://www.biolsci.org/ 期刊网址： http://www.biolsci.org/ 影响因子： 6.582 主题范畴： BIOCHEMISTRY & MOLECULAR BIOLOGY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal                     International Journal of Biological Sciences is an open access scientific journal published by Ivyspring International Publisher. It features original articles, reviews, and short research communications in all areas of biological sciences. Articles are archived in PubMed Central and abstracts are indexed in PubMed. The editor in chief is Chuxia Deng, Chief, Mammalian Genetics Section, GDDB, NIDDK, National Institutes of Health. Instructions to Authors The Journal publishes papers of high quality in any area of biology and biological sciences. Submission to the Journal is on the understanding that the article has not been previously published in any other form and is not under consideration for publication elsewhere. Research Paper: There is no restriction on the length of research paper, although authors are encouraged to be concise. Supplementary materials can be published if necessary. Please include in the main paper a set of keywords and an abstract followed by Introduction, Materials and Methods, Results, Discussion, Acknowledgments, Conflict of Interests, and References. Short Research Communication: It presents a concise study, or sometimes preliminary but innovative research finding that might be less substantial than a full research paper. Short Research Communication is limited to 2500 words (excluding references and abstract). It should have a set of keywords and an abstract summarizing background of the work, the results and their implications. Results and Discussion Section should be combined and followed by Conclusion. Materials and Methods will remain as a separate section. The number of references is limited to 40 and the number of figures and/or tables combined is limited to 4. Letter: Description of novel finding that might not be suitable for a regular research paper or short research communication can be published as letter. Limited to a maximum of 1200 words, letter can have one figure/table and a maximum of 10 references. Commentary: This is the place for discussing controversial and/or interdisciplinary topics, viewpoints and any other issues of interest to our readers. It is limited to a maximum of 800 words and a maximum of 10 references. Review or mini-review should be authoritative and of broad interest to the readers of general biological community. Review/Decisions Manuscripts (other than those that are of insufficient quality or unlikely to be competitive enough for publication) will be reviewed and a decision typically returns to the authors in about one month. Manuscripts with significant results will be reviewed and published at the highest priority and speed. Possible decisions on manuscripts are: accept as is, minor revision, major revision, or reject. Revised manuscripts should be returned within 1 month in the case of minor revision, or 3 months in the case of major revision. To submit a revision please sign in here and use the submit button at the right side of page. Submission Authors can format their papers in any convenient style for submission and review purpose. Please embed figures and tables in the manuscript to become one single file for submission. Details for submission can be found in the submission page. Reprints Reprints can be ordered after copyediting and publication (in manuscript login page). Reprints are now printed on glossy paper with cover page. They are made of highest quality suitable for scientific corresponding. Publication Charges Published articles of International Journal of Biological Sciences are open access and full texts appear in PubMed Central. This effectively removes the barriers for timely distribution of the articles and ensures that they can be read by as many as possible. The amount of fee charged by the journal is lower than many other PubMed Central journals (comparing to the fees charged by BioMedCentral and PLOS). Publication fee is required to cover the cost of publication. Payment can be made by credit card, bank transfer, money order or check. Instruction for payment is sent during publication process and is also available in the manuscript login page as soon as manuscript is accepted. The Journal charges the following publication fee if and when the manuscript is accepted for publication: Research paper/ Review/ Short research communication/ Case report $US 1100 (890 Euro) Letter $US 250 (200 Euro) Editorial Free Format for Publication Upon acceptance of the manuscript, please provide a final version (in Microsoft Word file) for copyediting purpose. Figures should be of high quality and high resolution, and can be embedded in the manuscript Word file. If the figures are created using PowerPoint, Photoshop, Microsoft Excel etc, please also provide the original files from those programs. Title Page Include in the first page the article title, author's names, affiliations, corresponding author's phone/fax number and/or email. Abstract should not contain citations to references. Also provide 5-6 keywords. For author's names, please put first and/or middle names before surname, e.g., Mike C. Johnson. Citation of Tables and Figures Tables and Figures should be numbered consecutively. Citation of tables and figures should use the format: Table 1, Figure 1, or Fig. 2, Fig. 3. Parts in a figure can be identified by a, b, c, d, ... . and cited as Figure 2a, Figure 2b, Figure 2c. The abbreviation of "Table" to "Tab." for example "Tab. 1" should be avoided. Math Formulas and Symbols Simple mathematical formulas should be constructed using superscript, subscript, italic, and symbols in the Microsoft Word. Use symbols in the Fonts: (normal text) or Symbol fonts. To insert a symbol, use Insert/symbol in the Word menu. Use / for "divide" or "over". For example, 1/7, 5/(4+6). Use Symbol fonts for "±"; "≤" and "≥" (avoid underline). References References are numbered starting from 1. Avoid putting personal communications, unpublished observations, conference abstracts or conference papers as references. Journal Paper Please use the PubMed citation format. Journal paper should have journal name or journal abbreviation, year, volume and page numbers. Please use ":" to separate volume and first page number. Omit any "." in the journal abbreviations. It is not necessary to highlight or italicize the title, journal name, or any part of references. The sequence is as: [Author surname] [Author initials], [Other author surnames & initials]. [Article title]. [Journal name abbreviation]. [Year]; [Volume]: [First page number]-[Last page number]. Example: 1. Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002; 347: 2010-9. Supplement example: 2. Volk HD, Reinke P, Krausch D, et al. Monocyte deactivation-rationale for a new therapeutic strategy in sepsis. Intensive Care Med. 1996; 22 (Suppl 4):S474-S481. No author given example: 3. [No authors listed]. Medicare program; criteria for Medicare coverage of adult liver transplants-HCFA. Final notice. Fed Regist. 1991; 56(71):15006-15018. In press example: 4. Cheung TMT, et al. Effectiveness of non-invasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome. Chest; in press. Epub ahead of print example: 5. Li W, Chen Y, Cameron DJ, et al. Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice. Vision Res 2007; [Epub ahead of print]. Book Kiloh LG, Smith JS, Johnson GF, et al. Physical treatment in psychiatry. Boston, USA: Blackwell Scientific Publisher; 1988. Chapters in Edited Book Beckenbough RD, Linscheid RL. Arthroplasty in the hand and wrist. In: Green DP, ed. Operative Hand Surgery, 2nd ed. New York: Churchill Livingstone; 1988: 167-214. Web Site [Internet] WHO: Geneva, Switzerland. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. Revised 26 September 2003. http://www.who.int/csr/sars/country/table2003_09_23/en/ [Internet] Kornberg R. http://nobelprize.org/nobel_prizes/chemistry/laureates/2006/press.html Ethics Committee Approval and Patient Consent Experimental research involving human or animals should have been approved by author's institutional review board or ethics committee. This information can be mentioned in the manuscript including the name of the board/committee that gave the approval. Investigations involving humans will have been performed in accordance with the principles of Declaration of Helsinki. And the use of animals in experiments will have observed the Interdisciplinary Principles and Guidelines for the Use of Animals in Research, Testing, and Education by the New York Academy of Sciences, Ad Hoc Animal Research Committee. If the manuscript contains photos or parts of photos of patients, informed consent from each patient should be obtained. Patient's identities and privacy should be carefully protected in the manuscript. Conflict of Interests Conflict of interests that might interfere with the objective presentation of the research findings contained in the manuscript should be declared in a paragraph heading "Conflict of interests" (after Acknowledgment section and before References). Examples of conflict of interests are ownership of stock in a company, grants, board membership, etc. If there is no conflict of interests, please use the statement "The authors have declared that no conflict of interest exists". Author Biography Authors now have the option to publish a biography together with the paper, with information such as MD/PhD degree, past and present positions, research interests, awards, etc. This increases the profile of the authors and is well received by international readers. Author biography can be added to the end of paper, in a section heading "Author biography". See a sample of author biography. For general information about preparing biomedical manuscripts, please consult the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication", available from http://www.icmje.org/. Editorial Board Editor-in-Chief Chuxia Deng, Ph. D. Chief, Mammalian Genetics Section NIDDK, National Institutes of Health Bethesda, USA Editor-in-Chief's Profile Editors & Editorial Members Rodolfo Aramayo Department of Biology Texas A&M University College Station, TX, USA Shawn S. Li Department of Biochemistry University of Western Ontario London, Ontario, Canada Suk-Chul Bae Institute for Tumor Research Chungbuk National University Cheongju City, 361-763, South Korea Thomas G. Boyer Department of Molecular Medicine Institute of Biotechnology University of Texas Health Science Center at San Antonio San Antonio, Texas 78245-3207, USA Hal E. Broxmeyer Chairman & Professor of Microbiology/Immunology Scientific Director of Walther Oncology Center Indiana University School of Medicine Indianapolis, IN 46202-5181, USA Ellen Carpenter Department of Psychiatry and Biobehavioral Science UCLA School of Medicine Los Angeles, CA 90095, USA Mario R. Capecchi *# Professor, Department of Human Genetics University of Utah Salt Lake City, Utah 84112, USA Zhu Chen * Vice President, Chinese Academy of Sciences and Director, Shanghai Institute of Hematology Rui-Jin Hospital affiliated to Shanghai Second Medical University Shanghai, China Igor B. Dawid * Laboratory of Molecular Genetics NICHD/NIH 9000 Rockville Pike Bethesda, MD 20892, USA Alberto Diaspro MicroScoBio Research Center, Department of Physics University of Genoa Genoa, Italy Zigang Dong The Hormel Institute University of Minnesota Austin, MN 55912, USA Ari Elson Department of Molecular Genetics The Weizmann Institute of Science Rehovot 76100, Israel Jian (Jerry) Q. Feng, MD, PhD Biomedical Sciences Baylor College of Dentistry TX A&M Health Science Center Dallas, TX 75246, USA Albert J. Fornace Jr. Lombardi Comprehensive Cancer Center Georgetown University Washington, DC 20057-1468, USA I. David Goldman Department of Medicine Albert Einstein College of Medicine Bronx, NY, USA Paul Hasty Department of Molecular Medicine University of Texas Health Science Center at San Antonio San Antonio, TX 78245-3207, USA Lothar Hennighausen Chief, Laboratory of Genetics and Physiology National Institutes of Health/NIDDK Bethesda, MD 20892, USA William A. Horton Director, Research Center, Shriners Hospital for Children Professor of Molecular & Medical Genetics Oregon Health & Science University Portland, Oregon, USA Yunhan Hong Department of Biological Sciences National University of Singapore 10 Kent Ridge Crescent Singapore 119260 Celina Janion Institute of Biochemistry and Biophysics Polish Academy of Sciences Warszawa, Poland Zhihua Jiang Department of Animal Sciences Washington State University Pullman WA 99164 - 6351, USA Dhinakar S. Kompala Chemical & Biological Engineering Department University of Colorado Boulder, CO, USA Ashok Kumar, Ph.D. Head Bioengineering Division Dept. of Biological Sciences & Bioengineering Indian Institute of Technology Kanpur-208016, India Hui Y. Lan Professor, Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong, China Derek LeRoith Chief, Division of Endocrinology and Diabetes Department of Medicine The Mount Sinai School of Medicine New York, NY 10029-6574, USA Andre Levchenko Dept. of Biomedical Engineering Johns Hopkins University Baltimore, MD, USA Qiao Li Department of Surgery University of Michigan Medical Center 1520A MSRB-1 Ann Arbor, MI 48109-0666, USA Morris Maduro Department of Biology University of California Riverside, CA, USA Wojciech Makalowski Professor and Director Institute of Bioinformatics, Faculty of Medicine University of Muenster Muenster, D-48149 Germany James M. Mason Laboratory of Molecular Genetics National Institute of Environmental Health Sciences Research Triangle Park, NC, USA Alessandro Minelli Department of Biology University of Padova Padova, Italy Nagathihalli Nagaraj Department of Surgery Vanderbilt University School of Medicine Nashville, USA Toru Ouchi Department of Medicine, ENHRI Feinberg School of Medicine Northwestern University Evanston, IL 60201, USA Jeffrey D. Parvin, MD, PhD Louis Levy Professor for Cancer Department of Biomedical Informatics 904 Biomedical Research Tower 460 W. 12th Avenue Columbus, OH 43210, USA Wensheng Qin Biorefining and Biotechnology Laboratory Lakehead University Thunder Bay, Ontario P7B 5E1, Canada Mercedes Rincon Department of Medicine/Immunobiology Program Given Medical Building D305 University of Vermont Burlington, VT 05405, USA Hyun-Mo Ryoo Department of Cell and Developmental Biology School of Dentistry and Dental Research Institute Seoul National University Seoul, Korea Urs Schmidt-Ott Department of Organismal Biology and Anatomy The University of Chicago Chicago, IL, USA Ken-ichi Shinoda Department of Anthropology The National Science Museum Tokyo, Japan Ulrich Siebenlist The Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD, USA Eduardo Sontag BioMaPS Institute for Quantitative Biology Rutgers University New Brunswick, NJ, USA Bin Sun Laboratory of Molecular Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031, China Patrick P.L. Tam Embryology Unit, Children's Medical Research Institute University of Sydney Sydney, NSW, Australia Makoto M. Taketo Department of Pharmacology Graduate School of Medicine, Kyoto University Yoshida-Konoe-cho, Sakyo, Kyoto 606-8501, Japan Teruhisa Tsuzuki Department of Medical Biophysics and Radiation Biology Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582, Japan Mohammed Akaaboune Department of Molecular, Cellular and Developmental Biology University of Michigan Ann Arbor, Michigan, USA Xiao-Jing Wang, M.D., Ph.D Depts of Pathology, Otolaryngology, and Dermatology, University of Colorado Denver Aurora, CO 80045, USA Jun Wang, Ph.D. VP, Discovery Biology Shanghai Medicilon Inc. Pudong, Shanhai 201200, P.R. China Michael Weinstein Department of Molecular Genetics and Division of Human Cancer Genetics Ohio State University 484 W. 12th Ave., Columbus, OH 43210, USA Heiner Westphal Laboratory of Mammalian Genes and Development National Institute of Child Health and Human Development National Institutes of Health Bethesda, MD 20892, USA Francis Willard Lilly Research Laboratories Eli Lilly & Company Indianapolis, IN 46285, USA Jianming Xu Department of Molecular and Cellular Biology Baylor College of Medicine Houston, Texas 77030, USA Tian Xu Department of Genetics Yale University School of Medicine New Haven, CT, USA Xiao Yang, Ph.D. Proferssor of Genetics Chief, Genetic Laboratory of Development and Diseases Beijing Institute of Biotechnology 20 Dongdajie, Beijing 100071 P.R. China Rolf Zeller DKBW Centre for Biomedicine University of Basel Medical School Mattenstrasse 28, CH - 4058 Basel SWITZERLAND Ming Hao Zheng Centre of Orthopaedic Research School of Surgery University of Western Australia NEDLANDS WA 6009 AUSTRALIA Special issue editor Jordi Garcia-Fernàndez Professor of Genetics Dep. Genètica, Fac. Biologia, Universitat de Barcelona Av. Diagonal 645, 08028 Barcelona, Spain