期刊名称:NATURE MEDICINE

ISSN:1078-8956
版本:SCI-CDE
出版频率:Monthly
出版社:NATURE PORTFOLIO, HEIDELBERGER PLATZ 3, BERLIN, Germany, 14197
  出版社网址:http://www.nature.com/
期刊网址:http://www.nature.com/nm/index.html
影响因子:53.44
主题范畴:BIOCHEMISTRY & MOLECULAR BIOLOGY;    CELL BIOLOGY;    MEDICINE, RESEARCH & EXPERIMENTAL

期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)   



About the journal

 Nature Medicine is the premier journal for biomedical research. Respected internationally for papers published on immunotherapy, infectious diseases, vaccines, cancer, gene therapy, stem-cell biology and transplantation and many other areas, Nature Medicine elucidates the molecular mechanisms involved in pathogenesis of disease and bridges the gap between basic research and clinical application.

What is Nature Medicine?

The rapid evolution of biomedical research has changed fundamentally the way we approach pathogenesis and treatment in medicine. The descriptive and observation-based approach of traditional medical investigation has given way to a science-based approach to understanding the mechanisms responsible for health and disease. The application of this mechanistic approach to designing new prevention and treatment strategies holds great promise for the future of medicine.

Biomedical research encompasses virtually all areas of the life sciences. In its broadest interpretation it includes all biology-based research that aims to understand and improve the human condition. Typically it involves studying fundamental aspects of disease in model systems, be they artificial in vitro systems or in vivo animal models, and then applying the lessons learned to patients. It is a long-term approach. The experiments of today, if successful, might yield clinical effects in five to ten years or beyond.

Nature Medicine is a biomedical research journal devoted to publishing the latest and most exciting advances in biomedical research for scientists and physicians, with an emphasis on clarity of presentation. Articles cover fields such as cancer biology, cardiovascular research, gene therapy, immunology, vaccine development, and neuroscience, aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings and that explicitly put developments in science into a medical context. Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation, and are submitted from research groups at universities, independent research institutions, and biotechnology and pharmaceutical industries world-wide. As a cross-disciplinary journal at the heart of the international biomedical research community, Nature Medicine publishes the most relevant original research articles, news, and commentary that form the foundations of tomorrow's medicine.

 


Instructions to Authors
Click here for printable PDF versions of the Digital Figures Guide and Research Article Submission Guide.


About Nature Medicine

 
Nature Medicine is the monthly international journal of biomedical research. Our aim is to present research that bridges the gap between cutting-edge biological research and more clinically orientated human investigations.

Nature Medicine takes a broad view of this biomedical research to include high-quality, original research in all disciplines of biomedical science, with the emphasis on thorough peer review and rapid publication. Manuscripts are selected according to an editorial assessment of their potential interest, impact and implications for the biomedical community at large and the future of clinical medicine. Nature Medicine favors those submissions that represent a conceptual advance or an original approach to understanding the molecular basis of pathogenesis or to developing new therapies, diagnostic procedures and a greater understanding of human disease.

Nature Medicine believes that as biomedical science necessarily becomes more specialized, it is essential that there be a journal that will provide readers with clear access to the advances and achievements of disciplines other than their own. To this end, we emphasize clear writing and presentation, with a particular emphasis on titles and abstracts that are accessible to readers from a variety of backgrounds. This first-rate research is accompanied by the latest international News of particular interest to the biomedical research community. A large News & Views section presents analyses, by carefully selected experts, of some of the most important advances represented in the original research from within the pages of both Nature Medicine and other leading journals. Reviews and Commentaries, also written by leading members of the biomedical research community, cover subjects as diverse as the funding of science and medicine, the ethics of the latest medical procedures and detailed yet clearly presented reviews of the most exciting developments in science and medicine. Book Reviews, articles and digests covering Technical Reports, Correspondence and a monthly Editorial complete each issue.

We welcome comment and criticism from the community and encourage you to contact us at our editorial office.

Nature Medicine
345 Park Avenue South
New York NY 10010-1707
email: medicine@natureny.com
telephone: 212.726.9325
facsimile: 212.683.5751

 
Conditions of Publication

 
PRESS COVERAGE

Publication in Nature Medicine is conditional on there being no prior disclosure of the work to the media. Thus, authors should not give press conferences or otherwise encourage or cooperate with media coverage of submitted work, except on the understanding that the embargo will be respected. Failure to do so may prejudice further consideration of the manuscript. This policy is in no way intended to restrict legitimate scientific discussion, thus the presentation of results at scientific meetings (including the publication of brief abstracts) is acceptable, as is the deposition of data in electronic archives.

Once scheduled for publication, some contributions are selected by the editors for inclusion in the weekly press release. This provides a brief summary, together with contact details for the authors, and is distributed to the media a week before the publication date. Authors of accepted contributions scheduled for publication may also arrange their own publicity (for instance through their institutional press offices), but they must strictly adhere to our press embargo.

ADVANCE ONLINE PUBLICATION

Note that Nature Medicine now supports Advance Online Publication (AOP) of research articles, which benefits authors with an earlier publication date and allows our readers access to accepted papers weeks before they are printed. Authors will be provided an estimated AOP publication date when the galley proofs are sent for preview. Note that papers published online are definitive and may be altered only through the publication of a print corrigendum or erratum. For details, please see the overview of advanced online publication.

COMPETING FINANCIAL INTERESTS

In the interests of transparency, Nature Medicine now requires authors of research articles (including Technical Report articles to declare any competing financial interests in relation to papers accepted for publication. For details, please see our policy.

MATERIALS

As a condition of publication, authors are required to make materials and methods used freely available to academic researchers for their own use. Authors are required to state in the methods section any conditions for use of materials, and to provide full disclosure of the conditions on a freely accessible, identified web site.

This requirement includes antibodies and the constructs used to make transgenic animals, but not the animals themselves. Mutant strains of mice generated without the use of constructs must be submitted to a public repository at the time of publication, unless authors can ensure prompt distribution to academic researchers on request.

Papers reporting protein or DNA sequences and crystallographic structures will not be accepted without an accession number to GenBank/EMBL/DDBJ, Brookhaven, SWISS-PROT or other appropriate, identified, publicly available database in general use in the field that gives free access to researchers from the date of publication (see Nature 394, 105; 1998 and 404, 317; 2000). Accession numbers are provided directly to authors by these databases on deposition of data, and must be included in the Nature paper before publication. Microarray data should be made freely available to academic researchers on authors' own web sites or other freely available web site (the URL to be provided in the paper) until a public database is available.

MICROARRAYS

Please see the MGED open letter specifying microarray standards at http://www.mged.org/Workgroups/MIAME/miame_checklist.html, and see 419, 323; 2002 for explanation of the policies of the journal and the Nature family of journals. In brief, authors submitting manuscripts containing microarray data must supply the data on a CD at the time of submission. The data must be MIAME-compliant and supplied in a form that is widely accessible, with the completed MIAME checklist also placed on the CD. Five copies of the CD are required, so that they can be sent to referees. Nature Medicine also requires submission of microarray data to the GEO ( http://www.ncbi.nlm.nih.gov/geo/) or ArrayExpress (http://www.ebi.ac.uk/arrayexpress/) databases, with accession numbers at or before acceptance for publication. Data may be posted on the Nature Medicine website as Supplementary Information only by prior agreement, as generally we are unable to host very large Supplementary Information files.

Other supporting data sets must be made available to any interested reader on the publication date from the authors directly.

Researchers who encounter a persistent refusal by an author of a Nature paper to comply with these guidelines should contact the Editor of Nature Medicine, at medicine@natureny.com. (See 416, 1; 2002. )

PERSONAL COMMUNICATIONS AND UNPUBLISHED DATA

If you cite personal communications or unpublished data from any individuals who are not authors of your manuscript, we require a written statement of permission from the primary investigator of each group cited. Please submit an appropriate permission letter(s) (printouts of email are acceptable) with your manuscript.

ANIMAL WELFARE AND INFORMED HUMAN CONSENT

In cases where a study involves the use of live animals or human subjects, the Methods section of the manuscript should include a statement that all experiments were performed in compliance with the relevant laws and institutional guidelines, and should identify the institutional committee(s) that have approved the experiments. A statement should also be included that informed consent was obtained for any experimentation with human subjects. Referees may be asked to comment specifically on any cases in which concerns arise.

NOMENCLATURE

Authors should make sure that they use appropriate nomenclature for gene symbols. Please consult the appropriate nomenclature committee for correct gene name and symbol. Approved human gene symbols are provided by HUGO Gene Nomenclature Committee (HGNC), e-mail: nome@galton.ucl.ac.uk; http://www.gene.ucl.ac.uk/nomenclature/. Approved mouse nomenclature are provided by The Jackson Laboratory, e-mail: nomen@informatics.jax.org; http://www.informatics.jax.org/mgihome/nomen/.

 
Authorship and Copyright

 
Submission is taken to imply that all coauthors have approved the contents of the manuscript and its submission by the corresponding author. (The corresponding author for editorial purposes need not be the senior author, or the person to whom correspondence is addressed after publication.) Statements of equal contribution from more than one author are permitted. The cover sheet of the manuscript should indicate the date of submission (or revision/resubmission). If the manuscript includes personal communications, please provide a written statement of permission from any person who is quoted. Printouts of e-mail permission messages are acceptable.

The Nature Publishing Group does not require authors to transfer their copyright. Instead, we ask for an exclusive licence. In return, authors will be free to reuse their papers in any of their future printed work, and have the right to post a copy of the published paper on their own web sites.

In addition, authors - and the institutions in which they work - will be free to use their papers in course packs.

For form and detailed explanation, click here. US government employees, click here
 

How to Submit

 
Nature Medicine invites unsolicited submissions for the following categories:

  • Article
  • Letter
  • Brief Communication
  • Technical Report
  • Review
  • Correspondence
  • Commentary
  • Perspective
Authors are encouraged to seek the editors' general level of interest in any proposed article by sending an abstract and general description of the intended article through our online submission system, at http://www.nature.com/nm/esubmission/index.html. Detailed instructions for the preparation of these categories of articles are given below.

Authors interested in contributing to News, News & Views or Book Reviews should contact the editorial office before submitting these.

All submissions should be sent to us through our online manuscript submission system, please see the website at http://www.nature.com/nm/esubmission/index.html for complete information.

 
Types of Contributions

PRIMARY RESEARCH FORMATS

An Article is a substantial novel research study, with a complex story often involving several techniques or approaches. The main text (excluding abstract, Methods, references and figure legends) is 3000 words. The abstract is typically 150 words, unreferenced. Articles have a maximum of 6 display items (figures and/or tables); figures are limited to 8 panels. An introduction (without heading) is followed by sections headed Results, Discussion and Methods. The Results and Methods should be divided by topical subheadings; the Discussion may contain subheadings at the editors' discretion. References are limited to 50.

Articles include a competing financial interests statement and received/accepted dates. They may be accompanied by supplementary information. Articles are peer reviewed.

A Letter reports an important novel research result, but is less substantial than an Article. This format begins with an introductory paragraph (not abstract) of approximately 150 words, summarizing the background, rationale, main results and implications. This paragraph should be referenced, as in Nature style, and should be considered part of main text, so that any subsequent introductory material avoids too much redundancy with the introductory paragraph. The text is limited to 1500 words, excluding the introductory paragraph, Methods, references and figure legends. References are limited to 30. Letters should have no more than 4 display items (figures/tables). Letters are not divided by headings, except for the Methods heading.

Letters include a competing financial interests statement and received/accepted dates. They may be accompanied by supplementary information. Letters are peer reviewed.

A Technical Report presents primary research data on a new technique that is likely to be influential. This format is not a review of technology, but its primary report in the literature. It may involve a new biological discovery to prove the usefulness of the technique, but this is not a requirement. Technical Reports have a format broadly similar to that of Articles, though many Technical Reports are shorter than a typical Article. They begin with an unreferenced abstract (typically 150 words) followed by separate sections for introduction, Results, Discussion (with optional subheadings) and Methods. References are normally limited to 30. Technical reports have maximum of 5 display items (figures/tables).

Technical Reports include a competing financial interests statement and received/accepted dates. They may be accompanied by supplementary information. Technical Reports are peer reviewed.

A Brief Communication reports a study of high quality and broad interest that is less fully developed than a Letter or Article. This format may not exceed 2 printed pages. Brief Communications begin with a brief unreferenced abstract (no more than 70 words or 3 sentences), which will appear on Medline. The main text is typically 1000 words, including abstract, references and figure legends, and contains no headings. Brief Communications have no more than 2 display items (figures/tables). References are limited to 15. Article titles are omitted from the reference list.

Brief Communications include a competing financial interests statement and received/accepted dates. They may be accompanied by supplementary information. Brief Communications are peer reviewed.

OTHER FORMATS

Correspondence (formerly Letters to the Editor) is a flexible format that may include anything of interest to the journal's readers, from policy debates to announcements to 'matters arising' from research papers. A Correspondence may describe primary research data, but only in summary form; this format is not intended for full presentation of data. Correspondence should never be more than one printed page, and usually much less. References from a Correspondence and its Reply are combined into a single list, numbered in order of appearance and placed at the end of the Reply. The number of references should not exceed 10 for either the Correspondence or its Reply. Titles are supplied by the editors.

Correspondence is the only section of the journal that may include replies from people whose views or findings are being criticized. Authors whose primary research data are being criticized should normally have the right of public reply. Criticism of opinions or other secondary matter do not involve an automatic right of reply.

Except for refutations, Correspondence is not normally peer reviewed (although it may be at the editors' discretion).

A Review is an authoritative, balanced and scholarly survey of recent developments in a research field. The requirement for balance need not prevent authors from proposing a specific viewpoint, but if there are controversies in the field, the authors must treat them in an even-handed way. Reviews are normally 3,000-4,000 words, and illustrations are strongly encouraged. References are limited to 100, with exceptions possible in special cases. Citations should be selective. The scope of a Review should be broad enough that it is not dominated by the work of a single laboratory, and particularly not by the authors' own work.

A competing financial interests statement is optional, at the authors' discretion. Received/accepted dates are not included. Reviews are always peer reviewed to ensure factual accuracy, appropriate citations and scholarly balance.

Commentary is a very flexible format; Commentaries may be on policy, science and society or purely scientific issues. The main criteria are that they should be of immediate interest to a broad readership and should be written in an accessible, non-technical style. In contrast to a Review, publication as a Commentary does not imply editorial endorsement of the authors' opinions. Their length is typically 1-4 pages, although some may be longer. Because the content is variable, the format is also flexible. Commentaries do not contain primary research data, although they may present 'sociological' data (funding trends, demographics, bibliographic data, etc.). References are limited to 25, and article titles are omitted from the reference list.

The related format Historical Commentary is a journalistic treatment of the history of a particular discovery or technical development. These pieces may be a personal account by one of the participants or may present strong personal opinions. This format does not necessarily seek scholarly balance, and it should be journalistic and accessible rather than scholarly in style.

A competing financial interests statement is optional, at the authors' discretion, although authors are encouraged to indicate their affiliations. Commentaries may be peer reviewed at the editors' discretion.

Perspective is a new format for scholarly reviews and discussions of the primary research literature that are too technical for a Commentary but do not meet the criteria for a Review—either because the scope is too narrow, or because the author is advocating a controversial position or a speculative hypothesis or discussing his/her own work. Two reviews advocating opposite sides in a research controversy are normally published as Perspectives. The text should not normally exceed 3000 words. References are limited to 50.

The related format Historical Perspective is a more technical account of a particular scientific development. Like other Perspectives, and in contrast to Historical Commentary, Historical Perspectives are scholarly reviews, including citation of key references, aiming to present a balanced account of the historical events, not merely personal opinions or reminiscences.

A competing financial interests statement is optional, at authors' discretion. Received/accepted dates are not included. Perspectives are always peer reviewed.

GENERAL STYLE POINTS

Use the active, not passive voice throughout the text: "We examined the retinas of the mice.", not "The retinas of the mice were examined."
Abbreviations are not used in abstracts. Spell out abbreviations at first use in body of text.
Mutants are referred to with superscript as follows: "C1qa+/+" and not "C1qa+/+" or "+/+". Gene designation only is italicized; the designation for 'zygosity' is superscripted and not italicized.
The "P" for P values is upper-case and italicized.
The "n" for number is lower-case and italicized.
Kilodalton is abbreviated kDa.
Full postal and email address is required for each author.
We strongly recommend that the article be read by a native English-speaking scientist not directly related to your field of research.

Display Items

In the text, refer to figures as (Fig. 1a, b and c) or (Table) in parentheses, at end of text referring to figure (not "As shown in Fig. 1, ...")
"Fig." is abbreviated and followed with a period; "F" is upper-case (Fig.). Panel letter should be lower-case, and boldface.
Figures must appear in text in order: 1a, 1b, 2a, 2b.
Tables must be supplied as part of a simple word document, if possible, convert the table to text using tabs to separate entries.
Provide a brief title (one sentence of less than 10 words) describing the figure or table as a whole in the figure legend.

Methods

Remove all methodology and discussion from the figure legends. This includes concentrations, incubation times temperatures, and so on.
Oligonucleotide sequences are written 5'-GATCGACT-3' (note: no spaces between the upper-case nucleotide letters).
Provide locations of manufacturers, without abbreviations (city and state, for US; city and country for non-US): (Vector, Burlingame, California).
Units except for % should be preceded by a space (7 °C; 12mM; 55%).
Use symbol font for "micro": µM, not uM. If using Microsoft Word, go to "insert/symbols" to make sure the symbols do not drop out when the font changes.

FORMAT FAQ

1. How many figures can I include with my article? A- You may submit up to six figures (images and/or tables) for a long article and up to three figures for a short article.

2. How should I submit tables? A- Please submit tables in the body of the word processing document. Do not submit them as scannable images. Also, do not set up elaborate tables in the word processing document as the information is rearranged when drawing the Nature Medicine pages. To ensure the correct rendering of the table, convert the table to text and separate the entities with tabs.

3. Where should I put the figure legends? A- Please place the figure legends at the end of the article text, immediately following the reference section.

REFERENCE LIST GUIDELINES

Only published materials and those in press are included in the reference list.
Everything else (meeting abstracts, web site urls, unpublished data and personal communictions) is cited in the text. Manuscripts submitted or accepted, but not yet in press, are described simply as "unpublished data".
Abstracts should be cited as (J. Smith, personal communication); manuscripts under consideration should be cited as (J. Smith et al., unpublished data) unless the author is an author of the current paper (J.S. et al., unpublished data).
Reference numbers must be in order in the text (1,2,3...)
Reference numbers are superscripted when next to full words, for example, "protein12,13"
Reference numbers are not superscripted next to numbers or abreviations, for example, 1.45 (ref. 12); dATP (ref. 13)
For the reference list, please ensure that references are correct and complete: Smith, J.B., Brown, G. & Jones, W. Title of paper in full. J. Abbrev. XX, XXX-XXX (19XX).
All abbreviations are followed by a period.
Authors are cited as "Smith, J.B."
The final author cited should be preceded by "&", which should not be preceded by a comma.
For papers with more than 5 authors, cite the first author followed by et al. Note that "et al." is italicized and followed by a period, and there is no comma preceding "et al."
Provide full titles of articles; only the first letter of the first word is upper-case.
Provide Index Medicus abbreviations of journal titles; these are italicized.
Volume number is bolded and followed by a de-bolded comma.
Provide page ranges (not just first page), with full page numbers.
Year of publication is in parentheses, followed by a period.
Book references: Author, A. in Title of Book Vol. X 2nd edn. (ed. Editor, E.) 123-456 (Press, City, State, 19XX).

 
Digital Figures Guide

 
For figures accompanying an online submission, please see our online submission guidelines at http://www.nature.com/nm/esubmission/art.htm. For guidelines pertaining to publication-quality figures, click here for a printable PDF version of the Digital Figure Guide.


Once your submission has been accepted in principle for publication, we will ask you to submit high-quality figures for its eventual publication. When possible, Nature Medicine prefers to use original digital figures to ensure the highest quality reproduction in the journal. When creating and submitting digital files, please follow the guidelines below. If the figures cannot be submitted electronically, please provide two high quality print outs on glossy paper.

| Format | Style | Resolution | Sending files |
| FTP site | FAQ | Contact |

Format

Style

Please give careful thought to clarity and layout, bearing in mind the final size of the printed page (170mm x 240mm). We try to size figures to approximately 1/4 of a page (85mm x 120mm), and only in unique situations do we publish figures much larger.

  • Figures should be created at approximately the desired reproduction size.
  • Do not place figure labels (a,b,c, etc.) on digital files. File names should identify the figure and panel; hard copies should be labeled on the reverse.
Please avoid the following:
  • Gratuitous use of color for decorative effect
  • Using boxes or borders around graphs and figures
  • Highly pixilated computer drawings
  • Small type and symbols on large graphs; type will be unreadable once reduced to a printable size

Resolution

  • Color: 266 d.p.i. minimum
  • Grayscale: 600 d.p.i. minimum, such as blots and black & white photographs
  • Line art: 1200 d.p.i. minimum, such as graphs and illustrations using only black and white, no grey
  • Please do not scan laser printouts of figures and send them to us as digital files

Sending Files

Please send your files as soon as possible following your manuscript's acceptance by Nature Medicine. The following formats are acceptable.

Always submit two high quality printouts of your figures, original photograph (camera-ready) or glossy white paper preferred. Please follow same Style guidelines as above. Photocopies and poor laser printouts will not be accepted as they may produce moire patterns when printed.

Please indicate on submission whether artwork is available in digital format.

Digital Figure FAQ

1. If my figures were created in a program like Microsoft PowerPoint, Microsoft Excel, MacDraw Pro or Canvas will they be digitally acceptable for Nature Medicine?
A- No. Programs like PowerPoint create figures to be viewed on a computer monitor, which has a maximum resolution of 72 dots per inch (DPI). They are not of sufficient resolution to be published in Nature Medicine. Even if the files are converted into TIFF or EPS format, they will still be of insufficient quality because the files were created in a program with a resolution far below printable quality.

2. How can I make my Digital figures acceptable for Nature America if they were created in PowerPoint or Exel?
A- Ideally, the figures should be re-drawn in a vector-based graphic program like Adobe Illustrator of Macromedia Freehand. This will ensure that the figures will look the best when the magazine is printed. But if that is not possible, then provide a high quality printout of the figures so they can be scanned easily and accurately.

3. Should I label (a, b, c, etc.) the figures?
A- No. Please label the hard copies of the figures, but do not label the digital figures, as Nature Medicine has its own style requirements for labels.

4. What font does Nature Medicine prefer to have for figure text?
A- Nature Medicine uses an 8-pt. sans serif font. Also, make sure the font is big enough to be easily legible at the approximate size the image will be displayed on the page.

Contact

Contact Nature Medicine's Production Department with any additional questions: r.lucas@natureny.com.


Supplementary Information Guide

 
Authors should note that Supplementary Information is not copy edited by Nature Medicine, so they should ensure that it is clearly and succinctly presented, and that the style of terms conforms with the rest of the paper. The following guidelines (also available as a separate printable PDF) detail the creation, citation and submission of supplementary information.

Publication Guide

Proofs:
Within a few weeks after acceptance of your final manuscript, you will receive galley proofs for corrections. As editorial changes will have been made to ensure clarity, proofs should be examined very carefully. The Editors may have suggested certain areas that warrant updating or revising on the proofs. Corrected proofs should be faxed or express mailed back to the Production Editor as soon as possible.


Editorial Board

General editorial inquiries and correspondence should be directed to:

The Editor
Nature Medicine
345 Park Avenue South
New York NY 10010-1707

telephone: 212.726.9325
facsimile: 212.683.5751
email: medicine@natureny.com


Manuscripts should be sent to the above address (see Guide to Authors for more information). Please do not send complete manuscripts by e-mail unless specifically requested.



 
Presubmission Inquiries see
Presubmission Inquiries page.
Please follow the instructions on that page.



 
Inquiries about editorial policies may be directed to
Editor, Beatrice Renault
b.renault@natureny.com

Inquiries about manuscript status, submissions, referee's reviews or any other matters may be directed to
Editorial Assistant, Gaibrielle Matthews
medicine@natureny.com



 
Inquiries about production matters (proofs, electronic figure submission, etc.) should be directed to
Production Editor (main contact), Renee Lucas
r.lucas@natureny.com

Corrected proofs should be faxed to
Production Editors
fax: (212) 696-0652



 

Reprints and Permissions information can be found here.


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