期刊名称：GENES CHROMOSOMES & CANCER
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Genes, Chromosomes & Cancer will offer rapid publication of original full-length research articles, brief communications, perspectives, reviews, letters to the editors, as well as editorial commentaries on genetic analysis as related to the study of neoplasia. Particular emphasis will be placed on work combining molecular and cytogenetic analyses of the genomic alterations of cancer cells. While preference will be given to research using analytical approaches, descriptive studies and case reports will also be welcomed, particularly when they offer insights regarding basic biologic mechanisms or the clinical management of neoplastic disorders.
Specific areas covered will include:
- Chromosomal abnormalities in all benign and malignant disorders, including changes that occur during neoplastic progression
- Changes in gene structure and regulation as a consequence of genomic rearrangements
- Chromosomal alterations involving genes related to the regulation of cell proliferation and differentiation
- The correlation between genomic abnormalities and cellular phenotypic alterations
- The predictive value of alterations at the chromosomal and DNA levels in disease prognosis, and in designing and monitoring cancer therapies
- Cytogenetic, molecular, and epidemiologic analyses of inherited disorders predisposing to cancer
- Chromosomal and/or genetic damage caused by external factors
- Descriptions of novel molecular biological and cytogenetic methods for genomic analysis.
Instructions to Authors
Manuscript Submission
Authors should send the original and two copies of their manuscripts (including three sets of glossy prints of figures--not photocopies) to either of the editors-in-chief.
Professor Felix Mitelman; Department of Clinical Genetics; University Hospital; S-221 85 Lund, Sweden; Telephone: + 46 (46) 17 33 60; FAX: + 46 (46) 13 10 61
Professor Janet D. Rowley; Section of Hematology/Oncology; The University of Chicago Medical Center; 5841 S. Maryland Avenue, MC 2115; Chicago, IL 60637, U.S.A. Telephone: +1 (773) 702-6117; FAX: +1 (773) 702-3002
Manuscripts must be prepared on 8 1/2 x 11 inch or A4 white bond paper, in a double-spaced format with wide (1 inch) margins.
All manuscripts submitted to Genes, Chromosomes & Cancer must be submitted solely to this journal and may not have been published in another publication of any type, professional or lay. Upon acceptance of a manuscript for publication, the author will be requested to sign an agreement transferring copyright to the publisher, who reserves copyright. No published material may be reproduced or published elsewhere without the written permission of the publisher and the author. The Journal will not be responsible for the loss of manuscripts at any time. All statements in, or omissions from, published manuscripts are the responsibility of the authors, who will assist the editorial office by reviewing proofs before publication. Reprint order forms will be sent with the proofs.
Manuscript Preparation
Brief Communications should not exceed 2,500 words. They can report preliminary data or ongoing work that does not warrant a full-length article. An Abstract is required; do not use any section headings except for Acknowledgments and References.
Review Articles review a specific field through an appropriate literature survey. An Abstract is required. Materials and Methods and Results sections are not required. Although there are no restrictions on the number of pages or figures, the Review should be as concise as possible. Review articles are usually invited; the editors welcome proposals and suggestions for topics.
Research Articles should report original data and contain sections in the following order: Title Page, Abstract, Introduction, Materials and Methods, Results, Discussion, Acknowledgments (optional), References, Tables, and Figure Legends. Use generic names of drugs and give manufacturer, city, and state or country of all trademarked equipment mentioned in the text.
Letters to the Editors comment on a work previously published in the journal; however, comments on works published in other journals, as well as other topics, are also accepted. These should be kept brief, in general not longer than one printed page, but may be illustrated. No abstract is required. Authors of the work commented on will be invited to reply in the same issue of the Journal.
Perspective Articles are intended to shed light on general topics in cancer genetics in a manner different from that normally found in Research Articles and Review Articles. They should be provocative and juxtapose lines of reasoning that are conventionally seen as separate, to achieve a deeper understanding of the problems discussed. Perspective Articles are usually invited; the editors welcome proposals and suggestions for topics. An abstract is required.
Format of Manuscript Elements
Title Page. Give a descriptive title with no abbreviations. Provide first and last names of each author and department and institutional affiliations. Give full address of corresponding author and telephone, telex, and FAX numbers and an abbreviated title not to exceed 45 characters. Avoid nonstandard abbreviations; do not abbreviate single words (see "Conventions and Nomenclature").
Abstract. Limit the abstract to a single paragraph of not more that 250 words. It must describe work and include purpose, brief statement of methods, and results. Literature references should not be given in the Abstract. Definitions of abbreviations (see "Conventions and Nomenclature") must be repeated when the abbreviation is used for the first time in the text.
Materials and Methods. Experimental procedures should be described in sufficient detail to enable the work to be repeated. References to other papers describing the techniques may be given. Correct chemical names should be given and strains of organisms, clones, etc. should be specified. The names and addresses for suppliers of uncommon reagents or instruments should be mentioned. Authors should draw attention to any particular chemical or biological hazards that may be involved in carrying out the experiments described. Any relevant safety precautions should be described; if an accepted code of practice has been followed, a reference to the relevant standards should be given.
References.
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The accuracy of references is the responsibility of the authors. Only published articles and those in press may be included in the reference list. Unpublished data and submitted manuscripts, but not meeting abstracts, must be cited parenthetically within the text. Personal communications should also be cited within the text; permission in writing from the communicator is required to publish the information. In the text, references to the literature should be made by author's name followed by year of publication arranged chronologically and then alphabetically. When there are more than two authors, use the first author's name and et al. When references are made to more than one paper by the same author, published in the same year, they are to be designated as a, b, etc.
In the reference list, references are to be arranged alphabetically listing all authors, and then by year of publication. Journal titles should be abbreviated according to Index Medicus; the titles of unindexed journals should be spelled out in full. Use the following style when preparing references.
Journal:
Travis JA, Sandberg AA, Neff JR, Bridge JA. 1994. Cytogenetic findings in malignant triton tumor. Genes Chromosomes Cancer 9:1-7.
Book Chapter:
Gray JW, Cram LS. 1990. Flow karyotyping and chromosome sorting. In: Melamed MR, Lindmo T, Mendelsohn ML, editors. Cytometry and sorting. New York: John Wiley & Sons, Inc. p 503-552.
Book:
Helm S, Mitelman F. 1995. Cancer cytogenetics. 2nd ed. New York: Wiley-Liss. 1223 p.
Tables. All tables must be cited in the text and have titles. Number them consecutively with arabic numerals. Cite each table at the most appropriate point in the text. Tables should present comparisons of data that are too cumbersome to describe in the text; they should not merely repeat text information. Each table should be typed double-spaced on a separate sheet of paper and should include a title and, in a footnote, definitions of all abbreviations used in it (even if abbreviations are defined in the text), indicated by lowercase superscript letters, a, b, c, etc. Authors may wish to submit complex tables as camera-ready copy. In this way, they are spared tedious proofreading and the chance of error is reduced. Tables submitted as camera-ready copy should be typed single-spaced whenever possible, and preferably submitted as 7 1/8 x 9-inch glossy prints.
Figures. Figures should be numbered in one consecutive series using arabic numerals, and keyed into the text. The journal requires three good quality originals of all photographs. It is necessary for reviewers to receive glossy copies, since important details may be lost in photocopying. High-resolution computer graphics will also be accepted. All original letters, numbers, and symbols must be large enough that, when reduced to journal format (8 1/4 x 11 inch double-column), they will remain at least 2mm high. Figures not properly prepared will be returned to the contributor for revision. Each figure requires a corresponding legend; legends should be double-spaced and grouped on a separate page(s). Each legend should describe briefly the information presented; detailed descriptions of procedures should appear in the Materials and Methods section. Abbreviations used in figures and photographs must match exactly those used in the text. Identify each figure with the number, first author's name, and title of the paper, preferably on a label placed on the back of the photograph. Clearly indicate the top of the photograph to ensure its correct orientation in the printed article. Do not write directly on glossy prints, front or back, and do not use devices like paper clips, which might scratch or dent a photographic print. Upon acceptance of color illustrations, the publisher will provide price quotes.
Conventions and Nomenclature. In the description of karyotypes, authors should follow the most recent recommendations of the International Standing Committee on Human Cytogenetic Nomenclature: ISCN. 1995. An International System for Human Cytogenetic Nomenclature. F. Mitelman, editor. S. Karger, Basel, 1995. For gene mapping nomenclature, the most recent guidelines of the Human Gene Mapping Nomenclature Committee should be used. Additional nomenclature guidelines may be found in V.A. McKusick, Mendelian Inheritance in Man, Johns Hopkins University Press. Authors should use SI units and follow the guidelines for abbreviations and symbols of the IUPAC-IUB Joint Commission on Biochemical Nomenclature. See Eur J Biochem (1970) 15:203-208; corrected (1972) 25:1-4. For bases in nucleic acid sequences, see Eur J Biochem (1985) 150:1-5. All nonstandard abbreviations used in the text should be defined when first used.
Submission of Data to the Genetics Databases. The editorial policy of the journal is to encourage the use of genetics databases (e.g., HGML, GenBank, EMBL) as repositories for detailed DNA sequences and mapping assignments, etc. Authors are encouraged to complete data entry and annotation forms for the appropriate databases, which can be obtained from the databases. Include copies of these summaries and database entries/accession information with the manuscripts at the time of submission. Where possible, published articles will be accompanied by footnotes with accession information for retrieving and cross-referencing data from the genetic information repositories.
Disk Submission Instructions
Please return your final, revised manuscript on disk as well as hard copy.
The hard copy must match the disk.
The Journal strongly encourages authors to deliver the final, revised version of their accepted manuscripts (text, tables, and, if possible, illustrations) on disk. Given the near-universal use of computer word-processing for manuscript preparation, we anticipate that providing a disk will be convenient for you, and it carries the added advantages of maintaining the integrity of your keystrokes and expediting typesetting. Please return the disk submission slip below with your manuscript and labeled disk(s).
Guidelines for Electronic Submission
Text
Storage medium. 3-1/2" high-density disk in IBM MS-DOS, Windows, or Macintosh format.
Software and format. Microsoft Word 6.0 is preferred, although manuscripts prepared with any other microcomputer word processor are acceptable. Refrain from complex formatting; the Publisher will style your manuscript according to the Journal design specifications. Do not use desktop publishing software such as Aldus PageMaker or Quark XPress. If you prepared your manuscript with one of these programs, export the text to a word processing format. Please make sure your word processing program's "fast save" feature is turned off. Please do not deliver files that contain hidden text: for example, do not use your word processor's automated features to create footnotes or reference lists.
File names. Submit the text and tables of each manuscript as a single file. Name each file with your last name (up to eight letters). Text files should be given the three-letter extension that identifies the file format. Macintosh users should maintain the MS-DOS "eight dot three" file-naming convention.
Labels. Label all disks with your name, the file name, and the word processing program and version used.
Illustrations
All print reproduction requires files for full color images to be in a CMYK color space. If possible, ICC or ColorSync profiles of your output device should accompany all digital image submissions.
Storage medium. Submit as separate files from text files, on separate disks or cartridges. If feasible, full color files should be submitted on separate disks from other image files. 3-1/2" high-density disks, CD, Iomega Zip, and 5 1/4" 44- or 88-MB SyQuest cartridges can be submitted. At authors' request, cartridges and disks will be returned after publication.
Software and format. All illustration files should be in TIFF or EPS (with preview) formats. Do not submit native application formats.
Resolution. Journal quality reproduction will require greyscale and color files at resolutions yielding approximately 300 ppi. Bitmapped line art should be submitted at resolutions yielding 600-1200 ppi. These resolutions refer to the output size of the file; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.
File names. Illustration files should be given the 2- or 3-letter extension that identifies the file format used (i.e., .tif, .eps).
Editorial Board
E D I T O R S - I N - C H I E F
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FELIX MITELMAN
Department of Clinical Genetics
University Hospital
S-221 85 Lund, Sweden
Tel: 46-(46) 17 33 60
Fax: 46-(46) 13 10 61
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JANET D. ROWLEY
Section of Hematology/Oncology
The University of Chicago Medical Center
5841 S. Maryland Ave., MC 2115
Chicago, IL 60637
Tel: (773) 702-6117
Fax: (773) 702-3002
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A S S O C I A T E E D I T O R S
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BERTIL JOHANSSON
FREDRIK MERTENS
Lund, Sweden
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MICHELLE M. LE BEAU
Chicago, IL
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A S S I S T A N T E D I T O R S
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THOAS FIORETOS
Lund, Sweden
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KATRIN CARLSON
NANCY ZELEZNIK-LE
Chicago, IL
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E D I T O R I A L B O A R D
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Mariano Barbacid
Madrid, Spain
Roland Berger
Paris, France
Garrett M. Brodeur
Philadelphia, Pennsylvania
Charles Buys
Groningen, The Netherlands
Raju S.K. Chaganti
New York, New York
Albert de la Chapelle
Helsinki, Finland
Francis S. Collins
Bethesda, Maryland
Thomas Cremer
Munich, Germany
Ronald A. DePinho
Boston, Massachusetts
Peter Devilee
Leiden, The Netherlands
Charis Eng
Columbus, Ohio
Eric R. Fearon
Ann Arbor, Michigan
Jonathan A. Fletcher
Boston, Massachusetts
Joe W. Gray
San Francisco, California
Gerard C. Grosveld
Memphis, Tennessee
Anne Hagemeijer
Leuven, Belgium
Nick Hayward
Queensland, Australia
Sverre Heim
Oslo, Norway
Kay Huebner
Philadelphia, Pennsylvania
Anne Kallioniemi
Tampere, Finland
Olli-P. Kallioniemi
Bethesda, Maryland
Yasuhiko Kaneko
Saitama, Japan
Scott E. Kern
Baltimore, Maryland
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Sakari Knuutila
Helsinki, Finland
Alfred G. Knudson
Philadelphia, Pennsylvania
Stanley J. Korsmeyer
St. Louis, Missouri
Christoph Lengauer
Baltimore, Maryland
A. Thomas Look
Memphis, Tennessee
Nils Mandahl
Lund, Sweden
Junia V. Melo
London, England
Cynthia C. Morton
Boston Massachusetts
Yusuke Nakamura
Tokyo, Japan
Susan L. Naylor
San Antonio, Texas
Peter C. Nowell
Philadelphia, Pennsylvania
Pier Giuseppe Pelicci
Milan, Italy
Marco Pierotti
Milan, Italy
Bruce Ponder
Cambridge, England
Terry H. Rabbitts
Cambridge, England
Thomas Ried
Bethesda, Maryland
Janet Shipley
Sutton, England
Joseph R. Testa
Philadelphia, Pennsylvania
Gilles Thomas
Paris, France
Barbara J. Trask
Seattle, Washingon
Jeffrey M. Trent
Bethesda, Maryland
Bert Vogelstein
Baltimore, Maryland
Bryan Young
London, Enland
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J o u r n a l P r o d u c t i o n
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John Wiley & Sons
Michael Bond
Senior Production Editor
Genes, Chromosomes and Cancer
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