期刊名称：INTERNATIONAL JOURNAL OF ONCOLOGY ISSN： 1019-6439 版本： SCI-CDE 出版频率： Monthly 出版社： SPANDIDOS PUBL LTD, POB 18179, ATHENS, GREECE, 116 10   出版社网址： http://www.spandidos-publications.com/ 期刊网址： http://www.spandidos-publications.com/ijo/ 影响因子： 5.65 主题范畴： ONCOLOGY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Included in Current Contents/Life Sciencies, Science Citation Index, Scisearch, Research Alert, Index Medicus/MEDLINE, BIOSIS, Chemical Abstracts Service, Cambridge Scientific Abstracts, INIST/PASCAL, SUBIS and Current Awareness in Biological Sciences. Instructions to Authors The principal aim of the above journals is to provide for the prompt publication of original works of high quality. Manuscripts will be accepted on the understanding that they report original unpublished works and are not under consideration for publication by another journal. All material submitted will be subject to review by appropriate referees selected by the Editorial Office. The Editors reserve the right to improve manuscripts on grammar and style. The corresponding author is responsible on behalf of all authors for the submission. Submission of manuscripts: Submit the text (including any Tables) as a single file, in a standard disk (3.5 inch, not high density; 100 and 250 MB Zip disk and CD are also accepted), together with two hard copies of the manuscript and two sets of figures (not photocopies). The type of computer and word processing package should be specified (IBM or Macintosh compatible). Our preferred format is Macintosh, Word, if this is not available, save the text as an ASCII file. Do not save figures in the disk. Ensure that the disk is identical to the manuscript.               The manuscripts (including the disk, Tables and Figures)               should be sent to:               By regular mail:               Professor D.A. Spandidos               P.O.B. 18179, Athens 116 10, Greece               By courier service (overnight mail):               Professor D.A. Spandidos               1, S. Merkouri Street, Athens 116 35, Greece Cover letter: State the journal you are submitting to, and summarize briefly the main importance of the submitted work. Format: Original work and review articles concerning fields of recognisable progress are accepted for evaluation. Papers should be written in concise English and should contain all essential data in order to make the presentation clear. General style: Title of the work, sub-titles and general headlines should be presented in lower case letters (not capitals). Indicate affiliations of the Authors by number (not symbols). Abstract should be continuous (without reference numbers, or headlines). Manuscripts: Submitted manuscripts should include abstract, text, figures and references. Manuscripts reporting experimental results should be divided into the following sections: (a) First page should include the title of the presented work, full names and full postal addresses of all Authors, name of the Author to whom correspondence is to be sent, key words and an abbreviated running title; (b) Abstract of approximately 150-300 words; (c) Introduction; (d) Materials and methods; (e) Results; (f) Discussion; (g) Acknowledgements and (h) References. The pages should be numbered consecutively. Footnotes should not be used. Reviews: Review articles may have different sections and headlines according to the subject matter and the Author's opinion; however, an Abstract is mandatory. The main headlines of the review should be summarized as a contents section immediately following the Abstract. Figures: Color figures are welcome, however, should be submitted only if reproduction in color is intended (a charge will be made for this). The figures should be clear, high contrast, glossy prints of the approximate size they are to appear in the journal; 8.00 cm (3.15 in) wide for a single column; 17.00 cm (6.70 in) for a double column; maximum height 20.00 cm (7.87 in). Graphs should not require any artwork or typesetting, symbols, numbering and lettering should be clearly legible and of appropriate size. The number, and top of each figure must be indicated on the reverse side. Tables: Each table should be submitted on a separate page, and typed using double-spacing. Tables should be numbered with Roman numerals and should include a short title. Nomenclature and Abbreviations: Nomenclature should follow that given in "Chemical Abstracts". Standard abbreviations are preferable. If a new abbreviation is used, it should be defined at its first usage. References: Citation of journal titles follow the standard form of "Index Medicus" and the references must be numbered consecutively. Do NOT use full stop after initials or abbreviations. In the text, references should be cited by number in soft brackets e.g. (1-3) (1,2). Inclusive page numbers should be given. Complete Author list is preferred, however, if there are more than 7 Authors, 3 names and et al can be used. Following are examples of order and style, which should be strictly adhered to:                 1.  Spandidos DA and Wilkie NM: Malignant transformation of early passage                       rodent cells by a single mutated human oncogene. Nature 310: 469-475, 1984.                 2.  Hall A, Morris JDH, Price B, Lloyd A, Hancock JF, Gardener S, Houslay MD,                       Wakelam MJO and Marshall CJ: The function of the mammalian Ras proteins. In:                       Ras oncogenes. Spandidos DA (ed.) Plenum Publ. Corp., New York, pp99-104,                       1989.                 Personal communications should be avoided. Manuscripts in preparation or                  submitted, but not yet accepted and abstracts from meetings, may be cited in the                  text and should NOT be included in the list of references. Proofs: It is of vital importance that Authors check their manuscripts carefully before submission, because any errors will be faithfully transferred into the typeset version. Proofs should be returned by fax, followed by the originals by mail for confirmation purposes.  Reprints: A reprint order form will accompany notification of acceptance of manuscript and should be completed and returned immediately. Page charges: Accepted manuscripts will be published on the understanding that the author(s) will pay a charge of US$80 for each page exceeding four printed pages.   Editorial Board Editorial Academy J.L. ABBRUZZESE, Houston, TX, USA R.J. ABLIN, Park Ridge, NJ, USA J. AISNER, Brunswick, NJ, USA A. Albini, Genova, Italy C.J. Allegra, Bethesda, MD, USA E. Alvarez FernÁndez, Madrid, Spain A. AMSTERDAM, Rehovot, Israel F.R. APPELBAUM, Seattle, WA, USA J.M. ARGILÉS, Barcelona, Spain R.B. ARLINGHAUS, Houston, TX, USA J.-P. ARMAND, Villejuif, France L. AURELIAN, Baltimore, MD, USA L.H. Baker, Ann Arbor, MI, USA P. BANNASCH, Heidelberg, Germany M. Barbacid, Madrid, Spain y. barenholz, Jerusalem, Israel R.C. BAST, Jr, Houston, TX, USA W.T. BECK, Chicago, IL, USA C.B. Begg, New York, NY, USA A. BEGLEITER, Winnipeg, Canada D.A. BELL, Research Triangle Park, NC, USA W.E. BERDEL, M¨¹nster, Germany J.F. BISHOP, Sydney, Australia C.D. BLOOMFIELD, Columbus, OH, USA V.A. BOHR, Baltimore, MD, USA B. BONAVIDA, Los Angeles, CA, USA E.C. BORDEN, Cleveland, OH, USA G.J. Bosl, New York, NY, USA L.W. BRADY, Philadelphia, PA, USA T.P. BRENT, Memphis, TN, USA J. BUBENIK, Prague, The Czech Republic G.T. BUDD, Cleveland, OH, USA P.A. BUNN Jr, Denver, CO, USA A.U. BUZDAR, Houston, TX, USA R.D. CARDIFF, Davis, CA, USA V. CASTRONOVO, Li¨¨ge, Belgium w.k. cavenee, La Jolla, CA, USA N.-K.V. Cheung, New York, NY, USA E. CHU,  New Haven, CT, USA L.W.K. CHUNG, Charlottesville, VA, USA L. COCCO, Bologna, Italy A.H. CONNEY, Piscataway, NJ, USA D.T. Curiel, Birmingham, AL, USA P.V. DANENBERG, Los Angeles, CA, USA Z. DARZYNKIEWICZ, Hawthorne, NY, USA M. DE LENA, Bari, Italy S.J. DeNARDO, Sacramento, CA, USA D.T. DENHARDT, Piscataway, NJ, USA R.A. DePinho, Boston, MA, USA V.T. DeVITA Jr, New Haven, CT, USA J. DIGIOVANNI, Smithville, TX, USA P.K. DONAHOE, Boston, MA, USA R.C. Donehower, Baltimore, MD, USA J.H. DOROSHOW, Duarte, CA, USA R.N. DuBOIS, Nashville, TN, USA P. DUESBERG, Berkeley, CA, USA R.L. Eckert, Cleveland, OH, USA W.S. EL-DEIRY, Philadelphia, PA, USA L.M. Ellis, Houston, TX, USA G.I. EVAN, San Francisco, CA, USA P.B. FARMER, Leicester, UK A. Fefer, Seattle, WA, USA I.J. FIDLER, Houston, TX, USA J.K. FIELD, Liverpool, UK W.D. Figg, Bethesda, MD, USA P.B. FISHER, New York, NY, USA P. FIShMAN, Petach-Tiqva, Israel J.A. FOEKENS, Rotterdam, The Netherlands K.A. FOON, Cincinnati, OH, USA A.J. FORNACE Jr, Bethesda, MD, USA E.C. FRIEDBERG, Dallas, TX, USA S.L. GEORGE, Durham, NC, USA E. GEBHART, Erlangen, Germany J.B. GIBBS, West Point, PA, USA B.C. Giovanella, Houston, TX, USA E. GLATSTEIN, Philadelphia, PA, USA D.W. GOLDE, New York, NY, USA F.L. GRAHAM, Hamilton, Canada J.W. GRAY, San Francisco, CA, USA F.P. GUENGERICH, Nashville, TN, USA R.C. GUPTA, Lexington, KY, USA S. GUPTA, Irvine, CA, USA J.-Å. GUSTAFSSON, Huddinge, Sweden S. HAKOMORI, Seattle, WA, USA B.W. HANCOCK, Sheffield, UK N. HANNA, San Diego, CA, USA L. HARDELL, Örebro, Sweden D.F. Hayes, Ann Arbor, MI, USA K. HEMMINKI, Huddinge, Sweden J.A. Hickman, Suresnes, France O. Hino, Tokyo, Japan W.K. HONG, Houston, TX, USA K.V. HONN, Detroit, MI, USA A. HORII, Sendai, Japan S.J. HORNING, Palo Alto, CA, USA G.N. HORTOBAGYI, Houston, TX, USA K.B. HORWITZ, Denver, CO, USA S.B. HORWITZ, Bronx, NY, USA J.A. Houghton, Memphis, TN, USA M.-C. HUNG, Houston, TX, USA K.J. ISSELBACHER, Charlestown, MA, USA R.K. JAIN, Boston, MA, USA A. JEFFREYS, Leicester, UK D.M. JERINA, Bethesda, MD, USA F.E. JOHNSON, St. Louis, MO, USA B.A. Kamen, Brunswick, NJ, USA M.B. KASTAN, Baltimore, MD, USA S.H.E. Kaufmann, Berlin, Germany J.J. Kavanagh, Houston, TX, USA D. Khayat, Paris, France K.-W. KIM, Seoul, Korea Y.S. Kim, San Francisco, CA, USA T.J. KINSELLA, Cleveland, OH, USA T. KISHIMOTO, Osaka, Japan H.K. Kleinman, Bethesda, MD, USA M. KODAMA, Nagoya, Japan H.P. KOEFFLER, Los Angeles, CA, USA S.J. Korsmeyer, Boston, MA, USA P.H. KRAMMER, Heidelberg, Germany M.L. KRIPKE, Houston, TX, USA G. KROEMER, Villejuif, France S. KUMAR, Manchester, UK E. KUN, San Francisco, CA, USA S.W.J. LAMBERTS, Rotterdam, The Netherlands D. LANE, Dundee, UK C. LARSSON, Stockholm, Sweden V.A. LEVIN, Houston, TX, USA J.A. LEVY, San Francisco, CA, USA D.A. Liebermann, Philadelphia, PA, USA M.W. LIEBERMAN, Houston, TX, USA T. Lindahl, South Mimms, UK L.A. LIOTTA, Bethesda, MD, USA M. LIPKIN, New York, NY, USA S.M. Lippman, Houston, TX, USA C.J. LOGOTHETIS, Houston, TX, USA D.L. LONGO, Baltimore, MD, USA R. LOTAN, Houston, TX, USA J.W. LOWN, Edmonton, Alberta, Canada L. Mao, Houston, TX, USA M. Markman, Cleveland, OH, USA S. Markowitz, Cleveland, OH, USA H.R. MAURER, Berlin, Germany D.J. McC,  Houston, TX, USA J.A. McCUBREY, Greenville, NC, USA P.J. McLaughlin, Hershey, PA, USA H. MELLSTEDT, Stockholm, Sweden F.L. Meyskens, Irvine, CA, USA E. MIHICH, Buffalo, NY, USA L. MILAS, Houston, TX, USA J.B. MITCHELL, Bethesda, MD, USA M.S. MItchell, Detroit, MI, USA F. MITELMAN, Lund, Sweden M. MORI, Beppu, Japan M. Morrow, Chicago, IL, USA H.C. MORSE III, Bethesda, MD, USA H. MUKHTAR, Madison, WI, USA Y. NAKAMURA, Tokyo, Japan A.G. NERLICH, M¨¹nchen, Germany P.E. Nielsen, Copenhagen, Denmark K. NILSSON, Uppsala, Sweden S. NISHIMURA, Ibaraki, Japan V. NOTARIO, Washington, DC, USA A.C. Ochoa, New Orleans, LA, USA K. OHYASHIKI, Tokyo, Japan J.-G. Park, Goyang, Korea N.-H. PARK, Los Angeles, CA, USA S. PARODI, Genova, Italy S. PATHAK, Houston, TX, USA A.E. PEGG, Hershey, PA, USA M. PERUCHO, La Jolla, CA, USA R.G. PESTELL, Bronx, NY, USA S. PESTKA, Piscataway, NJ, USA G.J. PETERS, Amsterdam, The Netherlands W.P. Peters, Detroit, MI, USA U. PETTERSSON, Uppsala, Sweden Y.G. POMMIER, Bethesda, MD, USA K.J. Pienta, Ann Arbor, MI, USA H.M. Pinedo, Amsterdam, The Netherlands D. PINKEL, Houston, TX, USA H.C. PITOT, Madison, WI, USA M.C. POIRIER, Bethesda, MD, USA N.C. Popescu, Bethesda, MD, USA H.D. PREISLER, Chicago, IL, USA C. PRIVES, New York, NY, USA T.H. RABBITTS, Cambridge, UK F.J. RAUSCHER, III, Philadelphia, PA, USA A. RAZ, Detroit, MI, USA J.S. RAO, Peoria, IL, USA M.S. RAO, Chicago, IL, USA B.S. REDDY, Valhalla, NY, USA J.K. REDDY, Chicago, IL, USA E. Reed, Morgantown, WV, USA R.A. REISFELD, La Jolla, CA, USA J.S. RHIM, Bethesda, MD, USA D.P. ROSE, Valhalla, NY, USA d. roy, Birmingham, AL, USA S.C. RUBIN, Philadelphia, PA, USA J. RUSSO, Philadelphia, PA, USA D.S. SALOMON, Bethesda, MD, USA A.V. SCHALLY, New Orleans, LA, USA V. SCHIRRMACHER, Heidelberg, Germany M. SCHMITT, M¨¹nchen, Germany H.M. SCHULLER, Knoxville, TN, USA M. SCHWAB, Heidelberg, Germany C. SCULLY, London, UK S. SEGAL, Beer-Sheva, Israel H.K. SEITZ, Heidelberg, Germany A.K. SETH, Toronto, Canada J.W. SHAY, Dallas, TX, USA H. SHIKU, Mie, Japan J.G. SINKOVICS, Tampa, FL, USA F.M. SIROTNAK, New York, NY, USA T.J. SLAGA, Denver, CO, USA T.E. STARZL, Pittsburgh, PA, USA J.S. Stehlin Jr, Houston, TX, USA G.S. STEIN, Worchester, MA, USA D.J. STEWART, Ottawa, Canada A. STRASSER, Melbourne, Australia H.W. STROBEL, Houston, TX, USA K. SUGIMACHI, Fukuoka, Japan M.M. TAKETO, Kyoto, Japan B.A. TEICHER, Indianapolis, IN, USA G. TRINCHIERI, Philadelphia, PA, USA A. ULLRICH, Martinsried, Germany P. VAUPEL, Mainz, Germany G. VECCHIO, Naples, Italy D.D. VON HOFF, San Antonio, TX, USA J.N. VOURNAKIS, Charleston, SC, USA G.M. Wahl, San Diego, CA, USA T.A. WALDMANN, Bethesda, MD, USA J.R. WANDS, Providence, RI, USA D.J. WAXMAN, Boston, MA, USA R.R. WEICHSELBAUM, Chicago, IL, USA T.L. WHITESIDE, Pittsburgh, PA, USA E. WINTERSBERGER, Wien, Austria J.A. WRIGHT, Toronto, Ontario, Canada A.H. WYLLIE, Cambridge, UK G.D. YANCOPOULOS, Terrytown, NY, USA J. YOKOTA, Tokyo, Japan I.S. Zagon, Hersey, PA, USA