期刊名称：GENE THERAPY ISSN： 0969-7128 版本： SCI-CDE 出版频率： Monthly 出版社： SPRINGERNATURE, CAMPUS, 4 CRINAN ST, LONDON, ENGLAND, N1 9XW   出版社网址： http://www.nature.com/ 期刊网址： http://www.nature.com/gt/about.html 影响因子： 5.25 主题范畴： BIOCHEMISTRY & MOLECULAR BIOLOGY;    BIOTECHNOLOGY & APPLIED MICROBIOLOGY;    GENETICS & HEREDITY;    MEDICINE, RESEARCH & EXPERIMENTAL 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal   Gene Therapy covers both the research and clinical applications of the new genetic therapy techniques currently being developed. The application of molecular biology has revolutionised our understanding of many diseases and has been readily applied for diagnostic purposes. Over the last decade, gene therapy protocols have entered clinical trials in increasing numbers. Covering a wide spectrum of diseases, these studies promise to unite the diverse organ based specialities into which modern medicine has become divided. Gene Therapy covers all aspects of gene therapy as applied to human disease, including preclinical animal experiments, novel platform technologies for gene transfer, and gene expression analysis.   Instructions to Authors   Guide for Authors Welcome to the electronic manuscript submission website for Gene Therapy. The instructions below are structured so you can quickly and easily answer the following questions: Is my manuscript suitable for Gene Therapy? (Scope + Editorial Policy) How do I format my manuscript for Gene Therapy? (Format of Papers) How do I submit my manuscript to Gene Therapy? (Submission of Papers) Gene Therapy is published 24 times a year by Nature Publishing Group and is abstracted or indexed in: Current Contents MEDLINE EMBASE/Excerpta Medica Index Medicus MEDLARS Elsevier Biobase/Current Awareness in Biological Sciences Chemical Abstracts Biotechnology Citation Index Current Contents Life Sciences Science Citation Index Derwent's Biotechnology Abstracts Derwent's Gene Therapy Database Scope The Editors welcome research papers, review articles, short reviews or short communications on all aspects of gene therapy and its application to human disease. Therapeutic development programmes using animal models will also be acceptable. Editorial Policy Editors: Nicholas Lemoine, London, UK Joseph C Glorioso, Pittsburgh, PA, USA Gene Therapy covers both the research and clinical applications of gene therapy and transgenic cell therapy techniques. The application of molecular biology has revolutionised our understanding of many diseases and has been readily applied for diagnostic purposes. Gene therapy and transgenic stem cell therapy approaches promise to unite the diverse organ based specialities into which modern medicine has become divided. Gene Therapy covers all aspects of gene and transgenic cell therapy as applied to human disease including preclinical animal experiments, novel platform technologies for gene transfer and gene expression analysis. Papers are sent for review to at least two experts in the field. Papers will be considered if they contribute original material that is likely to be of interest to readers involved in the field of gene therapy - clinical applications are particularly encouraged. Authors are asked to write their manuscripts in English using an easily readable style. Spelling and phraseology should conform either to standard English or to standard American usage and should be consistent throughout the paper (eg haematological, leukaemia, centre or hematologic, leukemia, center). A manuscript will be considered for publication on the understanding that all named authors have agreed to its submission and that if accepted it will not subsequently be published in the same or similar form in any language without the consent of the publishers. A covering letter should accompany all submissions confirming the above points. The editors also encourage submission of review articles on relevant topics and recent developments. Format of Papers Preparation of manuscripts Type preferably on A4 paper (210 x 297 mm) single-sided and double-lined spacing with 25 mm margins. The uploaded covering letter must state that the material has not been submitted for publication elsewhere while under consideration for Gene Therapy. Non-Native Speakers of English Authors who are not native speakers of English who submit manuscripts to international journals often receive negative comments from referees or editors about the English-language usage in their manuscripts, and these problems can contribute to a decision to reject a paper. To help reduce the possibility of such problems, we strongly encourage such authors to take at least one of the following steps: Have your manuscript reviewed for clarity by a colleague whose native language is English. Use a service such as one of those listed below. An editor will improve the English to ensure that your meaning is clear and identify problems that require your review. Note that the use of such a service is at the author's own expense and risk and does not guarantee that the article will be accepted. Nature Publishing Group accepts no responsibility for the interaction between the author and the service provider or for the quality of the work performed. American Journal Experts Inter-Biotec Inter-Biotec also provides a free online writing course to help biomedical scientists whose first language is not English to write and publish their papers in English-language journals. SPI Professional Editing Services Write Science Right Presentation Any special points should be emphasised in the covering letter from the submitting author. The paper should be arranged as follows: Title page Summary and keywords Introduction Results Discussion Materials (or Patients) and methods Acknowledgements References Tables Figures The overall length of the paper should not exceed eight published pages. As a guide, this is equivalent to approximately 8000 words, counting each half page figure or table as 500 words. Manuscripts which, when typeset, make over eight pages, will be subject to a page charge of ?20 per page for each additional page. The final word count should be displayed on the title page of the paper. The title page should also bear the title of the paper, the full names of the authors and their affiliations together with the name, full postal address, telephone, fax and e-mail address of the author to whom correspondence and reprint requests are to be sent. There should be a running title of not more than 50 letters and spaces and from three to six keywords. The Summary should not exceed 200 words. It should be written in a style that conveys the essential message of the paper in abbreviated form. The Introduction should assume that the reader is knowledgeable in the field and should therefore be as brief as possible. In the Materials and methods section, methods that have been published in detail elsewhere should not be described in detail. SI units should be used throughout the text. Authors are asked to include a short covering letter that draws the editors' attention to any relevant points. This is particularly relevant for resubmission of the manuscript following the review process. The letter should be from the corresponding author and include e-mail address, telephone and fax numbers. Editorials or brief reviews will be solicited by the editors but suggestions for such material are very welcome. Brief communications will have a shorter format than full length papers so that Introduction, Results and Discussion will be merged into a single report. Materials and methods will be included as legends to figures and tables. The upper limit will be five journal pages including figures. As a guide, this is equivalent to approximately 5000 words, counting each half page figure or table as 500 words. The final word count should be displayed on the title page of the paper. Editorial office Queries and editorial correspondence should be forwarded to Louise Lemoine, Editorial Assistant at genetherapy@btopenworld.com . References Only papers closely related to the author's work should be quoted. Exhaustive lists should be avoided. References should follow the Vancouver format. In the text they should appear as superscript numbers outside punctuation starting at 1. At the end of the paper they should be listed (double-spaced) in numerical order corresponding to the order of citation in the text. All authors should be quoted for papers with up to six authors; for papers with more than six authors, the first six should be quoted followed by et al. Abbreviations for titles of medical periodicals should conform to those used in the latest edition of Index Medicus. The first and last page numbers for each reference should be provided. Abstracts and letters must be identified as such. Papers in press and papers already submitted for publication may be included in the list of references. No citation is required for work that is not yet submitted for publication. Personal communications may be referred to in the text but are not to be listed in the references. Authors must obtain permission from the individual concerned to quote their unpublished work. Examples of references Journal article, up to six authors: Sargent CA, Dunham I, Campbell RD. Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III. EMBO J 1989; 8: 2305-2312. Journal article, in press: Gallardo RL, Juneja HS, Gardner FH. Normal human marrow stromal cells induce clonal growth of human malignant T-lymphoblasts. Int J Cell Cloning (in press). Journal article submitted for publication: Ohno H, Takimoto G, Mckeihan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell-cycle control (submitted for publication). Complete book: Gordon MY, Barre AJ. Bone Marrow Disorders: the Biological Basis of Clinical Problems. Blackwell Scientific Publications: Oxford, 1985, pp 51-56. Chapter in book Greenberger JS. Long-term hematopoietic cultures. In: Golde DW (ed). Hematopoiesis. Churchill-Livingstone: New York, 1984, pp. 203-242. Abstract Feig SA et al. Bone marrow transplant for neuroblastoma. Exp Hematol 1985; 13 (Suppl. 2): 362 (Abstr. 102). Letter to the Editor Raum D, Alper CA, Stein R. Genetic markers for insulin dependent diabetes mellitus. Lancet 1985; i: 106 (letter). Figures Figures and images should be labeled sequentially, numbered and cited in the text. Figure legends should be printed, double spaced, on a separate sheet titled ‘Titles and legends to figures? Figures should be referred to specifically in the text of the paper but should not be embedded within the text. The use of three-dimensional histograms is strongly discouraged when the addition of the third dimension gives no extra information. If a table or figure has been published before, the authors must obtain written permission to reproduce the material in both print and electronic formats from the copyright owner and submit it with the manuscript. This follows for quotes, illustrations and other materials taken from previously published works not in the public domain. The original source should be cited in the figure caption or table footnote. Colour figures can be reproduced if necessary, but the authors will be expected to contribute towards the cost of publication. A quote will be supplied upon acceptance of your paper. Artwork Guidelines Detailed guidelines for submitting artwork can be found by downloading the guidelines PDF. Using the guidelines, please submit production quality artwork with your initial online submission. If you have followed the guidelines, we will not require the artwork to be resubmitted following the peer-review process, if your paper is accepted for publication. Colour on the web Authors who wish their articles to have FREE colour figures on the web (only available in the HTML (full text) version of manuscripts) must supply separate files in the following format. These files should be submitted as supplementary information and authors are asked to mention they would like colour figures on the web in their submission letter. For Single Images: Width 500 pixels (authors should select "constrain proportions", or equivalent instructions, to allow the application to set the correct height automatically.) Resolution 125 dpi (dots per inch) Format JPEG for photographs GIF for line drawings or charts Filenaming Please save image with .jpg or .gif extension to ensure it can be read by all platforms and graphics packages. For Multi-part Images : Width 900 pixels (authors should select "constrain proportions", or equivalent instructions, to allow the application to set the correct height automatically.) 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Unlike figures or images, tables may be embedded into the word processing software if necessary, or supplied as separate electronic files. House Style As the electronic submission will provide the basic material for typesetting, it is important that papers are prepared in the general editorial style of the journal. See the artwork guidelines for information on labeling of figures Do not make rules thinner than 1pt (0.36mm) Use a coarse hatching pattern rather than shading for tints in graphs Color should be distinct when being used as an identifying tool Use Si units throughout Spaces, not commas should be used to separate thousands Abbreviations should be proceded by the words for which they stand in the first instance of use Text should be double spacing with a wide margin File Formats: File formats for manuscript files, figures and tables that are acceptable for our electronic manuscript submission process are given on the online forms. Further advice on file types is also available from the Tips webpage. Please follow our artwork guidelines for submitting figures, and use a common word-processing package (such as Microsoft Word) for the text. Either embed tables converted into images at the end of your Word document, or as a separate files in which ever program you used to generate them. If you submit raw data, this can be done in Excel, or tab/comma delimited format. Supplementary information Supplementary information is peer-reviewed material directly relevant to the conclusion of an article that cannot be included in the printed version owing to space or format constraints. It is posted on the journal's web site and linked to the article when the article is published and may consist of data files, graphics, movies or extensive tables. The printed article must be complete and self-explanatory without the supplementary information. Supplementary information enhances a reader’s understanding of the paper but is not essential to that understanding. Supplementary information must be supplied to the editorial office in its final form for peer review. On acceptance the final version of the peer reviewed supplementary information should be submitted with the accepted paper. To ensure that the contents of the supplementary information files can be viewed by the editor(s), referees and readers, please also submit a ‘read-me?file containing brief instructions on how to use the file. Supplying supplementary information files Authors should ensure that supplementary information is supplied in its FINAL format because it is not subedited and will appear online exactly as originally submitted. It cannot be altered, nor new supplementary information added, after the paper has been accepted for publication. Please supply the supplementary information via eJP, the electronic manuscript submission and tracking system, in an acceptable file format (see below). Authors should: Include a text summary (no more than 50 words) to describe the contents of each file. Identify the types of files (file formats) submitted. Include the text ‘Supplementary information is available at (the journal’s name)’s website?at the end of the article and before the references. Accepted file formats Quick Time files (.mov) Graphical image files (.gif) HTML files (.html) MPEG movie files (.mpg) JPEG image files (.jpg) Sound files (.wav) Plain ASCII text (.txt) Acrobat files (.pdf) MS Word documents (.doc) Postscript files (.ps) MS Excel spreadsheet documents (.xls) We cannot accept TeX and LaTeX. File sizes must be as small as possible, so that they can be downloaded quickly. 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Submission of papers The first thing you need to do, if you have not done so already, is register for an account. After this, please consult the instructions below to enable you to submit your article through our secure server. For optimum performance, we recommend that your browser should be either Netscape 4.7 or above, or Internet Explorer 5.0 and above. Please be sure that your browser is set to accept cookies. Our tracking system requires cookies for proper operation. (If you have Windows XP the defaults will need changing. For more details on this, please refer to the 'Tips' function on this site.) Navigating the System When you first access our tracking system, you will be taken to your Home page, where different categories of tasks are listed. If you are required to perform a pending action item or task, there will be a red arrow next to a 'Manuscript' link. Throughout the system, red arrows reflect pending action items which you should address. If there are no red arrows visible on your Home page, then you are finished and have no outstanding tasks to complete. At any time please press HOME to go to the submission home page. Process for Manuscript Submission Please make sure you have gathered all the required manuscript information listed above BEFORE starting the submission process. The manuscript submission process starts by pressing the "Submit Manuscript" link on your "Home" page. The manuscript submission process is broken down into a series of 4 screens which gather detailed information about your manuscript and allow you to upload the pertinent text and figure/image files. The screens run in this order: A form asking for author details, the manuscript title, abstract, other associated manuscript information and types/number of files to be submitted. A screen asking for the actual file locations (via an open file dialogue). You will be able to browse for the relevant files on your computer or disk. After completing this screen, your files will be uploaded to our server. A file upload completion screen that will provide you with a unique manuscript number for your submission. You will also need to specify the order in which you want your manuscript files presented during peer review. An approval screen which will allow you to verify that your manuscript has been uploaded and the files converted correctly to PDF format. You will need to approve PDF conversion to complete your manuscript submission. You will need to have the following details for all authors before commencing online submission. Items in parenthesis may not be compulsory for co-authors: Email Addresses First and Last Names Institution (Full Postal Address) (Work Telephone Numbers) Fax Numbers In addition you will need: Covering letter Title and Running Title (you can copy and paste this from your manuscript) Abstract (you can copy and paste this from your manuscript) Manuscript files in Word, WordPerfect, text or any RTF format Figures/Images in external files in TIFF or JPG, in either grayscale or CMYK colour, not in RGB Tables in Excel (preferred) as separate files or embedded at the end of the manuscript file Do not embed images and figures within the text from word processing software as embedded images are not acceptable for production. (Tables are an exception to this rule as you may be generating them using the same software and as resolution quality tends to be less important for tables.) 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This process can take up to 5 - 10 minutes before the PDF, created in the conversion process, is ready for approval. Please remember that your manuscript will not be submitted until you have approved the converted files. Getting Help If you need additional help, you can click on the help signs spread throughout the system. A help dialogue will pop up with context sensitive help. Should further assistance be required, then please contact Louise Lemoine, genetherapy@btopenworld.com. Manuscript Status After you approve your manuscript it is submitted and you will receive an acknowledgement email. You can check the status of your manuscript at any time in the review process by: Accessing the system with your password or link sent to you in the acknowledgement email Clicking on the link represented by your manuscript tracking number and abbreviated title. Clicking on the "Check Status" link at the bottom of the displayed page. 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Colour charges The colour charges for Gene Therapy are as follows: 1 Figure ?70 2-3 Figures ?70 for the first figure and ?30 per figure for the rest 4-5 Figures ?30 for the first three figures and ?40 per figure for the rest 6 Figures ?,330 7+ Figures ?,330 for the first six figures and ?20 per figure for the rest Note: Multiple part figures are one illustration: e.g. Fig 1(a) & (b) is one illustration, Fig 1 and Fig 2 are two illustrations Business Matters To find out who to contact for business correspondence and enquiries such as advertising, subscriptions, permissions, papers in production or publishing a supplement, please visit our publisher’s contacts page. Alternatively, you can write to: Gene Therapy, Nature Publishing Group, The Macmillan Building, 4 Crinan Street, London, N1 9XW, UK. Please press HOME to continue. Editorial Board   USA Editor J Glorioso, USA European Editor N Lemoine, UK Associate Editors E Alton, UK P Robbins, USA D Valerio, The Netherlands H Tahara, Japan D Curiel, USA Editorial Board SM Albelda, USA R Alemany, Spain S Ali駉, Spain C Baum, Germany J-P Behr, France T Blankenstein, Germany DM Bodine, USA X O Breakefield, USA M Brenner, USA J Bubenik, Czech Republic MC Capogrossi, Italy M G Castro, UK RB Cattaneo, USA J Chamberlain, USA Y Chernajovsky, UK WH Colledge, UK MKL Collins, UK M Conese, Italy K Cornetta, USA C Coutelle, UK RG Crystal, USA O Danos, France B Davidson, USA KE Davies, UK RJ Debs, USA ML Degos, France N DeLuca, USA J Dick, Canada S Eck, USA L Eisenbach, Israel C Evans, USA F Farzaneh, UK MC Favrot, France HJ Federoff, USA D Fink, USA TR Flotte, USA J Fujimoto, Japan F Gage, USA J M Goldman, UK B Groner, Germany D Gruenert, USA WH Guenzburg, Austria R E Hawkins, UK EP Hoffman, USA L Huang, USA MJ Imperiale, USA M Kay, USA HP Kiem, USA S Kim, Korea SM Kingsman, UK C Kinnon, UK DH Kirn, R Kotin, USA DW Kufe, USA J Leiden, USA AML Lever, UK PR Lowenstein, USA L Luzzatto, Italy RS McIvor, USA AD Miller, USA PA Morel, USA R Morgan, USA JD Mountz, USA R Mulligan, USA N Muzyczka, USA GJ Nabel, USA L Naldini, Italy BW O'Malley, USA W Ostertag, Germany G Palu, Italy M Perricaudet, France DJ Porteous, UK SD Rabkin, USA S Raper, USA C Reis e Sousa, UK B Roizman, USA SJ Russell, USA M Sadelain, USA J Samulski, USA PF Searle, UK LW Seymour, UK K Sikora, UK A Smith, USA CJ Springer, UK A Srivastava, USA G Stamatoyannopoulos, USA FC Szoka Jr, USA MA Vega, Argentina RG Vile, UK EK Wagner, USA DJ Wells, UK RJ Whitley, USA TJ Wickham, USA R Williamson, Australia JM Wilson, USA JH Wolfe, USA JA Wolff, USA SLC Woo, USA X Xiao, USA S Yl?Herttuala, Finland L Young, UK