期刊名称：BIOMEDICAL AND ENVIRONMENTAL SCIENCES ISSN： 0895-3988 出版频率： Bi-monthly 出版社： CHINESE CENTER DISEASE CONTROL & PREVENTION, 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, PEOPLES R CHINA, 102206   出版社网址： http://www.besjournal.com/ 期刊网址： http://www.besjournal.com/ 影响因子： 3.118 主题范畴： ENVIRONMENTAL SCIENCES;    PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH;    China Journals 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal ISSN 0895-3988 CN 11-2816/Q Aims & Scope   　　Biomedical and Environmental Sciences (BES) is an international English scientific periodical jointly established by Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, which is published bimonthly and distributed both in China and abroad. The editorial office is based in the headquarters of China CDC.  　　BES publishes research papers submitted from China and other countries in the areas of biomedical and environmental sciences, which cover public health virology, microbiology, epidemiology, parasitology, nutrition, toxicology, pharmacology, environmental health, chemistry, biological and toxicological effects of hazardous substances including environmental pollutants, food additives, pesticides and industrial chemicals as well as methodological research, including chemical, biochemical, pathological and immunological methods. Experimental studies on natural and synthetic pollutants of the distribution, metabolic characteristics, and their impact on human health are also included. Research on preventive medicine and public health are also welcomed. 　　Our Journal has joined the famous researching system, such as SCI, CA etc. We also got the sustentation fund of National Natural Foundation of China in 1999.  　　To meet the needs of national information development and widen authors academic exchange channel, we declare that the journal, Biomedical and Environmental Sciences, has joined the Net. The author's copyright using fee will be paid off in a lump sum. If an author doesn't agree to involve his article in the databases, please make a declaration on the time of his contribution for our appropriate processing. Impact Factor     The journal impact factor is a measure of the frequency with which the "average article" in a journal has been cited in a particular year. The impact factor will help you evaluate a journal's relative importance, especially when you compare it to others in the same field. * Source: ISI Web of Knowledge Journal Citation Reports. Updated 29 June 2012.   Instructions to Authors 一、对投稿的要求 （一）投给本刊的所有稿件均需提供以下材料，或对有关问题提供说明： 1英文润色 您的稿件可能会被送到国外同行进行评议，如果英文写作质量较差，可能会使评阅人员无法准确理解您的研究成果，导致评阅时间延长或得出负面评价。 为回避此类问题的发生，我们强烈建议您： l 请专业的英文润色公司对您的稿件进行加工； l 请母语为英语的科研人员帮您认真修改稿件。     请您在来稿时，说明自己稿件在英文润色方面所做的工作。 2单位证明 请提供单位证明，证明： 1.         稿件研究内容真实，无一稿两投； 2.         如有基金支持，提供受资助的基金项目及项目编号； 3.         参与本研究的全体人员对文章在BES杂志发表、署名及署名顺序无异议。 建议通过挂号信寄送。 邮寄地址：北京市昌平区昌百路155号，中国疾控中心信息中心，BES杂志 邮    编：102206 3作者签名及贡献说明 请提供全体作者按稿件署名顺序的亲笔签名，并列出每人在该项研究中的主要工作任务或贡献；该 签名页（用中文签名） 可同 单位证明 一同寄送。 建议在稿件结束处（参考文献之前）列出每人在该项研究中的主要工作任务或贡献。下载作者签名页 4基金资助标示 如有基金支持，请在稿件中标题右上角加 * 号，并在稿件角注中列出项目名称、编号。 5敏感信息 凡可能涉密或涉及公共安全的内容，请提供相关管理部门同意信息发布的证明。 6伦理审查 凡涉及人的生物医学研究，需符合卫生部《涉及人的生物医学研究伦理审查办法（试行）》有关规定，应符合《世界医学协会赫尔辛基宣言》倡议，进行伦理审核，并出具伦理委员会审查结论。例如：采用现代物理学、化学和生物学方法在人体上对人的生理、病理现象以及疾病的诊断、治疗和预防方法进行研究的活动；通过生物医学研究形成的医疗卫生技术或者产品在人体上进行试验性应用的活动，均请提供伦理委员会审核结果单复印件。 7重要的中文信息 除英文稿件必备内容外，请在稿件首页同时提供以下中文信息： 文章标题、全体作者人名、全部单位、关键词、百字以内简介该研究的创新点、具体通讯人员的电话、邮箱及通讯地址、第一作者简介、通讯作者简介 您提供的这些内容有助于我们的学术编辑快速了解稿件内容、准确查找同行专家；也有助于我们的工作人员未来及时为您寄送发票、杂志等材料。 8说明方式 您可在稿件首页，对上述内容加以简要说明，确认您是否向我们提供相关信息： 1.         （Yes / No）经专业机构作英文润色（机构名称：    ）或者 2.         （Yes / No）以英语为母语的科研人员修改完善 3.         （Yes / No）单位证明、作者签名及贡献说明已提供 4.         （Yes / No）敏感信息审查通过 5.         （Yes / No）伦理审查通过   建议您在投稿时，在相关栏目中列出“推荐同行专家”和“请编辑部回避的同行专家”。 （二）本刊可发表以下格式文章 Research Highlight Original Artical Letters to the editor Review Report Abstract （三）稿件写作要求 1文稿 论点明确，资料可靠。文字精炼，层次清楚，数据准确，必要时应做统计学处理。   2文题 力求简明、醒目，反映出文章的主题。标题Arial字体，小四号字，黑体，实词首字母大写。文题一般不宜超过10～12个实词, 不用生僻的外文缩略语。稿件如有资金资助，请在标题末尾标记*，并在首页脚注处标注出具体的资金项目名称和编号。最好不用副标题。 3作者 作者姓名在文题下按序排列，Times New Roman字体，10号字。姓在前，全部大写，名字在后首字母大写，两字名，字间空英文1字节；通讯作者用#上标；作者单位用阿拉伯数字上标。 4作者单位 Times New Roman字体，小五号字，斜体。非直辖市请注意书写省份，邮编应放在城市名后，之后书写省，国家名称，不同单位名称之间用分号（；）隔开。例如1.Henan University of Science & Technology, Luoyang 471003, Henan, China；2. Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China 列单位时，不必列出城市的区、街道、门牌号。 5摘要 Calibri字体，10号字。文摘格式采用结构式文摘，分“Objective, Methods, Results, and Conclusion”四个部分，单词数不超过240个为宜。Objective, Methods, Results, and Conclusion这些单词字体加黑，顶格书写，空英文2字节后接排。 6关键词 Calibri字体，10号字。需标引3～8个关键词。请尽量使用美国国立医学图书馆编辑的最新版《Index Medicus》中医学主题词表(MeSH)内所列的词。必要时可采用自由词并排列于最后。各关键词间用分号(;)分隔。关键词第1个字母大写。 7脚注 资金项目需列出名称和编号。通讯作者需列出“职称、学历，电话，邮箱”等，不必再列出单位；第一作者需列出“性别、出生年、学历、职称、主要研究方向”等内容。 8正文 对于Original Article，使用Calibri字体，10号。一级标题，字母全部大写、粗体、居中；二级标题：斜体，加粗居左，首字母大写，单独占一行；三级标题：居左，斜体，实词首字母大写，加粗，不单独占一行，空英文4字节后与正文接排；四级标题：居左，起始空四格，正体，段首字母大写，加粗，标题后再空英文4字节后与正文接排。 稿件需要编行号，以利同行评议和稿件加工过程中准确指出问题。 9图表 分别按其在正文中出现的先后次序连续编码。全文只有1幅图或表时，写作Figure 1或Table 1。采用三横线表(顶线、表头线、底线)，表内数据要求同一指标有效位数一致。表题居中，实词首字母大写，Table X或Figure X应黑体标记。标注中有符号的，请在表格中准确标出，并对应好，“Note”应“加粗”标记。线条图以计算机制图，高宽比例以5∶7左右为宜。照片图要求有良好的清晰度和对比度，注明放大或缩小倍数。图表均应出现在正文第一次提及的段落之后。例： Table 3. The Positive Integron and Multiresistance in Shigella spp. Group Number No. of Isolates (%) P value* Multiresistant to 3 and More than 3 Antibiotics Susceptive to all or Resistant to 2 and Less than 2 Antibiotics Positive of either integron 79 77(97.5) 2 (2.5) 0.072 Negative of all integrons 11  9(81.8) 2(18.2) Positive of intI1 gene 70 68(97.1) 2(2.9) 0.213 Negative of intI1 gene 20 18(90.0) 2(10.0) Positive of intI2 gene 76 76(100.0) 0(0.0) 0.000 Negative of intI2 gene 14 10(71.4) 4(28.6) Note. *Fisher’s Exact Test   10统计学符号 按GB3358-82《统计学名词及符号》的有关规定书写，常用如下：(1)样本的算术平均数用英文小写x (中位数仍用M)；(2)标准差用英文小写s；(3)标准误用英文小写sx；(4)t检验用英文小写t；(5)F检验用英文大写F；(6)卡方检验用希文小写χ2；(7)相关系数用英文小写r；(8)自由度用希文小写υ；(9)概率用英文大写P。以上符号均用斜体。 11数字 执行GB/T 15835-1995《关于出版物上数字用法的规定》。公历世纪、年代、年、月、日、时刻和计数、计量均用阿拉伯数字。小数点前或后超过3位数字时，每三位数字一节，节间空英文1字节，如“1，329.476，5”应写成“1 329.476 5”。但序数词和年份、页数、部队番号、仪表型号、标准号不分节。百分数的范围和偏差，前一个数的百分符号不能省略，如：5%～95%不要写成5～95%，而百分数公差其中心值与公差用圆括号括起，其后写“%”，如(65±2)%，不得写作“65±2%”，宜写作“65%±2%”。附有长度单位的数值相乘，按下列方式书写：4 cm×3 cm×5 cm，而不能写成4×3×5 cm3。 12医学名词 以1989年及其以后由全国自然科学名词审定委员会审定、公布，科学出版社出版的《医学名词》为准，暂未公布者仍以人民卫生出版社编的《英汉医学词汇》为准。生物属种、基因、内切酶前三个字母等均用斜体。 13缩略语 文中尽量少用。必须使用时于首次出现处先叙述其全称，然后括号注出缩略语，如该缩略语已公知，也可不注出其英文全称。缩略语不得转行。 14参考文献 Calibri字体，8号。参考文献按作者，文献标题，文献来源(杂志名称)，出版年份，卷(期)，页码的顺序排列。请注意，文献来源后用“,”，出版年份后用“;”，卷(期)后用“,”，请在标点符号后空英文1字节。如果文献是中文文献，请在页码后，标以(In Chinese)。列出前三位作者，未列完加et al.；期刊名用规范的缩写，不用全称。正文中参考文献标示法：数字加中括号并上标。请按以下参考文献书写： 1. Kotloff KL, Winickoff JP, Ivanoff B, et al. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull WHO, 1999; 77, 651-66.c 2. Collis CM, Hall RM. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J Bacteriol, 1992; 174, 1574-85.   15其他要求和注意事项 1.         根据《著作权法》，并结合本刊具体情况，凡来稿在接到本刊回执后3个月内未接到稿件处理通知者，系仍在审阅中。作者如欲投他刊，请先与本刊联系，切勿一稿两投。 2.         来稿文责自负。依照《著作权法》有关规定，本刊可对来稿做文字修改、删节，凡有涉及原意的修改，则提请作者考虑。 3.         稿件确认刊载后会酌收费用，用于杂志编辑及出版事务。稿件刊登后支付的稿酬含本刊以其他形式出版的稿酬。赠送当期杂志3本。 Editorial Board Editorial in Chief                                         Prof. Chunming CHEN   Prof. Chunming CHEN started the publication of Biomedical and Environmental Sciences in 1988.   Professor Chunming CHEN was trained and graduated as B.S. on Nutritional Sciences in the Department of Agricultural Chemistry of National Central University of China in 1947. She has been working on nutrition research since then, and has been engaged in research on rickets, vitamin D assay, and nationwide nutrition surveys. She has been focused on Population Nutrition and Nutrition Policy studies since 1982, and designed the current National Nutrition Surveillance System in China. Based on it, she edited the book . Obesity and iron fortification are the key issues to be addressed under her leadership. She is involved in the nutrition policy research   Professor CHEN has been the Director-General of the Department of Health and Epidemic Prevention of the Ministry of Health of China during 1982-1984 and as the founding President of the Chinese Academy of Preventive Medicine (Now the Chinese Center for Disease Control and Prevention) during 1983-1992. She has been deeply involved in public health activities in China.   As a member of the WHO Expert Panel on Nutrition during 1979-2002 and widely involved in nutrition studies in China, she has been actively participating international nutrition activities. She was elected as the Vice Chairperson of the FAO/WHO International Conference on Nutrition held in 1992. The Food and Agriculture Organization of United Nations awarded her the in 1992. She has been the director of the International Life Science Institute (ILSI) Focal Point in China since its establishment in 1993 till January 2004, which is working on scientific information for addressing nutrition and food safety issues in China. She was nominated as the Fellow of International Union of Nutritional Sciences (IUNS) in 1997, and awarded Gopalan Award by the Nutrition Society of India at the 9th Asian Congress on Nutrition in 2003.   Professor Chunming CHEN is a board member of GAIN (Global Alliance for Improved Nutrition) started in 2002. She has been a member of the Reference Group for WHO Global Strategy on Diet, Physical Activity and Health for NCD Prevention.     Managing Editor   Dr. Junshi CHEN                                                                     Dr. Junshi CHEN was graduated from the Beijing Medical College in 1956 and engaged in nutrition and food safety research for more than 40 years at the Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention (the former Chinese Academy of Preventive Medicine), Beijing.   He has conducted large epidemiologic studies on diet, nutrition and chronic diseases, in collaboration with Dr. T. Colin Campbell, Cornell University and Prof. Richard PETO, University of Oxford since 1983. From late 1980's, he conducted a series of studies on the protective effects of tea on cancer, including laboratory study and human intervention trials. He is the member of the expert panel who wrote the WCRF/AICR report “Food, Nutrition and the Prevention of Cancer: a Global Perspective” (1997). He currently serves as member of several advisory bodies to the Ministry of Health, including cancer, diabetes and food safety. Internationally, he serves as the member of JECFA (FAO/WHO Joint Expert Committee on Food Additives), deputy-director of ILSI (International Life Sciences Institute) Focal Point in China and adjunct professor of the Division of Nutritional Sciences, Cornell University, USA.   Dr. CHEN's research interests focus on nutrition epidemiology studies in the following areas: (1)  Relationship between diet, nutrition and non-communicable diseases in different geographical areas and population groups in China. (2)  The use of food frequency method in nutrition epidemiologic studies. (3)  Studies on the protective effect of edible plant (tea, vegetables, fruits, etc.) components on cancer formation with special emphasis on biomarkers and human intervention trial. Dr. Chen has published more than 120 articles in peer reviewed journals. Editorial Board   Biomedical and Environmental Sciences Editor in Chief         CHEN ChunMing    Chinese Center for Disease Control and Prevention ( China CDC ) Deputy Editor in Chief     chen Junshi George F. Gao yang Gonghuan dong Xiaoping wu Zhaosu China CDC China CDC Chinese Academy of Sciences, CAS China CDC China CDC Beijing Institute of Heart Lung and Blood Vessel Diseases                 Editorial Board    Mohamed ABOUDONIA Gary W. FLAMM Werner KLEIN qiang Zhengfu yang Xiaoguang Durham, USA Vero Beach, Florida, USA Schmallenberg, Germany Beijing, China Beijing, China Wayne W. CARMICHAEL ge Keyou Dennis LEMLY B. RYFFEL yao Chonghua Dayton, USA Beijing, China Blacksburg, USA South Africa Beijing, China José CASTRO Bernard D. GOLDSTEIN Basil K. LEONG shao Yiming yu Senhai Buenos Aires, Argentina Piscataway, New Jersey, USA Portage, USA Beijing, China Shanghai, China chen Bingheng Sidney GREEN li Guangwei Takashi SUGIMURA zeng Guang Shanghai, China Washington DC, USA Beijing, China Tokyo, Japan Beijing, China cHEN Yan Bruce M. GREENBERG li Shaohong Nico P. E. VERMEULEN zeng Yi Shanghai, China Waterloo, Canada Hong Kong SAR, China Amsterdam,Netherlands Beijing, China chen Yude gu Dongfeng liang mifang wang Kean zhang Jianzhong Beijing, China Beijing, China Beijing, China Beijing, China Beijing, China chen Zhenyu Pfister, Herbert lin Dongxin wang Xianlin zhang Qun Hong Kong SAR, China Cologne, Germany Beijing, China Beijing, China Beijing, China Momoko CHIBA hu Dayi Dominique LISON wang Zuoyuan ZHANG WeiHua Tokyo, Japan Beijing, China Brussels, Belgium Beijing, China London, UK Lucio G. COSTA Peter B. HUTT, Esq liu Bingci WU Lin zheng Xiaoying Seattle, USA Washington DC, USA Beijing, China Davis, USA Beijing, China Iwan DARMANSJAH jia Weiping liu lisheng wu Yangfeng zheng Yuxin Jakarta, Indonesia Shanghai, China Beijing, China Beijing, China Beijing, China Jiri DAVIDEK jin Qi liu Xiumei wu Yongning zhu Zonghan Prague, Czech Rupublic Beijing, China Beijing, China Beijing, China Beijing, China J. DESCOTES jin Shuigao ma Guansheng wu Zhenglai   Lyon, France Beijing, China Beijing, China Beijing, China   fang Fude kan Biao N. P. NAPALKOV wu Zhonghao   Beijing, China Beijing, China St. Petersburg, Russia Beijing, China   Walter L. FILHO Meryl H. KAROL Frederick W. OEHME xu Jianguo   Hamburg,Germany Pittsburgh, USA Manhattan, USA Beijing, China             Editorial Office Managing Editor: ZHANG Qun  张群，zhangqun@chinacdc.cn Editors: CAO Yu,    CUI YunShang,   XU YuanYuan,   SHEN XueYing,   ZHANG QiuYun,   ZHANG Ying Address: Editorial Office of Biomedical and Environmental Sciences, Chinese Center for Disease Control and Prevention  155 Changbai Road, Changping District, Beijing 102206, China      Tel: 86-10-58900404, 58900401   Fax: 86-10-58900445  E-mail: besj@263.net      bes@chinacdc.cn  Full Text and Submit Manuscripts: www.besjournal.com                  地址：北京市昌平区昌百路155号，中国疾病预防控制中心，BES杂志编辑部   　邮编：102206