期刊名称：GENE
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
The journal publishes papers on all structural, functional, and evolutionary aspects of genes, chromatin, chromosomes and genomes.
The table of contents for this journal is now available pre-publication, via e-mail, as part of the free ContentsDirect service from Elsevier. Please send an e-mail message to cdhelp@elsevier.co.uk for further information about this service.
Instructions to Authors
Before preparing a paper for submission to Gene, the author(s) should carefully read these instructions, and Gene's List of Abbreviations, thus avoiding needless delays during the editorial process. Papers should be carefully prepared in Gene's style and sent to one of the Editors after having consulted their areas of expertise. Always check the Editors' availability at the time of submission. If the subject of your paper does not coincide with the areas of expertise of any of Gene's Editors, please contact the Managing Editor concerning a possible ad hoc Editor. When a paper is submitted to Gene, the corresponding author is responsible for all authors having seen and approved the original paper and, eventually, the proofs. Papers and figures should be submitted to the chosen Editor in quadruplicate: one set of original figures ready for the printer + three sets of photocopies or three sets of half-tone photos of gels to permit proper refereeing. Floppy disks. Each submission should include an exactly matching version of the text on a floppy disk. This applies also to any subsequent revised versions of the article. Please mark your disk clearly with: first author; title; date of submission/version; wordprocessor used. See `Electronic Manuscripts' below. Important: Authors should also send to the Managing Editor (A. Bernardi, Gif-sur-Yvette; by e-mail or fax): (a) a copy of the title page and Abstract; (b) a copy of the letter of transmittal (see below); (c) the total number of pages of text in the paper, plus the number of figures and tables.
The paper should be accompanied by a letter of transmittal, in which the authors may specify the names of five or more potential referees (including complete addresses, phone and fax numbers, e-mail addresses and areas of expertise). In order to ensure a maximum of objectivity, the names of scientists the authors do not wish to be consulted in the reviewing process can also be provided, as well as any other special requests.
Gene requires all new nucleotide and amino acid sequences to be deposited. Obtain and include an accession number with all sequences. The most convenient method for submitting sequence data is by World Wide Web:
EMBL via Webin: http://www.ebi.ac.uk/embl/Submission/webin.html
GenBank via Bankit: http://www.ncbi.nlm.nih.gov/BankIt/
DDBJ via Sakura: http://sakura.ddbj.nig.ac.jp/
Alternatively, the stand-alone submission tool "Sequin" is available from the EBI at http://www3.ebi.ac.uk/Services/Sequin and from NCBI at http://www.ncbi.nlm.nih.gov/Sequin/
If requested the database will withhold release of data until publication.
If references are quoted as `In press', the relevant manuscript(s) should also be attached. Should authors be requested by the Editor to modify the text prior to publication, the revised version should be submitted within 2 months. After this period, the manuscript will be dealt with as a new one.
SPEED OF PEER REVIEW
All possible effort will be made by the Editors in order to obtain referees' comments rapidly. In principle, the authors will be informed of a decision within 6 weeks.
TYPES OF SUBMITTED PAPER
1.Regular Papers: Not exceeding a total of 25 double-spaced, typewritten pages, including references, tables, figures and their legends. The paper should be divided into: Abstract, Introduction, Materials and Methods, Results, Discussion. The last two sections may be combined.
N.B. Short communications are no longer accepted, but there is no lower limit to the length of Standard Paper manuscripts. Preliminary results or incompletely documented data will, however, not be considered for publication.
2. Reviews or Mini-reviews: will generally be solicited by the Editors of the journal. However, prospective authors interested in contributing such a paper are invited to contact the Editor-in-Chief.
DETAILED INSTRUCTIONS FOR PREPARING PAPERS
Papers should be in perfect English, conform to Gene's style, be typed/printed out entirely double-spaced and carefully proofread by all co-authors. Sections (but not the Abstract) should be numbered 1.1, 1.2, etc. In the text or legends, always refer to the specific section of the paper, ``see section 1.1, or 3.5...' (do not just refer to `the text'). Number all pages.
TITLE PAGE (page No. 1) must be prepared in this order: (a) a brief descriptive title (lower-case); (b) 4--6 key words (only words not already in the title); (c) the name(s) of the author(s) (lower-case; circle complicated or multiple family names); (d) affiliation(s): list the name of the institute, university, department, city, country (underline or italicize); if there is more than one affiliation, use superscript letters directly after the name, to refer to each affiliation; (e) mark the corresponding author with an asterisk and place the Address for Correspondence at the bottom of the page (including full address, phone and fax numbers and e-mail address if there is one); (f) separate footnotes with the present affiliations of author(s) who have moved to a different address; (g) abbreviations: consult Gene's List of Abbreviations and the pertinent literature for accepted abbreviations, especially for genes and proteins; list all those used, even if already in Gene's list (create new abbreviations if necessary). Be meticulous with symbols. For proteins, use Roman letters with at least the first letter capitalized (e.g., Hprt, HPRT or Gal; for genes (or DNA) use italicized letters (e.g., lacZ, hprt, HPRT or cat gene, not HPRTor CAT gene). Consult the nomenclature (or usage) for the particular organism concerned to use (or create) proper gene/protein abbreviations.
ABSTRACT (on a separate page) should be concise,describing the purpose and results of the study, and the final specific conclusions. Explain any abbreviations when used for the first time. Use Gene's style for references in the Abstract (i.e., give the complete sourcereference).
INTRODUCTION must be short and must mainly specify the background and aims of the work (not another Abstract).
MATERIALS AND METHODS should contain all the details necessary to repeat the experimental procedure. Avoid redescribing methods already published; only relevant modifications should be included in the text. All pertinent technical details should be specified and be detailed enough to permit repetition of the experiments. Please add to legends (for figures) or footnotes (for tables) details such as [temp.,time(s), voltage, concentrations, type and % of gel, markers,sizes (bp,kb,kDa), etc.], but outline methods themselves in the main text.
RESULTS and DISCUSSION sections should refer to the data shown in the figures and tables, and briefly discuss their significance. Divide these sections into numbered subsections with short subtitles (lower-case, Roman, not underlined). Where the Results section is combined with the Discussion section, the last subsection, subtitled Conclusions, should be short and be divided into points.
REFERENCES(20-30 per manuscript) should be assembled alphabetically and typed/printed double-spaced. They should be referred to by name and year (Harvard System). More than one citation from the same author(s)and year must be identified by the letters, a, b, c, etc., placed after the year of publication. In the text, when referring to a paper by more than two authors, only the name of the first author should be given, followed by a non-italicized `et al.'. When referring to a personal communication or unpublished paper, all initials and name(s) of all author(s) should be cited, and written permission from these authors should be submitted to the Editor. Literature references (rechecked in the library) must be in accord with a recent Gene issue. Journal titles should be abbreviated according to the `List of Serial Title Word Abbreviations' [1985; ISBN 2-904939-02 8; available from your library or International Serials Data System (ISDS), CIEPS, ISDS International Centre, 20, Rue Bachaumont, 75002 Paris, France].For reviews with a great number of references, employ the system used in Gene Vol. 100 (1991) 13--26.
TABLESshould be numbered 1, 2, 3, etc., and, at the top, bear a short descriptive title. Detailed footnote(s) identified by superscript, a,b,c...., usually one for each major column, should be presented double-spaced under the table.
FIGURESshould be numbered 1, 2, 3, etc., and line drawings (including graphs) should be prepared as laser-quality computer printouts.Send original printouts, not photographs. Only if a laser-qualityprinter is not available (dot matrix printers are unsatisfactory)should you present professionally drawn figures in black ink onwhite paper. Always use large and bold lettering and heavy smoothlines to permit photographic reduction. Ensure that all symbols in the figure are large and match the explanations in the legend. Sequence figures should be either 60 nucleotides (or amino acids)in width (to fit into a single printed column), or 120--150 nt. As a rule no more than a single page is allowed for sequence figures. Add bp, nt, kb or kDa symbols above the numerals in marker lanes. Legends should be typed/printed double-spaced, on pages separate from the figures themselves. The maximum size of figures is A4:present larger figures on two or more sheets.
Colour illustrations are reproduced at the author's expense (the publisher will provide the author with a cost estimate upon receipt of the accepted paper). In review articles, colour illustrations will be reproduced free of charge if essential for the presentation of results. This will be at the discretion of the Editor-in-Chief.
Instructions for authors regarding GenBank/DNA sequence linking
DNA sequences and GenBank Accession numbers
Many Elsevier journals cite 'gene accession numbers' in their running text and footnotes. Gene accession numbers refer to genes or DNA sequences about which further information can be found in the databases at the National Center for Biotechnical Information (NCBI) at the National Library of Medicine. Elsevier authors wishing to enable other scientists to use the accession numbers cited in their papers via links to these sources, should type this information in the following manner:
For each and everyaccession number cited in an article, authors should type the accession number in bold, underlined text. Letters in the accession number should always be capitalized. (See Example 1 below). This combination of letters and format will enable Elseiver's typesetters to recognize the relevant texts as accession numbers and add the required link to GenBank's sequences.
Example 1: '(GenBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T-cell lymphoma (GeneBank accession no. AA361117)'.
Authors are encouraged to check accession numbers very carefully. An error in a letter or number can result in a dead link..
In the final version of the printed article, the accession number text will not appear bold or underlined (see Example 2 below).
Example 2: 'GenBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accessionno.BE675048), and a T-cell lymphoma (GenBank accession no. AA361117)'.
In the final version of the electronic copy, the accession number text will be linked to the appropriate source in the NCBI databases enabling readers to go directly to that source from the article (see Example 3 below).
Example 3: 'GeneBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE67048), and a T-cell lymphoma (GenBank accession no. AA361117)').
PROOFREADING
Proofreading should be done carefully. Please note that it is the publisher's policy that only printer's errors may be corrected: no changes in, or additions to, the edited manuscript will be accepted.
NO PAGE CHARGES. There will be no page charges.
OFFPRINTS
Twenty-five offprints of each paper will be provided free of charge. Additional copies may be ordered at the prices shown on the Price List which will be sent by the publisher to the author together with the offprint order form upon receipt of the accepted manuscript.
ELECTRONIC MANUSCRIPTS
Electronic manuscripts have the advantage of not requiring rekeying of text, resulting in reliable and fast delivery of proofs. The preferred storage medium is a 5.25 or 3.5 inch disk in MS-DOS format, although other systems are welcome, e.g., Macintosh (in this case, save your file in the usual manner, do not use the option `Save in MS-DOS format'). Please specify the type of computer and word processing package used (do not convert your text file to plain ASCII). Ensure the letter ``l' and digit ``1' (also letter O and digit 0 ) have been used properly, and format your article (tabs, indents, etc.) consistently. Characters not available on your wordprocessor should not be left open, but indicated by a unique code (e.g., gralpha, @, #, etc., for the Greek letter ). Such codes should be used consistently throughout the entire text. Make a list of such codes and provide a key. Do not allow your wordprocessor to introduce word splits and do not use a `justified' layout. Please adhere strictly to the general instructions on style/arrangement and, in particular, the reference style of the journal. Further information may be obtained from the Issue Manager of Gene, Elsevier, P.O. Box 2759, 1000 CT Amsterdam, The Netherlands; e-mail: l.koning@elsevier.nl; Fax: +31 (20) 485 2459.
INFORMATION FOR AUTHORS
Authors can keep a track on the progress of their accepted article, and set up e-mail alerts informing them of changes to their manuscript's status, by using the "Track a Paper" feature of Elsevier's Author Gateway
Editorial Board
Editor-in-Chief:
G. Bernardi, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy. Fax: +39 081 2457 294, Email: gene@szn.it
Managing Editor:
A. Bernardi, B.P. 224, 91192 Gif-sur-Yvette Cedex, France. Fax: +33 1 6012 3080, Email: Alberto.Bernardi@wanadoo.fr
Reviews Editor:
A. Van Wijnen, University of Massachusetts, Department of Cell Biology, Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA Tel: +1 (508) 856 5942, Fax: +1 (508) 856 6800, Email: Andre.VanWijnen@umassmed.edu
Founding/Honorary Editor:
W. Szybalski
Editors: Areas of expertise:
F.G. Alvarez-Valin, Sección Biomatemática, Igua 4225, 11400 Montevideo, Uruguay. Molecular evolution, DNA sequence analysis, Trypanosomatidae evolution. Tel: +598 (2) 525 8618, Fax: +598 (2) 525 8617, Email: falvarez@fcien.edu.uy
E. Boncinelli, Director, International School for Advanced Studies, Via Beirut, n.2-4, 34014 Trieste, Italy. Development, homeobox, regulatory genes; pattern formulation; gene expression in development; brain; gastrulation. Tel: +39 (040) 378 7581, Fax: +39 (040) 378 7528, Email: bonci@sissa.it
A.M. Campbell, Department of Biological Sciences, Stanford University, Stanford CA 94305, USA, Prokaryotic genetics; prokaryotic molecular biology . Tel: +1 (0650) 723 1170, Fax: +1 (0650) 725 1848, Email: fa.amc@stanford.edu
H. Cedar, Department of Cellular Biochemistry, Hebrew University of Jerusalem, Jerusalem 91120, Israel. DNA methylation; replication timing; DNA replication origins; imprinting; allelic exclusion; X chromosome. Tel: +972 (2) 758 167, Fax: +972 (2) 415 848, Email: cedar@md2.huji.ac.il
O. Clay, Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy. DNA sequence analysis and computer simulations. Tel: +39 081 583 3314, Fax: +39 081 764 1355, Email: clay@infobiogen.fr
D.L. Court, Molecular Control and Genetics, National Cancer Institute, Bldg. 539 - NCI/FCRDC, Frederick, MD 21702, USA. Bacterial genetics; bacteriophage; bacterial gene regulation; double-stranded RNA; post-transcriptional controls. Tel: +1 301 846-5940, Fax: +1 301 846-6988, Email: court@ncifcrf.gov
J. Deutsch, Universit?P et M Curie, "Développement et Évolution case 241, 9 quai St-Bernard, 75252 Paris Cedex 05, France Evo-Devo; molecular evolution (proteins); chromatin regulation in Drosophila (Pc-G and trx-G genes) Tel: +33 1 44 27 25 76, Fax: +33 1 44 27 32 58, Email: jdeutsch@mail.snv.jussieu.fr
R. Di Lauro, Stazione Zoologica Anton Dohrn, Lab. of Biochem. and Molecular Biology, Villa Comunale, 80121 Napoli, Italy. Gene expression; transcription factors; differentiation; development; human genetics. Tel: +39 081 5833 278, Fax: + (081) 5833 285, Email: dilauro@alpha.szn.it
B. Dujon, Unit?de Génétiique Moléculaire des Levures, CNRS URA 1149, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris-Cedex 15, France, Yeast, chromosome; genome; sequence ; genetics. Tel: +33 (1) 4568 8482, Fax: +33 (1) 4061 3456, Email: bdujon@pasteur.fr
M D'Urso, Institute of Genetics and Biophysics, "A. Buzzati-Traverso", CNR, Via G. Marconi 10, 80125 Naples, Italy, Genetic diseases; gene expression; X inactivition; genomics; DNA sequencing. Tel: + 39 (081) 7257 247 297, Email: durso@iigbna.iigb.na.cnr.it
J.A. Engler, Department of Biochemistry and Molecular Genetics, University of Alabama, Room 460 BHSB, Birmingham AL 35294-0005, USA. DNA virology; gene cloning and in vitro mutagenesis; DNA sequencing. Tel: +1 (205) 934 4734, Fax: +1 (205) 934 0758, Email: jengler@bmg.bhs.uab.edu
D. Finnegan, University of Edinburgh, Michael Swann Building, The Kings Buildings, Mayfield Road, Edinburgh, UK EH9 3JR, Drosophila; transposable elements; retrotransposition; epigenic regulation. Tel: +44 (131) 650 5377, Fax: +44 (131) 650 8650, Email: D_Finnegan@ed.ac.uk
D.H.A. Fitch, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA molecular systematics, molecular adaptation, gene duplications, C. elegans genomics, evolution of development Tel: +1 212 998 8254, Email: david.fitch@nyu.edu
K. Gardiner, Eleanor Roosevelt Institute Cancer Research, 1899 Gaylor Street, Denver CO, USA, Human chromosome 21; genome organization; Downs syndrome; transcribed sequence identification; physical mapping. Fax: +1 (303) 333 8423, Email: gardiner@eri.uchsc.edu
T. Gojobori, Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan. Molecular evolution; bioinformatics. Tel: +81 (559) 81 6847, Fax: +81 (559) 81 6848, Email: tgojobor@genes.nig.ac.jp
D. Higgs, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK. Haemoglobin genes, long-range chromosone structure, chromatin structure, chromosome 16 Tel: +44 (1865) 222393, Fax: +44 (1865) 222500 , Email: drhiggs@molbiol.ox.ac.uk
B. Hohn, Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. Plant genomics, plant genome flexibility, homologous recombination in plants, Agrobacterium tumefaciens mediated T-DNA transfer to plants. Tel: +41 (61) 697 6651, Fax: +41 (61) 697 3976, Email: hohnba@fmi.ch
V. Larionov, Laboratory of Biosystems and Cancer, Genome Structure and Function Section, National Cancer Institute, NIH, Bldg. 37, Room 5032, Bethesda, MD 20892-4264, USAYeast chromosome transmission; extrachromosomal DNA; yeast artificial chromosomes or YACs; cloning of mammalian DNA in yeast as YACs; recombination/replication; physical mapping of human chromosomes; gene isolation. Tel: +1 301 496 7941, Fax: +1 301 480 2772, Email: larionov@mail.nih.gov
W. Makalowski, 514 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA Molecular evolution, bioinformatics, repetitive elements, computational biology, comparative genomics Tel: +1 (814) 865 5025, Fax: +1 (814) 865 9366, Email: wojtek@psu.edu
W. Martin, Institute of Botany III, University of Düsseldorf, Universitätsstr.1, 40225 Düsseldorf, Germany, Plant molecular genetics; primary metabolism; molecular evolution; endosymbiosis; organelle-to-nucleus gene transfer; introns. Tel: (00) +49 (211) 811 3011, Fax: (00) +49 (211) 811 3554, Email: w.martin@uni-duesseldorf.de
S.M. Mirkin, Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, 900 South Ashland Ave., Chicago, IL 60607, USA DNA replication; DNA structure and topology; trinucleotide repeat diseases; transcription; protein-DNA interaction Tel: +1 312 996 9610, Fax: +1 312 413 0353, Email: mirkin@uic.edu
G. Pesole, Dipartimento di Fisiologia e Biochmica Generali, University of Milan, via Celoria 26, 20133 Milan, Italy. Bioinformatics, mRNA untranslated regions, mitochondrial DNA, molecular evolution, DNA sequence analysis, molecular databases. Tel: +39 (02) 583 54915, Fax: +39 (02) 583 54912, Email: graziano.pesole@unimi.it
A. Roger, Department of Biochemistry and Molecular Biology, Dalhousie University, Rm 8B4 Sir Charles Tupper Medical Building, 5859 University Avenue, Halifax, NS B3H 4H7, Canada Molecular evolution; protist gene and genome evolution; anaerobic metabolism; phylogenetics; organelle evolution Tel: +1 902 494 2620, Fax: +1 902 494 1355, Email: roger@hades.biochem.dal.ca
F. Salvatore, Department of Biochemistry and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy human genetics; mutation detection; gene expression; molecular medicine; molecular aspects of hereditary and acquired diseases at gene level Tel: +39 081 7464 966, Fax: +39 081 7463 650, Email: salvator@unina.it
S. Salzberg, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville MD 20850, USA, Bioinformatics; computational gene finding; comparative genomics; sequence alignment; sequence analysis. Tel: +1 (301) 315 2537, Fax: +1 (301) 838 0209, Email: salzberg@tigr.org
M. Schartl, Physiologische Chemie I, Biozentrum der Universitat Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany, Teleost and elasmobranch gene structure and genomic organization; receptor tyrosine kinases; signal transduction; tumour-related genes; oncogenes; tumour suppressor genes in lower vertebrates; transgenic fish and gene transfer methods; homologous recombination and 'knock-out' approaches in lower vertebrates. Tel: (00) 49 931 888 4148, Fax: (00) 49 931 888 4150, Email: phch1@biozentrum.uni-wuerzburg.de
C.W. Schmid, Section of Molecular and Cellular Biology, University of California, Davis, CA 95616-8535, USA. DNA methylation; RNA polymerase III(Pol III); cell stress; SINEs and LINEs; retrotransposition. Tel: +1 530 752-3003, Fax: +1 530 752-3085, Email: cwschmid@ucdavis.edu
T. Sekiya, Translational Research Department, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya Machida, Tokyo, Japan Tel: +81 (42) 724 6222, Fax: +81 (42) 729 1252, Email: sekiya@libra.ls.m-kagaku.co.jp
A. Sippel, Institut für Biologie III, University of Freiburg, Schanzlestrasse 1, 79104 Freiburg, Germany. Cell-specific activation of gene loci; differeentiation of hematopoietic cells; chromatin organization of eukaryotic genes. Tel: +49 (761) 2032 760, Fax: +49 (761) 2032 745, Email: sippel@sun1.biologie.uni-freiburg.de
D.A. Tagle, Program Director, Neurogenetics, National Institute of Neurological Disorders and Stroke, NIH, Neuroscience Center, Room 2133, 6001 Executive Boulevard, Bethesda, MD 20892-9527, USANeurogenetics; structural genomics; functional genomics; comparative genomics; gene transfer; animal models Tel: +1 301 496 5745, Fax: +1 301 402 1501, Email: tagled@ninds.nih.gov
G. Theißen, University of Jena, Lehrstuhl for Genetics, Philosophenweg 12, D 07743 Jena, Germany Plant evolutionary developmental genetics; genetics of inflorescence and flower development; plant transcription factors; MADS-box genes; evolution of gene families; genetic aspects of biodiversity Tel: +49 3641 9 49550, Fax: +49 3641 9 49552, Email: guenter.theissen@uni-jena.de
A. Travers, MRC, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. Chromatin structure and function, bacterial transcriptional regulation, DNA structure. Tel: +44 (1223) 402419, Fax: +44 (1223) 412142, Email: aat@mrc-lmb.cam.ac.uk
A.J. Van Wijnen, University of Massachusetts, Department of Cell Biology, Medical Center, 55 Lake Avenue North, Worcester MA 01655, USA Cell cycle control; bone cell biology; transcriptional control of gene expression; chromatin and nuclear matrix; histone; osteoblast; homeodomanin. Tel: +1 (508) 856 5942, Fax: +1 (508) 856 6800, Email: Andre.VanWijnen@umassmed.edu
S. Yokoyama, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road, Emory University, Atlanta, GA 30322, USA, Moleuclar evolution; opsin; visual pigment and function; DNA sequencing; sequence analysis; vertebrate vision. Tel: +1 (404) 727 5379, Fax: +1 (404)) 727 2880, Email: syokoya@emory.edu
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