期刊名称：JOURNAL OF EXPERIMENTAL MEDICINE ISSN： 0022-1007 版本： SCI-CDE 出版频率： Monthly 出版社： ROCKEFELLER UNIV PRESS, 950 THIRD AVE, 2ND FLR, NEW YORK, USA, NY, 10022   出版社网址： http://jem.rupress.org/ 期刊网址： http://jem.rupress.org/ 影响因子： 14.307 主题范畴： IMMUNOLOGY;    MEDICINE, RESEARCH & EXPERIMENTAL 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal  The Journal of Experimental Medicine emphasizes studies on physiologic, molecular, and pathogenic mechanisms in such areas as immunology and inflammation, microbial pathogenesis, oncology, hematopoiesis, connective tissue and vascular biology. Sufficient space is provided to document conclusions and to describe insights at the level of the cell and organism. All animal and human studies must be approved by the authors' Institutional Review Board(s), and a statement to this effect must be included in Materials and Methods. All clinical investigation must have been conducted according to the principles expressed in the Helsinki Declaration.   Instructions to Authors Format We encourage online manuscript submission. If submitting hardcopy, four "original" copies, each with production quality figures, should be provided along with a disk containing a file with the full text of the manuscript and figure files. Total character counts must be included on the title page. The "Manuscript Submission Form" [download PDF version] and the "Manuscript Content Verification and Provisional Copyright Assignment and Publication Agreement" [download PDF version] must accompany all manuscript submissions. Manuscripts must be paginated throughout. They should include, in order, (1) an Abstract of no more than 200 words that provides a clear statement of the findings and thrust of the data; (2) an Introduction that explains the origin and goal of the research but is not an exhaustive review of the literature nor a detailed summary; (3) a Materials and Methods section that provides sufficient guidance to repeat and extend the experiments (all reagents must be accessible to others in the scientific community); (4) Results, in which the text is presented with accurate subheadings and all the illustrative material is new, fully labeled, and essential; and (5) a Discussion that enriches but does not repeat the material covered in the previous section. Results and Discussion sections may be combined, especially in Brief Definitive Reports. Article Length Calculation When estimating article length based on character count, include all text such as title page, abstract, legends, and references. Spaces should be included in the count. 1 journal text page = ~6,000 characters Full page figure or table = ~6,000 characters 1/2 page figure or table = ~3,000 characters 1/4 page figure or table = ~1,500 characters Full papers must not exceed 12 pages (72,000 characters or equivalent) and should contain no more than 80 references. Brief Definitive Reports must not exceed 6 pages (36,000 characters or equivalent) with no more than 5 display items and a maximum of 30 references. Calculation example: If an author submits a manuscript with 28,000 text characters (including spaces), two 1/4 page figures, and one 1/2 page table 28,000 + 1,500 +1,500 + 3,000 = 34,000 characters (5.67 pages) Failure to adhere to these requirements may result in the return of papers without review and/or publication delays of accepted papers. Statement Regarding Prior Publication Submission of a manuscript means that no similar paper has been or will be submitted elsewhere. A cover letter listing the name, address, phone and fax numbers, and email address of the corresponding author must accompany the manuscript. The cover letter must include or be accompanied by a statement from the corresponding author affirming that all authors concur with the submission and that the material submitted for publication has not been previously reported and is not under consideration for publication elsewhere. Any change in authorship or the title during or after the course of review will have to be approved by all authors. Pertinent unpublished articles must be included to aid reviewers and should be clearly marked so as not to be confused with the actual manuscript. Conflict of Interest All authors are expected to disclose any commercial affiliations or consultancies, stock or equity interests, or patent-licensing arrangements that could be considered to pose a conflict of interest regarding the submitted article. Specifics of such disclosures will remain confidential. If appropriate, general statements in the Acknowledgments section of the manuscript regarding such disclosures may be recommended by the Editors. All funding sources, institutional and corporate, should be credited in the Acknowledgments section. Review Process A two-tiered editorial process is used to deal as rapidly as possible with receipt of potentially acceptable papers that substantially exceed the space available for publication. In the first tier, the paper is evaluated by at least two editors and/or referees and the analyses are discussed at weekly meetings, at which time the manuscripts competing for space are compared. Emphasis is placed on rapid acceptance of some papers and return of others on a priority basis. It is the Journal's policy not to return written critiques with most of the latter papers, because decisions based on the difficult judgment of priority do not generate critiques that are helpful to the authors. In the second tier of the review process, papers are sent to referees to obtain further review and assessment of priority. Every effort is made to complete the first tier within 10 days and the full review process within one month of receipt of the manuscript. Confidentiality. The peer review process rests on the assumption that all manuscripts will be treated as privileged information, which cannot be divulged to other parties. A reviewer may request additional advice from another party, subject to the general principle of confidentiality and notification of the editorial office. Submission Fee The Journal charges a $50.00 handling fee for each new manuscript submission, which must accompany the submission of the original manuscript. Checks must have micro-encoding at the bottom, be drawn on a US bank, and be made payable to The Rockefeller University Press-JEM. The handling fee may also be charged to MasterCard, VISA, American Express, or Discover. Purchase orders will not be accepted for submittal fees. Page Charges for Accepted Manuscripts A basic page charge of $55.00 is made for each printed page. An author's ability to honor page changes will not affect publication. The cost for separation and printing of color figures is $700 for the first page and $350 for each additional page. Submission of Sequences The Journal will publish nucleic acid sequences only if the data have been submitted to GenBank/EMBL/DDBJ and have a database accession number. The DNA databases share information, so submission to one database is sufficient. It is recommended that authors obtain the blank sequence submission form (see instructions below) while writing the manuscript, and send the completed form to EMBL, GenBank, or DDBJ when the manuscript is submitted to the editorial office for review. The last line of the sequence's legend should read: "These sequence data are available from GenBank/EMBL/DDBJ under accession no. ______." If the number is not available in time to include it on the typescript, the author can fill in the number during the page proof stage. GenBank can provide an accession number within 24 hours of receipt of submission. Submission information is available at: GenBank http://www.ncbi.nlm.nih.gov/Genbank EMBL http://www.ebi.ac.uk/embl DNA Databank of Japan (DDBJ) http://www.ddbj.nig.ac.jp Style Capitalize trade names and indicate registered trademarks. Give the formal, chemical name of a compound as established by the international convention after the first use of the trivial name. Thereafter, the trivial name may be used. For special materials and equipment, give the manufacturer's name. Use metric system and the Systeme International d'Unites (SI) as noted in the Standard Abbreviations list. For biochemical abbreviations, use those currently recommended by The Journal of Biological Chemistry in its instructions to authors. When nonstandard abbreviations must be used, define them at first mention. Abbreviate units of measure only when used with numbers. Specify estimates of variance (e.g., SD, SE) and give references for statistical methods. Italicize genes and loci. For mouse H-2 genetics, authors should consult the revised nomenclature in Mouse Genome 92 (2) June 1994 and in Genetic Variants and Strains of the Laboratory Mouse, 3rd Edition. Current nomenclature is available online from The Jackson Laboratory through GBASE, Gopher, and World Wide Web. TCR Nomenclature. Nomenclature for TCR gene segments should follow the recommendations of the WHO-IUIS Sub-Committee on TCR Designation (Bull. WHO . 1993 71[1]:113). Title Page List the title, full names of all authors, department(s), institution(s), city, state, postal code, and country where the work was performed. Furnish a condensed title of not more than 72 characters and spaces, without abbreviations, as a running foot. Include a word and/or character count for the manuscript. Refer to a preliminary report or abstract in a footnote to the title. State the complete name, address, phone and fax numbers, and email address of the author to whom reprint requests and page proofs should be addressed. If you wish to have two corresponding authors listed for the paper, you must designate one of them to communicate with the editorial and production offices. State the source(s) of support in the form of grants, equipment, or drugs on a separate Acknowledgments page. Include a list of five key words that are not included in the title. Use standard MeSH-Medline major subject headings. These headings are in the volume Medical Subject Headings: Supplement to Index Medicus, which is found in all major libraries or at http://www.nlm.nih.gov/mesh Footnotes Designate footnotes to author/affiliation sections using superscript numbers. Designate footnotes to tables using lowercase superscript letters. References Type references double-spaced on a sheet separate from the text and number them in the order in which they appear in the text. References should not be included in the Abstract except where unavoidable, and then should be given parenthetically and in full. Do not format references as endnotes. Include all the authors' names (do not use "et al.", complete article titles, and articles in press with inclusive pagination. Abbreviate the names of journals according to PubMed. Spell out the names of unlisted journals. Numbered references are only to published material. Citations to "unpublished data" should be indicated (parenthetically) within the text as such and are not enumerated. Other phrases, such as "manuscript submitted", "manuscript in preparation", "unpublished observations", etc. should not be used. In consultation with the Editors, additional data may be published as Online Supplemental Material. When the source of the unpublished data is a person(s) who is not an author of the article under consideration, those data must be cited as a "personal communication", in which case the authors must provide a signed letter of permission to cite the the personal communication. Adhere to the format provided by the following examples: Journal Articles Two authors 1. Bevan, M., and P. Fink. 1978. The influence of thymus H-2 antigens on the specificity of maturing and killer and helper cells. Immunol. Rev. 42:3-19. More than two authors 2. Julius, M., E. Simpson, and L. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived lymphocytes. Eur. J. Immunol. 3:645-649. In press 3. Myers, L.K., J.M. Stuart, and A.H. Kang. 1990. A CD4 cell is capable of transferring suppression of collagen-induced arthritis. J. Clin. Immunol. In press. Online Peer-reviewed References Published article with only DOI 4. Tang, C., and J.P. Klinman. The catalytic function of bovine lysyl oxidase in the absence of copper. (June 6, 2001) J. Biol. Chem. 10.1074/jbc.C100138200 Published article with both DOI and pagination 5. Prowse, C.N., and J. Lew. 2001. Mechanism of activation of ERK2 by dual phosphorylation. J. Biol. Chem. 276:99¨C103. First published on October 2, 2000; 10.1074/jbc.M008137200 Complete Books 6. Myant, N.B. 1981. The Biology of Cholesterol and Related Steroids. Heinemann Medical Books, London. 882 pp. Articles in Books 7. Pink, J.R.L., O. Lassila, and O. Vainio. 1987. B-lymphocytes and their self-renewal. In Avian Immunology. A. Toivanen and P. Toivanen, editors. CRC Press, Inc., Boca Raton, FL. 65-78. Abstract 8. Packman, C.H., S.I. Rosenfeld, and J.P. Leddy. 1981. Inhibition of the C8/C9 steps of complement lysis by a high density lipoprotein (HDL) of human serum. Fed. Proc. 40:976a. (Abstr.) Abbreviations The Journal publishes a Standard Abbreviations list at the front of most issues. These Standard Abbreviations (e.g., IL, IFN, HIV) do not need to be spelled out within papers (except in the Abstract). However, in using nonstandard abbreviations, the full term should be spelled out on first appearance and the abbreviation should be used consistently thereafter. Illustrations General. Illustrations must be clearly labeled and cited in numerical order in the text. Printed illustrations must not exceed the Journal page dimension of 17.5 x 23.5 cm and should be originals. Micrographs should be planned so that they may be reproduced without reduction. Single-column figures must not exceed 8.25 x 23.5 cm. Double-column figures must not exceed 17.5 x 23.5 cm. Include the name of the corresponding author, figure number, and indicate the top of the figure on the reverse side. Original figures will not be returned to authors after publication. Gels. Plan labeling so that upon reduction the height of numbers and capital letters will be 1.75 mm and lane width will be 5 mm. Micrographs. Limit the field of the micrograph to the structures specifically discussed in the report. Be sure that symbols and areas of special interest are not too close to the edges and that the corners are squared. Include magnifications in the legend. Labeling should be Helvetica or Arial Bold, 10 pt. Symbols used on the micrograph must be explained in the legend. On the reverse of each figure of the reproduction set, indicate the top of the figure. Line Drawings. Provide original computer-generated drawings or sharp glossy prints. They will be reduced to one column (8.25 cm) or less when practical. Make lettering sans serif and of such size that capitals, numbers, and symbols will reduce to a height of 1.5-1.75 mm. Use the Journal's standard abbreviations (h, min) in axis labels. Color Illustrations. Use bendable, reflective art. The cost for separation and printing of color figures is as follows: first page, $700; additional pages, $350 per page. FACS Tracings. Label both axes and provide some measure of quantitation, e.g., log10 fluorescence, to make clear the ratio of fluorescence intensity between peaks. Digital Images Image acquisition and manipulation. No specific feature within an image may be enhanced or moved. The grouping of images from different gels, fields, or exposures must be made explicit by the arrangement of the figure and in the text of the figure legend. Adjustments of brightness, contrast or color balance are acceptable, if they are applied to the whole image. Non-linear adjustments (e.g., gamma settings) must be disclosed in the figure legend.   All digital images in manuscripts accepted for publication will be scrutinized by our production department for any indication of improper manipulation. Questions raised by the production department will be referred to the Editors, who will request the original data from the authors for comparison to the prepared figures. Cases of deliberate misrepresentation of data will be reported to the corresponding author's home institution or funding agency. "Digital Expert". Authors can use Digital Expert Online (a free service provided by The Sheridan Group) to check whether their image files comply with our formatting guidelines. Filenames. The filename of each figure should begin with the eight-digit manuscript number assigned during the review process (or the corresponding author's name if submitted prior to review) followed by an underscore(_) and the number of the figure (and the panel letter if the file is only part of a figure). The three-letter suffix should indicate the file format. For example, if your assigned manuscript number is 20001234, the file for Figure 2 panel A should be named "20001234_2A.TIF" or "20001234_2A.EPS." Grayscale Art. Submitted digital halftones must have an image resolution of at least 300 dpi at publication size. To check the size and resolution of the image in Adobe Photoshop, select "Image Size" in the "Image" menu. Make sure the "Resample Image" box in "Image Size" dialog window is not checked and the "Width", "Height", and "Resolution" boxes are linked by the graphic chain. (It may be necessary to click twice on the "Resample Image" box to establish this link.) This will mean that no resolution (i.e., dots or data) is lost when reducing the dimensions of an image and that dots are not added to an image when increasing its dimensions. Set the print size to the desired size of the image in the printed journal and make sure that the resolution at this size is above 300 dpi. Please submit in the TIFF format by selecting this choice in the format box of the "Save" dialog window. Continuous-Tone Color Art. As above, resolution should be at least 300 dpi, dot gain 12%, and tonal range 2-98%. We can only use files in the CMYK format; make certain the hardcopy is created with the same CMYK mode. Acceptable file formats are EPS or TIFF files (both must be openable in Adobe Photoshop). Although every attempt will be made to match the colors, software may not print uniformly across different platforms, and requests to rescan art to match color will be charged to the author. Line Art. Vector files created in illustration programs such as Adobe Illustrator, Macromedia Freehand, CorelDRAW, Deneba Canvas, etc., must be saved and submitted in EPS or TIFF format at a minimum resolution of 1,000 dpi. Only Times, Helvetica, Arial, or Symbol fonts should be used. All fonts should be converted to outlines or paths, eliminating the possibility of character loss or change. To do this in Illustrator, select the text object and go to Type/Create Outline; in Freehand, select text object and go to Text/Convert to Paths; in Canvas, select text object and go to Object/Path/Convert to Path; in CorelDRAW, select text object and go to Arrange/Convert to Curves. For details, please see the instruction manual for your specific application. All color art MUST be in CMYK format. Color or Grayscale with Fonts or Lines. 1) Import grayscale or color image (minimum 600 dpi at publication size) into Adobe Photoshop (or similar program). (2) Crop the image. (3) In the "Layers" menu, select "New Layer." (4) Create labels in the new layer (make sure the anti-aliased box in the "Type Tool" window is not checked). (5) Save as a TIFF file. ftp Instructions. The ftp server should only be used when specifically requested by a production editor. For Windows users, we recommend using Internet Explorer: direct your browser to ftp://ftprup.rockefeller.edu/JEM/. For Mac users, use an ftp client such as Fetch. The ftp address for the production office is ftprup.rockefeller.edu, and files should be uploaded to the "JEM" directory via anonymous ftp. Please note, all files uploaded are confidential, and the server is protected from unauthorized downloads. Authors will not be able to download any files in the Inbox (including their own). Please alert your Production Editor via email after all files have been transferred. Online Supplemental Material The Journal can post supplemental materials at www.jem.org. Videos. Videos must be cited both at the relevant place in the text of the Results section, and in the legends of any figures that contain video stills or images related to the video. In addition, an "Online Supplemental Material" paragraph, providing a brief description of each video, must appear at the end of the Materials and Methods section. Each video must also be accompanied by a text legend. Videos must be peer reviewed with the manuscript. Videos must be QuickTime files no larger than 10 MB. We recommend Sorenson or Cinepak compression, although other codecs may be used. However, please do not use Intel Indeo because of incompatibilities across platforms. Color depth should be kept to a minimum, using grayscale for black and white videos. Frame size should be limited to 450 x 375 pixels for best viewing within a browser on most monitors. Videos should be named by order of citation appearance (e.g., video1.mov). If a video is directly related to a figure or table, name accordingly (e.g., Fig4video3.mov). Lengthy file names should be avoided. For hard copy submissions, include copies of video files on four separate CDs or ZIP disks with your original manuscript submission. Figure Legends Include a short title after the figure number. In addition, a short explanation may be given in sufficient detail to make the data intelligible without reference to the text (ideally figure legends should be no more than 150 words). Methods described in detail in the Materials and Methods section should not be repeated in the legend. A key to the symbols used in the figure must be included if the key is not already indicated in the figure itself. Tables Type double-spaced on sheets separate from the text. Tables should be self-contained and self-explanatory. Provide a title for the table. Use superscript lowercase letters for footnotes. Give sufficient explanation and detail in the legend to make the experiment or procedure intelligible without reference to the text. Do not use vertical lines; do not submit photographs of tables. Tables with different material in the boxheads should be submitted as individual tables (e.g., Tables 1, 2, 3) and not as sections of one table (e.g., Table IA, IB, IC). Cover Submissions Authors may submit cover images for consideration. Black-and-white and color submissions are both welcome. Cover submissions should be unmounted, with orientation indicated on the back of the image if necessary, and a brief cover legend should be submitted with the image. Authors may submit as many versions of their subject as they wish. Additional information can be obtained from the editorial office (Phone: 212-327-8575; FAX: 212-327-8511; email: jem@rockefeller.edu). Publication Time With the cooperation of the authors at the time of page proofs, full papers are published as quickly as possible, generally within 8 to 12 weeks of acceptance and Brief Definitive Reports within 6 to 8 weeks. The Journal does not prioritize manuscripts that are accepted for publication, but publishes papers in the order in which authors' corrected proofs are received by the Production Office. Disks To expedite the review process, we encourage online submission. If you choose to submit via mail, the Journal requires authors to submit a floppy, CD, or ZIP disk containing the manuscript with the original submission. An updated disk must also accompany the final revised version of the manuscript. Although most word processing formats are acceptable, Microsoft Word files are preferred. When preparing your files, please be aware of the following guidelines:    • Do not try to achieve a 'typeset' look, as most formatting will be removed during the production process and may interfere with file conversion.    • Please DO NOT use the "Insert Symbol" palette in Word. Instead, key in Greek or special characters using Symbol font.    • Use your software's built-in superscript and subscript attributes rather than changing a character's font size/position. Proofs and Offprints Proofs. Galley proofs are either emailed (as a PDF attachment) or faxed or to the corresponding author, along with instructions on handling text and figure proofs. Proofs must be returned within 48 hours. An Authors' guide will be provided with information on authors' charges for offprints and special services. The cost of authors' text alterations in proof is $4.00 per change. Figure reshoots at the author's request will be charged at $20.00 per black & white image, and $90.00 per color image. Offprints. Authors may purchase offprints of their articles; an order form, which must be returned before the journal goes to press, will be sent with the galley proof. Online submission To submit new and revised manuscripts online, from the Journal of Experimental Medicine home page at www.jem.org, click the "Submit Online" button. OR Submission Address Direct new and revised manuscripts and questions about manuscripts in review to: The Journal of Experimental Medicine Submissions Editorial Office The Rockefeller University Press 1114 First Avenue New York, NY 10021-8325 Phone: (212) 327-8575, Fax: (212) 327-8511 email: jem@rockefeller.edu Each manuscript is acknowledged by the editorial office. The author should notify the office if acknowledgment is not received within a reasonable time. Production Address All correspondence concerning the copyediting and production of accepted manuscripts, as well as requests for permission to reproduce figures or portions of text, should be addressed to: The Journal of Experimental Medicine Production Office The Rockefeller University Press 1114 First Avenue New York, NY 10021-8325 Phone: (212) 327-8527, FAX: (212) 327-8513 email: jexpmed@rockefeller.edu Submission Forms The following forms are required with manuscript submission: Manuscript Submission Form [Download PDF version] Manuscript Content Verification and Provisional Copyright Assignment and Publication Agreement [Download PDF version] Assignment of copyright Under the current copyright law, implicit understanding that an author's submission of an article carries with it assignment of copyright is not sufficient. Therefore, all submissions must include the Journal's Manuscript Content Verification and Provisional Copyright Assignment and Publication Agreement form. Editorial Board Frederick W. Alt K. Frank Austen Marco Baggiolini Jacques Banchereau Albert Bendelac Michael J. Bevan Christine Biron Christian Bogdan Thierry Boon Thomas J. Braciale Hal E. Broxmeyer Michael Carroll Yongwon Choi Robert L. Coffman Jason Cyster Lisa Denzin Keith Elkon Victor H. Engelhard Ferric Fang Douglas T. Fearon Ten Feizi Olivera J. Finn Vincent A. Fischetti Amanda Fisher John Fraser Shu Man Fu Stephen J. Galli Ronald N. Germain Laurie H. Glimcher Christopher Goodnow Siamon Gordon Emil C. Gotschlich Sergio Grinstein Pierre A. Henkart David D. Ho Tasuku Honjo Kayo Inaba Ralph Isberg Elliott Kieff Gary Koretzky Vijay K. Kuchroo Tomohiro Kurosaki Lewis L. Lanier Antonio Lanzavecchia Michael J. Lenardo Klaus F. Ley Xiaojing Ma H.R. MacDonald Linda MacPhail Bernard Malissen Philippa Marrack Diane Mathis Lloyd F. Mayer Ira Mellman Louis H. Miller John P. Moore Muriel Moser Michael Neuberger Victor Nussenzweig Anne O¡¯Garra William E. Paul Hidde Ploegh Fiona Powrie Klaus Rajewsky Anjana Rao Jeffrey Ravetch Westley H. Reeves A.B. Rickinson Steven Rosen Alexander Rudensky Shimon Sakaguchi Matthew D. Scharff Hans Schreiber Gerold Schuler Robert A. Seder Rafick-P. S¨¦kaly Charles N. Serhan Steven D. Shapiro Nilabh Shastri Stephen Shaw Alan Sher Roy L. Silverstein Jonathan Sprent Janet Stavnezer Ursala Storb Susan Swain Thomas J. Templeton Giorgio Trinchieri Herbert Virgin Ulrich von Andrian Harald von Boehmer Sharon M. Wahl Arthur Weiss Raymond M. Welsh Zena Werb Linda S. Wicker Ian Wilson Samuel D. Wright Kai W. Wucherpfennig Wayne M. Yokoyama       Editorial Assistants Karen Cheung • Mary E. Donnelly • Nickey Henry • John Toniolo The Rockefeller University Press, 1114 First Avenue, New York, NY 10021 phone: (212) 327-8575 • fax: (212) 327-8511 • email: jem@rockefeller.edu Copyediting & Production Colleen M. Smith • Alexandra E. MacWade • Jessica H. Dickson email: jexpmed@rockefeller.edu   Suzanne M. Runyan, Production Director Aisha Caruth, Copy Editing Coordinator   Robert J. O'Donnell, Electronic Publishing Director Erinn A. Grady, Electronic Publishing Coordinator