期刊名称：CIRCULATION RESEARCH ISSN： 0009-7330 版本： SCI-CDE 出版频率： Semi-monthly 出版社： LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, USA, PA, 19103   出版社网址： http://www.lww.com/ 期刊网址： http://circres.ahajournals.org/ 影响因子： 17.367 主题范畴： CARDIAC & CARDIOVASCULAR SYSTEMS;    HEMATOLOGY;    PERIPHERAL VASCULAR DISEASE 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Editorial Scope. Circulation Research is a forum for fundamental, mechanistic research of relevance to the cardiovascular system from various disciplines including biochemistry, biophysics, cellular biology, molecular biology, genetics, pathology, physiology, and pharmacology. The journal publishes manuscripts on basic cardiac and vascular biology and encourages the submission of work that uses state-of-the-art approaches to illuminate mechanisms of human disease. A welcome is also extended to clinical research that yields fundamental insights. Circulation Research is an official journal of the American Heart Association and is the official journal of the Basic Cardiovascular Sciences Council of the American Heart Association. Instructions to Authors Submitted manuscripts must not contain previously published material and must not be under consideration for publication elsewhere in whole or in part in any language (except as an abstract; See "Prior Publication" for the definition of an abstract). Manuscripts should conform to "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" N Engl J Med. 1997;336:309-315 and the American Medical Association Manual of Style, 9th ed, Baltimore, Md, Williams & Wilkins, 1998. Address all correspondence to the Circulation Research Editorial Office: Eduardo Marbán, MD, PhD Editor in Chief, Circulation Research 2700 Lighthouse Point East Suite 230 Baltimore, MD 21224 Phone: 410-327-5005 Fax: 410-614-7660 E-mail: circulation.research@circresearch.com Online submission: http://submit-circres.ahajournals.org Editorial Conflict-of-Interest Policy. Original manuscripts authored or coauthored by the Editor in Chief and/or any of the Associate Editors are handled by a Consulting Editor, who makes all decisions about the manuscript (including choice of referees and ultimate acceptance or rejection). The entire process is handled confidentially. All manuscripts submitted from the Editor's home institution are also handled entirely by a Consulting Editor. The Editor in Chief and/or Associate Editors may additionally, from time to time, refer a manuscript to a Consulting Editor to avoid a perceived or real conflict of interest. Online and Print Publication. Circulation Research is published as a print journal with 24 issues per year. The full contents of the print edition and online-only material are published online at 4:00 PM EST on the day before the cover date of a given print issue. The online journal, accessible at http://circres.ahajournals.org, is the journal of record. Original research articles are published ahead of print in proof form 5 to 9 business days after acceptance and are accessible through the Online First link at http://circres.ahajournals.org. ONLINE MANUSCRIPT SUBMISSION IS REQUIRED FOR CIRCULATION RESEARCH. Please go to http://submit-circres.ahajournals.org and follow the detailed instructions located on our online submission Web site. Online Submission. Authors are instructed to input all manuscript information online and to upload all relevant manuscript documents online. Authors must then forward the following items to the Circulation Research Editorial Office within 48 hours after completion of online manuscript submission: 1 full set of original figures, on glossy-finish paper Copyright Transfer Agreement (may be faxed to editorial office) Acknowledgment release signatures, if applicable (may be e-mailed to editorial office) 1 copy of any potentially overlapping work that is in preparation, has been previously submitted or published, or is in-press, if applicable (if not uploaded online) 1 copy of any article currently in-press, which is cited in the References, if applicable (if not uploaded online) 1 copy of any abstracts published or submitted for publication, if applicable (if not uploaded online) Journal Categories. Note the length restrictions and other eligibility criteria listed below. ORIGINAL CONTRIBUTIONS. The purpose of this category is to publish articles consisting of new material or original research. REPORTS. The purpose of this category is to enable rapid review and publication of important scientific findings that can be explained and documented concisely. A first decision is reached within 21 days of submission, and publication in the print journal is within 4 weeks of acceptance. The length is strictly limited to three printed pages in the journal. Reports may use more or less words depending on the number and size of display items. Submissions that are overly long will either be returned for abbreviation or processed in another category, according to the authors' preference. The abstract should be terse and limited to an explanation of the question addressed and the central findings. Within the text, separation into sections (Introduction, Materials and Methods, Results, Discussion) is optional. Citations should follow journal style. ULTRARAPID COMMUNICATIONS. The category of UltraRapid Communications uses the medium of Web publishing. A first decision on these manuscripts, which should be of unusually high priority, is made within 21 days of receipt at the editorial office. Once accepted, the full article is published ONLINE ONLY in the next available issue, with the abstract published in the print version. UltraRapid Communications undergo the same peer review and copyediting processes as Original Contributions, are assigned volume and page numbers for citation, and are listed in indexing services such as MEDLINE. Please note that no color reprints are available to authors for UltraRapid Communications, although online material can appear in color. RESEARCH COMMENTARIES. Research Commentaries provide a peer-reviewed forum for focused critiques on work that has been published in this journal. Research Commentaries contain new material or original research related to the prior published work but are sufficiently focused that consideration in other categories is not appropriate. Research Commentaries are published online with a condensed abstract appearing in the print journal. The authors of the article being critiqued are invited to respond. Both the Research Commentary and the response undergo peer review. Research Commentaries follow the same submission guidelines as Original Contributions. Please note that no color reprints are available to authors for Research Commentaries. MINIREVIEWS. MiniReviews are intended to highlight timely topics in the biology of the cardiovascular system. The majority of MiniReviews are commissioned; however, noncommissioned articles may be considered at the editors' discretion. All MiniReviews, whether commissioned or not, undergo regular peer review. MiniReviews are intended to be succinct discussions dealing with a particular question of current interest. Figures are encouraged, but only of a diagrammatic nature. REVIEWS. Longer and more comprehensive than MiniReviews, Reviews may be considered as definitive summaries of important areas. As with MiniReviews, most are commissioned; however, noncommissioned articles may be considered at the editors' discretion. All Reviews, whether commissioned or not, undergo regular peer review. EDITORIALS. Generally these are brief commentaries on articles that appear in Circulation Research. Editorials are invited and are subject to review by the editors. SPECIAL ARTICLES. The Editors may, at their discretion, choose to publish select manuscripts as Special Articles. Such articles are generally commissioned and may present a combination of personal opinion and factual data. LETTERS TO THE EDITOR. Letters are opinion pieces on work published in Circulation Research and are reviewed by the Editors solely to establish scientific decorum. Replies are not routinely solicited in advance from the authors of articles addressed, but are welcome if the authors believe a reply is warranted. Letters to the Editor (and replies, which are also published as Letters) will appear online only. Letters to the Editor must not exceed 1000 words in length. Figures and tables are not permitted. Citations should follow journal style. Letters are distinguished from Research Commentaries by their length and content: Research Commentaries are substantive articles containing new data; unlike Letters, Research Commentaries undergo peer review, and a reply is routinely solicited from the authors of the article that prompted the commentary. For all categories, excessive figures, discussion, and references are discouraged. Submission Policies 1. General Instructions for New Submissions Manuscripts must be typed, double-spaced, including references, figure legends, and tables, on one side of the page only. Word Limits (INCLUDES ALL SECTIONS OF THE MANUSCRIPT---Title Page, Text, References, Figure Legends, Tables. Online Data Supplements excluded): Original Contributions--6000 words Reports--2200 words (10,000 characters) UltraRapid Communications--no limit Research Commentaries--6000 words MiniReviews--4000 words Reviews--10,000 words Editorials--2000 words Letters to the Editor--1000 words Leave 1-inch margins on all sides. Number all pages--including figure legends, tables, and figures-- except the title page. Cite each figure and table in text in numerical order. Cite each reference in text in numerical order and list in the References section. In text, reference numbers may be repeated but not omitted. Use SI units of measure in all manuscripts. For example, molar (M) should be changed to mol/L; mg/dL to mmol/L; and cm to mm. Units of measure previously reported as percentages (ie, hematocrit) are expressed as a decimal fraction. Measurements currently not converted to SI units in biomedical applications are blood and oxygen pressures, enzyme activity, H+ concentration, temperature, and volume. The SI unit should be used in text, followed by the conventionally used measurement in parentheses. Materials submitted, including figures, cannot be returned to authors regardless of the disposition of the article. 2. General Instructions for Revisions Current policy allows for a maximum of ONE revision per article. At the editors' discretion, one additional minor revision may be permitted if the initital revision is responsive. Time limit for receipt of revisions from last decision letter: Original Contributions and Research Commentaries--90 days MiniReviews and Reviews--30 days Reports and UltraRapid Communications--10 days (limited to minor clarifications and additions) If revisions are not received within the specified time limit, the manuscript is assigned a new number. At the editors' discretion, and in cases where substantial new data are required, extensions may be granted for revisions. In such cases, every effort will be made to retain the original reviewers. Number each page in the top right corner, using your manuscript number followed by /R1 to denote a first revision. In your written response to the reviewers' comments, give the exact page number(s), paragraph(s), and line number(s) where each revision was made. 3. Title Page Include the full title, short title of 50 characters or less including spaces, and all author information: affiliations, mailing address, telephone, fax, e-mail. Include two to five subject codes that best classify your manuscript, using the Subject Code List for Authors. 4. Abstracts Abstract length is limited to 250 words. Do not cite references in abstract, and limit use of acronyms and abbreviations. Do not use subheadings. The abstract must include the rationale for the study, a brief description of methods and presentation of significant results, and a succinct statement of data interpretation. Provide between three and five key words for use as indexing terms. These words may later be copyedited to conform to journal style. 5. Materials and Methods Materials and Methods should be limited to essential new information. Information that is presented from previous publications should be cited rather than repeated. Although a limit of 500 words is suggested, longer Materials and Methods sections are acceptable as long as the overall word count does not exceed that stipulated for the corresponding manuscript category. Expanded Materials and Methods can be published online only (see "Online Data Supplements"). Manuscripts that feature gene chip array technology and other high-throughput genomics methods must meet the following criteria (for details see Circ Res 2001;89:469): The salient results of the genomic screen must be confirmed by complementary methods (such as Northern blot analysis), for selected transcripts of greatest relevance or interest. The principal findings must be reproducible, ie, confirmed with multiple chips using multiple sources of RNA. 6. Online Data Supplements This optional section provides an opportunity for authors to present supporting materials to the manuscript. The manuscript appears both in the print version and online, whereas Online Data Supplements are independent from the manuscript and appear ONLY online. Online Data Supplements undergo peer review and therefore must be submitted simultaneously with original submissions. Online Data Supplements can consist of any of the following, in any combination: Expanded Materials and Methods Additional Figures and supporting information Additional Tables and supporting information Video Files If citations are made in an Online Data Supplement, the Online Data Supplement must contain its own independent Reference Section with references numbered sequentially, beginning with Reference 1, even if some of these references duplicate those in the print version. The Editorial Office is not responsible for extracting Online Data Supplement material from print manuscript material. The Table of Contents highlights articles that contain Online Data Supplements by a paperclip and/or video camera icon, and lists the URL where supplements can be accessed. 7. Text Abbreviations must be defined at first mention in the text. Materials and Methods section. The following information should be included either in the print version or in an Online Data Supplement. For animals used in experiments, state the species, strain, number used, and other pertinent descriptive characteristics. For human subjects or patients, describe their characteristics. When describing surgical procedures on animals, identify the preanesthetic and anesthetic agents used and state the amount or concentration and the route and frequency of administration for each. The use of paralytic agents, such as curare or succinylcholine, is not an acceptable substitute for anesthetics. For other invasive procedures on animals, report the analgesic or tranquilizing drugs used. If none were used, provide justification for such exclusion. Generic names of drugs must be given. Manuscripts that describe studies on humans must indicate that the study was approved by an institutional review committee and that the subjects gave informed consent. Reports of studies on both animals and humans must indicate that the procedures followed were in accordance with institutional guidelines. New DNA sequences should be submitted to GenBank and the accession number incorporated into the text of the manuscript. 8. Acknowledgments The Acknowledgments section recognizes all sources of research support (including commercial or institutional support) plus substantive contributions of individuals. Authors must provide written permission/approval from all individuals mentioned by name in the Acknowledgments section of the manuscript. Authors must completely spell out all grant funding agency abbreviations, with the exception of NIH. 9. Conflict-of-Interest Disclosure Statement Authors must disclose any and all relationships that could be perceived as real or apparent conflict(s) of interest as a FOOTNOTE after the Acknowledgments section. Conflict-of-interest disclosure will be published as a footnote to the accepted article. This pertains to relationships with pharmaceutical companies, biomedical device manufacturers, or other corporations whose products or services are related to the subject matter of the article. Such relationships include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, being on the board of directors, or being publicly associated with the company or its products. Other areas of real or perceived conflict of interest could include receiving honoraria or consulting fees or receiving grants or funds from such corporations or individuals representing such corporations. 10. References References must conform to journal style. Consult the American Medical Association Manual of Style, 9th ed, Baltimore, Md, Williams & Wilkins, 1998. Example of Journal Reference Style: Patel VA, Zhang Q-J, Siddle K, Soos MA, Goddard M, Weissberg PL, Bennett MR. Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling. Circ Res. 2001;88:895-902. Example of Book Reference Style: Gourdie RG, Litchenberg WH, Eisenberg LM. Gap junctions in heart development. In: DeMello WC, Janse MJ, eds. Heart Cell Communication in Health and Disease. Boston, Mass: Kluwer; 1998:19-44. Authors must ensure accuracy of reference data. Verify all entries against original sources. All authors must be listed in references. Shortened lists of author names followed by "et al" must be replaced with complete information. Cite references in numerical order according to first mention in text. Personal communications, unpublished observations, and submitted manuscripts are not legitimate references and must be cited in the text as "(unpublished data, [year])." Abstracts may be cited only if they are the sole source and must be identified in the reference as "Abstract." "In-press" citations must be accepted for publication and must include the name of the journal or book publisher. Note that copies of all such articles must be submitted with the manuscript at the time of original submission. 11. Figures and Legends Total number of figures and/or tables limited to: Original Contributions and Research Commentaries--8 Reports--1 to 3, depending on size UltraRapid Communications--no limit MiniReview--3 Reviews--8 Additional figures may be submitted for online-only publication as an Online Data Supplement, subject to peer review (see "Online Data Supplements"). Figures are black-and-white line drawings, graphs, color illustrations, or halftones (gel blots/stains). Authors are responsible for the cost of printing color illustrations. Label on the FRONT of the figure: THE FIGURE NUMBER and any lanes, bars, panels, etc. in a simple font that is uniform in size and style. Label on the REVERSE side of the figure: first author, short manuscript title, and orientation of figure, ie, top and bottom. Limit white space between all panels and between panels and panel lables. Supply a scale bar with photomicrographs. Figure legend copy must be double spaced. Abbreviations/symbols used in any figure but not already defined in the main text must be defined in the figure legend. 12. Tables Submit tables on separate pages, not embedded in main manuscript text. Supply a brief, informative title for each table numbered using Arabic numerals. Table text must be consistent in size and style with main manuscript text. Supply brief column headings and indicate footnotes using symbols in this order: *, ? ? ? ||, ? #, **, ††. Use only horizontal borders above and below the column headings and at the bottom of the table. Use extra space to delineate rows and columns. Abbreviations/symbols used in any table but not already defined in the main text must be defined in the table or table legend. 13. Cover Figures The editors encourage submission of color images for consideration as potential cover figures. These may be submitted initially, upon revision, or immediately after acceptance. Authors should send 2 hard copies of any potential cover figure, with an accompanying figure legend, to the Editorial Office. Cover figures should not simply duplicate images already in the article. Instead, they should be associated with the general topic of the article, or they may be altered/enhanced versions of an original figure within the manuscript. SCHEMATIC FIGURES OR FLOWCHARTS ARE DISCOURAGED. Cover figure submissions must follow the same guidelines as original figure submissions attached to manuscripts (see "Figures and Legends"). 14. Prior Publication and Overlapping Work By virture of submitting an article for consideration by Circulation Research, the authors certify that the manuscript and the material in the manuscript have not been published and are not being considered for publication elsewhere in whole or in part in any language, including publicly accessible Web sites or e-print servers, except as an abstract. The authors also certify that any and all other work in preparation, submitted, in press, or published that is potentially overlapping either in the actual data presented or in the conceptual approach is enclosed along with the original submission. If some or all of the work in the manuscript has been published or submitted in abstract form, and/or overlapping data exists, the following rules apply: The published or submitted abstract must accompany the submitted manuscript. The abstract in question cannot be longer than 400 words. The abstract cannot itself have been referenced in MEDLINE or PubMed. The potentially overlapping work and a separate explanation of the nature of any possible overlap with the submitted manuscript must accompany the submitted manuscript. 15. Embargo Policy Articles published in Circulation Research cannot be discussed by journalists or presented in other public media before 4:00 PM EST on the day before the cover date of the issue, except when articles are posted online ahead of the print version (Online First). In such cases, the embargo date will be 4:00 PM EST on the day of online posting. Although the Editorial Office will endeavor to notify authors of the anticipated online publication date, neither the Editorial Office nor the AHA will be responsible for any consequences of early online posting with regard to intellectual property rights. To safeguard their intellectual property, authors should ensure that appropriate reports of invention and patent applications have been filed before the manuscript is accepted. Prior presentations at scientific meetings are allowed, but the authors should be aware that such presentations may undermine their intellectual property rights. Questions regarding the embargo policy should be directed to Carole Bullock, Senior Communications Manager, News Media Relations Department, AHA National Center, 7272 Greenville Ave., Dallas, TX 75231-4596. Tel: 214-706-1279; fax: 214-369-3685; e-mail: caroleb@heart.org 16. Permissions If any figures, tables, or portions of the manuscript have been previously published in any form, include written permission from the copyright holder to use such material. This written permission must include permission to use the material in print and electronic formats and in all languages. Permission to reproduce figures, tables, or portions of articles originally published in Circulation Research should be sought directly from the Publisher, not from the Editorial Office. The address for correspondence regarding permissions is Rights and Permissions Desk, Lippincott Williams & Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436, telephone 410-528-4050, fax 410-528-8550, e-mail: journalpermissions@lww.com 17. Costs to Authors Authors are charged: $60 per printed page of an article to defray costs of publication (information is sent with author's proof) or $30 per page in the case of copyedited online-only material (UltraRapid Communications or Research Commentaries). Expense for color reproduction of figures (estimate of cost will be provided by the publisher for author's approval). Expense for replacing poor-quality art. Expense for reprints (price lists are sent with author's proof). No color reprints are available for online-only articles (UltraRapid Communications and Research Commentaries). $50 per printed page for excessive author alterations. $100 per page for printing a correction (erratum) after publication of the article that results from an author's error. Errata will generally be published ONLINE ONLY. Editorial Board Editor Eduardo Marbán Associate Editors Roberto Bolli Gerda Breitwieser Rudi F.E. Busse Hal C. Dietz Masao Endoh Toren Finkel Kathy K. Griendling David A. Kass Charles Lowenstein Marlene Rabinovitch Gordon F. Tomaselli Editorial Office Kara E. Hansell Keehan, Managing Editor Melissa Barney, Assistant Managing Editor Michelle Strotman, Assistant Managing Editor Gemma Bridges, Editorial Assistant Editorial Board Piero Anversa Stephen L. Archer Peter H. Backx Robert S. Balaban C. William Balke Jeffrey R. Balser Michelle Bendeck Ivor J. Benjamin Martin R. Bennett Ronald Berger Bradford C. Berk Judith A. Berliner Donald M. Bers Nanette Bishopric Meredith Bond Karin E. Bornfeldt Nancy Boudreau Penelope Boyden Ralf P. Brandes Frank V. Brozovich Janis M. Burt John M. Canty, Jr. Nipavan Chiamvimonvat Horacio E. Cingolani Angela Clerk Alexander W. Clowes Peter F. Davies Mario Delmar Linda Demer Pieter de Tombe David A. Dichek Stefanie Dimmeler Kevin Donahue Gerald W. Dorn II James M. Downey Helmut Drexler David Eisner Igor Efimov Thomas Eschenhagen Suzanne G. Eskin Frank Faraci Giora Z. Feuerstein Loren Field Glenn I. Fishman Ingrid Fleming Jane E. Freedman Joe G.N. Garcia Cecilia Giachelli Wayne R. Giles D. Neil Granger Augustus O. Grant Garrett Gross David Gutterman Roger Hajjar Joshua M. Hare David G. Harrison Gerd Hasenfuss Joan Heller Brown Gerd Heusch Thomas Hintze Masayasu Hiraoka Julien I.E. Hoffman Brian D. Hoit Masatsugu Hori Steven R. Houser Eva Hurt-Camejo Raymond E. Ideker Seigo Izumo Jose Jalife Larry R. Jones Gabor Kaley Timothy J. Kamp Daniel Kelly Ralph A. Kelly Margaret L. Kirby Richard N. Kitsis Andr?G. Kléber Issei Komuro Evangelia G. Kranias Yoshihisa Kurachi Satoshi Kurihara Hideo Kusuoka B. Lowell Langille Richard T. Lee Leslie A. Leinwand James K. Liao Gary D. Lopaschuk Joseph Loscalzo Pamela A. Lucchesi Thomas F. Lüscher Mark W. Majesky Andrew R. Marks Roger R. Markwald A.J. Marian Hiroaki Matsubara Elizabeth McNally Gerhard Meissner Michael E. Mendelsohn Joseph M. Miano Ryuichi Morishita Richard L. Moss Anne M. Murphy Elizabeth Murphy Charles E. Murry Ryozo Nagai Stanley Nattel Mark T. Nelson Jeanne M. Nerbonne Eric N. Olson Brian O'Rourke Cam Patterson Teresa Perez-Garcia Mutuh Periasmy Peipei Ping Daniel Rader Elaine W. Raines Jeffrey Robbins Marschall Runge Junichi Sadoshima Allen Samarel Michael C. Sanguinetti Toshiaki Sato Jutta Schaper Wolfgang Schaper Valerie Schini-Kerth Michael D. Schneider Karsten Schror Stephen M. Schwartz Christine E. Seidman Gregg L. Semenza William Sessa Richard P. Shannon Paul C. Simpson Karin Sipido R. John Solaro Deepak Srivastava Jonathan Stamler Charles Steenbergen Susan F. Steinberg Robin Steinhorn Duncan J. Stewart Harold C. Strauss Peter H. Sugden Heinrich Taegtmeyer Tetsuro Takamatsu Akira Takeshita Mark B. Taubman Alain Tedgui Andre Terzic Eric J. Topol James N. Topper Jennifer E. Van Eyk Yibin Wang J. Anthony Ware Keith A. Webster James N. Weiss Raymond Winslow Andrew L. Wit Michael S. Wolin Rui-Ping Xiao George Yancopoulos Atsuko Yatani Mitsuhiro Yokoyama Andreas M. Zeiher Irving H. Zucker Jay Zweier Consulting Editors Francois M. Abboud Eugene Braunwald Harry A. Fozzard Donald D. Heistad Peter Libby Elizabeth G. Nabel Hans Michael Piper Michael R. Rosen Hiroyuki Suga Stephen F. Vatner Richard A. Walsh James T. Willerson Scientific Publishing Committee, American Heart Association Richard A. Walsh, Chair Robert Shirrell, Vice Chair Ivor J. Benjamin Robin L. Brey William Bryson Campbell Robert L. Carson N.A. Mark Estes, III Janet H. Fisher Jerome Kassirer Rita F. Redberg Christine E. Seidman Diane M. Sullenberger