期刊名称：NATURE CHEMICAL BIOLOGY ISSN： 1552-4450 出版频率： Monthly 出版社： NATURE PORTFOLIO, HEIDELBERGER PLATZ 3, BERLIN, Germany, 14197   出版社网址： http://www.nature.com/ 期刊网址： http://www.nature.com/nchembio/index.html 影响因子： 15.04 主题范畴： BIOCHEMISTRY & MOLECULAR BIOLOGY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal AIMS AND SCOPE OF JOURNAL Nature Chemical Biology is a monthly multidisciplinary journal providing an international forum for the timely publication of significant new research at the interface between chemistry and biology. Published in hard copy and online, Nature Chemical Biology is a medium for rapid publication and for the exchange of ideas between scientists in both the chemical and the life sciences. Nature Chemical Biology is committed to publishing the top tier of original research in chemical biology through a fair and rapid review process that emphasizes rigorous chemical and biological characterization. The journal is particularly interested in contributions from chemists who are applying the principles, language and tools of chemistry to the understanding of biological problems and from biologists who are interested in understanding biological processes at the molecular level. Priority is given to work that reports fundamental new advances in biology or chemistry and provides insight into the molecular mechanisms of biological processes. Research areas at the interface of chemistry and biology covered in the journal include, but are not limited to: Chemical Synthesis Diversity-oriented synthesis Template-directed synthesis Biomolecular modification and labeling chemistry Solid-phase biomolecular synthesis: peptides, oligonucleotides, oligosaccharides Synthesis of small biomolecules: lipids, carbohydrates, nucleosides, amino acids Combinatorial chemistry Natural products synthesis Biomimetic synthesis Asymmetric catalysis Expanding Chemistry through Biology Enzymatic synthesis Natural products isolation and characterization Combinatorial biosynthesis Biosynthetic engineering Virus-based chemistry Directed evolution and characterization of macromolecular catalysts and receptors Chemical informatics Chemical Mechanisms in Biology Enzyme inhibition and reaction mechanisms Mechanisms of drug action in vivo Small molecule-biological target interactions Evolution and novel chemistry of catalytic nucleic acids Pharmacological determination of protein function in vivo Molecular probes of biological function Mechanistic analyses of post-translational modification chemistry Chemical insights into post-genomic approaches, including RNA interference and proteomics Metal ions in biological systems Chemical imaging agents Single-molecule chemistry of small molecules and biomolecules Experimentally-validated theoretical simulations and modeling of biomolecules Molecular recognition Small molecular model systems for metalloenzymes Molecular machines Pharmacologically active natural products Biosynthetic pathway elucidation Chemical approaches to protein interaction networks Chemical ecology Expanding Biology through Chemistry Chemical genetics and high-throughput screening Biomolecular and small molecular array fabrication and validation Chemical insights into drug design and development Synthetic biology Unnatural biomolecular analogs in biological systems Chemical genomics Chemical regulation of biosynthetic pathways Chemical methods for protein, carbohydrate and nucleic acid design Chemical approaches to systems biology Instructions to Authors guide to authors.pdf Editorial Board About the editors  Editor: Terry L. Sheppard Before assuming the Editorship of Nature Chemical Biology, Terry spent 6 years at Northwestern University's Department of Chemistry, where he developed an independent program in nucleic acid chemical biology, which included investigations of oxidative DNA damage and repair, template-directed synthesis, and nucleoside therapeutics. This followed his appointment as a NASA postdoctoral fellow with Gerald F. Joyce at The Scripps Research Institute, where he discovered, using in vitro evolution, a "DNA enzyme" that catalyzed DNA depurination and strand cleavage. Terry completed his Ph.D. in organic chemistry with Ronald Breslow at Columbia University in 1995, where he synthesized 2',5'-linked DNA and evaluated its promise for antisense therapeutic applications. Terry is based in the East Coast US editorial office of Nature Chemical Biology in Boston and can be contacted at: Terry L. Sheppard Nature Chemical Biology Editorial Office 25 First Street, Suite 104 Cambridge, MA 02141 USA Tel: +1 617 475 9273 Fax: +1 617 494 4960 E-mail: t.sheppard@boston.nature.com Senior Editor: Joanne Kotz Prior to joining Nature Chemical Biology, Joanne undertook industry-based postdoctoral research at Genentech, working with Andrea Cochran, where her research focused on developing combinatorial methods to study protein stability and using chemical tools to investigate the biological role of a mitotic kinase. This followed postdoctoral research in bacterial pathogenesis with Xavier Nassif at the Necker-Enfants Malades Hospital in Paris. Joanne obtained her PhD in 2000 from the University of California, Berkeley, where she studied enzyme mechanism in copper amine oxidases with Judith Klinman. Joanne is based in the East Coast US editorial office of Nature Chemical Biology in Boston and can be contacted at: Joanne Kotz Nature Chemical Biology Editorial Office 25 First Street, Suite 104 Cambridge, MA 02141 USA Tel: +1 617 475 9204 Fax: +1 617 494 4960 E-mail: j.kotz@boston.nature.com Associate Editor: Mirella Bucci Before joining Nature Chemical Biology, Mirella spent 3 years working in editorial and science writing positions, including an editorial position at Nature. Her research in molecular cell biology took her to Washington University, where she worked as a graduate student with Susan Wente studying the dynamics of nuclear pore complexes. She went on to Stanford University, where as a postdoctoral fellow she studied protein folding and protein aggregation in the context of several neurodegenerative diseases with Ron Kopito. Mirella completed her undergraduate degree in chemistry and biology at Carnegie Mellon University, where she studied with Robert Murphy at CMU's Molecular Biosensor and Imaging Center. Mirella is based in the West Coast US editorial office of Nature Chemical Biology in San Francisco and can be contacted at: Mirella Bucci Nature Chemical Biology Editorial Office 225 Bush Street, Suite 1453 San Francisco, CA 94104 USA Tel: +1 415 403 9036 Fax: +1 415 718 3805 E-mail: m.bucci@naturesf.com Associate Editor: Catherine Goodman Before joining the team at Nature Chemical Biology, Catherine worked as an NIH postdoctoral fellow with Bill DeGrado at the University of Pennsylvania, where she focused on the structural design of non-natural and transmembrane peptides. This followed a PhD obtained under the guidance of Vince Rotello at the University of Massachusetts, where her research included biomimetic investigations of flavin cofactors as well as development of DNA-binding nanoparticles. Catherine started her scientific career at Rice University synthesizing modified DNA nucleotides for Scott Singleton. Catherine is based in the East Coast US editorial office of Nature Chemical Biology in Boston and can be contacted at: Catherine Goodman Nature Chemical Biology Editorial Office 25 First Street, Suite 104 Cambridge, MA 02141 USA Tel: +1 617 475 9240 Fax: +1 617 494 4960 E-mail: c.goodman@boston.nature.com