期刊名称：JOURNAL OF APPLIED PHYSIOLOGY
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Journal of Applied Physiology
The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.
The wide scientific span of the Journal rests on physiology as its keystone. However, the boundaries of physiology have enlarged as demarcations between concepts and techniques in the physiological, pharmacological, and biochemical sciences become increasingly blurred. Moreover, theoretical articles on research at any level of biological organization ranging from molecules to humans fall within the broad scope of the Journal. Papers dealing with topics in other basic sciences that impinge on physiology are also welcome.
Instructions to Authors
New! APS publications must now comply with the MIAME Standard for microarray data analysis.
Considering submission to an APS journal?
Please review the following:
Ready to submit your work?
You have submitted your paper. What next?
Information about the various stages of review and publication:
This document will take you through all the major steps of preparing your manuscript for submission to the American Physiological Society Journals, from how best to format and organize the paper itself, to how to create digital images suitable for print and web publication, to advice on how to present supplemental data files such as video clips and long tables.
When you are ready to submit, see the Guide to Uploading Manuscripts.
These instructions pertain to all of the American Journal of Physiology sections, as well as the Journal of Applied Physiology, the Journal of Neurophysiology, and Physiological Genomics. Advances in Physiology Education, News in Physiological Sciences (invited only), and Physiological Reviews (invited only) have specific instructions that you should review if you are submitting to them.
Exceptions for the Journal of Neurophysiology
The Journal of Neurophysiology departs from usual Journal style in some areas; specifically regarding keywords, and references. These exceptions are marked below with the "JN" icon:  , and bordered to the left with a bold black line.
Main Contents
General Information
Ethical Policies and Standards
Technical Requirements
Manuscript Sections
Types of Articles
Figures
Tables
Mathematical Equations and Modeling
Data Supplements
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The American Physiological Society (APS) Journals seek definitive papers that present the entire contents of a research project. In general, all data from a group of subjects, animals, or samples should be presented together in a single paper. If this cannot be done, then the manuscript should be cross-referenced. Identical subject, animal, and sample numbers should be used in the different manuscripts to identify their commonality.
Section Contents
Peer Review Policy
Copyright and Permissions
Cost of Publication
Restrictions on Prepublication
Authorship Changes
Conflict of Interest
Use of Previously Published Illustrations
"Submitted" and "Accepted" Dates
"Advertisement" Note
Manuscripts are refereed critically by two or more reviewers. Acceptance of manuscripts is based on scientific content and presentation of the material; membership in the Society is not a prerequisite for publication. The Editor/Associate Editor selects the reviewers, corresponds with the author, and makes the final decision on the acceptance or rejection of the manuscript. If a manuscript is submitted by an Editor of the Journal, another Editor handles that manuscript. The APS Peer Review office helps ensure confidentiality by setting up blinded user records in the APS Central system to be used for this purpose. See also Peer Review and Revision.
The Mandatory Submission Form serves as the official copyright transfer form. (Forms customized to your manuscript will become available on completion of the submission process; check the Home Page of the journal you are submitting to for blank forms.) The APS Journals are copyrighted for the protection of authors and the Society. The code at the bottom of the first page of an article indicates the copyright owner's consent that copies of that article may be made beyond what is permitted by sections 107 and 108 of the US Copyright Law -- unless the copies are for general distribution, for advertising, for creating new works, or for resale -- provided the per-copy fee is paid through the Copyright Clearance Center, Inc.:
Copyright Clearance Center, Inc.
222 Rosewood Dr.
Danvers, MA 01923
For information about any of these exceptions or for permission to reproduce previously published illustrations or tables, write to:
Publications Office
American Physiological Society
9650 Rockville Pike
Bethesda, MD 20814-3991
Include an explicit statement of intended use and detailed specification of the material to be reproduced.
Mandatory Submission Fee
Page Charges
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To recover part of publication costs, the APS charges authors of research articles $70 per printed page. By signing the Mandatory Submission Form, the author agrees to pay page charges once his/her paper is published. (Forms customized to your manuscript will become available on completion of the submission process; check the Home Page of the journal you are submitting to for blank forms.)
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Excessive changes made in proof will be subject to additional charges.
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The page charges are waived for invited authors and for those publishing in Physiological Reviews, Physiological Genomics, News in Physiological Sciences, and Advances in Physiology Education.
Cost of Color
Among scholarly publishers, the APS offers one of the most favorable terms for color figure publication.
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We publish color figures free of charge if the first or the last author is an APS nonstudent member in good standing.
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The APS student members and nonmembers will be charged the low subsidized rate of $300 per color figure.
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Color is free for authors publishing in Physiological Reviews, Physiological Genomics, and News in Physiological Sciences.
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At proof stage, if the author requests a color Iris proof copy of his/her figure(s), a service charge of $75 per figure will be added to the article publication fees.
Open Access choice for authors of Physiological Genomics
Starting July 1, 2003, authors can choose to pay a $1,500 fee to have their article published online with Open Access from the first date of publication or choose to pay no author fees and leave their article under Subscription Access.
Upon acceptance, you will be asked to download a form, where you will choose author-fee-based Open Access or Subscription Access. If you choose Open Access, you will be asked to provide a credit card number, purchase order, or check for $1,500. Once your payment or purchase order is processed, your online article will be made free to all. The print journal containing your article will still be available for a subscription fee.
Reprint Services
The APS provides high quality reprints to its authors.
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Please order reprints when you receive the electronic or mailed proof of your article.
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The Reprint Order Form is enclosed in the proof package. Please fill it out and send within 48 hours to the address indicated on the form. Please note that the articles containing color can ONLY be ordered at proof stage.
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If your article has color figures, there is an additional press charge of $90 per 100 reprints ordered.
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Toll-free link: at your request, the APS can create a link from your online published article to a URL you specify. Readers accessing your article from this URL can do so without a subscription to the journal. The per-article cost is $150 ($250 for articles in Physiological Reviews) and can be noted on the Reprint Order Form. Payment for the link will be added to the invoice for publication fees.
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See the current reprint prices.
Except in reviews and invited editorials, the APS Journals will not accept submissions in which, other than in abstracts of less than 400 words, a significant portion of the data in the form of figures and/or tables has been published elsewhere. For the APS guidelines regarding duplicate and/or prior publication, see the APS Ethical Policies and Procedures.
Changes to authorship are handled differently depending on when the error is noticed, i.e., on the stage of publication of the paper.
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After submission but before acceptance
If you realize that changes to authorship (e.g., altering the order of authorship or adding/removing a name) are needed, please follow these steps:
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Download the Change of Authorship Form.
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Have ALL authors sign it.
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Fax, mail, or e-mail the signed form to the APS Peer Review office (301-634-7243)
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After publication in Articles in PresS
If you have realized that an author's name was misspelled in such way as to affect finding the article in PubMed or through other searches, notify the Peer Review office so that the article can be fixed by amending the Article in PresS edition. Please note: this is the ONLY case when Articles in PresS edition will be corrected. Follow the steps above when submitting the correction. Other authorship corrections can still be made for the final print and online editions (see point 3 below).
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During production of the final print and online editions
Changes to authorship (e.g., altering the order of authorship; adding/removing a name; adding or changing an initial) can still be made during production. You will need to follow these steps:
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Download the Change of Authorship Form.
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Have ALL authors sign it.
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Fax, mail, or e-mail the signed form to the Journal Editorial Office (301-634-7243).
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After the final edition has been published in print and online
Any changes to authorship can only be made through a corrigendum to the print edition. The online version will have a permanent link to the corrigendum. Follow the steps in point 3 when submitting the changes.
Authors of research articles are required at the time of submission to disclose to the APS Publications Office any potential conflict of interest (e.g., consultancies, stock ownership, equity interests, patent-licensing arrangements, lack of access to data, or lack of control of the decision to publish). In such cases, the author(s) will be asked to fill out a Conflict of Interest Disclosure form. The information provided in the form, unless already disclosed in the submitted article, will be held in confidence while the paper is under review. If the article is accepted for publication, information on the potential conflict of interest -- including a lack of control of the decision to publish -- will be included in the Disclosures section, following the Acknowledgments section.
APS Journals do not allow the use of previously published illustrations in regular research papers. If scientifically appropriate, previously published illustrations may be included only in reviews, invited editorials, or other invited papers, and only if permission is obtained from both the author and the original publisher. Authors are responsible for obtaining permission letters and must include them with their accepted manuscript in advance of publication. Authors are also responsible for providing publication-quality electronic files or laser prints of the previously published illustrations. These are best obtained from the original publisher or original author. Previously published images downloaded from the Internet are not acceptable for publication. See also Special Considerations for Invited Authors.
The "submitted" date for a manuscript is the date when the manuscript was submitted to APS Central online peer review system. The "accepted" date is the date when the official letter of acceptance is sent out (usually via e-mail) from the review Editor. For specific requirements, see Paper Acceptance.
The APS is required by US Postal regulations to affix the following note on the title page of all articles for which page charges are assessed: "The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked 'advertisement' in accordance with 18 U.S.C. Section 1734 solely to indicate this fact."
Ethical Policies and Standards
[back to top]
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Section Contents
APS Ethical Policy
Use of Humans and/or Animals in Experiments
Fetal Tissue Research Policy
MIAME Standard for Microarray Data
HUGO Gene Nomenclature
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It is mandatory that all papers using microarray data analysis and submitted after January 1, 2003 to any of the APS publications comply with the Minimum Information About Microarray Experiments (MIAME) standard. The access to the GEO database is free and open for all, and the database is maintained by NCBI.
Rationale
Within a short time span, microarrays have become an important, commonly used tool in molecular genetics and physiology research. For microarray analysis of gene expression to have any long-term impact, it is crucial that the issue of reproducibility be adequately addressed. In addition, since microarray analytic standards are certain to change, it is crucial that authors identify the nature of the experimental conditions prevalent at the time of their research. If today’s research is to be relevant tomorrow, the core elements that are immune to obsolescence must be made clear. The APS Journals are adopting the MIAME standards to ensure that what is cutting edge today is not obsolete few years later.
The outline below indicates the general nature of the information we expect you to provide, but we request that you follow the specific guidelines provided at the MGED web site.
Summary of requested information
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Experimental design detailing the parameters of the microarray hybridization experiment including the number of hybridizations, whether dye switching was utilized, and the use of any reference samples.
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Details of the samples including the tissue from which nucleic acids were extracted, the materials and methods used for extraction, and the labeling protocol.
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Hybridization procedures.
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Measurement data and specifications in the form of tab-delimited tables or Excel spreadsheets. As summarized in the published guidelines to the format, “The first could contain the ‘raw?output of the image analysis software (spot quantitation matrix), the second could contain the ‘processed?data following normalization and transformation (gene expression data matrix), and if one is produced, the final table could contain ‘summary?data that was ultimately used in the analysis, such as the subset of differentially expressed genes identified or gene clusters.?/li>
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Array design including complete details of the location and identification of each feature on the array, whether commercial or noncommercial, information on the design of the array, and the spotting protocols.
How to ensure compliance with the MIAME standard
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On the MGED website, read the pertinent information and follow the guidelines provided before preparing your microarray information for deposit.
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Deposit your microarray data in the GEO data base, following the required guidelines.
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Provide the accession numbers for your GEO-deposited data in the Methods section of your paper to make it available during the peer review of your submitted paper.
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All text and image files must be saved as a single PDF or Postscript file, regardless of the original software used, for successful submission via APS Central. Authors are encouraged to take advantage of the latest version of APS Central and submit word-processing and figure files directly. For specific instructions on how to submit online, see our Guide to Uploading Manuscripts to APS Central.
After the paper is accepted (for detailed information, see Paper Acceptance), the text must be sent to APS preferably as a Microsoft Word file (version 6.0 or later), and the images must be prepared at publication quality resolution, using software capable of generating high-resolution TIFF or EPS files. For detailed information on the preparation of graphics in TIFF and EPS formats, see the Cadmus website. See also Special Symbols.
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The manuscript must be double-spaced with wide margins in an 8.5 x 11-in. document.
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The pages should be numbered in the upper right-hand corner (beginning with the first page of text). All sections should begin on separate pages, arranged as follows:
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title page
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abstract and keywords on same page
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main text (introduction; Materials and/or Methods, or Experimental Procedures; Results; Discussion, with conclusions)
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text footnotes
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acknowledgments
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references
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figure legends
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tables
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Enclose figures in a separate envelope or on a disk: 1 set of digital files and 1 set of paper copies.
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Be sure the text is clear and concise, conforming to accepted standards of American English style and usage. Avoid jargon, clichés, and laboratory slang.
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See Manuscript Sections for further description.
All abbreviations must be explicitly defined at first usage. However, internationally accepted biochemical abbreviations such as ADP, NADH, and Pi do not need to be defined; please consult the list of accepted abbreviations. Other abbreviations need only be defined at first mention. For word usage, symbols, etc., authors are referred to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (6th ed., 1994). For chemical and biochemical terms and abbreviations, consult the recommendations of the IUPAC-IUB Combined Commission on Biochemical Nomenclature. Isotope specification must conform to the IUPAC system. Authors are referred to the following articles for style in specialized fields: "Glossary on respiration and gas exchange" (J Appl Physiol 34: 549-558, 1973); and "Glossary of terms for thermal physiology" (J Appl Physiol 35: 941-961, 1973).
For special characters not available on the standard 104-key keyboard (e.g., Greek characters, mathematical symbols, figure symbols), use the Symbol font or use the "Insert Symbol" function in Microsoft Word; do not use Math font or image files (e.g., GIF) within the text for special characters or text constructions. Please also note that we cannot process files prepared in LaTex.
Authors should consult Webster's Third New International Dictionary or Merriam Webster's Collegiate Dictionary, 10th edition, for spelling and compounding. The APS Journals follow American English rules for spelling.
Citations of submitted papers still in preparation, in peer review, or of other unpublished materials cannot be included in the reference list, which may only contain published work. Such citations can, however, be provided in parentheses in text as unpublished observations (e.g., "JMK Smith, unpublished observation").
The APS Journals discourage the use of personal communications. However, if they are used, the author(s) must have in their file a letter granting permission from the communicant and stating that the person whose opinion is cited has seen and approved the actual wording of the citation. If requested, the author will send the letter to the APS Publications office.
For both unpublished observations and personal communications provide the cited person's last name and all initials.
Proprietary (trademarked) names should be capitalized, with the spelling carefully checked. The chemical or generic name should be lowercase and precede the trade name or abbreviation of a drug the first time it appears.
The source of cells utilized (species, sex, strain, race, age of donor, whether primary or established) should be clearly indicated. The source of reagents should be stated (name, city, and state within parentheses) when first cited. If tests to rule out the presence of mycoplasmal contamination were not performed, this fact should be clearly stated. Other data relating to unique biological, biochemical, and/or immunological markers should also be included if available, with their source identified. Publication of results is based on the principle that results must be independently verifiable. Authors are expected to make unique reagents available to qualified investigators either directly or through a recognized distributor. See also Unique Materials and Data Banks and Ethical Policies and Standards for other requirements.
Work published in the APS Journals must necessarily be independently verifiable. Authors describing results derived from the use of antibodies, recombinant plasmids and cloned DNAs, mutant cell lines or viruses, and other similarly unique materials are expected to make such materials available to qualified investigators on request. Authors should also submit published nucleic acid/amino acid sequences to a widely accessible data bank. Sequence data submission forms for the National Biomedical Research Foundation-Protein Information Resource (NBRF-PIR) database (pirmail@nbrf.georgetown.edu) are available from the APS Publications Office (publicat@the-APS.org). Also, for other special types of submissions (e.g., genomes, bulk submissions), additional submission protocols are available from the following organizations:
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DDBJ: Center for Information Biology and DNA Data Bank of Japan.
National Institute of Genetics
1111 Yata
Mishima, Shizuoka 411-8540
Japan
Tel: +81 559 81 6853
Fax: +81 559 81 6849
ddbj@ddbj.nig.ac.jp
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EMBL: EMBL Nucleotide Sequence Submissions, European Bioinformatics Institute
Wellcome Trust Genome Campus
Hinxton, Cambridge CB10 1SD
UK
Tel: +44 1223 494499
Fax: +44 1223 494472
datasubs@ebi.ac.uk
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GenBank: National Center for Biotechnology Information
National Library of Medicine
Bldg. 38A, Rm. 8N-803
Bethesda, MD 20894
Tel: 301-496-2475
Fax 301-480-9241
info@ncbi.nlm.nih.gov
See also MIAME Standards for Microarray Data and Data Supplements.
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Editorial Board
Editor-in-Chief: Gary Sieck
e-mail
Dr. Gary Sieck has been Editor-in-Chief of the Journal of Applied Physiology since 1999. He also presently serves on the Editorial Board of the Journal of Respiratory and Critical Care Medicine and on International Advisory Boards for Acta Physiologica Sinica (China), the Journal of Anesthesiology and Intensive Care (Kazakstan), and Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie (Germany). In addition
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Editors Corner
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